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1. 发明申请

US20070110670A1 Method for evaluating hair damage using an oxidized protein in hair as an indicator 审中-公开
标题翻译：使用毛发中的氧化蛋白作为指标来评价毛发损伤的方法
公开(公告)号：US20070110670A1
公开(公告)日：2007-05-17
申请号：US10581361
申请日：2004-12-08
申请人： Hiroshi Fujita , Sanae Kubo , Masaaki Yasuda , Tetsuji Hirao , Tomoyuki Kawasoe
发明人： Hiroshi Fujita , Sanae Kubo , Masaaki Yasuda , Tetsuji Hirao , Tomoyuki Kawasoe
IPC分类号： A61K49/00 , C12P19/42 , G01N33/48
CPC分类号： G01N33/6842 , G01N21/6428 , G01N33/4833 , G01N33/68
摘要： The present invention provides a method for evaluating hair damage. The method comprises specifically labeling the carbonyl group of an oxidized protein in hair with fluorescence and detecting the fluorescence. The damage can be caused by any of perm treatment, bleach treatment, treatment with an oxidation hairdye, combing, heat treatment, exposure to ultraviolet rays, and exposure to hypochlorous acid in swimming pools, or a combination thereof.
摘要翻译：本发明提供一种评估头发损伤的方法。该方法包括用荧光特异性标记头发中的氧化蛋白质的羰基并检测荧光。损伤可以由烫发处理，漂白处理，氧化发丝处理，梳理，热处理，暴露于紫外线以及暴露于游泳池中的次氯酸或其组合中的任何一种引起。

2. 发明授权

US5352443A Permanent waving composition 失效
标题翻译：永久性挥发性成分
公开(公告)号：US5352443A
公开(公告)日：1994-10-04
申请号：US67346
申请日：1993-05-25
申请人： Sanae Kubo , Thomas M. Schultz
发明人： Sanae Kubo , Thomas M. Schultz
IPC分类号： A61K8/34 , A61K8/44 , A61K8/49 , A61Q5/04 , A61K7/09 , A61K7/11
CPC分类号： A61Q5/04 , A61K8/347 , A61K8/447 , A61K8/49 , A61K8/492 , A61K8/498
摘要： An improved permanent waving lotion is attained by incorporating into an otherwise conventional composition an organic compound having at least one function position definable as an alpha, beta-unsaturated ketone in conjunction with a carbon-carbon double bond. By employing the present invention, improved curl formation is attained and the malodor typically associated with permanently waved hair is substantially eliminated. Compounds incorporating the desired alpha, beta-unsaturated ketone can be used directly, in the permanent waving lotion, or chemical precursors can be employed to produce the desired alpha, beta-unsaturated ketone when exposed to oxidation or to alkaline materials.
摘要翻译：通过将常规组合物掺入具有至少一个可定义为α，β-不饱和酮与碳 - 碳双键的功能位置的有机化合物来获得改进的永久性挥发洗剂。通过使用本发明，获得了改进的卷曲形成，并且基本上消除了通常与永久挥发的头发相关的恶臭。掺入所需α，β-不饱和酮的化合物可直接用于永久性挥发性洗剂，或者化学前体可用于在暴露于氧化或碱性物质时产生所需的α，β-不饱和酮。

3. 发明授权

US4560554A Neutralizer for cold waving 失效
标题翻译：中和器用于寒冷的挥舞
公开(公告)号：US4560554A
公开(公告)日：1985-12-24
申请号：US596225
申请日：1984-04-03
申请人： Sanae Kubo , Emiko Kawada
发明人： Sanae Kubo , Emiko Kawada
IPC分类号： A61K8/00 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61Q5/04 , C07C49/00 , A61K7/09 , A61K7/11
CPC分类号： A61Q5/04 , A61K8/35 , A61K8/355
摘要： A neutralizer for cold waving comprising: (i) an oxidizing agent and (ii) at least one compound selected from the group consisting of the compounds having the general formula (I) to (XII), as follows. ##STR1## wherein --R.sub.1 and --R.sub.2 are independently --CH.sub.3, --CH.sub.2 OH, --CH.sub.2 Cl, --CH.sub.2 Br, --CH.sub.2 I, ##STR2## --CH.sub.2 COOR.sub.6, --CH.sub.2 CH.sub.2 COOR.sub.6, --CH.sub.2 COR.sub.6, --COR.sub.6, ##STR3## --R.sub.3, --R.sub.4, and --R.sub.5 are independently --H, --COR.sub.6, --COOR.sub.6, --Cl, --Br, --I, --NO.sub.2, --OCH.sub.3, --OH, and --COOH;--R.sub.6 is hydrogen atom, or an alkyl or alkenyl group having up to 3 carbon atoms;--R.sub.7 is --H, --OH, or --CH.sub.3 ; and--R.sub.8 is --H, --COCH(CH.sub.3).sub.2, --COCH.dbd.C(CH.sub.3).sub.2, --COCH.sub.3, ##STR4## This neutralizer generates no substantial mercaptan or other unpleasant odor when applied to the hair and forms an elastic and shiny permanent wave.
摘要翻译：一种用于冷挥发的中和剂，包括：（i）氧化剂和（ii）至少一种选自具有通式（I）至（XII）的化合物的化合物，如下所述。其中-R1和-R2独立地是-CH 3，-CH 2 OH，-CH 2 Cl，-CH 2 Br，-CH 2 I，-CH 2 CO 2，-CH 2 COOR 6 ，-CH 2 CH 2 COOR 6，-CH 2 COR 6，-COR 6，R 3，-R 4和-R 5独立地是-H，-COR 6，-COOR 6，-Cl，-Br，-I，-NO 2，-OCH 3，-OH 和-COOH; -R6是氢原子或具有至多3个碳原子的烷基或链烯基; -R 7是-H，-OH或-CH 3; 和-R8is -H，-COCH（CH3）2，-COCH = C（CH3）2，-COCH3，该中和剂在施用于头发时不会产生实质的硫醇或其他令人不快的气味，并形成弹性和闪亮的永久性波。

4. 发明授权

US4548811A Waving lotion for cold waving 失效
标题翻译：挥挥手洗汗
公开(公告)号：US4548811A
公开(公告)日：1985-10-22
申请号：US545817
申请日：1983-10-27
申请人： Sanae Kubo , Fumiaki Nakamura
发明人： Sanae Kubo , Fumiaki Nakamura
IPC分类号： A61K8/00 , A61K8/35 , A61K8/40 , A61K8/46 , A61K8/73 , A61L9/01 , A61Q5/04 , C08L5/16 , A61K7/09 , A61K7/11
CPC分类号： A61Q5/04 , A61K8/35 , A61K8/355 , A61K8/46 , A61K8/738
摘要： A waving lotion for cold waving comprising:(i) a mercapto compound and (ii) an aqueous mixture obtained by heating (a) at least one compound selected from the group consisting of the compounds having the general formulae (I) to (XX), ##STR1## wherein R.sub.1 is hydrogen or an electron attractive group, R.sub.2 is hydrogen or an alkyl group having 1 to 4 carbon atoms, and R.sub.3 is hydrogen, a hydroxyl group, or a methyl group and (b) at least one cyclodextrin selected from the group consisting of .alpha., .beta., .gamma., and .delta.-cyclodextrins in an aqueous phase at a mole ratio of (a):(b)=1:9-1:1 at a temperature of 50.degree. C. to 100.degree. C.This waving lotion has no substantial mercaptan odor and generates no substantial or less of a mercaptan odor when applied to the hair.
摘要翻译：一种用于寒冷挥发的挥发性洗剂，包括：（i）巯基化合物和（ii）通过加热（a）至少一种选自具有通式（I）至（XX）的化合物的化合物的化合物，其中，R 1为氢或吸电子基团，R 2为氢或碳原子数为1〜4的烷基，R 3为氢，羟基或甲基和（b）至少一种选自α，β，γ和δ-环糊精的环糊精，其摩尔比为（a）：（b）= 1：9-1： 1，温度为50℃至100℃。这种挥发性洗剂没有实质的硫醇气味，当施用于头发时不产生显着或更少的硫醇气味。

5. 发明授权

US5199954A Hair coloring dyes incorporating aryl amines and aryl aldehydes 失效
标题翻译：包含芳基胺和芳基醛的染发染料
公开(公告)号：US5199954A
公开(公告)日：1993-04-06
申请号：US840522
申请日：1992-02-25
申请人： Thomas M. Schultz , Catherine Grillo , Sanae Kubo
发明人： Thomas M. Schultz , Catherine Grillo , Sanae Kubo
CPC分类号： A61K8/33 , A61K8/411 , A61Q5/065
摘要： An easily employed, effective and predictable hair dye composition is obtained by combining aryl amines with aryl aldehydes along with an inorganic metal salt having a valence between +1 and +3. By employing this formulation, a permanent, long-lasting, non-fading hair coloring is achieved. In the preferred embodiment, the inorganic metal salt is selected from the group consisting of aluminum chloride, ferric chloride, lithium bromide, manganese chloride, copper chloride, and manganese nitrate. In carrying out the teaching of the present invention, the aryl amine and aryl aldehyde may be applied to the hair separately or in combination, along with the inorganic metal salt. In addition, this inorganic metal salt can be applied after the application and removal of the aryl amine and aryl aldehyde.
摘要翻译：通过将芳基胺与芳基醛以及价数在+1和+3之间的无机金属盐组合，可以获得易于使用，有效和可预测的染发组合物。通过使用这种配方，可实现持久，持久，不褪色的头发着色。在优选的实施方案中，无机金属盐选自氯化铝，氯化铁，溴化锂，氯化锰，氯化铜和硝酸锰。在进行本发明的教导时，可以将芳基胺和芳基醛与无机金属盐一起单独地或组合地施加到头发上。此外，该无机金属盐可以在施加和除去芳基胺和芳基醛之后进行应用。

6. 发明授权

US5637297A Reducing agents for permanent waving of hair 失效
标题翻译：减少头发永久挥发剂
公开(公告)号：US5637297A
公开(公告)日：1997-06-10
申请号：US352386
申请日：1994-12-08
申请人： Andrew Savaides , Edward Borish , Thomas M. Schultz , Sanae Kubo , Adalberto Fleitas
发明人： Andrew Savaides , Edward Borish , Thomas M. Schultz , Sanae Kubo , Adalberto Fleitas
IPC分类号： A61K8/44 , A61K8/46 , A61Q5/04 , A61K7/06 , A61K7/09
CPC分类号： A61Q5/04 , A61K8/447 , A61K8/46
摘要： An improved, highly effective permanent waving lotion is attained by employing a reducing agent which consists of a lower alkyl ester of cysteine in combination with a thiol compound selected from the group consisting of ammonium salts and glyceryl esters of thioglycolic acid, thiolactic acid and thiopropionic acid. By employing the reducing agent of this invention, the pH level at which the permanent wave is performed can be substantially reduced, thereby improving comfort and reducing adverse reactions. The reducing agent of this invention is employed either as an aqueous solution of the two components or in association with desired additives for imparting additional benefits to the permanently waved hair. Preferably, the reducing agents of the present invention are employed in a permanent waving lotion having a pH ranging between about 5.0 and 9.5.
摘要翻译：通过使用由半胱氨酸的低级烷基酯与选自由巯基乙酸的铵盐和甘油酯，硫羟酸和硫代丙酸组成的组的硫醇化合物组成的还原剂，可以获得改进的高效永久性挥发洗剂。通过使用本发明的还原剂，可以显着降低进行永久波的pH值，从而提高舒适性并减少不良反应。本发明的还原剂既可用作两种组分的水溶液，也可用于所需的添加剂，以赋予永久挥发的头发额外的益处。优选地，将本发明的还原剂用于pH在约5.0和9.5之间的永久性挥发性洗剂。

7. 发明授权

US5617883A Reducing agents for permanent waving of hair 失效
标题翻译：减少头发永久挥发剂
公开(公告)号：US5617883A
公开(公告)日：1997-04-08
申请号：US305574
申请日：1994-09-14
申请人： Andrew Savaides , Thomas M. Schultz , Sanae Kubo , Edward Borish
发明人： Andrew Savaides , Thomas M. Schultz , Sanae Kubo , Edward Borish
IPC分类号： A45D7/04 , A45D7/06 , A61K8/20 , A61K8/46 , A61Q5/04 , B01F15/02 , A61K7/09
CPC分类号： A61Q5/04 , A45D7/04 , A61K8/20 , A61K8/46
摘要： A highly effective permanent waving lotion is attained by employing one compound selected from the group consisting of glyceryl monothiopropionate, glyceryl thiolactate, and combinations of glyceryl monothiopropionate and glyceryl thiolactate as the sole reducing agent. In accordance with this invention, the reducing agent is employed either independently in an aqueous solution or in association with desired additives for imparting additional benefits to the permanently waved hair. Preferably, the reducing agents of the present invention are employed in a permanent waving lotion having a pH ranging between about 6.0 and 9.5. In this way, processing time is reduced and long lasting permanently waved hair is attained with substantially less malodor being produced.
摘要翻译：通过使用一种选自甘油单硫代丙酸酯，甘油基硫代乳酸酯和甘油单硫代丙酸甘油酯和甘油基硫代乳酸酯的化合物作为唯一的还原剂，获得了高效的永久性挥发洗剂。根据本发明，还原剂独立地在水溶液中或与所需的添加剂结合使用，以赋予永久挥发的头发额外的益处。优选地，本发明的还原剂用于pH在约6.0和9.5之间的永久性挥发性洗剂。以这种方式，减少处理时间并且持续挥发持久的挥发毛发达到，而产生的恶臭显着减少。

8. 发明授权

US5419895A Composition for treating human hair and method of use 失效
标题翻译：用于治疗人的头发的组合物和使用方法
公开(公告)号：US5419895A
公开(公告)日：1995-05-30
申请号：US921350
申请日：1992-07-29
申请人： Sanae Kubo , Tomiyuki Nanba , Toshihiko Nakane
发明人： Sanae Kubo , Tomiyuki Nanba , Toshihiko Nakane
IPC分类号： A61K8/00 , A61K8/23 , A61K8/44 , A61K8/46 , A61Q5/00 , A61Q5/04 , A61Q5/08 , A61Q5/10 , A61Q9/04 , A61K7/09 , A61K7/06
CPC分类号： A61Q5/04 , A61K8/46
摘要： A composition for treating hair comprised of a thiol compound that is a superior hair reductant and hair cosmetic, especially in terms of waving effect, odor, hair damage, texture and safety and where the thiol compound has the formula HS--(CH2)n--NH--(CH2)-m-NH2 and the n and the m are integers from 1 to 4. The composition may include the salts of the compound. The composition is useful for a method of treating hair by applying the composition to the hair; leaving the composition on the hair for a sufficient period of time, depending on the desired effect; and then removing the composition. The invention, in particular, relates to hair reductants as well as primary agents for permanent waving, pretreatment agents for hair dyeing, cosmetics for heated hair curling, cosmetics for frizzy hair and cosmetics for human hair removing.
摘要翻译：一种用于治疗头发的组合物，其特征在于挥发效果，气味，毛发损伤，质地和安全性，其中硫醇化合物具有优异的毛发还原剂和毛发化妆品，并且其中硫醇化合物具有式HS-（CH 2） NH-（CH 2）m-NH 2，n和m为1至4的整数。该组合物可包括该化合物的盐。该组合物可用于通过将组合物施用于毛发来治疗头发的方法; 取决于期望的效果将组合物留在头发上足够长的时间; 然后除去组合物。本发明特别涉及头发还原剂以及用于永久挥发的初级试剂，用于染发的预处理剂，用于加热卷发的化妆品，用于卷发毛发的化妆品和用于人发脱毛的化妆品。

9. 发明授权

US4547365A Waving lotion for cold waving 失效
标题翻译：挥挥手洗汗
公开(公告)号：US4547365A
公开(公告)日：1985-10-15
申请号：US545816
申请日：1983-10-27
申请人： Sanae Kubo , Fumiaki Nakamura
发明人： Sanae Kubo , Fumiaki Nakamura
IPC分类号： A61K8/00 , A61K8/35 , A61K8/40 , A61K8/46 , A61K8/73 , A61L9/01 , A61Q5/04 , C08L5/16 , A61K7/09 , A61K7/11
CPC分类号： A61Q5/04 , A61K8/35 , A61K8/355 , A61K8/46 , A61K8/738
摘要： An aqueous waving lotion for cold waving comprising:(i) a mercapto compound, (ii) at least one compound selected from the group consisting of the compounds having the general formulae (I) to (XX), ##STR1## wherein R.sub.1 is hydrogen or an electron attractive group, R.sub.2 is hydrogen or an alkyl group having 1 to 4 carbon atoms, and R.sub.3 is hydrogen, a hydroxyl group, or a methyl group, and (iii) a cyclodextrin.This aqueous waving lotion has no substantial mercaptan odor and generates no substantial or less of a mercaptan odor when applied to the hair.
摘要翻译：一种用于冷颤的水性挥发性洗剂，其包含：（i）巯基化合物，（ii）至少一种选自具有通式（I）至（XX）的化合物，（VII）（VII）<图像>（III）（IV）（IV）（V）（VI）（ⅩⅩ）

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