专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

US20240199575A1 COMPOUNDS USEFUL FOR TREATING LIVER DISEASES 审中-公开
公开(公告)号：US20240199575A1
公开(公告)日：2024-06-20
申请号：US18549398
申请日：2022-03-08
申请人： ABIONYX PHARMA SA
发明人： Jean-Louis Henri Dasseux
IPC分类号： C07D401/04 , A61K31/095 , A61K31/4192 , A61K31/426 , A61K31/4439 , A61P3/10 , C07C323/20 , C07D249/06 , C07D277/24
CPC分类号： C07D401/04 , A61K31/095 , A61K31/4192 , A61K31/426 , A61K31/4439 , A61P3/10 , C07C323/20 , C07D249/06 , C07D277/24
摘要： This invention provides compounds, for example, of Formulae (A)-(H) and (J)-(AA) and pharmaceutically acceptable salts, solvates, esters, amides, and prodrugs thereof. The invention further provides pharmaceutical compositions comprising a compound of the invention, and a pharmaceutically acceptable carrier or vehicle. The compounds and compositions disclosed herein are useful for treating or preventing various diseases and conditions, for example liver disease such as liver fibrosis, fatty liver disease, non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH), and kidney diseases such as acute kidney injury (AKI).

2. 发明申请

US20180180998A1 CHEMICALLY AMPLIFIED NEGATIVE RESIST COMPOSITION AND RESIST PATTERN FORMING PROCESS 审中-公开
公开(公告)号：US20180180998A1
公开(公告)日：2018-06-28
申请号：US15854990
申请日：2017-12-27
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Masaaki Kotake , Satoshi Watanabe , Keiichi Masunaga , Kenji Yamada , Masaki Ohashi
IPC分类号： G03F7/038 , G03F7/004 , C07C323/20 , C08F212/14
摘要： A negative resist composition comprising a sulfonium compound having formula (A) and a base polymer is provided. The resist composition exhibits a high resolution during pattern formation and forms a pattern with minimal LER.

3. 发明授权

US09904167B2 Compound, active light sensitive or radiation sensitive resin composition, resist film using same, resist-coated mask blank, photomask, pattern forming method, method for manufacturing electronic device, and electronic device 有权
公开(公告)号：US09904167B2
公开(公告)日：2018-02-27
申请号：US14982759
申请日：2015-12-29
申请人： FUJIFILM Corporation
发明人： Tomotaka Tsuchimura
IPC分类号： G03F7/004 , H01L21/027 , C07D327/08 , C07C309/15 , C07D333/76 , C07C311/16 , C07C327/24 , C07C381/12 , C07D209/48 , C07D333/46 , C07D335/16 , C07D339/08 , C07C311/14 , C07D347/00 , C07C311/48 , C07C311/51 , C07C327/22 , C07C327/26 , C07D493/08 , C07C25/18 , C07J31/00 , C07J41/00 , C07C309/19 , C07C321/28 , C07C323/09 , C07C323/20 , H01L29/16 , G03F7/038 , G03F7/039
CPC分类号： G03F7/0045 , C07C25/18 , C07C309/15 , C07C309/19 , C07C311/14 , C07C311/16 , C07C311/48 , C07C311/51 , C07C321/28 , C07C323/09 , C07C323/20 , C07C327/22 , C07C327/24 , C07C327/26 , C07C381/12 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/18 , C07C2603/24 , C07C2603/74 , C07D209/48 , C07D327/08 , C07D333/46 , C07D333/76 , C07D335/16 , C07D339/08 , C07D347/00 , C07D493/08 , C07J31/006 , C07J41/0055 , C07J41/0061 , G03F1/76 , G03F7/038 , G03F7/0382 , G03F7/0392 , G03F7/0397 , H01L21/0271 , H01L21/0276 , H01L29/16
摘要： Provided is an active light sensitive or radiation sensitive resin composition which contains a compound (A) represented by General Formula (I) or (II): in the formulae, each of Y1 and Y2 represents a monovalent organic group; each of M1+ and M2+ represents an organic onium ion; each of X1 and X2 represents a group that is represented by —S—, —NH—, or —NR1—; R1 represents a monovalent organic group; each of n1 and n2 represents an integer of 1 or more; and R1 and Y1 or Y2 may bond with each other to form a ring.

4. 发明申请

US20170320898A1 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury 审中-公开
公开(公告)号：US20170320898A1
公开(公告)日：2017-11-09
申请号：US15607826
申请日：2017-05-30
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人： Neil Hukriede , Billy W. Day , Lee A. McDermott
IPC分类号： C07F9/48 , C07C323/62 , C07C323/60 , C07C323/52 , C07C323/47 , C07C323/20 , C07C323/16 , C07C321/28 , C07C317/44 , C07D213/75 , C07C317/22
CPC分类号： C07F9/4841 , C07C317/22 , C07C317/44 , C07C321/28 , C07C323/16 , C07C323/20 , C07C323/47 , C07C323/52 , C07C323/60 , C07C323/62 , C07D213/75 , C07F9/3229 , C07F9/5325
摘要： Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.

5. 发明申请

US20150031769A1 METHODS FOR REDUCING TRIGLYCERIDE, TOTAL CHOLESTEROL AND LOW DENSITY LIPOPROTEIN BLOOD LEVELS 审中-公开
公开(公告)号：US20150031769A1
公开(公告)日：2015-01-29
申请号：US14339331
申请日：2014-07-23
申请人： MEDICINOVA, INC.
发明人： Kazuko MATSUDA
IPC分类号： C07C323/22 , C07C323/20
CPC分类号： A61K31/192 , C07C323/22
摘要： A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for reducing blood levels of one or more of triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) in human subjects.

6. 发明申请

US20120135823A1 METHOD FOR SELECTING ORGANIC SULFUR COMPOUND FOR GOLF BALL, METHOD FOR PRODUCING GOLF BALL, AND GOLF BALL 有权
标题翻译：选择高尔夫球有机硫化合物的方法，生产高尔夫球的方法和高尔夫球
公开(公告)号：US20120135823A1
公开(公告)日：2012-05-31
申请号：US13277656
申请日：2011-10-20
申请人： Ayaka HIBI , Chiemi Mikura , Kazuhisa Fushihara , Yumi Kanemitsu , Mikio Yamada
发明人： Ayaka HIBI , Chiemi Mikura , Kazuhisa Fushihara , Yumi Kanemitsu , Mikio Yamada
IPC分类号： A63B37/06 , C07C323/22 , A63B37/02 , C07C323/32 , C07C323/20 , C08F136/06 , C07C323/09 , C07C323/62
CPC分类号： A63B37/02 , A63B37/0003 , A63B37/0039 , A63B37/0051 , A63B37/0073 , A63B37/0074 , A63B37/0076 , A63B45/00 , C08K5/375 , C08L21/00
摘要： An object of the present invention is to provide a golf ball having high resilience. The gist of the present invention resides in selecting an organic sulfur compound used for a golf ball rubber composition containing (a) a base rubber, (b) a co-crosslinking agent, (c) a crosslinking initiator, and (d) the organic sulfur compound from organic sulfur compounds having specific structures such that a sum of substituent constants of the substituents X in a structure represented by the following formula (4) is 0.2 or more and SP value of the structure represented by the following formula (4) is in a range from 19.0 (J/cm3) using the same.
摘要翻译：本发明的目的是提供一种具有高弹性的高尔夫球。本发明的要点在于选择用于高尔夫球橡胶组合物的有机硫化合物，其含有（a）基础橡胶，（b）共交联剂，（c）交联引发剂，和（d）有机具有特定结构的有机硫化合物的硫化合物使得由下式（4）表示的结构中的取代基X的取代常数之和为0.2以上，由下式（4）表示的结构的SP值为在19.0（J / cm3）的范围内。

7. 发明申请

US20110110886A1 SMALL MOLECULE INHIBITORS OF AUTOTAXIN AND METHODS OF USE 审中-公开
标题翻译：自由基的小分子抑制剂及其使用方法
公开(公告)号：US20110110886A1
公开(公告)日：2011-05-12
申请号：US12993397
申请日：2009-06-15
申请人： Demetrios Braddock
发明人： Demetrios Braddock
IPC分类号： A61K31/675 , C07F9/6558 , C07F9/655 , C07C39/15 , C07D311/86 , C07C323/20 , C07D327/08 , C07F9/74 , C07C63/331 , A61K31/665 , A61K31/055 , A61K31/352 , A61K31/10 , A61K31/39 , A61K31/285 , A61K31/194 , A61P35/00 , A61P35/02 , A61K39/395 , A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/506 , A61K38/20 , A61K38/46 , A61K33/24 , A61K38/21
CPC分类号： A61K31/047 , A61K31/10 , A61K31/352 , A61K45/06 , A61K2300/00
摘要： Autotaxin (ATX) is a prometastatic enzyme initially isolated from the conditioned media of human melanoma cells that stimulates a myriad of biological activities including angiogenesis and the promotion of cell growth, survival, and differentiation through the production of lysophosphatidic acid (LPA). ATX increases the aggressiveness and invasiveness of transformed cells, and ATX levels directly correlate with tumor stage and grade in several human malignancies. To study the role of ATX in the pathogenesis of malignant melanoma, we developed antibodies and small molecule inhibitors against recombinant human protein. Immunohistochemistry of paraffin embedded human tissue demonstrates that ATX levels are markedly increased in human primary and metastatic melanoma relative to benign nevi. Chemical screens identified several small molecule inhibitors with binding constants ranging from nanomolar to low micromolar. Cell migration and invasion assays with melanoma cell lines demonstrate that ATX markedly stimulates melanoma cell migration and invasion, an effect suppressed by ATX inhibitors. The migratory phenotype can be rescued by the addition of ATX's enzymatic product, LPA, confirming that the observed inhibition is linked to suppression of LPA production by ATX. Chemical analogues of the inhibitors demonstrate structure activity relationships important for ATX inhibition and indicate pathways for their optimization. These studies suggest that ATX is an approachable molecular target for the rational design of chemotherapeutic agents directed against human malignancies driven by the ATX/LPA axis, especially including malignant melanoma, among numerous others including breast and ovarian cancers.
摘要翻译： Autotaxin（ATX）是最初从人类黑素瘤细胞的条件培养基中分离出来的一种前导酶，它刺激无数的生物学活性，包括血管生成和通过产生溶血磷脂酸（LPA）促进细胞生长，存活和分化。 ATX增加转化细胞的侵袭性和侵袭性，ATX水平与几种人类恶性肿瘤的肿瘤分期和分级直接相关。为了研究ATX在恶性黑色素瘤发病机制中的作用，我们开发了针对重组人蛋白质的抗体和小分子抑制剂。石蜡包埋的人体组织的免疫组织化学证实，相对于良性痣，人原发性和转移性黑素瘤中ATX水平显着增加。化学筛选出几种具有纳摩尔至低微摩尔浓度的结合常数的小分子抑制剂。细胞迁移和黑色素瘤细胞系侵袭测定表明ATX显着刺激黑素瘤细胞迁移和侵袭，这是ATX抑制剂抑制的作用。迁移表型可以通过添加ATX的酶产物LPA来拯救，证实观察到的抑制与ATX产生的LPA抑制有关。抑制剂的化学类似物表现出对ATX抑制重要的结构活性关系，并指示其优化途径。这些研究表明ATX是针对ATX / LPA轴驱动的人类恶性肿瘤的化学治疗剂的合理设计的一个平易近人的分子靶点，特别是包括恶性黑素瘤，其中包括乳腺癌和卵巢癌。

8. 发明授权

US06964983B2 Compounds that modulate PPAR activity and methods for their preparation 失效
公开(公告)号：US06964983B2
公开(公告)日：2005-11-15
申请号：US10979629
申请日：2004-11-02
申请人： Bruce J. Auerbach , Larry D. Bratton , Gary F. Filzen , Andrew G. Geyer , Bharat K. Trivedi , Paul C. Unangst
发明人： Bruce J. Auerbach , Larry D. Bratton , Gary F. Filzen , Andrew G. Geyer , Bharat K. Trivedi , Paul C. Unangst
IPC分类号： A61K31/19 , A61K31/192 , A61K31/353 , A61K31/381 , A61K31/404 , A61K31/4168 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/4245 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/4525 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/00 , A61P43/00 , C07C27/02 , C07C51/09 , C07C59/135 , C07C59/70 , C07C59/72 , C07C315/04 , C07C317/22 , C07C319/20 , C07C323/19 , C07C323/20 , C07C323/21 , C07D209/10 , C07D211/14 , C07D211/18 , C07D213/20 , C07D213/30 , C07D213/32 , C07D231/12 , C07D233/68 , C07D235/18 , C07D261/08 , C07D271/06 , C07D271/10 , C07D295/092 , C07D307/79 , C07D311/58 , C07D333/54 , C07D405/06 , C07D405/10 , C07D405/12 , C07D413/04 , C07D413/12 , C07D521/00 , C07C51/00
CPC分类号： C07C323/20 , C07C59/70 , C07C59/72 , C07C317/22 , C07C323/19 , C07C2602/08 , C07C2603/18 , C07D209/10 , C07D211/14 , C07D213/30 , C07D213/32 , C07D231/12 , C07D233/56 , C07D233/68 , C07D235/18 , C07D249/08 , C07D261/08 , C07D271/06 , C07D271/10 , C07D295/088 , C07D307/79 , C07D311/58 , C07D333/54 , C07D405/12 , C07D413/04 , C07D413/12
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of supressing appetite and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.

9. 发明申请

US20050234125A1 Alpha-sulfonylamino-acetonitriles 有权
公开(公告)号：US20050234125A1
公开(公告)日：2005-10-20
申请号：US10517977
申请日：2003-06-18
申请人： Martin Eberle , Daniel Stierli , Urs Muller
发明人： Martin Eberle , Daniel Stierli , Urs Muller
IPC分类号： A01N41/06 , A01N41/10 , A01N43/16 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/78 , A01N43/824 , A01N43/836 , A01N47/16 , A01N47/38 , C07C303/38 , C07C303/40 , C07C311/13 , C07C317/20 , C07C323/20 , C07D207/26 , C07D207/27 , C07D213/30 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/12 , C07D233/54 , C07D233/60 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/60 , C07D241/42 , C07D249/08 , C07D271/10 , C07D277/20 , C07D277/24 , C07D277/34 , C07D277/36 , C07D277/42 , C07D285/08 , C07D285/12 , C07D295/18 , C07D295/205 , C07D295/215 , C07D311/16 , A01N37/34 , C07C317/32
CPC分类号： C07D207/27 , A01N41/06 , A01N43/36 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/653 , A01N43/78 , C07C311/13 , C07C317/20 , C07C323/20 , C07D213/30 , C07D213/643 , C07D213/85 , C07D231/12 , C07D233/54 , C07D239/26 , C07D239/42 , C07D239/60 , C07D241/42 , C07D249/08 , C07D271/10 , C07D277/24 , C07D277/34 , C07D277/36 , C07D277/42 , C07D285/08 , C07D285/12 , C07D295/205 , C07D295/215
摘要： The invention relates to α-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally substituted aryl or heteroaryl group, R1, and R2 stand independently of each other for hydrogen, optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R3 designates hydrogen, C3-C5alkenyl, C3-C5alkynyl or optionally substituted C1,-C5alkyl; R4 is optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R5 and R6 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R7, and R8 are independently of each other hydrogen or optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; W designates a bridge selected from —O— —S(O)m- or —NR3—; X designates a direct bond or a bridge selected from —O—, —S(O)m- or —NR3—; a and b independently of each other stand for a number 1, 2 or 3; and c and m independently of each other stand for a number zero, 1 or 2. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

10. 发明申请

US20050119504A1 New process for the preparation of a biphenyl ether compound 审中-公开
标题翻译：制备联苯醚化合物的新方法
公开(公告)号：US20050119504A1
公开(公告)日：2005-06-02
申请号：US10945001
申请日：2004-09-20
申请人： Christopher Ashcroft , Lynsey Hesmondhalgh , Iain Gladwell , Laurence Harris , Michael Hughes , Juergen Klotz , Philip Levett , Matthew Morland , Nicholas Thomson
发明人： Christopher Ashcroft , Lynsey Hesmondhalgh , Iain Gladwell , Laurence Harris , Michael Hughes , Juergen Klotz , Philip Levett , Matthew Morland , Nicholas Thomson
IPC分类号： C07C311/18 , C07C319/20 , C07C323/20
CPC分类号： C07C323/20 , C07C319/20
摘要： The present invention is concerned with an improved process for the preparation of the selective serotonin reuptake inhibitor 3-[(Dimethylamino)methyl]-4-[4-(methylsulfanyl)phenoxy]benzenesulfonamide (L) or (D) tartrate (I) and with intermediate products therein.
摘要翻译：本发明涉及制备选择性5-羟色胺再摄取抑制剂3 - [（二甲基氨基）甲基] -4- [4-（甲硫基）苯氧基]苯磺酰胺（L）或（D）酒石酸盐（I）和其中具有中间产品。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式