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1. 发明授权

US11976219B2 Photo-cleavable primer compositions and methods of use 有权
公开(公告)号：US11976219B2
公开(公告)日：2024-05-07
申请号：US17865683
申请日：2022-07-15
申请人： Ormco Corporation
发明人： Byung Jun Ahn , Bruce H. Lipshutz , Sam L. Nguyen , Roscoe Linstadt
IPC分类号： C09D7/63 , A61K6/20 , A61K6/62 , A61K6/65 , A61K6/78 , B05D3/00 , B05D3/10 , C07C69/01 , C07C205/42 , C07C205/43 , C07C235/06 , C07C235/20 , C07C271/16 , C07D217/16 , C07F7/08 , C07F9/12 , C07F9/62 , C09D5/00 , C08K5/107 , C08K5/13
CPC分类号： C09D7/63 , A61K6/20 , A61K6/62 , A61K6/65 , A61K6/78 , B05D3/002 , B05D3/10 , B05D3/107 , C07C69/01 , C07C205/42 , C07C205/43 , C07C235/06 , C07C235/20 , C07C271/16 , C07D217/16 , C07F7/0896 , C07F9/12 , C07F9/62 , C09D5/002 , C08K5/107 , C08K5/13 , A61K6/30 , C08L33/10 , A61K6/40 , C08L33/10
摘要： In one embodiment, the present application discloses a photo-cleavable surface binding compound of the Formula I and Formula II:

wherein the variables EG, EG1, SP1, SP2, SP3, Ar and BG are as defined herein. In another embodiment, the application discloses a method for forming a coating on a surface of a substrate using the surface binding compound.

2. 发明授权

US11739223B2 Surface primer compositions and methods of use 有权
公开(公告)号：US11739223B2
公开(公告)日：2023-08-29
申请号：US17740350
申请日：2022-05-10
申请人： Envista
发明人： Byung Jun Ahn , Bruce H. Lipshutz , Sam L. Nguyen
IPC分类号： C09D7/63 , C09D5/00 , A61K6/65 , A61K6/20 , A61K6/62 , A61K6/78 , B05D3/00 , B05D3/10 , C07C69/01 , C07C205/42 , C07C205/43 , C07C235/06 , C07C235/20 , C07C271/16 , C07D217/16 , C07F7/08 , C07F9/12 , C07F9/62 , C08K5/107 , C08K5/13
CPC分类号： C09D5/002 , A61K6/20 , A61K6/62 , A61K6/65 , A61K6/78 , B05D3/002 , B05D3/10 , B05D3/107 , C07C69/01 , C07C205/42 , C07C205/43 , C07C235/06 , C07C235/20 , C07C271/16 , C07D217/16 , C07F7/0896 , C07F9/12 , C07F9/62 , C09D7/63 , C08K5/107 , C08K5/13
摘要： In one embodiment, the present application discloses a surface binding compound of the Formula I or Formula II:

wherein the variables EG, EG1, SP1, SP2, SP3, Ar and BG are as defined herein. In another embodiment, the application discloses a method for forming a coating on a surface of a substrate using the surface binding compound of the Formula I or Formula II.

3. 发明公开

US20230212113A1 AFFINITY ILLUDOFULVENE CONJUGATES 审中-公开
公开(公告)号：US20230212113A1
公开(公告)日：2023-07-06
申请号：US18175495
申请日：2023-02-27
申请人： AF Chemicals, LLC,
发明人： MICHAEL KELNER
IPC分类号： C07C317/44 , C07C225/14 , A61K38/06 , C07K5/083 , A61K31/4015 , C07K5/062 , A61K31/265 , C07D207/444 , A61K31/215 , A61K31/27 , A61K47/54 , A61K38/05 , C07C271/34 , C07C309/72 , C07C311/16 , A61K31/255 , C07C205/42
CPC分类号： C07C317/44 , C07C225/14 , A61K38/06 , C07K5/0806 , A61K31/4015 , C07K5/06052 , A61K31/265 , C07K5/06026 , C07D207/444 , A61K31/215 , A61K31/27 , A61K47/554 , A61K38/05 , C07C271/34 , C07C309/72 , C07C311/16 , A61K31/255 , C07C205/42 , C07C2603/94
摘要： In an embodiment of the invention, a composition for treating a cell population comprises a medicant. The medicant moiety can be an illudofulvene analog. In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The affinity moiety can be an antibody, an antibody fragment, a receptor protein, a peptidic growth factor, an anti-angiogenic protein, a specific binding peptide, protease cleavable peptide, a glycopeptide, a peptide, a peptidic toxin, a protein toxin and an oligonucleotide. The affinity moiety can be covalently bound to the medicant via a linker.

4. 发明授权

US11453790B2 Photo-cleavable primer compositions and methods of use 有权
公开(公告)号：US11453790B2
公开(公告)日：2022-09-27
申请号：US16877097
申请日：2020-05-18
申请人： Envista
发明人： Byung Jun Ahn , Bruce H. Lipshutz , Sam L. Nguyen , Roscoe Linstadt
IPC分类号： C09D7/63 , C09D5/00 , C07C205/43 , A61K6/20 , A61K6/62 , A61K6/65 , A61K6/78 , B05D3/10 , C07C69/01 , C07C205/42 , C07C235/06 , C07C271/16 , C07F7/08 , C07F9/12 , B05D3/00 , C07C235/20 , C07D217/16 , C07F9/62 , C08K5/13 , C08K5/107
摘要： In one embodiment, the present application discloses a photo-cleavable surface binding compound of the Formula I and Formula II: wherein the variables EG, EG1, SP1, SP2, SP3, Ar and BG are as defined herein. In another embodiment, the application discloses a method for forming a coating on a surface of a substrate using the surface binding compound.

5. 发明申请

US20050148801A1 Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for producing thereof 有权
标题翻译：光学活性硝基醇衍生物，光学活性氨基醇衍生物及其制备方法
公开(公告)号：US20050148801A1
公开(公告)日：2005-07-07
申请号：US11044223
申请日：2005-01-28
申请人： Masakatsu Shibasaki , Hiroaki Sasai , Yasuo Urata , Mamoru Fujita
发明人： Masakatsu Shibasaki , Hiroaki Sasai , Yasuo Urata , Mamoru Fujita
IPC分类号： C07C201/12 , C07C205/16 , C07C205/17 , C07C205/37 , C07C205/42 , C07C213/02 , C07C217/10 , C07C217/70 , C07C219/30 , C07D317/54 , C07D319/08 , C07F7/18 , C07C25/16
CPC分类号： C07D319/08 , B01J31/223 , B01J2231/342 , B01J2531/0266 , B01J2531/37 , B01J2531/38 , C07B2200/07 , C07C205/16 , C07C205/17 , C07C205/35 , C07C205/37 , C07C205/40 , C07C205/42 , C07C213/02 , C07C215/60 , C07C217/10 , C07C217/70 , C07C219/30 , C07D317/54 , C07F7/1804 , C07F7/1892
摘要： Optically active 1-substituted phenyl-2-nitro alcohol derivatives having the formula (1) and the process for producing thereof, and 1-substituted phenyl-2-amino alcohol derivatives having the formula (2) and the process for producing thereof from the optically active 1-substituted phenyl-2-nitro alcohol derivatives. From these nitro alcohols, pharmaceuticals such as (R)-albutamin and (R)-sarmeterol useful as a bronchodilator is obtained via optically active amino alcohols which are useful pharmaceutical intermediates.
摘要翻译：具有式（1）的光学活性1-取代苯基-2-硝基醇衍生物及其制备方法和具有式（2）的1-取代苯基-2-氨基醇衍生物及其制备方法光学活性的1-取代苯基-2-硝基醇衍生物。通过这些硝基醇，可以通过作为有用的药物中间体的光学活性氨基醇获得用作支气管扩张剂的（R） - 丁二胺和（R） - 三异胺的药物。

6. 发明授权

US6166074A Pharmaceutical compositions 失效
标题翻译：药物组合物
公开(公告)号：US6166074A
公开(公告)日：2000-12-26
申请号：US669407
申请日：1996-10-04
申请人： Erik Olai Pettersen , Rolf Olaf Larsen , John Michael Dornish , Bernt B.o slashed.rretzen , Reidar Oftebro , Thomas Ramdahl , Vidar Moen
发明人： Erik Olai Pettersen , Rolf Olaf Larsen , John Michael Dornish , Bernt B.o slashed.rretzen , Reidar Oftebro , Thomas Ramdahl , Vidar Moen
IPC分类号： C07D317/34 , A61K31/19 , A61K31/22 , A61K31/235 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61P35/00 , A61P43/00 , C07C205/42 , C07C255/55 , C07D213/30 , C07D307/46 , C07D307/71 , C07D333/16 , A01N37/10
CPC分类号： A61K31/38 , A61K31/22 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/44
摘要： Pharmaceutical compositions which are useful for the treatment of cancer or illnesses which arise due to an abnormally elevated cell proliferation comprise acyl derivatives of aromatic aldehydes, especially arylidene diesters and .alpha.-alkoxyarylidene esters of general formula (I). ##STR1##
摘要翻译： PCT No.PCT / NO95 / 00003 Sec。 371日期1996年10月4日第 102（e）日期1996年10月4日PCT 1995年1月3日PCT PCT。 WO95 / 18607 PCT出版物日期1995年7月13日可用于治疗由于异常升高的细胞增殖而引起的癌症或疾病的药物组合物包括芳族醛，特别是亚芳基二酯和通式（I）的α-烷氧基亚芳基酯的酰基衍生物。

7. 发明授权

US5733479A Positive photoactive compounds based on 2,6-dinitro benzyl groups 失效
标题翻译：基于2,6-二硝基苄基的阳性光活性化合物
公开(公告)号：US5733479A
公开(公告)日：1998-03-31
申请号：US685062
申请日：1996-07-22
申请人： Charles F. Kahle, II , Neil D. McMurdie , Raphael O. Kollah , Daniel E. Rardon , Gregory J. McCollum
发明人： Charles F. Kahle, II , Neil D. McMurdie , Raphael O. Kollah , Daniel E. Rardon , Gregory J. McCollum
IPC分类号： C07C201/08 , A61K9/00 , A61K9/32 , C07C201/12 , C07C205/11 , C07C205/19 , C07C205/23 , C07C205/26 , C07C205/34 , C07C205/42 , C07C215/14 , C07C271/08 , C07C301/00 , C07C309/67 , C07C309/73 , C07C319/14 , C07C323/16 , C07C323/25 , C07C323/29 , C08G18/38 , C08G59/50 , C08G63/685 , C08L101/00 , C09D163/00 , G03F7/00 , G03F7/004 , G03F7/039 , G03F7/16 , C09K15/16
CPC分类号： C07C323/25 , A61K9/0004 , C07C205/11 , C07C205/19 , C07C205/26 , C07C215/14 , C08G18/384 , C08G59/50 , C08G59/504 , C08G63/6856 , C09D163/00 , G03F7/0045 , G03F7/039 , G03F7/164
摘要： Photoreactive compounds are synthesized from 2,5- or 2,6-dinitrobenzyl groups. Also disclosed are methods of synthesizing reactive monomers containing 2,5- or 2,6-dinitrobenzyl groups.
摘要翻译：光反应性化合物由2,5-或2,6-二硝基苄基合成。还公开了合成含有2,5-或2,6-二硝基苄基的反应性单体的方法。

8. 发明授权

US5714628A Preparation of glutaric acid derivatives 失效
标题翻译：戊二酸衍生物的制备
公开(公告)号：US5714628A
公开(公告)日：1998-02-03
申请号：US672682
申请日：1996-06-28
申请人： Stephen Challenger
发明人： Stephen Challenger
IPC分类号： C07C67/42 , C07C69/757 , C07C205/42 , C07C69/74
CPC分类号： C07C67/42 , C07C201/12 , C07C69/757
摘要： The invention provides a process for preparing a compound of the formula: ##STR1## or a base salt thereof, wherein R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl optionally substituted by up to 3 substituents each independently selected from the group consisting of C.sub.1 -C.sub.6 alkoxy and C.sub.1 -C.sub.6 alkoxy(C.sub.1 -C.sub.6 alkoxy)-; and R.sup.3 is C.sub.1 -C.sub.6 alkyl or benzyl, said benzyl group being optionally ring-substituted by up to 2 nitro or C.sub.1 -C.sub.4 alkoxy substituents. comprising reacting a compound of the formula: ##STR2## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl, phenyl or benzyl or C.sub.1 -C.sub.4 alkoxy; and R.sup.2 and R.sup.3 are as previously defined for a compound of the formula (I), with hydrogen peroxide or a source of peroxide ions: said process being optionally followed by conversion of the compound of the formula (I) to a base salt thereof. The present invention also relates to novel compounds of the formula (II).
摘要翻译：本发明提供了制备下式化合物或其碱盐的方法：其中R 2为氢或任选被至多3个取代基取代的C 1 -C 6烷基，所述取代基各自独立地选自C1 -C 1-6烷氧基和C 1 -C 6烷氧基（C 1 -C 6烷氧基） - ; 并且R 3是C 1 -C 6烷基或苄基，所述苄基任选被至多2个硝基或C 1 -C 4烷氧基取代基环取代。包括使下式化合物：其中R 1是C 1 -C 4烷基，苯基或苄基或C 1 -C 4烷氧基; 并且R2和R3如先前对于式（I）化合物所定义，与过氧化氢或过氧化物离子的来源：所述方法任选地随后将式（I）化合物转化为其碱式盐。本发明还涉及新的式（II）化合物。

9. 发明授权

US4996314A 6-(disubstituted amino)carbapenem compounds 失效
标题翻译： 6-（二取代氨基）碳青霉烯化合物
公开(公告)号：US4996314A
公开(公告)日：1991-02-26
申请号：US246071
申请日：1988-09-19
申请人： Takeo Yoshioka , Noritaka Chida , Azuma Watanabe , Yasuo Fukagawa , Tomoyuki Ishikura
发明人： Takeo Yoshioka , Noritaka Chida , Azuma Watanabe , Yasuo Fukagawa , Tomoyuki Ishikura
IPC分类号： C07D477/00 , C07C205/42 , C07D205/085 , C07D403/04 , C07D477/24
CPC分类号： C07D403/04 , C07C205/42 , C07D205/085 , C07D477/24 , Y02P20/55
摘要： A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic.The compounds of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.

10. 发明授权

US4778914A Chemical intermediates 失效
标题翻译：化学中间体
公开(公告)号：US4778914A
公开(公告)日：1988-10-18
申请号：US831061
申请日：1986-02-19
申请人： David Cartwright , David J. Collins
发明人： David Cartwright , David J. Collins
IPC分类号： A01N37/40 , A01N37/46 , A01N37/48 , A01N41/06 , A01N43/40 , A01N43/88 , A01N47/30 , C07C17/093 , C07C37/045 , C07C37/055 , C07C65/24 , C07C205/26 , C07C205/42 , C07C205/43 , C07C205/59 , C07C69/76
CPC分类号： C07C255/00 , A01N37/40 , A01N37/46 , A01N37/48 , A01N41/06 , A01N43/40 , A01N43/88 , A01N47/30 , C07C17/093 , C07C205/26 , C07C205/42 , C07C205/43 , C07C205/59 , C07C37/045 , C07C37/055 , C07C65/24
摘要： Herbicidal mixtures comprising (1) a diphenyl ether of the formula: ##STR1## or a salt thereof, wherein R.sup.1 is, for example, alkyl; R.sup.2 is hydrogen, halogen or nitro; R.sup.3 is hydrogen, halogen, alkyl, trifluoromethyl or cyano; R.sup.4 is hydrogen, halogen or trifluoromethyl; R.sup.5 is hydrogen, halogen or trifluoromethyl and R.sup.6 is hydrogen or alkyl of 1 to 6 carbons and (2) another herbicide not of formula (I). Intermediates for preparing the formula (I) compounds and processes for using these compounds are also disclosed.
摘要翻译：包含（1）下式的二苯醚或其盐的除草混合物，其中R 1是例如烷基; R2是氢，卤素或硝基; R3是氢，卤素，烷基，三氟甲基或氰基; R4是氢，卤素或三氟甲基; R5是氢，卤素或三氟甲基，R6是氢或1-6个碳的烷基，和（2）不是式（I）的另一除草剂。还公开了用于制备式（I）化合物的中间体和使用这些化合物的方法。

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