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1. 发明授权

US4918172A Anthracycline antibiotics 失效
标题翻译：蒽环类抗生素
公开(公告)号：US4918172A
公开(公告)日：1990-04-17
申请号：US252636
申请日：1988-10-03
申请人： Akihiro Yoshimoto , Osamu Jodo , Yoshio Watanabe , Rokuro Okamoto , Tomoyuki Ishikura , Hiroshi Naganawa , Tsutomu Sawa , Tomio Takeuchi
发明人： Akihiro Yoshimoto , Osamu Jodo , Yoshio Watanabe , Rokuro Okamoto , Tomoyuki Ishikura , Hiroshi Naganawa , Tsutomu Sawa , Tomio Takeuchi
IPC分类号： C07H15/252
CPC分类号： C07H15/252
摘要： Disclosed are anthracycline antibiotics of a formula (I): ##STR1## in which R.sup.1 and R.sup.2 are hydroxyl groups, R.sup.3 is ethyl group, R.sup.4 is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1 and R.sup.2 are hydroxyl groups, R.sup.3 is 1-hydroxyethyl group, R.sup.4 is hydrogen atom and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1, R.sup.2 and R.sup.4 are hydroxyl groups, R.sup.3 is ethyl group and X represents daunosamine-rhodenose, daunosamine-deoxyfucose, rhodosamine-rhodenose, N-monomethyldaunosamine-rhodenose or N-monomethyldaunosamine-deoxyfucose; orR.sup.1 is methoxy group, R.sup.2 is hydroxyl group, R.sup.3 is ethyl group, R.sup.4 is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1 and R.sup.4 are hydroxy groups, R.sup.2 is hydrogen atom, R.sup.3 is ethyl group and X represents daunosamine-deoxyfucose, as well as pharmaceutically acceptable acid addition salts thereof. The antibiotics (I) have a carcinostatic activity and are useful as a carcinostatic for murine leukemia L1210 cells in culture.

2. 发明授权

US4592999A Process for producing daunomycin 失效
标题翻译：生产道诺霉素的方法
公开(公告)号：US4592999A
公开(公告)日：1986-06-03
申请号：US514678
申请日：1983-07-18
申请人： Hamao Umezawa , Tomio Takeuchi , Kageaki Kouno , Tomoyuki Ishikura , Akihiro Yoshimoto , Yukio Takatsuki , Hiroyasu Tobe
发明人： Hamao Umezawa , Tomio Takeuchi , Kageaki Kouno , Tomoyuki Ishikura , Akihiro Yoshimoto , Yukio Takatsuki , Hiroyasu Tobe
IPC分类号： C12P17/06 , C07H15/252 , C12P19/56 , C12R1/465
CPC分类号： C07H15/252 , C12P19/56 , C12R1/465 , Y10S435/886
摘要： This invention is to provide a new microbial process for producing daunomycin by a mutant strain belonging to the genus Streptomyces.
摘要翻译：本发明提供一种用于通过属于链霉菌属的突变菌株生产道诺霉素的新的微生物方法。

3. 发明授权

US4517127A .beta.-Lactam derivatives and process for production thereof 失效
标题翻译： β-内酰胺衍生物及其制备方法
公开(公告)号：US4517127A
公开(公告)日：1985-05-14
申请号：US559681
申请日：1983-12-09
申请人： Takeo Yoshioka , Kenichi Yamamoto , Yasuo Fukagawa , Yasutaka Shimauchi , Tomoyuki Ishikura
发明人： Takeo Yoshioka , Kenichi Yamamoto , Yasuo Fukagawa , Yasutaka Shimauchi , Tomoyuki Ishikura
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/42 , A61P31/04 , C07D477/10 , C07D487/00 , C07D487/04
CPC分类号： C07D477/10
摘要： A compound represented by the following formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxyl group, R.sub.2 represents a group of the formula --CH.sub.2 NO.sub.2, --CN.fwdarw.O or ##STR2## in which A represents a group of the formula ##STR3## in which R.sub.4 represents a hydrogen atom or an alkoxycarbonyl group, R.sub.5 represents a phenyl, alkoxycarbonyl or alkanoyloxymethyl group, R.sub.6 represents an alkyl group and R.sub.7 represents a phenyl, naphthyl, pyridyl, furyl or thienyl group; and R.sub.3 represents a hydrogen atom or a substituted or unsubstituted hydrocarbon group, and a process for production thereof.
摘要翻译：由下式表示的化合物：其中R1表示氢原子或羟基，R2表示式-CH2NO2，-CN-> O或其中A表示式其中R 4表示氢原子或烷氧基羰基，R 5表示苯基，烷氧基羰基或烷酰氧基甲基，R 6表示烷基，R 7表示苯基，萘基，吡啶基，呋喃基或噻吩基。 R 3表示氢原子或取代或未取代的烃基，及其制造方法。

4. 发明申请

US20130059375A1 METHOD FOR PREPARING ES CELLS 审中-公开
标题翻译：制备ES细胞的方法
公开(公告)号：US20130059375A1
公开(公告)日：2013-03-07
申请号：US13639059
申请日：2011-04-01
申请人： Haruhiko Koseki , Takanori Hasegawa , Tomoyuki Ishikura , Masashi Matsuda
发明人： Haruhiko Koseki , Takanori Hasegawa , Tomoyuki Ishikura , Masashi Matsuda
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , A01K67/0275 , C12N2501/115 , C12N2501/235 , C12N2501/42 , C12N2501/727 , C12N2501/855
摘要： The present invention provides a method of producing a mammalian ES cell, including cultivating a mammalian inner cell mass in a medium containing adrenocorticotropic hormone, an FGF receptor inhibitor, an MEK activation inhibitor and a GSK3 inhibitor, and isolating a mammalian ES cell from the culture.
摘要翻译：本发明提供一种哺乳动物ES细胞的制备方法，包括在含有促肾上腺皮质激素的培养基，FGF受体抑制剂，MEK活化抑制剂和GSK3抑制剂的培养物中培养哺乳动物内细胞团，并从培养物中分离哺乳动物ES细胞。

5. 发明授权

US4939248A Optically active azetidinones 失效
标题翻译：光学活性氮杂环丁酮
公开(公告)号：US4939248A
公开(公告)日：1990-07-03
申请号：US246826
申请日：1988-08-18
申请人： Takeo Yoshioka , Machiko Watanabe , Yasuo Fukagawa , Tomoyuki Ishikura
发明人： Takeo Yoshioka , Machiko Watanabe , Yasuo Fukagawa , Tomoyuki Ishikura
IPC分类号： C07D405/06 , C07D205/08 , C07D405/04 , C07D521/00
CPC分类号： C07D231/12 , C07D205/08 , C07D233/56 , C07D249/08 , C07D405/04 , Y02P20/55
摘要： This invention provides compounds of the formula ##STR1## wherein Y represents an acetyl, 1-hydroxyethyl or 1-fluoroethyl group, R.sub.1 represents a hydrogen atom or an easily splittable amino-protecting group, and R.sub.2 and R.sub.3 are identical or different and each represents a hydrogen atom, a lower alkyl group, a phenyl group, a benzyl group or a diphenylmethyl group, or R.sub.2 and R.sub.3 together represent a lower alkylene group; and processes for production thereof. These compounds are useful as synthesis intermediates for production of various medicines, particulary carbapenam or carbapenem antibiotics, such as a carbapenem antibiotic of the following formula which has excellent antimicrobial activity and relatively good stability to kidney dehydropeptidase. ##STR2##
摘要翻译： PCT No.PCT / JP87 / 00991 Sec。 371日期1988年8月18日 102（e）日期1988年8月18日PCT Filted 1987年12月18日PCT公布。出版物WO88 / 04656 日本6月30日，1988年。本发明提供式（I）的化合物，其中Y表示乙酰基，1-羟乙基或1-氟乙基，R 1表示氢原子或易裂解的氨基保护基， R2和R3相同或不同，各自表示氢原子，低级烷基，苯基，苄基或二苯基甲基，或R2和R3一起表示低级亚烷基; 及其生产方法。这些化合物可用作生产各种药物，特别是碳青霉烯或碳青霉烯类抗生素的合成中间体，如下式的碳青霉烯类抗生素，其具有优异的抗微生物活性，对肾脱水肽酶具有较好的稳定性。（A）

6. 发明授权

US4438201A Amidohydrolase having ability to depantothenylate an antibiotic 失效
标题翻译：酰胺水解酶具有使抗生素脱苯甲酸化的能力
公开(公告)号：US4438201A
公开(公告)日：1984-03-20
申请号：US394169
申请日：1982-07-01
申请人： Katsuro Kubo , Yasuo Fukagawa , Tomoyuki Ishikura
发明人： Katsuro Kubo , Yasuo Fukagawa , Tomoyuki Ishikura
IPC分类号： C12N9/80 , C12P13/02 , C12P17/18 , C12R1/465
CPC分类号： C12N9/80 , C12P17/184 , Y10S435/886
摘要： A novel enzyme, amidohydrolase, having the ability to depantothenylate antibiotic OA-6129A represented by the following formula ##STR1## but no substantial ability to deacetylate antibiotic PS-5 represented by the following formula ##STR2##
摘要翻译：具有下式（IMAGE）表示的抗生素OA-6129A的脱苯甲酸化的能力的新型的酶酰氨基水解酶，但是没有实质上由下式表示的抗生素PS-5脱乙酰化的能力

7. 发明授权

US4426390A Novel .beta.-lactam compounds, process for producing thereof, and use thereof as medicines 失效
标题翻译：新型β-内酰胺化合物，其制备方法及其作为药物的用途
公开(公告)号：US4426390A
公开(公告)日：1984-01-17
申请号：US306931
申请日：1981-09-29
申请人： Mitsuyasu Okabe , Takeo Yoshioka , Yasuo Fukagawa , Rokuro Okamoto , Kageaki Kouno , Tomoyuki Ishikura
发明人： Mitsuyasu Okabe , Takeo Yoshioka , Yasuo Fukagawa , Rokuro Okamoto , Kageaki Kouno , Tomoyuki Ishikura
IPC分类号： C12P37/00 , C07D477/20 , C12P17/18 , C07D487/04 , A61K31/40
CPC分类号： C07D477/20 , C12P17/184
摘要： A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, --OH or --OSO.sub.3 H, and R.sub.2 represents a hydrogen atom or an unsubstituted or substituted benzyl group; and a salt thereof; processes for production thereof by fermentation; and uses thereof as antimicrobial agents.
摘要翻译：式（I）的化合物，其中R 1表示氢原子，-OH或-OSO 3 H，R 2表示氢原子或未取代或取代的苄基; 及其盐; 通过发酵生产的方法; 并将其用作抗微生物剂。

8. 发明授权

US4424342A Anthracycline antibiotic compounds 失效
标题翻译：蒽环类抗生素化合物
公开(公告)号：US4424342A
公开(公告)日：1984-01-03
申请号：US361175
申请日：1982-03-24
申请人： Toshikazu Oki , Akihiro Yoshimoto , Yasue Matsuzawa , Tomoyuki Ishikura , Hamao Umezawa , Tomio Takeuchi
发明人： Toshikazu Oki , Akihiro Yoshimoto , Yasue Matsuzawa , Tomoyuki Ishikura , Hamao Umezawa , Tomio Takeuchi
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465 , C07H15/24 , A61K31/71
CPC分类号： C07H15/252 , C12P19/56 , C12R1/465
摘要： Disclosed are an antitumor compound having the chemical structure ##STR1## or its acid addition salts; and its preparation method which consists of treating a compound represented by the chemical structure ##STR2## wherein R is a COCH.sub.3 or CH(OH)CH.sub.3 group, by a streptomycetes strain or its mutants.
摘要翻译：公开了具有化学结构（I）或其酸加成盐的抗肿瘤化合物; 及其制备方法，该方法由化学结构（IMAGE）（II）表示的化合物

9. 发明授权

US4996314A 6-(disubstituted amino)carbapenem compounds 失效
标题翻译： 6-（二取代氨基）碳青霉烯化合物
公开(公告)号：US4996314A
公开(公告)日：1991-02-26
申请号：US246071
申请日：1988-09-19
申请人： Takeo Yoshioka , Noritaka Chida , Azuma Watanabe , Yasuo Fukagawa , Tomoyuki Ishikura
发明人： Takeo Yoshioka , Noritaka Chida , Azuma Watanabe , Yasuo Fukagawa , Tomoyuki Ishikura
IPC分类号： C07D477/00 , C07C205/42 , C07D205/085 , C07D403/04 , C07D477/24
CPC分类号： C07D403/04 , C07C205/42 , C07D205/085 , C07D477/24 , Y02P20/55
摘要： A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic.The compounds of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.

10. 发明授权

US4734493A Novel anthracycline antibiotics 失效
标题翻译：新型蒽环类抗生素
公开(公告)号：US4734493A
公开(公告)日：1988-03-29
申请号：US849229
申请日：1986-04-07
申请人： Akihiro Yoshimoto , Osamu Jodo , Yoshio Watanabe , Tomoyuki Ishikura , Tsutomu Sawa , Tomio Takeuchi , Hamao Umezawa
发明人： Akihiro Yoshimoto , Osamu Jodo , Yoshio Watanabe , Tomoyuki Ishikura , Tsutomu Sawa , Tomio Takeuchi , Hamao Umezawa
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/00 , C07H15/252 , C12P19/56 , C12R1/465 , C07H15/24
CPC分类号： C07H15/252
摘要： The antibiotics designated obelmycins exhibit high proliferation inhibiting action against leukemia cells and are effective as anti-cancer agents.
摘要翻译：称为替米yc嗪的抗生素对白血病细胞表现出高增殖抑制作用，作为抗癌剂是有效的。

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