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1. 发明申请

US20040265962A1 Staphylococcus aureus genes & polypeptides 审中-公开
标题翻译：金黄色葡萄球菌基因和多肽
公开(公告)号：US20040265962A1
公开(公告)日：2004-12-30
申请号：US10823785
申请日：2004-04-14
申请人： Human Genome Sciences, Inc.
发明人： Camella Bailey , Gil H. Choi
IPC分类号： C07H021/04 , C12P021/04 , C12N001/21 , C07K014/315
CPC分类号： C12N15/1093 , A61K39/00 , C07K14/31 , C12N15/52
摘要： The present invention relates to novel genes from S. aureus and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of S. aureus polypeptide activity. The invention additionally relates to diagnostic methods for detecting Staphylococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Staphylococcus.
摘要翻译：本发明涉及来自金黄色葡萄球菌的新基因及其编码的多肽。还提供载体，宿主细胞，抗体以及用于制备它们的重组方法。本发明还涉及用于鉴定金黄色葡萄球菌多肽活性的激动剂和拮抗剂的筛选方法。本发明还涉及在生物样品中检测葡萄球菌核酸，多肽和抗体的诊断方法。本发明还涉及用于预防或减轻葡萄球菌感染的新型疫苗。

2. 发明申请

US20040259211A1 Rapid induction of Alzheimer's amyloid plaque formation by sulfated glycosaminoglycans 审中-公开
标题翻译：通过硫酸化糖胺聚糖快速诱导阿尔茨海默氏淀粉样斑块形成
公开(公告)号：US20040259211A1
公开(公告)日：2004-12-23
申请号：US10698259
申请日：2003-10-31
发明人： Beth P. Nguyen , Virginia J. Sanders , Gerardo Castillo , Alan D. Snow , Paula Y. Choi
IPC分类号： A61K031/737 , C12P021/04
CPC分类号： C07K14/4711
摘要： A method of induction of amyloid plaques includes immobilizing a quantity of a selected sulfated glycosaminoglycan (SGAG) on a selected medium and adding to the immobilized SGAG on the medium a quantity of dissolved low fibrillar Anull 1-40 (LFAnull). The LFAnull is added preferably in a Anull:SGAG w/w ratio of about 1:1. SGAGs are preferably selected from heparin, heparan sulfate, keratan sulfate, dermatan sulfate, chondroitin-4-sulfate and chondroitin-6-sulfate. Screening methods and kits for screening either immobilize a quantity of a selected sulfated glycosaminoglycan (SGAG) on a selected medium, followed by adding to a quantity of dissolved low fibrillar Anull 1-40 (LFAnull) a selected quantity of the selected amyloid therapeutic candidate to create a test solution, and then adding to the immobilized SGAG on the medium a selected quantity of the test solution to test for inhibition, or preform amyloid plaques on the medium by immobilizing a quantity of a selected sulfated glycosaminoglycan (SGAG) or a GAG-related macromolecule on a selected medium and then adding a selected quantity of dissolved low fibrillar Anull 1-40 (LFAnull), followed by adding to the amyloid plaques on the medium a selected quantity of a test solution of a selected amyloid therapeutic candidate to test for disruption.
摘要翻译：诱导淀粉样蛋白斑块的方法包括将一定数量的选择的硫酸葡糖胺聚糖（SGAG）固定在选定的培养基上，并向培养基上的固定化SGAG加入一定量的溶解的低纤维Aβ1-40（LFAbeta）。 LFAbeta优选以约1:1的Abeta：SGAG w / w比添加。 SGAG优选选自肝素，硫酸乙酰肝素，硫酸角质素，硫酸皮肤素，硫酸软骨素-4-硫酸盐和硫酸软骨素-6-硫酸盐。用于筛选的筛选方法和试剂盒在选定的培养基上固定一定量的选择的硫酸葡糖胺聚糖（SGAG），然后将一定量的所选择的淀粉样蛋白治疗候选物加入到一定量的溶解的低纤维Aβ1-40（LFAbeta）中产生一个测试溶液，然后在培养基上加入一定量的测试溶液中的固定化SGAG以测试抑制，或者通过将一定量的选择的硫酸糖胺聚糖（SGAG）或GAG- 然后加入选定量的溶解的低纤维Abeta 1-40（LFAbeta），然后向培养基上的淀粉样蛋白斑添加选定量的所选淀粉样蛋白治疗候选物的测试溶液，以测试中断

3. 发明申请

US20040249126A1 Chimeric antigen-specific t cell-activating polypeptides 有权
标题翻译：嵌合抗原特异性t细胞活化多肽
公开(公告)号：US20040249126A1
公开(公告)日：2004-12-09
申请号：US10478179
申请日：2004-06-16
发明人： Esteban Celis
IPC分类号： C07H021/04 , C12P021/04 , C07K014/74 , C12N005/08
CPC分类号： C07K14/811 , A61K39/00 , C07K14/4748 , C07K14/52 , C07K14/70503 , C07K2319/00
摘要： The invention provides an immunogenic or antigenic polypeptide containing a translocation domain, a peptide epitope, at least one biologically active agent, and cleavage sites. These polypeptides are useful for activating T cell responses.
摘要翻译：本发明提供了含有易位结构域，肽表位，至少一种生物活性剂和切割位点的免疫原性或抗原性多肽。这些多肽可用于激活T细胞应答。

4. 发明申请

US20040235118A1 Portions of soluble recombinant botulinum toxins 审中-公开
标题翻译：部分可溶性重组肉毒杆菌毒素
公开(公告)号：US20040235118A1
公开(公告)日：2004-11-25
申请号：US10727898
申请日：2003-12-04
申请人： Allergan, Inc., Allergan Botox Limited
发明人： James A. Williams
IPC分类号： C12P021/04
CPC分类号： C07K14/33 , A61K39/00 , A61K2039/505 , C07K14/245 , C07K16/02 , C07K16/1282 , C07K2317/34 , C07K2319/00 , Y02A50/469
摘要： The present invention includes portions of soluble recombinant botulinum toxins. The invention also includes soluble fusion proteins which may comprise a portion of a botulinum toxin protein and a non-toxin protein sequence.
摘要翻译：本发明包括可溶性重组肉毒杆菌毒素的部分。本发明还包括可能包含一部分肉毒杆菌毒素蛋白质和非毒素蛋白质序列的可溶性融合蛋白。

5. 发明申请

US20040235011A1 Production of multimeric proteins 审中-公开
标题翻译：多聚蛋白的生产
公开(公告)号：US20040235011A1
公开(公告)日：2004-11-25
申请号：US10746943
申请日：2003-12-24
发明人： Richard K. Cooper , William C. Fioretti , Gary G. Cadd
IPC分类号： C12Q001/68 , A01K067/00 , C07H021/04 , C12P021/04
CPC分类号： C07K14/62 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/30 , A01K2267/01 , A23L15/00 , A23V2002/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/00 , C07K16/02 , C07K16/1063 , C07K16/26 , C07K2317/23 , C12N15/85 , C12N15/8509 , C12N2800/90 , C12N2830/003 , C12N2830/008 , C12N2830/90 , C12N2840/20 , A23V2300/21
摘要： The present invention provides a new, effective and efficient method of producing multimeric proteins in an individual. Multimeric proteins include associated multimeric proteins (two or more associated polypeptides) and multivalent multimeric proteins (a single polypeptide encoded by more than one gene of interest). Expression and/or formation of the multimeric protein in the individual is achieved by administering a polynucleotide cassette containing genes of interest that encode portions of the multimeric protein to the individual. The polynucleotide cassette may additionally contain one or more pro sequences, prepro sequences, cecropin prepro sequences, and/or cleavage site sequences.
摘要翻译：本发明提供了在个体中产生多聚体蛋白质的新的，有效的和有效的方法。多聚体蛋白包括相关的多聚体蛋白（两个或更多个相关多肽）和多价多聚体蛋白（由多于一个感兴趣的基因编码的单个多肽）。个体中多聚体蛋白的表达和/或形成是通过向个体施用含有编码多聚体蛋白部分的感兴趣的基因的多核苷酸盒来实现的。多核苷酸盒可另外含有一个或多个前序列，前序列，天蚕素前序列和/或切割位点序列。

6. 发明申请

US20040208890A1 Secreted chlamydia polypeptides, polynucleotides coding therefor, therapeutic and diagnostic uses thereof 审中-公开
标题翻译：分泌衣原体多肽，其编码的多核苷酸，其治疗和诊断用途
公开(公告)号：US20040208890A1
公开(公告)日：2004-10-21
申请号：US10784880
申请日：2004-02-24
申请人： INSTITUT PASTEUR
发明人： Agathe Subtil-Sands , Alice Dautry-Varsat
IPC分类号： C07K014/295 , C07H021/04 , C12P021/04 , A61K039/02 , C12N001/21
CPC分类号： C07K14/295 , A61K38/00 , A61K39/00 , A61K2039/505
摘要： The present invention relates to secreted Chlamydia polypeptides, which may be expressed by a Gram-negative bacterial strain and secreted by the type III secretion pathway of said bacterial strain. The present invention also relates to polynucleotides coding for these polypeptides, as well as to the therapeutic and vaccination uses of these secreted Chlamydia polypeptides.
摘要翻译：本发明涉及分泌的衣原体多肽，其可以由革兰氏阴性菌株表达并且被所述细菌菌株的III型分泌途径分泌。本发明还涉及编码这些多肽的多核苷酸以及这些分泌的衣原体多肽的治疗和接种用途。

7. 发明申请

US20040203117A1 Method of expressing genetically modified protein carrying sugar chain having sialic acid added thereto in insect cells 审中-公开
标题翻译：在昆虫细胞中表达携带唾液酸的携带糖链的转基因蛋白质的方法
公开(公告)号：US20040203117A1
公开(公告)日：2004-10-14
申请号：US10487949
申请日：2004-03-05
发明人： Satoko Watanabe , Takehiro Kokuho , Takayuki Kubota , Shigeki Inumaru
IPC分类号： C07H021/04 , C12P021/04 , C07K014/52
CPC分类号： C12N15/63 , C07K14/555 , C12N2799/026
摘要： Provided is a method of expressing a recombinant protein having sialic acid added thereto in insect cells, which is advantageous in administration to animals. In this method, a recombinant protein carrying a sugar chain having sialic acid added thereto is expressed in an insect or insect cells, including suppressing, inhibiting or eliminating N-acetylglucosaminidase activity inherent in the insect cells.
摘要翻译：提供了在昆虫细胞中表达添加有唾液酸的重组蛋白质的方法，其对于给予动物是有利的。在该方法中，在昆虫或昆虫细胞中表达携带有唾液酸的糖链的重组蛋白，包括抑制或消除昆虫细胞中固有的N-乙酰氨基葡糖苷酶活性。

8. 发明申请

US20040197875A1 Modified cDNA factor VIII and its derivatives 审中-公开
标题翻译：修饰的cDNA因子VIII及其衍生物
公开(公告)号：US20040197875A1
公开(公告)日：2004-10-07
申请号：US10721997
申请日：2003-11-26
发明人： Hans-Peter Hauser , Thomas Weimer , Martin Phillips
IPC分类号： C12P021/04 , C07H021/04 , C07K014/745
CPC分类号： A61K38/37 , C07K14/755
摘要： Modified human factor VIII cDNA wherein mutations are inserted either in the wild-type factor VIII cDNA or in a factor VIII cDNA in which the B-domain is partially or completely deleted and may be replaced by a DNA linker segment and A) one or several codons of the human factor VIII cDNA which are not identical with the corresponding codon in the same position of the porcine factor VIII cDNA are substituted by a different codon in such a way that when the human sequence contains a codon for a neutral amino acid whereas the porcine sequence contains a codon for a charged amino acid then a codon for an amino acid with the same charge as found in the porcine sequence is introduced into the human sequence; when the human sequence contains a codon for a charged amino acid whereas the porcine sequence contains a codon for a neutral amino acid then a codon for a neutral amino acid or a codon for an amino acid of the opposite charge is introduced into the human sequence, when the human sequence contains a codon for a charged amino acid whereas the porcine sequence contains a codon for an amino acid with the opposite charge then a codon for an amino acid with the opposite charge is introduced into the human sequence or B) one or several codons for a charged amino acid which are found in the FVIII cDNA of a hemophilic patient are replaced by a codon for an amino acid of the opposite charge.
摘要翻译：修饰的人因子VIII cDNA，其中突变插入到野生型因子VIII cDNA或其中B结构域部分或完全缺失的因子VIII cDNA中，并且可以被DNA接头片段代替，并且A）一个或多个与人因子VIII cDNA相同位置的相应密码子不同的人因子VIII cDNA的密码子被不同的密码子取代，使得当人序列含有中性氨基酸的密码子时猪序列含有带电荷的氨基酸的密码子，然后将与猪序列中发现的相同电荷的氨基酸的密码子引入人序列; 当人序列含有带电荷氨基酸的密码子，而猪序列含有中性氨基酸的密码子时，则将中性氨基酸的密码子或相反电荷的氨基酸的密码子引入人序列中，当人类序列含有带电荷氨基酸的密码子，而猪序列含有具有相反电荷的氨基酸的密码子时，具有相反电荷的氨基酸的密码子被引入人序列或B）一个或多个在血友病患者的FVIII cDNA中发现的带电荷的氨基酸的密码子被相反电荷的氨基酸的密码子替代。

9. 发明申请

US20040191241A1 Antigen with haptenic mannitol epitopes and a method of preparing antibodies specific to D-mannitol 审中-公开
标题翻译：具有半抗原甘露醇表位的抗原和制备对D-甘露糖醇特异性的抗体的方法
公开(公告)号：US20040191241A1
公开(公告)日：2004-09-30
申请号：US10400919
申请日：2003-03-28
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
发明人： Yeldur Padmanabha Rao Venkatesh , Venkatesh Laxminarayan Hegde
IPC分类号： A61K039/395 , C12Q001/70 , C12P021/04 , C07K014/47 , C07K016/18
CPC分类号： C07K16/44
摘要： The present invention provides a hapten-carrier conjugate as antigen having haptenic mannitol epitopes, the invention also provides a method of preparing hapten-carrier conjugate as immunogen possessing mannitol groups or epitopes to raise antibodies specific to D-mannitol and the present invention further provides a use of hapten-carrier conjugate as an antigen to detect D-Mannitol specific human IgE.
摘要翻译：本发明提供了具有半抗体甘露糖醇表位的抗体的半抗原 - 载体缀合物，本发明还提供了制备半抗原 - 载体缀合物作为具有甘露醇基团或表位的免疫原以产生对D-甘露醇特异性抗体的方法，本发明还提供了使用半抗原 - 载体缀合物作为抗原检测D-甘露醇特异性人IgE。

10. 发明申请

US20040185535A1 Industrial-scale serum-free production of recombinant FVII in mammalian cells 审中-公开
标题翻译：在哺乳动物细胞中重组FVII的工业规模无血清生产
公开(公告)号：US20040185535A1
公开(公告)日：2004-09-23
申请号：US10394086
申请日：2003-03-21
发明人： Giles Wilson , Ida Molgaard Knudsen
IPC分类号： G01N033/53 , C12P021/04 , C07K014/745
CPC分类号： C12N9/6437 , C12P21/02 , C12Y304/21021
摘要： The invention provides a method for industrial-scale production of FVII polypeptides in mammalian cell culture free of animal-derived components.
摘要翻译：本发明提供了在不含动物衍生成分的哺乳动物细胞培养物中工业规模生产FVII多肽的方法。

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