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1. 发明申请

US20040053865A1 Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein 有权
标题翻译：结合埃博拉糖蛋白的单克隆抗体和互补决定区
公开(公告)号：US20040053865A1
公开(公告)日：2004-03-18
申请号：US10226795
申请日：2002-08-23
发明人： Mary Kate Hart , Julie Wilson
IPC分类号： A61K031/70 , A01N043/04 , A61K039/395 , A61K039/12 , C12N005/06 , C12N005/16
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565
摘要： In this application are described Ebola GP monoclonal antibodies, epitopes recognized by these monoclonal antibodies, and the sequences of the variable regions of some of these antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of Ebola virus infections in vitro and in vivo.
摘要翻译：在本申请中描述了埃博拉GP单克隆抗体，由这些单克隆抗体识别的表位，以及其中一些抗体的可变区的序列。还提供了本发明的抗体的混合物，以及使用个体抗体或其混合物在体外和体内检测，预防和/或治疗埃博拉病毒感染的方法。

2. 发明申请

US20030186435A1 Methods of modulating FabH activity 审中-公开
标题翻译：调节FabH活性的方法
公开(公告)号：US20030186435A1
公开(公告)日：2003-10-02
申请号：US10443432
申请日：2003-05-22
申请人： SmithKline Beecham Corporation , SmithKline Beecham p.l.c.
发明人： Alexandros K. Konstantinidis , John Timothy Lonsdale , Glenn Scott Van Aller
IPC分类号： C12Q001/68 , A61K039/12 , C12N005/06 , C12N005/16
CPC分类号： C12N9/1029 , A61K38/00 , C07K14/31 , C07K14/315
摘要： The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供FabH多肽和编码FabH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用FabH多肽筛选抗菌化合物的方法。

3. 发明申请

US20030180894A1 Oligonucleotides and method for characterizing and detecting Genogroup II type small round structured virus 失效
标题翻译：用于表征和检测Genogroup II型小圆结构病毒的寡核苷酸和方法
公开(公告)号：US20030180894A1
公开(公告)日：2003-09-25
申请号：US10441126
申请日：2003-05-20
申请人： TOSOH CORPORATION
发明人： Noriyoshi Masuda , Takahiko Ishiguro , Juichi Saito , Toshiki Taya , Kiyoshi Yasukawa
IPC分类号： C12Q001/68 , C12P019/34 , C12N005/06 , C12N005/16
CPC分类号： C12Q1/701
摘要： Nucleic acid sequences, oligonucleotides and a method for detection of SRSV, in particular, a virus which belongs to Genotype II (GII), in clinical examinations, public health examinations, food evaluations and food poisoning examinations are provided.
摘要翻译：提供了核酸序列，寡核苷酸和用于检测SRSV的方法，特别是属于基因型II（GII）的病毒，用于临床检查，公众健康检查，食物评估和食物中毒检查。

4. 发明申请

US20030170228A1 Compositions and methods for the treatment of tumor 审中-公开
公开(公告)号：US20030170228A1
公开(公告)日：2003-09-11
申请号：US10210951
申请日：2002-08-02
申请人： Genentech, Inc.
发明人： Avi J. Ashkenazi , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , Scot A. Marsters , James Pan , Robert M. Pitti , Margaret Ann Roy , Victoria Smith , Donna M. Stone , Colin K. Watanabe , William I. Wood
IPC分类号： A61K039/395 , C12P021/04 , C12N005/16 , C12N005/06 , C07K016/40 , C07H021/04
CPC分类号： C07K16/30
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

5. 发明申请

US20030157689A1 Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
公开(公告)号：US20030157689A1
公开(公告)日：2003-08-21
申请号：US10241332
申请日：2002-09-11
发明人： Jay G. Calvert , Michael G. Sheppard , Siao-Kun W. Welch
IPC分类号： C12Q001/68 , C12P019/34 , A61K039/12 , A61K039/155 , C12N007/00 , C12N007/01 , C12N005/06 , C12N005/16
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , A61K2039/5254 , A61K2039/5256 , A61K2039/552 , C12N7/00 , C12N15/86 , C12N2770/10022 , C12N2770/10034 , C12N2770/10061 , C12N2770/10062 , C12N2770/20034
摘要： The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.

6. 发明申请

US20030148511A1 Induction of immunity using inhibitors of granzymes 失效
标题翻译：使用颗粒酶抑制剂诱导免疫
公开(公告)号：US20030148511A1
公开(公告)日：2003-08-07
申请号：US09993363
申请日：2001-11-14
发明人： Philip G. Ashton-Rickardt , Joseph T. Opferman
IPC分类号： A61K031/70 , A01N043/04 , C12N005/06 , C12N005/16
CPC分类号： C12N5/0636 , A61K31/70 , A61K35/17 , A61K38/57 , A61K47/6849 , C12N2510/00 , Y02A50/385
摘要： The present invention provides methods for enhancing host immunity to a virus and/or a cancer and methods for enhancing the cytotoxic T-cell (CTL) mediated immune responses by providing granzyme B inhibitors to a subject. One objective of the invention is to induce long-term protective immunity to a subject in need thereof This is accomplished by providing granzyme inhibitors to the subject which increase the number of memory-CTLs and thereby prevent or alleviate viral infections and/or treat. Providing granzyme inhibitors is also effective in the prevention of cancers. Some examples of granzyme inhibitors contemplated within the present invention include the endogenous serpins such as SPI6 and PI9, other suicide substrates of granzyme B, granzyme B antibodies, etc. Also provided are methods for expression of nucleic acids encoding granzyme inhibitors in cytotoxic T-lymphocytes (CTLs).
摘要翻译：本发明提供了增强宿主对病毒和/或癌症免疫的方法以及通过向受试者提供颗粒酶B抑制剂来增强细胞毒性T细胞（CTL）介导的免疫应答的方法。本发明的一个目的是对有需要的受试者诱导长期保护性免疫。这是通过向受试者提供增加记忆CTL数量并从而预防或减轻病毒感染和/或治疗的颗粒酶抑制剂来实现的。提供颗粒酶抑制剂在预防癌症中也是有效的。本发明中考虑的颗粒酶抑制剂的一些实例包括内源性丝氨酸蛋白酶例如SPI6和PI9，颗粒酶B的其他自杀底物，颗粒酶B抗体等。还提供了在细胞毒性T淋巴细胞中表达编码粒酶抑制剂的核酸的方法（CTLs）。

7. 发明申请

US20030138453A1 Microparticles for delivery of heterologous nucleic acids 审中-公开
标题翻译：用于递送异源核酸的微粒
公开(公告)号：US20030138453A1
公开(公告)日：2003-07-24
申请号：US09967464
申请日：2001-09-28
发明人： Derek O'Hagan , Gillis Otten , John Donnelly , John Polo , Susan Barnett , Manmohan Singh , Jeffrey Ulmer , Thomas Dubensky
IPC分类号： C12Q001/70 , A61K039/12 , C12N007/00 , C12N007/01 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N005/00 , C12N005/02 , C12N005/06 , C12N005/16
CPC分类号： C12N15/86 , A61K9/1647 , A61K9/167 , A61K39/00 , A61K39/12 , A61K39/21 , A61K47/6927 , A61K2039/53 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C12N2740/16134 , C12N2740/16234 , C12N2770/36143 , Y02A50/388
摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(null-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nomonic detergents. Also provided are microparticles in the form of submicron emulsions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. The surface of the microparticles efficiently adsorb polypeptides, such as antigens, and nucleic acids, such as ELVIS vectors and other vector constructs, containing heterologous nucleotide sequences encoding biologically active macromolecules, such as polypeptides, antigens, and adjuvants. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and uses of the microparticle compositions for vaccines are also provided.
摘要翻译：公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。微粒包括聚合物，例如聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等，并且使用阳离子，阴离子或正性洗涤剂形成。还提供了具有可代谢油和乳化剂的油滴乳液的亚微米乳液形式的微粒。微粒的表面有效地吸收多肽，如抗原和核酸，如ELVIS载体和其他载体构建体，其含有编码生物活性大分子如多肽，抗原和佐剂的异源核苷酸序列。还提供了刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及微粒组合物用于疫苗的用途。

8. 发明申请

US20030119050A1 Flow cytometer for analysis of general diagnostic factors in cells and body fluids 审中-公开
公开(公告)号：US20030119050A1
公开(公告)日：2003-06-26
申请号：US10354203
申请日：2003-01-30
发明人： Shafrira Shai
IPC分类号： C12Q001/68 , G01N033/53 , C12N005/06 , C12N005/16
CPC分类号： G01N33/56966 , G01N15/14 , G01N2333/295 , G01N2333/59 , G01N2333/70589 , G01N2800/52
摘要： The present invention relates to a system to analyse general diagnostic factors in cells and body fluids using a flow cytometer, and in particular to a system featuring a number of different fertility tests, in a simple, expedited format, in order to investigate factors affecting fertility, preferably in a semi or fully automated manner. Specifically, a preparative method has been developed to increase the success of in vitro fertilisation (I.V.F) and intrauterine insemination (I.U.I) in cases of immunoinfertility by removing sperm-bound antibodies from sperm cells. A special device has been designed to collect only motile sperm cells from semen samples. Thus, this invention provides improved methods for general diagnostic testing and infertility screening and enables gynecologists to obtain information from an infertile couple in a preliminary test, which until now has been time consuming and only possible to run in sophisticated laboratories.

9. 发明申请

US20030099634A1 Compositions and methods for eliciting CTL immunity 审中-公开
公开(公告)号：US20030099634A1
公开(公告)日：2003-05-29
申请号：US10128711
申请日：2002-04-22
发明人： Maria A. Vitiello , Robert W. Chesnut , Alessandro D. Sette , Esteban Celis , Howard Grey
IPC分类号： A61K039/395 , A61K039/40 , A61K039/42 , C07K002/00 , C07K004/00 , C07K005/00 , C07K007/00 , C07K014/00 , C07K016/00 , C07K017/00 , A61K038/00 , C12N005/06 , C12N005/16
CPC分类号： C07K14/005 , A61K39/00 , C07K14/33 , C07K14/705 , C12N2710/20022 , C12N2730/10122 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2760/16122 , C12N2770/24222
摘要： Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, of CTL-inducing peptide and an adjuvant or a lipidated peptide which induces a helper T cell (HTL) response stimulate the antigen specific CTL response. Among the viral antigens to which the CTL responses are effectively induced in humans are those of hepatitis B. The CTL response may be optimized by a regimen of two or more booster administrations. Cocktails of two or more CTL inducing peptides are employed to optimize epitope and/or MHC class I restricted coverage.

10. 发明申请

US20030086905A1 In utero oral nucleic acid immunization 有权
公开(公告)号：US20030086905A1
公开(公告)日：2003-05-08
申请号：US10155867
申请日：2002-05-23
发明人： Volker Gerdts , Lorne Babiuk , Sylvia van Drunen Littel-van den Hurk , Philip J. Griebel
IPC分类号： C12Q001/70 , G01N033/53 , A61K048/00 , A01N063/00 , C12N005/06 , C12N005/16
CPC分类号： A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5252 , A61K2039/53 , A61K2039/54 , A61K2039/542 , A61K2039/55505 , A61K2039/57 , C12N2710/16734 , C12N2730/10134
摘要： Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.

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