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1. 发明申请

US20170197356A1 FABRICATION AND APPLICATION OF SHAPE MEMORY POLYMER POSSESSING TRANSESTERIFICATION INDUCED PERMANENT RESHAPING PROPERTY 审中-公开
公开(公告)号：US20170197356A1
公开(公告)日：2017-07-13
申请号：US15323397
申请日：2016-07-21
申请人： ZHEJIANG UNIVERSITY
发明人： TAO XIE , JINGJUN WU , QIAN ZHAO , WEIKE ZOU
IPC分类号： B29C61/06 , C08G67/04 , B29C61/00 , C08G18/42 , C08G18/78 , C08G63/91 , C08G59/24
CPC分类号： B29C61/06 , B29C61/003 , B29K2067/00 , C08F299/04 , C08G18/165 , C08G18/2072 , C08G18/246 , C08G18/4238 , C08G18/4277 , C08G18/7664 , C08G18/7831 , C08G18/7843 , C08G59/245 , C08G59/42 , C08G63/912 , C08G67/04 , C08G2280/00
摘要： The present invention discloses the fabrication and application of a shape memory polymer possessing transesterification-induced permanent reshaping. The ester-containing crosslinked polymer is obtained by crosslinking ester bearing polymer precursors or by reaction of monomers which yield ester bonds. The transition temperature falls between 20-150° C. The reshaping temperature is tuned by catalyst amount and should be 20° C. above the transition temperature. The breakthrough of the present invention lies in integrating shape memory effect and plastic deformation into the same polymer and triggering the respective function at different occasions. The permanent shape of as synthesized polymer could be modified arbitrarily and cumulatively. Therefore, the hierarchical structure which could not otherwise be obtained due to the limit of mold fabrication process should expand the practical application of SMPs.

2. 发明授权

US09289631B2 Polymer-bound UV absorbers in personal care compositions 有权
公开(公告)号：US09289631B2
公开(公告)日：2016-03-22
申请号：US14727558
申请日：2015-06-01
申请人： ISP INVESTMENTS INC.
发明人： Osama M. Musa , Jenn S. Shih
IPC分类号： A61K8/30 , A61K9/72 , A61Q17/04 , C08G67/04 , A61K8/81 , C08F8/30
CPC分类号： A61Q17/04 , A61K8/8164 , A61K2800/57 , C08F8/30 , C08F222/06
摘要： Personal care compositions comprising a polymer-bound UV absorber are described that provide enhanced properties, including customizable UV spectrum protection, broad-spectrum UV spectrum protection, water resistance, and labile UV stabilization. The polymer comprises anhydride functionality, such as maleic anhydride or a derivative thereof, and the UV absorber contains at least one hydroxyl, primary amine, or secondary amine group.The personal care compositions may be used to treat and/or protect against burns, cancers, erythema, lentigo (“liver spots”), keratotic lesions, wrinkles, and cellular changes of the skin; and/or color changes, embrittlement, lack of luster, tangles, split ends, and/or unmanageability of the hair.

3. 发明授权

US08449916B1 Antimicrobial compositions and methods 有权
标题翻译：抗微生物组合物和方法
公开(公告)号：US08449916B1
公开(公告)日：2013-05-28
申请号：US12940872
申请日：2010-11-05
申请人： Bryan Bellaire , Balaji Narasimhan
发明人： Bryan Bellaire , Balaji Narasimhan
IPC分类号： A61K9/14 , A61K9/51 , C08G67/04 , C08L73/02 , C09D173/02
CPC分类号： A61K31/765 , A61K9/14 , A61K9/5031 , A61K9/5146 , A61K31/496 , A61K31/65 , A61K31/7036 , C08G67/04 , C08J2373/02 , C08L73/02 , C09D173/02 , Y02A50/401 , Y02A50/402 , Y02A50/478 , Y02A50/481 , Y10S977/906 , A61K2300/00
摘要： The invention provides compositions and methods to treat microbial infections in animals, to inhibit the replication of microbes in infected cells, and to kill pathogens in infected cells. The methods can include administering to an animal in need of such treatment an effective antimicrobial amount of a composition comprising polyanhydride microparticles or nanoparticles that encapsulate a plurality of antimicrobial agents. The polyanhydride microparticles or nanoparticles can be, for example, copolymers of sebacic anhydride (SA) and 1,6-bis-(p-carboxyphenoxy)hexane (CPH) anhydride, copolymers of 1,8-bis(carboxyphenoxy)-3,6-dioxaoctane (CPTEG) anhydrides and 1,6-bis-(p-carboxyphenoxy)hexane (CPH) anhydride, or various combinations thereof. The microparticles or nanoparticles can accumulate in infected monocytes, dendritic cells, both, or on or in other infected cells, and degrade by surface erosion over a period of time to release the antimicrobial agents, thereby killing or inhibiting the microbes and treating the infection.
摘要翻译：本发明提供了治疗动物微生物感染，抑制感染细胞中微生物的复制并杀死感染细胞中的病原体的组合物和方法。所述方法可以包括向需要这种治疗的动物施用有效的抗微生物量的包含聚酐微粒或包封多种抗微生物剂的纳米颗粒的组合物。聚酐微粒或纳米粒子可以是例如癸二酸酐（SA）和1,6-双 - （对羧基苯氧基）己烷（CPH）酐的共聚物，1,8-双（羧基苯氧基）-3,6 - 二氧杂辛烷（CPTEG）酐和1,6-双 - （对羧基苯氧基）己烷（CPH）酐或其各种组合。微粒或纳米颗粒可以在受感染的单核细胞，树突状细胞，或在其他感染细胞上或其他感染细胞中积累，并在一段时间内通过表面侵蚀降解以释放抗微生物剂，从而杀死或抑制微生物并治疗感染。

4. 发明申请

US20120058155A1 SLOW-DEGRADING POLYMERS FOR UNDELAYED AND SUSTAINED DRUG DELIVERY 有权
标题翻译：缓慢降解的聚合物用于缓解和持续的药物递送
公开(公告)号：US20120058155A1
公开(公告)日：2012-03-08
申请号：US13213843
申请日：2011-08-19
申请人： Kathryn E. Uhrich , Roselin Rosario-Meléndez
发明人： Kathryn E. Uhrich , Roselin Rosario-Meléndez
IPC分类号： A61K31/775 , B32B5/16 , A61P27/02 , A61P19/02 , C08G67/04 , A61K9/14
CPC分类号： A61K31/185 , A61K31/775 , C08G67/04 , Y10T428/2982
摘要： The invention provides polymers and methods for their use. Certain embodiments of the invention provide slow degrading microspheres for undelayed and sustained drug delivery.
摘要翻译：本发明提供了聚合物及其使用方法。本发明的某些实施方案提供用于不延迟和持续的药物递送的缓慢降解微球。

5. 发明申请

US20050267280A1 Lactone bearing absorbable polymers 失效
标题翻译：内酯可吸收聚合物
公开(公告)号：US20050267280A1
公开(公告)日：2005-12-01
申请号：US11114452
申请日：2005-04-26
申请人： Francis Ignatious
发明人： Francis Ignatious
IPC分类号： A61K9/14 , A61K20060101 , A61K9/00 , A61K9/50 , A61K9/52 , A61K38/04 , A61K38/09 , A61K38/10 , A61K38/22 , A61K38/23 , A61K38/24 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/31 , A61K38/34 , A61K47/48 , C08G63/02 , C08G63/08 , C08G63/199 , C08G63/66 , C08G63/672 , C08G63/91 , C08G64/00 , C08G64/02 , C08G67/04 , C08G79/02 , C08G85/00 , C08L101/06
CPC分类号： A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/5031 , A61K38/043 , A61K38/046 , A61K38/09 , A61K38/105 , A61K38/2235 , A61K38/23 , A61K38/24 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/31 , A61K38/34 , A61K47/593 , A61K47/60 , A61K47/62 , C08G63/08 , C08G63/199 , C08G63/672 , C08G64/00 , C08G64/0208 , C08G67/04 , Y10T428/1352
摘要： The present invention pertains to biodegradable polymers comprising a non-polymerizable lactone, biodegradable compositions comprising the polymer and a therapeutic agent, the use of the compositions for the sustained release of therapeutic agents, wherein the therapeutic agent is reversibly immobilized on the polymer matrix using ionic complexation between the latent carboxylic groups present on the lactone bearing polymer matrix and a cationic group on the therapeutic agent.
摘要翻译：本发明涉及包含不可聚合内酯的可生物降解的聚合物，包含聚合物和治疗剂的可生物降解的组合物，所述组合物用于治疗剂的持续释放的用途，其中所述治疗剂使用离子性可逆地固定在所述聚合物基质上存在于含有内酯的聚合物基质上的潜在羧基与治疗剂上的阳离子基团之间的络合。

6. 发明授权

US5955096A Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients 失效
公开(公告)号：US5955096A
公开(公告)日：1999-09-21
申请号：US670326
申请日：1996-06-25
申请人： Camila A. Santos , Jules S. Jacob , Benjamin A. Hertzog , Gerardo P. Carino , Edith Mathiowitz
发明人： Camila A. Santos , Jules S. Jacob , Benjamin A. Hertzog , Gerardo P. Carino , Edith Mathiowitz
IPC分类号： B82B1/00 , A61K9/16 , A61K9/51 , C08G67/04 , A61F2/00 , A61K9/00
CPC分类号： A61K9/5138 , A61K9/1641 , A61K9/1647 , A61K9/5153
摘要： Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a polymer are enhanced by incorporating an anhydride oligomer into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydride oligomers which enhance the bioadhesive properties of a polymer include oligomers synthesized from dicarboxylic acid monomers, preferably those found in Krebs glycolysis cycle, especially fumaric acid. The oligomers can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, anhydride oligomers can be incorporated within polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The oligomers can either be solubilized and blended with the polymer before manufacture or else used as a coating with polymers over existing systems. The polymers, for example in the form of microspheres, have improved ability to adhere to mucosal membranes, and thus can be used to deliver a drug or diagnostic agent via any of a range of mucosal membrane surfaces including those of the gastrointestinal, respiratory, excretory and reproductive tracts.

7. 发明授权

US5545409A Delivery system for controlled release of bioactive factors 失效
标题翻译：用于控制释放生物活性因子的递送系统
公开(公告)号：US5545409A
公开(公告)日：1996-08-13
申请号：US222880
申请日：1994-04-05
申请人： Cato T. Laurencin , Paul A. Lucas , Glenn T. Syftestad , Abraham Domb , Julianne Glowacki , Robert S. Langer
发明人： Cato T. Laurencin , Paul A. Lucas , Glenn T. Syftestad , Abraham Domb , Julianne Glowacki , Robert S. Langer
IPC分类号： A61K9/00 , A61K9/20 , A61L27/18 , A61L27/22 , A61L27/54 , A61L27/58 , C08G67/04 , A61F2/28 , A61K38/39 , C07K14/485 , C07K14/51
CPC分类号： A61K9/0024 , A61K9/2031 , A61K9/204 , A61L27/18 , A61L27/227 , A61L27/54 , A61L27/58 , C08G67/04 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S530/84
摘要： A composition and method for controlled release of water-soluble proteins comprising a surface-eroding polymer matrix and water-soluble bioactive factors is described. The composition bioerodes in the biological environment of the subject at a controlled rate, thereby releasing the water soluble proteins at a rate which allows them to interact with local cell populations.
摘要翻译：描述了包含表面侵蚀聚合物基质和水溶性生物活性因子的水溶性蛋白质的控制释放组合物和方法。组合物以受控的速率在受试者的生物环境中生物反应，从而以允许其与局部细胞群体相互作用的速率释放水溶性蛋白质。

8. 发明授权

US5418297A Crosslinking agent and curable composition 失效
标题翻译：交联剂和可固化组合物
公开(公告)号：US5418297A
公开(公告)日：1995-05-23
申请号：US27152
申请日：1993-03-16
申请人： Osamu Isozaki
发明人： Osamu Isozaki
IPC分类号： C08G59/42 , C08G67/04 , C08L63/00 , C08L73/02 , C09D133/06
CPC分类号： C08L63/00 , C08G59/42 , C08G67/04 , C08L73/02 , C09D133/068
摘要： The invention provides a crosslinking agent comprising a compound having at least two noncyclic acid anhydride groups and represented by the following formula ##STR1## wherein R is a monovalent hydrocarbon group having 2 to 50 carbon atoms, R' is a bivalent hydrocarbon group having 2 to 50 carbon atoms, the hydrocarbon groups R and R' containing or not containing an ether linkage, urethane linkage or ester linkage, and n is an integer of 1 to 500.The invention also provides a curable composition including (A) at least one resin selected from the group consisting of (i) a resin having at least one epoxy group and at least one hydroxyl group in the molecule, (ii) a resin mixture of a resin having at least two epoxy groups in the molecule and a resin having at least two hydroxyl groups in the molecule, and (iii) a resin having at least two epoxy groups in the molecule, and (B) the above-mentioned crosslinking agent.
摘要翻译： PCT No.PCT / JP92 / 01543 Sec。 371日期1993年3月18日 102（e）1993年3月18日PCT提交1992年11月26日PCT公布。公开号WO93 / 11188 日本6月10日，1993年。本发明提供一种交联剂，其包含具有至少两个非环状酸酐基团并由下式表示的化合物（I），其中R是具有2-50个碳原子的一价烃基， R'为碳原子数2〜50的二价烃基，含有或不具有醚键的烃基R，R'，氨基甲酸酯键或酯键，n为1〜500的整数。本发明还提供一种所述固化性组合物包含（A）至少一种选自（i）分子中具有至少一个环氧基和至少一个羟基的树脂的树脂，（ii）具有至少两个分子中具有至少两个羟基的树脂，和（iii）分子中具有至少两个环氧基的树脂和（B）上述交联剂。

9. 发明授权

US5171812A Polyanhydrides of oligomerized unsaturated aliphatic acids 失效
标题翻译：低聚不饱和脂肪酸的多糖
公开(公告)号：US5171812A
公开(公告)日：1992-12-15
申请号：US467635
申请日：1990-01-19
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： A61K9/00 , A61K6/00 , A61K9/20 , A61K9/22 , A61K9/32 , A61K9/70 , A61K47/34 , A61K47/48 , A61L31/06 , A61L31/16 , C08G67/00 , C08G67/04 , C08J5/18
CPC分类号： C08G67/04 , A61K47/48176 , A61K9/2031 , A61L31/06 , A61L31/16 , A61L2300/802
摘要： A polyanhydride suitable for use as a matrix material in controlled delivery devices polymerized from monomers of the general formula: ##STR1## wherein R, R', and R" are the same or a different aliphatic chain of C.sub.1 to C.sub.20 or hydrogen; m, n, and p are integers from 0 and 20; y is 0 or 1; and, if y is 0, one of R or R' is not H.
摘要翻译：适合用作基本材料的聚酐，其受控于下列通式的单体聚合的受控输送装置：其中R，R'和R“是相同或不同的C1至C20或氢的脂族链; m，n和p是0和20的整数; y为0或1; 并且如果y是0，R或R'中的一个不是H.

10. 发明授权

US4886870A Bioerodible articles useful as implants and prostheses having predictable degradation rates 失效
标题翻译：用作具有可预测降解速率的植入物和假体的生物蚀刻制品
公开(公告)号：US4886870A
公开(公告)日：1989-12-12
申请号：US702168
申请日：1985-02-15
申请人： Patricia D'Amore , Kam W. Leong , Robert S. Langer
发明人： Patricia D'Amore , Kam W. Leong , Robert S. Langer
IPC分类号： A61L17/10 , A61L27/18 , A61L27/58 , C08G67/04
CPC分类号： C08G67/04 , A61L17/10 , A61L27/18 , A61L27/58
摘要： A novel series of articles useful as implants and prostheses and methods for their preparation and use are provided which utilize polyanhydride polymeric matrices as a general class of materials. These articles are biocompatible, non-inflammatory and degrade predictably into non-toxic residues after introduction in-vivo. The articles may be formed in any desired dimensions and configuration and may take specific shape as vascular or skin grafts, as biodegradable sutures or as orthopedic appliances such as bone plates and the like.
摘要翻译：提供了可用作植入物和假体的新型系列文章及其制备和使用方法，其利用聚酐聚合物基质作为一般材料类。这些制品在生物相容性，非炎症性和体内引入后可预测地降解成无毒性残留。制品可以以任何期望的尺寸和构型形成，并且可以具有特定形状作为血管或皮肤移植物，例如可生物降解的缝线或矫形器具如骨板等。

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