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1. 发明授权

US09011830B2 Poly(CPP-SA) anhydride as a reactive barrier matrix against percutaneous absorption of toxic chemicals 有权
标题翻译：聚（CPP-SA）酐作为反应性屏障基质，用于经皮吸收有毒化学物质
公开(公告)号：US09011830B2
公开(公告)日：2015-04-21
申请号：US13422874
申请日：2012-03-16
申请人： Mohammad Erfan , Hamid Reza Moghimi , Azadeh Haeri , Tahereh Sadat Jafarzadeh Kashi , Farhad Jafarzade
发明人： Mohammad Erfan , Hamid Reza Moghimi , Azadeh Haeri , Tahereh Sadat Jafarzadeh Kashi , Farhad Jafarzade
IPC分类号： A61K31/775 , A61P17/00 , C08G63/66 , C08L73/02 , A61K9/00 , A61K47/14 , C08G67/04
CPC分类号： A61K31/775 , A61K9/0014 , A61K47/14 , C08G67/04 , C08L73/02
摘要： The present invention relates to a protective agent suitable to protect the human skin against toxic materials, particularly against chemicals with nucleophilic sites. The active moiety is a polyanhydride derivative. The active transdermal retardant offers a barrier property and chemically and/or physically reacts with harmful chemicals to decrease percutaneous absorption. In the preferred embodiments, polyanhydride in its low molecular weight form reduced flux of nicotine and nitrofurazone significantly. Additionally, polyanhydride in its high molecular weight form prevented nicotine absorption and decreased nitrofurazone permeation dramatically. Moreover, the polyanhydride in its high molecular weight form reduced nitroglycerin flux to a lesser extent.
摘要翻译：本发明涉及适于保护人体皮肤免受有毒物质特别是具有亲核部位的化学物质的保护剂。活性部分是聚酐衍生物。活性透皮阻滞剂提供阻隔性质，并与有害化学物质化学和/或物理反应以降低经皮吸收。在优选的实施方案中，其低分子量形式的聚酐显着降低了尼古丁和呋喃西林的通量。另外，其高分子量形式的聚酐阻止了尼古丁吸收，并显着降低了呋喃西林的渗透。此外，其高分子量形式的聚酐在较小程度上减少了硝酸甘油的通量。

2. 发明申请

US20090258074A1 MIXTURES OF TANNINS, THEIR PRODUCTION AND USE IN MEDICAMENTS OR AS DISINFECTANTS 审中-公开
标题翻译：鞣制混合物，其生产和用于药物或作为消毒剂
公开(公告)号：US20090258074A1
公开(公告)日：2009-10-15
申请号：US12301118
申请日：2007-02-28
申请人： Stephan Hüffer , Oliver Reese , Günter Scherr , Sebastien Garnier , Ulrich Mrowietz
发明人： Stephan Hüffer , Oliver Reese , Günter Scherr , Sebastien Garnier , Ulrich Mrowietz
IPC分类号： A61K9/50 , A61K9/12 , A61Q11/00 , A61K8/18 , A61Q17/04
CPC分类号： C08G8/28 , A61K31/775 , A61K31/795 , C08G8/18 , C08G8/24 , C08G14/08
摘要： The invention relates to a mixture comprising i) at least one condensation product (A) obtainable by reaction of a1) at least one aromatic system or heteroaromatic system, a2) at least one carbonyl compound, a3) if appropriate at least one sulfonating agent and a4) if appropriate at least one urea derivative, where the condensation product (A) has an Mw value ≧9000 g/mol, and ii) at least one tanning agent having an Mw value ≦3000 g/mol.
摘要翻译：本发明涉及一种混合物，其包含i）至少一种通过a1）至少一种芳族体系或杂芳族体系的反应获得的缩合产物（a2），a2）至少一种羰基化合物，a）如果合适的话，至少一种磺化剂和 a4）如果合适，至少一种脲衍生物，其中缩合产物（A）具有> = 9000g / mol的Mw值，和ii）至少一种Mw值<= 3000g / mol的鞣剂。

3. 发明授权

US06534049B2 Synthetic soil-extract materials and medicaments for human immunodeficiency viruses based thereon 失效
公开(公告)号：US06534049B2
公开(公告)日：2003-03-18
申请号：US09976557
申请日：2001-10-11
申请人： Richard J. Laub
发明人： Richard J. Laub
IPC分类号： A61K3174
CPC分类号： A61K31/775
摘要： Phenolic polymers are prepared by oxidizing and polymerizing starting organic compounds comprising at least one hydroxyl group and at least one carbonyl group or at least two hydroxyl groups on an aromatic structure. One or more inorganic compounds or salts is added and the solution is allowed to stand at about 20° C. to 80° C. for a period of about at least 2 hours. Salt molecules as well as starting compounds and other low molecular-weight materials below about 500 to about 10,000 daltons are removed from the product solution. Purified phenolic polymers are prepared in concentrated aqueous solution or in dried powder form in a final step if necessary. The resultant phenolic polymers exhibit physicochemical properties strongly resembling those of typical commercially-available natural-product soil extracts. The materials are active human immunodeficiency anti-viral agents, and are effective in anti-viral compositions for treating or preventing human immunodeficiency viral diseases.

4. 发明申请

US20030044381A1 Synthetic soil-extract materials and medicaments for influenza viruses based thereon 失效
标题翻译：合成土壤萃取物质和基于此的流感病毒药物
公开(公告)号：US20030044381A1
公开(公告)日：2003-03-06
申请号：US10141477
申请日：2002-05-08
发明人： Richard J. Laub
IPC分类号： A61K031/765 , A61K031/235
CPC分类号： A61K31/775
摘要： Phenolic polymers are prepared by oxidizing and polymerizing starting organic compounds comprising at least one hydroxyl group and at least one carbonyl group or at least two hydroxyl groups on an aromatic structure. One or more inorganic compounds or salts is added and the solution is allowed to stand at about 20null C. to 80null C. for a period of about at least 2 hours. Salt molecules as well as starting compounds and other low molecular-weight materials below about 500 to about 10,000 daltons are removed from the product solution. Purified phenolic polymers are prepared in concentrated aqueous solution or in dried powder form in a final step, if necessary. The resultant phenolic polymers exhibit physicochemical properties strongly resembling those of typical commercially-available natural-product soil extracts. The materials are active influenza anti-viral agents, and are effective in anti-viral compositions for treating or preventing influenza viral diseases.
摘要翻译：通过在芳族结构上氧化和聚合包含至少一个羟基和至少一个羰基或至少两个羟基的起始有机化合物来制备酚醛聚合物。加入一种或多种无机化合物或盐，并将溶液在约20℃至80℃下静置约至少2小时。从产品溶液中除去盐分子以及起始化合物和低于约500至约10,000道尔顿的其它低分子量材料。如果需要，在最终步骤中，将浓缩的水溶液或干燥粉末形式的纯化酚醛聚合物制备。所得到的酚类聚合物显示出与典型的商业上可获得的天然产物土壤提取物相似的物理化学性质。这些材料是活性流感抗病毒剂，并且在用于治疗或预防流感病毒性疾病的抗病毒组合物中是有效的。

5. 发明授权

US06525019B2 Use of melanin for inhibition of angiogenesis and macular degeneration 失效
公开(公告)号：US06525019B2
公开(公告)日：2003-02-25
申请号：US09966282
申请日：2001-09-28
申请人： Robert J. D'Amato
发明人： Robert J. D'Amato
IPC分类号： A61K3800
CPC分类号： A61K31/00 , A61K31/65 , A61K31/775 , A61K31/787 , C08F2/32 , C08F20/28 , C08J2201/028 , C08J2203/08 , C08J2207/12
摘要： Composition and methods of using melanin, or melanin-promoting compounds, for inhibiting angiogenesis to treat angiogenesis-dependent diseases, such as macular degeneration and cancer.

6. 发明授权

US06524566B2 Synthetic soil-extract materials and medicaments for herpes viruses based thereon 失效
公开(公告)号：US06524566B2
公开(公告)日：2003-02-25
申请号：US09974658
申请日：2001-10-09
申请人： Richard J. Laub
发明人： Richard J. Laub
IPC分类号： A61K3174
CPC分类号： A61K31/775
摘要： Phenolic polymers are prepared by oxidizing and polymerizing starting organic compounds comprising at least one hydroxyl group and at least one carbonyl group or at least two hydroxyl groups on an aromatic structure. One or more inorganic compounds or salts is added and the solution is allowed to stand at about 20° C. to 80° C. for a period of about at least 2 hours. Salt molecules as well as starting compounds and other low molecular-weight materials below about 500 to about 10,000 daltons are removed from the product solution. Purified phenolic polymers are prepared in concentrated aqueous solution or in dried powder form in a final step if necessary. The resultant phenolic polymers exhibit physicochemical properties strongly resembling those of typical commercially-available natural-product soil extracts. The materials are active herpes anti-viral agents, and are effective in anti-viral compositions for treating or preventing human herpes viral diseases.

7. 发明授权

US5945446A Process for preparing synthetic soil-extract materials and medicaments based thereon 失效
标题翻译：基于此制备合成土壤提取物材料和药物的方法
公开(公告)号：US5945446A
公开(公告)日：1999-08-31
申请号：US798329
申请日：1997-02-10
申请人： Richard J. Laub
发明人： Richard J. Laub
IPC分类号： A61K9/02 , A01N65/00 , A61K9/08 , A61K9/12 , A61K9/20 , A61K9/72 , A61K31/765 , A61K31/775 , A61K35/14 , A61K35/16 , A61K36/00 , A61K38/00 , A61P3/04 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/20 , A61P31/22 , A61P43/00 , C08G61/00 , A61K31/35 , A61K35/78
CPC分类号： A61K31/775 , A61K35/14 , A61K38/37 , A61K9/0014 , A61K9/0019 , A61K9/0056 , A61K9/06 , A61K9/08 , A61K9/10
摘要： Phenolic polymers are prepared by dissolving one or more organic phenols along with sodium periodate in aqueous base at pH 8-11, and allowing the mixtures to stand between 35 and 80.degree. C. for a period of 30 minutes to 100 hours. One or more inorganic compounds or salts is added and the solution is allowed to stand at room temperature between 2 and 48 hours. Salt molecules as well as starting compounds and other low molecular-weight materials below about 500 to about 10,000 daltons are removed from the product solutions. Purified phenolic polymers are prepared in concentrated aqueous solution or in dried powder form in a final step if necessary. The resultant phenolic polymers exhibit physicochemical properties strongly resembling those of typical commercially-available natural soil extracts. The materials are active anti-viral and anti-microbial agents, and are effective in anti-viral amounts in blood product compositions, in methods for reducing or eliminating virus in blood products and in anti-viral and anti-microbial compositions for treating or preventing human or animal viral or microbial diseases.
摘要翻译：通过在pH 8-11下将一种或多种有机酚与高碘酸钠一起溶解在碱性水溶液中制备酚醛聚合物，并使混合物在35-80℃之间放置30分钟至100小时。加入一种或多种无机化合物或盐，并将溶液在室温下放置2至48小时。从产品溶液中除去盐分子以及起始化合物和低于约500至约10,000道尔顿的其它低分子量材料。如果需要，在最终步骤中，将浓缩的水溶液或干燥粉末形式的纯化酚醛聚合物制备。所得酚类聚合物显示出与典型的商业可得的天然土壤提取物类似的物理化学性质。这些材料是活性抗病毒和抗微生物剂，并且在血液制品组合物中的抗病毒量，减少或消除血液制品中的病毒的方法和用于治疗或预防的抗病毒和抗微生物组合物中有效人或动物病毒或微生物疾病。

8. 发明授权

US5658560A Method of treating endotoxemia by administering tyloxapol 失效
标题翻译：通过施用tyloxapol治疗内毒素血症的方法
公开(公告)号：US5658560A
公开(公告)日：1997-08-19
申请号：US289116
申请日：1994-08-11
申请人： Vladimir B. Serikov
发明人： Vladimir B. Serikov
IPC分类号： A61K31/77 , A61K31/775 , A61K31/765 , A61K38/00
CPC分类号： A61K31/77 , A61K31/775
摘要： A method of treatment of toxemia in bacterial infection by administration of a pharmaceutical composition comprising a non-ionic biologically active detergent is provided.
摘要翻译：提供了通过施用包含非离子生物活性洗涤剂的药物组合物来治疗细菌感染中的毒血症的方法。

9. 发明授权

US08741317B2 Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery 有权
标题翻译：包含水杨酸的缓慢降解聚合物用于不延迟和持续的药物递送
公开(公告)号：US08741317B2
公开(公告)日：2014-06-03
申请号：US13213843
申请日：2011-08-19
申请人： Kathryn E. Uhrich , Roselin Rosario-Meléndez
发明人： Kathryn E. Uhrich , Roselin Rosario-Meléndez
IPC分类号： A61K9/00 , A61K31/765 , C08G63/181 , A61K31/185 , C08G67/04
CPC分类号： A61K31/185 , A61K31/775 , C08G67/04 , Y10T428/2982
摘要： The invention provides polymers and methods for their use. Specifically, certain embodiments of the present invention provide a polymer that comprises a plurality of salicylic acid-adipic (SA-Adipic) units of the following formula and a plurality of salicylic acid-diethylmalonic (SA-DEM) units of the following formula Certain embodiments of the invention also provide slow degrading microspheres comprising polymers described herein for undelayed and sustained drug delivery. Certain embodiments of the present invention provide methods for treating a chronic eye disease or arthritis in a patient, comprising administering to the patient a therapeutically effective amount of a polymer or microsphere as described herein.
摘要翻译：本发明提供了聚合物及其使用方法。具体地，本发明的某些实施方案提供了包含下列结构式的多种水杨酸 - 己二酸（SA-己二酸）单元和多种下式的水杨酸 - 二乙基丙二酸（SA-DEM）单元的聚合物：本发明还提供缓慢降解的微球，其包含本文所述的聚合物用于不延迟和持续的药物递送。本发明的某些实施方案提供了治疗患者慢性眼病或关节炎的方法，包括向患者施用治疗有效量的如本文所述的聚合物或微球。

10. 发明申请

US20090275666A1 CONDENSATION PRODUCTS, METHOD FOR THEIR PRODUCTION AND USE THEREOF IN MEDICAMENTS, AS DISINFECTANTS OR AS A TANNIN 审中-公开
标题翻译：冷凝产品，其生产方法及其在药物，作为消毒剂或作为鞣剂中的用途
公开(公告)号：US20090275666A1
公开(公告)日：2009-11-05
申请号：US12301170
申请日：2007-02-28
申请人： Stephan Hueffer , Sebastien Garnier , Oliver Reese , Guenter Scherr , Joachim Roser , Ulrich Mrowietz
发明人： Stephan Hueffer , Sebastien Garnier , Oliver Reese , Guenter Scherr , Joachim Roser , Ulrich Mrowietz
IPC分类号： C07C45/45 , A61K31/12
CPC分类号： C08G14/08 , A61K31/775 , A61K31/795 , C08G8/18 , C08G8/24 , C08G8/28 , C14C3/20
摘要： The invention relates to a condensation product obtainable by reaction of a1) at least one aromatic or heteroaromatic, where the aromatic or heteroaromatic is substituted by at least one hydroxyl group (—OH) and at least one carboxyl group (—COOH), and where the hydroxyl and/or carboxyl group can be present in salt form, a2) at least one carbonyl compound, a3) optionally at least one sulfonating agent a4) optionally at least one urea derivative, and a5) optionally at least one further aromatic or heteroaromatic, or a physiologically tolerable salt thereof, with the precondition that the component a1) is not salicylic acid or sulfosalicylic acid if the component a4) is melamine.
摘要翻译：本发明涉及通过a1）至少一种芳族或杂芳族化合物的反应获得的缩合产物，其中芳族或杂芳族被至少一个羟基（-OH）和至少一个羧基（-COOH）取代，其中羟基和/或羧基可以以盐形式存在，a2）至少一种羰基化合物，a3）任选的至少一种磺化剂a4）任选的至少一种脲衍生物，和5）任选的至少一种其它芳族或杂芳族或其生理上可耐受的盐，前提是组分a1）不是水杨酸或磺水杨酸，如果组分a4）是三聚氰胺。

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