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1. 发明授权

US08290579B2 Device, methods and sponges for iontophoretic drug delivery 有权
标题翻译：用于离子电渗药物递送的装置，方法和海绵
公开(公告)号：US08290579B2
公开(公告)日：2012-10-16
申请号：US10546204
申请日：2004-02-19
申请人： Abraham J. Domb
发明人： Abraham J. Domb
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： Disclosed are devices and methods for administration of charged drugs to tissues of the oral cavity and for intra-tissue administration.The disclosed drug applicator for intra-tissue use includes an introducer such as a needle or catheter that is adapted to penetrate into a living tissue. The introducer has a drug-providing portion, and the applicator has current-generating element to pass through it an electrical current. Passing an electrical current through the drug-providing portion causes the drug to eject into treated tissue.Also disclosed are charged drugs suitable for iontophoretic administration, which include a bioactive agent encapsulated in charged nano-particles.
摘要翻译：公开了用于将带电药物施用于口腔组织和组织内施用的装置和方法。所公开的用于组织内使用的药物施用器包括适于渗入生物体组织的引导器，例如针或导管。导引器具有药物提供部分，并且施加器具有电流产生元件以使其通过电流。将电流通过药物提供部分导致药物喷射到处理过的组织中。还公开了适用于离子电渗治疗的带电药物，其包括包封在带电的纳米颗粒中的生物活性剂。

2. 发明授权

US08197553B2 Composite scaffolds and methods using same for generating complex tissue grafts 有权
标题翻译：复合支架和使用它们的方法产生复杂的组织移植物
公开(公告)号：US08197553B2
公开(公告)日：2012-06-12
申请号：US12285107
申请日：2008-09-29
申请人： Dan Gazit , Abraham J. Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
发明人： Dan Gazit , Abraham J. Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
IPC分类号： A61F2/02
CPC分类号： A61L27/3604 , A61L27/18 , A61L27/20 , A61L27/22 , A61L27/3625 , A61L27/38 , A61L27/3839 , A61L27/3886 , A61L27/3891 , A61L27/3895 , A61L27/40 , A61L27/48 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2300/604 , A61L2430/36 , C12M25/14 , C12N5/0068 , C12N5/0662 , C12N2501/155 , C12N2502/28 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C08L67/04 , C08L71/02
摘要： A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 μm.
摘要翻译：提供了一种用于工程异质组织的复合支架。所述复合支架包括：（a）第一支架能够支撑其上形成第一组织类型; 和（b）第二支架能够支持其上形成第二组织类型; 其中所述第一支架和所述第二支架相对于彼此布置，使得当所述第一支架支撑所述第一组织类型并且所述第二支架支撑所述第二组织型时，所述第二组织类型的任何细胞与所述第一组织之间的距离类型不超过200μm。

3. 发明申请

US20110295226A1 DELIVERY DEVICE FOR DELIVERING BIOACTIVE AGENTS TO INTERNAL TISSUE IN A BODY 有权
标题翻译：用于向身体内部组织递送生物剂的递送装置
公开(公告)号：US20110295226A1
公开(公告)日：2011-12-01
申请号：US12599823
申请日：2008-05-13
申请人： Shaul Shohat , Eli Machlev , Dana Haimovich , Abraham J. Domb
发明人： Shaul Shohat , Eli Machlev , Dana Haimovich , Abraham J. Domb
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61M25/10 , A61L29/146 , A61L29/148 , A61L29/16 , A61L2300/232 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/30 , A61L2300/604 , A61M25/1029 , A61M2025/0056 , A61M2025/0681 , A61M2025/105 , A61M2025/1054 , A61M2025/1088
摘要： A device and method for administering a bioactive agent to internal tissue in a body, by introducing a balloon in a deflated condition into the body, inflating the balloon, introducing the bioactive agent into the balloon at the time of, after, or before the inflation of the balloon, and delivering the bioactive agent from the balloon to the tissue.
摘要翻译：一种将生物活性剂施用于身体内部组织的装置和方法，通过将处于放气状态的气囊引入体内，使气囊膨胀，在膨胀之前，之后或之前将生物活性剂引入气囊中并将生物活性剂从气囊输送到组织。

4. 发明申请

US20110244039A1 ABSORBABLE SOLID COMPOSITIONS FOR TOPICAL TREATMENT OF ORAL MUCOSAL DISORDERS 审中-公开
标题翻译：用于局部治疗口腔粘膜疾病的可吸收固体组合物
公开(公告)号：US20110244039A1
公开(公告)日：2011-10-06
申请号：US13077350
申请日：2011-03-31
申请人： Abraham J. Domb , Joseph S. Wolnerman
发明人： Abraham J. Domb , Joseph S. Wolnerman
IPC分类号： A61K9/20 , A61K33/06 , A61K36/288 , A61K36/28 , A61K36/752 , A61K38/43 , A61P31/04 , A61P29/00 , A61P31/10 , A61P31/12
CPC分类号： A61K9/006 , Y02A50/406
摘要： The invention provides a solid, self-bioadhesive composition for topical application that adheres to the oral mucosal tissue comprising a therapeutically effective amount of at least one herbal or homeopathic active agent; and a pharmaceutically acceptable solid bioadhesive carrier in an amount from about 40 to 99 percent based on the weight of the whole composition.
摘要翻译：本发明提供了一种用于局部应用的固体，自生物粘附性组合物，其粘附于包含治疗有效量的至少一种草药或顺势疗法活性剂的口腔粘膜组织; 和药学上可接受的固体生物粘附载体，其量为基于整个组合物重量的约40至99％。

5. 发明申请

US20090232867A1 Modified conductive surfaces having active substances attached thereto 审中-公开
标题翻译：具有附着于其上的活性物质的改性导电表面
公开(公告)号：US20090232867A1
公开(公告)日：2009-09-17
申请号：US11632697
申请日：2005-07-19
申请人： Abraham J. Domb , Daniel Mandler , Ishaiahu Danziger , Miriam Oron , Regina Okner , Galit Shustak , Avi Swed , Noam Tal
发明人： Abraham J. Domb , Daniel Mandler , Ishaiahu Danziger , Miriam Oron , Regina Okner , Galit Shustak , Avi Swed , Noam Tal
IPC分类号： A61F2/00 , B05D7/24 , B05C3/02 , A61L27/34 , A61L27/54
CPC分类号： C09D5/4476 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/62 , B82Y30/00
摘要： Novel processes for coating metal surfaces and/or for attaching active substances to metal surfaces, objects having coated metal surfaces and/or active substances attached thereto and uses thereof in the preparation of implantable devices are disclosed.
摘要翻译：公开了用于将金属表面和/或用于将活性物质附着到金属表面，具有涂覆金属表面的物体和/或附着于其上的活性物质的新方法及其在可植入装置的制备中的用途。

6. 发明授权

US06365173B1 Stereocomplex polymeric carriers for drug delivery 失效
标题翻译：用于药物递送的立体络合物聚合物载体
公开(公告)号：US06365173B1
公开(公告)日：2002-04-02
申请号：US09231552
申请日：1999-01-14
申请人： Abraham J. Domb , Zeev Zehavi
发明人： Abraham J. Domb , Zeev Zehavi
IPC分类号： A61F200
CPC分类号： A61K9/5153 , A61F2250/0067 , A61K9/1647 , Y10S514/944 , Y10S514/969
摘要： A polymeric carrier for delivery of bioactive or bioreactive molecules is provided, including a stereocomplex of one or more biocompatible polymers and having incorporated on or within the complex the molecules to be delivered. In a preferred embodiment, the biocompatible stereoselective polymers are linear or branched D-PLA homo- and block-polymers, linear or branched L-PLA homo- and block-polymers, copolymers thereof, or mixtures thereof, in stereocomplexed form. In one preferred embodiment, the polymeric carrier is complexed with a complementary stereospecific bioactive molecule. In other embodiments, the bioactive, or bioreactive (for example, for use in diagnostic applications), is bound to the complex by ionic, hydrogen, or other non-covalent binding reactions not involving stereocomplexation, or is physically entrapped within the complex, either at the time of complex formation or when the polymeric material is formulated into particles, tablets, or other form for pharmaceutical application. Exemplary bioactive molecules include peptides, proteins, nucleotides, oligonucleotides, sugars, carbohydrates, and other synthetic or natural organic molecules, as well as stereoselective drugs of a molecular weight of 300 daltons or higher. Examples demonstrate preparation of stereocomplexes, as well as their use for controlled and/or sustained release.
摘要翻译：提供用于递送生物活性或生物反应性分子的聚合物载体，包括一种或多种生物相容性聚合物的立体络合物，并且在配合物上或内部掺入待分送的分子。在优选的实施方案中，生物相容性立体选择性聚合物是立体复合形式的直链或支链D-PLA均聚物和嵌段聚合物，直链或支链L-PLA均聚物和嵌段聚合物，其共聚物或其混合物。在一个优选的实施方案中，聚合物载体与互补的立体特异性生物活性分子络合。在其他实施方案中，生物活性或生物反应性（例如，用于诊断应用）通过离子，氢或其它非共价结合反应与复合物结合，不涉及立体络合，或物理地包埋在复合物内在复合形成时或当将聚合物材料配制成用于药物应用的颗粒，片剂或其它形式时。示例性生物活性分子包括分子量为300道尔顿或更高的肽，蛋白质，核苷酸，寡核苷酸，糖，碳水化合物和其它合成或天然有机分子，以及立体选择性药物。实施例证明立体络合物的制备以及它们用于受控和/或持续释放的用途。

7. 发明授权

US5762638A Anti-infective and anti-inflammatory releasing systems for medical devices 失效
标题翻译：用于医疗器械的抗感染和抗炎释放系统
公开(公告)号：US5762638A
公开(公告)日：1998-06-09
申请号：US601251
申请日：1996-02-14
申请人： Alain H. Shikani , Abraham J. Domb
发明人： Alain H. Shikani , Abraham J. Domb
IPC分类号： A61K9/00 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61M16/04 , A61M25/00 , A61M5/32
CPC分类号： A61L29/16 , A61K9/0024 , A61L29/08 , A61L29/085 , A61L2300/106 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/606 , A61M16/04 , A61M16/0465 , A61M16/0497 , A61M2025/0056 , A61M25/0017 , A61M25/0045
摘要： Medical devices for implantation into the body are coated with anti-infective and or anti-inflammatory agents. The medical devices can be, for example, endotracheal/tracheostomy tubes and catheters. The devices have a polymer coating containing an anti-infective agent and/or an anti-inflammatory agent. The preferred anti-infective agent is iodine and the preferred anti-inflammatory agent is steroidal.
摘要翻译：用于植入体内的医疗装置涂有抗感染和/或抗炎剂。医疗装置可以是例如气管内/气管造口管和导管。该装置具有包含抗感染剂和/或抗炎剂的聚合物涂层。优选的抗感染剂是碘，优选的抗炎剂是甾族化合物。

8. 发明授权

US5286763A Bioerodible polymers for drug delivery in bone 失效
标题翻译：用于骨中药物递送的生物可分解聚合物
公开(公告)号：US5286763A
公开(公告)日：1994-02-15
申请号：US908438
申请日：1992-06-30
申请人： Tobin N. Gerhart , Cato T. Laurencin , Abraham J. Domb , Robert S. Langer , Wilson C. Hayes
发明人： Tobin N. Gerhart , Cato T. Laurencin , Abraham J. Domb , Robert S. Langer , Wilson C. Hayes
IPC分类号： A61K9/00 , A61K9/20 , A61L17/10 , A61L24/00 , A61L27/18 , A61L27/22 , A61L27/54 , A61L27/58 , C08G67/04 , A61M31/00 , C08G63/02
CPC分类号： A61K9/0024 , A61K9/2027 , A61K9/2031 , A61K9/204 , A61L17/10 , A61L24/0015 , A61L27/18 , A61L27/227 , A61L27/54 , A61L27/58 , C08G67/04 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/604 , A61L2430/02
摘要： Bioerodible polymers which degrade completely into nontoxic residues over a clinically useful period of time, including polyanhydrides, polyorthoesters, polyglycolic acid, polylactic acid, and copolymers thereof, are used for the delivery of bioactive agents, including antibiotics, chemotherapeutic agents, inhibitors of angiogenesis, and simulators of bone growth, directly into bone.
摘要翻译：用于在临床有用的时间段内完全降解成无毒残留物的生物可降解聚合物，包括聚酐，聚原酸酯，聚乙醇酸，聚乳酸及其共聚物，用于递送生物活性剂，包括抗生素，化学治疗剂，血管发生抑制剂，和骨骼生长的模拟器，直接进入骨骼。

9. 发明授权

US5240963A Branched polyanhydrides 失效
标题翻译：支链聚酐
公开(公告)号：US5240963A
公开(公告)日：1993-08-31
申请号：US948136
申请日：1992-09-18
申请人： Abraham J. Domb , Manoj Maniar
发明人： Abraham J. Domb , Manoj Maniar
IPC分类号： A61K6/00 , A61K9/16 , A61K9/20 , A61K47/48 , A61L31/06 , A61L31/16 , C08G67/04
CPC分类号： C08G67/04 , A61K47/48192 , A61K9/1641 , A61K9/2031 , A61L31/06 , A61L31/16 , A61L2300/602
摘要： Branched polyanhydrides that have superior properties for use in the controlled delivery of substances, prepared by the polymerization of a dicarboxylic acid monomer and a branching agent. The branching agent is a polycarboxylic acid monomer such as 1,3,5-benzenetricarboxylic acid ("BTC"), or an oligomerized fatty acid trimer. Alternatively, the branching agent is a polycarboxylic acid polymer such as poly(acrylic acid) ("PAA"). These branched polymers have significantly higher molecular weights and lower specific viscosity than linear polymers prepared under similar conditions. A major advantage of branched polyanhydrides is that the degradation and release kinetics can be substantially altered without significantly changing the physical properties of the polymer relative to the corresponding linear polymer. By manipulating both the diacid and the branching agent, a wide variety of biodegradable controlled delivery devices for diverse applications can be prepared.
摘要翻译：具有优异性能的支链聚酐，用于通过二羧酸单体和支化剂的聚合制备的物质的受控输送中。支化剂是诸如1,3,5-苯三甲酸（“BTC”）或低聚脂肪酸三聚体的多元羧酸单体。或者，支化剂是聚羧酸聚合物，例如聚（丙烯酸）（“PAA”）。这些支化聚合物具有比类似条件下制备的线性聚合物显着更高的分子量和更低的比粘度。支链聚酐的主要优点在于，相对于相应的线性聚合物，降解和释放动力学可以基本上改变而不显着改变聚合物的物理性质。通过操纵二酸和支化剂，可以制备用于各种应用的各种可生物降解的受控递送装置。

10. 发明授权

US5179189A Fatty acid terminated polyanhydrides 失效
标题翻译：脂肪酸封端的聚酐
公开(公告)号：US5179189A
公开(公告)日：1993-01-12
申请号：US756483
申请日：1991-09-09
申请人： Abraham J. Domb , Manoj Maniar
发明人： Abraham J. Domb , Manoj Maniar
IPC分类号： A61K9/22 , A61K6/00 , A61K9/20 , A61K47/30 , A61K47/48 , A61L31/06 , A61L31/16 , C08G63/00 , C08G67/00 , C08G67/04 , C08G69/10 , C08G69/48
CPC分类号： A61L27/16 , A61K47/48192 , A61K9/2031 , A61L27/18 , A61L31/06 , A61L31/16 , C08G67/04 , A61L2300/00
摘要： Fatty acid terminated polyanhydrides suitable for use as controlled release matrices in biodegradable sustained release drug delivery systems and methods for making thereof are described. The polymers are more soluble in organic solvents, and have a lower melting point than the corresponding non-fatty acid terminated polyanhydrides. The fatty acid terminated polyanhydrides are also more hydrophobic than the corresponding polyanhydrides that are not terminated with a fatty acid, and combine the properties of thermodynamic and hydrolytic stability, and easy storage. The polymers can be produced with a controlled and low molecular weight. The polyanhydrides are useful in a number of applications, including as a matrix in biodegradable drug delivery systems.
摘要翻译：描述适用于可生物降解的持续释放药物递送系统中的控制释放基质的脂肪酸封端的聚酐及其制备方法。聚合物更易溶于有机溶剂，并且具有比相应的非脂肪酸封端的聚酐更低的熔点。脂肪酸封端的聚酐也比不用脂肪酸终止的相应的多酸酐更疏水，并且结合了热力学和水解稳定性的特性，并且易于储存。聚合物可以以受控和低分子量生产。聚酐可用于许多应用，包括作为可生物降解药物递送系统中的基质。

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