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1. 发明授权

US5043333A Zinc-lysocelling therapeutic and growth promoting agents 失效
标题翻译：锌溶血细胞治疗和生长促进剂
公开(公告)号：US5043333A
公开(公告)日：1991-08-27
申请号：US262138
申请日：1988-10-21
申请人： Jerome L. Martin
发明人： Jerome L. Martin
IPC分类号： A23K20/195 , A23K20060101 , A61K20060101 , A61K31/33 , A61K35/74 , A61P9/04 , A61P31/04 , A61P43/00 , C07D405/08 , C07D407/00 , C07D407/04 , C07D407/14 , C07D493/00 , C07D493/10 , C07D493/20 , C07F20060101 , C07G20060101 , C07G11/00 , C07H19/01 , C07H23/00 , C12P1/06 , C12P9/00 , C12P17/06 , C12P17/10 , C12P17/14 , C12P17/16 , C12R1/01 , C12R1/03 , C12R1/465 , C12R1/47 , C12R1/485 , C12R1/52 , C12R1/545 , C12R1/55
CPC分类号： C07H19/01 , A23K20/195 , C07H23/00
摘要： A zinc complex of lysocellin is provided. The complex acts as a coccidiostat and growth-promoting agent when administered to poultry.
摘要翻译：提供了溶素原的锌络合物。该复合物在被给予家禽时作为球虫抑制剂和生长促进剂。

2. 发明授权

US4668662A Polypeptides with an anticoagulant action, a process to prepare or obtain them, their use and agents containing them 失效
标题翻译：具有抗凝血作用的多肽，制备或获得抗体的方法，其使用和含有它们的药剂
公开(公告)号：US4668662A
公开(公告)日：1987-05-26
申请号：US724332
申请日：1985-04-17
申请人： Dominique Tripier
发明人： Dominique Tripier
IPC分类号： C07K1/113 , A61K35/56 , A61K35/62 , A61K38/00 , A61K38/46 , A61K38/55 , A61P7/02 , C07C20060101 , C07G20060101 , C07K1/20 , C07K14/00 , C07K14/815 , A61K37/43 , C07K7/10
CPC分类号： C07K14/815 , A61K38/00 , Y10S930/26
摘要： The invention relates to polypeptides of the formula I ##STR1## in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring .alpha.-amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring .alpha.-amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.
摘要翻译：本发明涉及式I的多肽，其中m表示0-50，n表示0-100，R表示酚氢或酚酯基，X表示天然存在的α-氨基酸的相同或不同的残基，Y表示Val，Ile，Thr，Leu或Phe，Z表示天然存在的α-氨基酸的相同或不同的残基，其中Cys残基通过二硫键成对连接到制备或获得它们的方法和含有它们的试剂。

3. 发明授权

US4160860A Active plant extracts of hypoxidaceae and their use 失效
标题翻译：活性植物提取物及其用途
公开(公告)号：US4160860A
公开(公告)日：1979-07-10
申请号：US856507
申请日：1977-12-01
申请人： Karl H. Pegel
发明人： Karl H. Pegel
IPC分类号： A61K20060101 , A61K36/00 , A61K36/88 , A61K36/896 , C07G20060101 , C07G3/00 , C07J9/00 , C07J17/00 , C07J21/00 , A61K31/705 , A61K35/78
CPC分类号： A61K36/896 , Y10S514/859 , Y10S514/861 , Y10S514/869 , Y10S514/87 , Y10S514/927
摘要： Plant material derived from the family Hypoxidaceae is heated at a temperature of at least 60.degree. C. for a sufficient period to ensure enzyme destruction and is then extracted at a temperature of 0.degree.-30.degree. C. with aqueous alcohol containing 30-75 volume percent ethanol for about 1 to 15 days to obtain a pharmaceutically active material.
摘要翻译：衍生自低氧the科的植物材料在至少60℃的温度下加热足够的时间以确保酶破坏，然后在含有30-75体积的含水醇的0℃-30℃的温度下萃取百分比乙醇约1至15天以获得药物活性物质。

4. 发明授权

US4118563A Production of 7-(2-aminomethylphenylacetamido-3-(1-carboxymethyltetrazol-5-ylthiomethy l)-3-cephem-4-carboxylic acid 失效
标题翻译：制备7-（2-氨基甲基苯基乙酰氨基-3-（1-羧甲基四唑-5-基硫甲基）-3-头孢烯-4-羧酸
公开(公告)号：US4118563A
公开(公告)日：1978-10-03
申请号：US854457
申请日：1977-11-25
申请人： Gary M. F. Lim , Yvon G. Perron
发明人： Gary M. F. Lim , Yvon G. Perron
IPC分类号： C07D501/06 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , B01J25/02 , C07D20060101 , C07D501/04 , C07D501/24 , C07D501/30 , C07D501/36 , C07G20060101
CPC分类号： C07D501/24
摘要： A new synthetic route is provided for the production of 7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
摘要翻译：提供了一种新的合成路线用于生产7-（2-氨基甲基苯基乙酰胺基）-3-（1-羧甲基四唑-5-基硫代）-3-头孢烯-4-羧酸。

5. 发明授权

US3712884A Preparation of monomethyl ethers of digoxin 失效
标题翻译： D-吡喃酮的单甲醚的制备
公开(公告)号：US3712884A
公开(公告)日：1973-01-23
申请号：US3712884D
申请日：1970-11-19
申请人： BOEHRINGER MANNHEIM GMBH
发明人： VOIGTLANDER W , KAISER F
IPC分类号： C07J19/00 , A61K20060101 , A61K31/585 , C07D20060101 , C07G20060101 , C07H3/06 , C07J17/00 , C07C173/00
CPC分类号： C07J19/005 , C07J41/0055
摘要： DIGOXIN IS REACTED WITH DIMETHYL SULFATE IN DIMETHYL FORMAMIDE IN THE PRESENCE OF BARIUM HYDROXIDE TO PRODUCE THE MONOMETHYL ETHER, BY HAVING ALUMINUM OXIDE AND AN INERT SOLVENT PRESENT, THE 4''" ETHER IS PRODUCED AND BY HAVING ALUMINUM ISOPROPYLATE PRESENT THE 3''" -ETHER IS PRODUCED. THE REACTION PRODUCT IS WORKED UP IN CHLOROFORM AND WATER IS USED TO REMOVE UNREACTED DIGOXIN WHICH IS RECYCLED FOR FURTHER ETHERIFICATION.

6. 发明申请

US20050171286A1 Copolymer-1 improvements in compositions of copolymers 有权
标题翻译：共聚物组合物中共聚物-1的改进
公开(公告)号：US20050171286A1
公开(公告)日：2005-08-04
申请号：US11098432
申请日：2005-04-05
申请人： Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
发明人： Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
IPC分类号： A61K31/785 , A01N37/18 , A61K20060101 , A61K31/74 , A61K38/00 , A61K38/03 , A61K38/16 , A61P25/00 , A61P25/28 , A61P37/00 , A61P43/00 , C07G20060101 , C07K20060101 , C07K14/00 , C07K14/47 , C08G69/08 , C08G69/10 , C08G69/46 , C08G69/48 , C08L77/06 , C08L23/00
CPC分类号： A61K38/1703 , C07K14/4713 , C08G69/10 , Y10S514/903
摘要： The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
摘要翻译：本发明涉及共聚物-1的改进组合物，其包括基本上不含分子量超过40千道尔顿的物质的共聚物-1。

7. 发明授权

US5800808A Copolymer-1 improvements in compositions of copolymers 失效
公开(公告)号：US5800808A
公开(公告)日：1998-09-01
申请号：US447146
申请日：1995-05-22
申请人： Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
发明人： Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
IPC分类号： A61K31/785 , A01N37/18 , A61K20060101 , A61K31/74 , A61K38/00 , A61K38/03 , A61K38/16 , A61P25/00 , A61P25/28 , A61P37/00 , A61P43/00 , C07G20060101 , C07K20060101 , C07K14/00 , C07K14/47 , C08G69/08 , C08G69/10 , C08G69/46 , C08G69/48 , C08L77/06 , A61K27/00
CPC分类号： A61K38/1703 , C07K14/4713 , C08G69/10 , Y10S514/903
摘要： The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.

8. 发明授权

US4165363A Process for the production of chlorosilanes 失效
标题翻译：氯硅烷生产工艺
公开(公告)号：US4165363A
公开(公告)日：1979-08-21
申请号：US328362
申请日：1973-01-31
申请人： Wolfgang Weigert , Eugen Meyer-Simon , Rudolf Schwarz
发明人： Wolfgang Weigert , Eugen Meyer-Simon , Rudolf Schwarz
IPC分类号： C01B33/107 , C01B20060101 , C01B33/00 , C01B33/08 , C07G20060101
CPC分类号： C01B33/04 , C01B33/107
摘要： Hydrogen containing chlorosilanes, preferably trichlorosilanes, are prepared by reacting silicon tetrachloride with hydrogen at a temperature of 600.degree.-1200.degree. C. with a SiCl.sub.4 /H.sub.2 mixture having a molar composition between 1:1 and 1:50 in equilibrium with SiHCl.sub.3 and HCl and suddenly quenching the mixture to below 300.degree. C.
摘要翻译：通过使四氯化硅与氢气在600-1200℃下与SiCl 4 / H 2混合物与摩尔组成为1:1至1:50的SiCl 4和H 2混合物与SiHCl 3和HCl平衡来制备含氢氯硅烷，优选三氯硅烷并将混合物突然熄灭至300℃以下。

9. 发明授权

US4096330A 7.beta.-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]acyl cephalosporins 失效
标题翻译： 7 {62 - {8 {8 {8（2-氰基甲基）氨基{9-1,2-二氧代乙基{9氨基{9酰基头孢菌素
公开(公告)号：US4096330A
公开(公告)日：1978-06-20
申请号：US789467
申请日：1977-04-21
申请人： Uwe D. Treuner , Hermann Breuer
发明人： Uwe D. Treuner , Hermann Breuer
IPC分类号： A61K20060101 , C07D501/36 , C07G20060101
CPC分类号： C07C255/00
摘要： 7.beta.-[[[(2-Cyanomethyl)amino]-1,2-dioxoethyl]amino]-acyl cephalosporins which have the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, trihaloethyl or a salt forming ion; R.sub.1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl, phenyl, phenyl-lower alkyl, substituted phenyl or certain heterocyclic groups; R.sub.2 is hydrogen or methoxy; R.sub.3 is hydrogen, lower alkyl, phenyl-lower alkyl or cycloalkyl; R.sub.4 and R.sub.5 each is hydrogen or lower alkyl; and X is hydrogen, lower alkanoyloxy, carbamoyloxy, lower alkoxy, lower alkylthio ##STR2## or certain heterothio groups, are useful as antibacterial agents.
摘要翻译： 7β-[[[（2-氰基甲基）氨基] -1,2-二氧代乙基]氨基] - 酰基头孢菌素，其具有式其中R是氢，低级烷基，苯基 - 低级烷基，二苯基 - 低级烷基，三（低级烷基）甲硅烷基，三（低级烷基）甲锡烷基，三卤代乙基或成盐离子; R 1是氢，低级烷基，饱和或不饱和环烷基，苯基，苯基 - 低级烷基，取代的苯基或某些杂环基; R2是氢或甲氧基; R3是氢，低级烷基，苯基 - 低级烷基或环烷基; R4和R5各自为氢或低级烷基; X为氢，低级烷酰氧基，氨基甲酰氧基，低级烷氧基，低级烷硫基或某些杂硫基，可用作抗菌剂。

10. 发明授权

US3932533A Process for the recovery of pure alpha-bisabolol 失效
标题翻译：回收纯α-红没药醇的方法
公开(公告)号：US3932533A
公开(公告)日：1976-01-13
申请号：US459205
申请日：1974-04-08
申请人： Otto Isaac , Heribert Offermanns
发明人： Otto Isaac , Heribert Offermanns
IPC分类号： C07C29/88 , A61K20060101 , A61K8/18 , A61Q13/00 , C07C20060101 , C07C7/04 , C07C7/12 , C07C27/00 , C07C33/05 , C07C33/14 , C07C35/02 , C07C35/18 , C07C67/00 , C07G20060101 , C11B9/00 , C11B9/02 , C07C29/30
CPC分类号： C07C403/08 , C07C2101/16
摘要： .alpha.- Bisabolol of plant origin is purified by being treated with alkali hydroxide, alkali alcoholate, alkali carbonate, alkali bicarbonate, alkaline earth hydroxide, alkaline earth oxide or aluminium hydroxide. Preferably activated carbon is also used in the purification. Preferably the .alpha.-bisabolol is treated with pure nitrogen gas before the alkali treatment.
摘要翻译：通过用碱金属氢氧化物，碱性醇盐，碱金属碳酸盐，碱金属碳酸氢盐，碱土金属氢氧化物，碱土金属氧化物或氢氧化铝处理来纯化植物来源的α-红假单胞菌素。活性炭优选也用于纯化。优选地，在碱处理之前用纯氮气处理α-对映体。

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