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1. 发明授权

US5698519A Polypeptide specifically inhibiting cathepsin L 失效
标题翻译：多肽特异性抑制组织蛋白酶L
公开(公告)号：US5698519A
公开(公告)日：1997-12-16
申请号：US478520
申请日：1995-06-07
申请人： Nobuhiko Katsunuma , Vito Turk
发明人： Nobuhiko Katsunuma , Vito Turk
IPC分类号： A61K38/55 , A61K38/00 , A61P3/00 , A61P19/10 , A61P43/00 , C07K1/22 , C07K14/47 , C07K14/81 , C07K14/00 , C12N15/15 , C07K7/10
CPC分类号： C07K14/8139 , A61K38/00
摘要： The present invention provides a polypeptide having an amino acid sequence represented by Sequence No. 1 and a cathepsin L-specific inhibitor and therapeutic agent for osteoporosis comprising the polypeptide as its effective component. Since the polypeptide possesses potent inhibitory action specific to cathepsin L as well as strong bone resorption inhibitory action, the polypeptide is useful in the treatment of osteoporosis, particularly, senile osteoporosis.
摘要翻译：本发明提供了具有由序列号1表示的氨基酸序列的多肽和组织蛋白酶L特异性抑制剂和用于骨质疏松症的治疗剂，其包含该多肽作为其有效成分。由于多肽具有对组织蛋白酶L特异性的有效的抑制作用以及强的骨吸收抑制作用，所以该多肽可用于治疗骨质疏松症，特别是老年性骨质疏松症。

2. 发明授权

US5563243A Anti-obesity proteins 失效
公开(公告)号：US5563243A
公开(公告)日：1996-10-08
申请号：US381037
申请日：1995-01-31
申请人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
发明人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K7/10
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

3. 发明授权

US5547937A Pulmonary surfactant protein fragments 失效
标题翻译：肺表面活性蛋白片段
公开(公告)号：US5547937A
公开(公告)日：1996-08-20
申请号：US296898
申请日：1994-08-29
申请人： Madhup K. Dhaon , Edwin O. Lundell , Virender K. Sarin , Constance H. Baxter , Darryl R. Absolom
发明人： Madhup K. Dhaon , Edwin O. Lundell , Virender K. Sarin , Constance H. Baxter , Darryl R. Absolom
IPC分类号： A61K38/00 , A61K38/17 , C07K14/785 , C07K7/08 , C07K7/10
CPC分类号： A61K38/1709 , C07K14/785
摘要： This invention discloses that certain fragments of a pulmonary surfactant protein exhibit unexpected surface activity. These protein fragments are useful in preparing formulations for the treatment of respiratory distress syndrome.
摘要翻译：本发明公开了肺表面活性蛋白的某些片段表现出意想不到的表面活性。这些蛋白质片段可用于制备治疗呼吸窘迫综合征的制剂。

4. 发明授权

US5541161A Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin 失效
标题翻译：水蛭素的稳定磺酸盐，硫酸盐，膦酸盐和磷酸盐衍生物
公开(公告)号：US5541161A
公开(公告)日：1996-07-30
申请号：US123576
申请日：1993-09-17
申请人： John L. Krstenansky , Simon J. T. Mao
发明人： John L. Krstenansky , Simon J. T. Mao
IPC分类号： A61K38/55 , A61K38/00 , A61P7/02 , C07K7/06 , C07K7/08 , C07K14/815 , C07K7/10
CPC分类号： C07K14/815 , A61K38/00
摘要： This invention relates to peptide derivatives which are useful anticoagulant agents.
摘要翻译：本发明涉及有用的抗凝剂的肽衍生物。

5. 发明授权

US5376638A Methods for treating renin-related disorders with amylin antagonists 失效
标题翻译：用胰岛淀粉样多肽拮抗剂治疗肾素相关疾病的方法
公开(公告)号：US5376638A
公开(公告)日：1994-12-27
申请号：US939106
申请日：1992-09-01
申请人： Andrew A. Young , Timothy J. Rink
发明人： Andrew A. Young , Timothy J. Rink
IPC分类号： A61K38/22 , A61K38/23 , A61K45/00 , A61P3/00 , A61P9/12 , A61P43/00 , G01N33/74 , A61K37/02 , C07K7/10
CPC分类号： G01N33/74 , A61K38/22 , A61K38/23
摘要： Methods for treating conditions associated with elevated, inappropriate or undesired renin activity are disclosed which comprise administration of an effective amount of any amylin antagonist alone or in conjunction with other anti-hypertensive agents. Methods for screening for and/or evaluating anti-renin amylin antagonists are also described.
摘要翻译：公开了治疗与升高，不适当或不期望的肾素活性相关的病症的方法，其包括单独或与其它抗高血压药联合施用有效量的任何胰岛淀粉样多肽拮抗剂拮抗剂。还描述了用于筛选和/或评估抗肾素胰岛淀粉样多肽的拮抗剂的方法。

6. 发明授权

US5352659A Endothelin analogs and uses thereof 失效
标题翻译：内皮素类似物及其用途
公开(公告)号：US5352659A
公开(公告)日：1994-10-04
申请号：US837780
申请日：1992-02-14
申请人： Mitsuhiro Wakimasu , Takashi Kikuchi , Kazuki Kubo
发明人： Mitsuhiro Wakimasu , Takashi Kikuchi , Kazuki Kubo
IPC分类号： A61K38/00 , C07K14/575 , A61K37/02 , C07K7/10
CPC分类号： C07K14/57536 , A61K38/00
摘要： Disclosed are a peptide represented by formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein M represents a mercaptoacyl group; P, Q, R, S, T, U, V, W, X, Y and Z each represent amino acid residues, wherein an amino acid side chain of Y is either a substituted saturated aliphatic hydrocarbon group having 1 to 15 carbon atoms or an unsubstituted saturated aliphatic hydrocarbon group having 4 to 15 carbon atoms other than (1S)-1-methylpropyl; (2) a method for producing the above-mentioned peptide or the salt thereof, which comprises subjecting a peptide represented by formula (II) or a salt thereof to an oxidation reaction:M-P-Cys-Q-R-S-T-Asp-U-Glu-Cys-Val-Tyr-V-Cys-His-W-X-Y-Ile-Z-OH(II)wherein M, P, Q, R, S, T, U, V, W, X, Y and Z are as diefined above; and (3) use of the above-mentioned peptide or the pharmaceutically acceptable salt thereof as an anti-endothelin agent.
摘要翻译：公开了由式（I）表示的肽或其药学上可接受的盐：巯基酰基; P，Q，R，S，T，U，V，W，X，Y和Z各自表示氨基酸残基，其中Y的氨基酸侧链是具有1至15个碳原子的取代的饱和脂族烃基或除（1S）-1-甲基丙基以外具有4〜15个碳原子的未取代的饱和脂肪族烃基; （2）上述肽或其盐的制造方法，其特征在于，将由式（II）表示的肽或其盐进行氧化反应：MP-Cys-QRST-Asp-U-Glu-Cys 其中M，P，Q，R，S，T，U，V，W，X，Y和Z的Val-Tyr-V-Cys-His-WXY-Ile-Z-OH（II）和（3）使用上述肽或其药学上可接受的盐作为抗内皮素剂。

7. 发明授权

US5306808A Peptide derivatives having vasodilating activity 失效
标题翻译：具有血管扩张活性的肽衍生物
公开(公告)号：US5306808A
公开(公告)日：1994-04-26
申请号：US768269
申请日：1991-10-17
申请人： Mitsuhiro Wakimasu , Takashi Kikuchi , Kazuki Kubo
发明人： Mitsuhiro Wakimasu , Takashi Kikuchi , Kazuki Kubo
IPC分类号： A61K38/00 , C07K14/575 , C07K7/10
CPC分类号： C07K14/57536 , A61K38/00
摘要： Disclosed are a peptide derivative represented by the formula [I] or a pharmaceutically acceptable salt thereof: ##STR1## wherein A, B, C, D, E and F each represent amino acid residues, and satisfy any one condition of (i) A=Ser, B=Ser, C=Ser, D=Leu, E=Met and F=Phe, (ii) A=Ser, B=Ser, C=Ser, D=Trp, E=Leu and F=Phe, and (iii) A=Thr, B=Phe, C=Thr, D=Tyr, E=Lys and F=Tyr; and W, X, Y and Z each represent amino acid residues, and satisfy any one condition of (i) at least one of W and Y is an amino acid residue other than an L-alanine residue or other than an L-cysteine residue, (ii) X is an amino acid residue other than an L-Lysine residue, and (iii) Z is an amino acid residue other than an L-aspartic acid residue; (2) a method for producing the peptide derivative or the salt thereof; and (3) an agent for improving a circulatory function mainly comprising the peptide derivative or the salt thereof, such as a vasodilator or a vasoconstrictor.
摘要翻译： PCT No.PCT / JP91 / 00165 Sec。 371日期1991年10月17日 102（e）日期1991年10月17日PCT 1991年2月12日提交PCT公布。出版物WO91 / 13089 1991年9月5日公开。公开是由式（I）表示的肽衍生物或其药学上可接受的盐：（*化学结构*）-Ile-Ile-Trp-OH其中A，B，C，D，E （i）A = Ser，B = Ser，C = Ser，D = Leu，E = Met和F = Phe的任何一个条件，（ii）A = Ser，B = Ser，C = Ser，D = Trp，E = Leu和F = Phe，和（iii）A = Thr，B = Phe，C = Thr，D = Tyr，E = Lys和F = Tyr; 并且W，X，Y和Z各自表示氨基酸残基，并且满足（i）W和Y中的至少一个是L-丙氨酸残基以外的氨基酸残基或L-半胱氨酸残基以外的任一条件，（ii）X是除L-赖氨酸残基以外的氨基酸残基，（iii）Z是除了L-天冬氨酸残基以外的氨基酸残基; （2）生成肽衍生物或其盐的方法; 和（3）主要由肽衍生物或其盐例如血管扩张剂或血管收缩剂改善循环功能的药剂。

8. 发明授权

US5302581A Pulmonary surfactant protein fragments 失效
标题翻译：肺表面活性蛋白片段
公开(公告)号：US5302581A
公开(公告)日：1994-04-12
申请号：US826323
申请日：1992-01-22
申请人： Virender K. Sarin , Jack L. Fox , Shanker L. Gupta , Darryl R. Absolom
发明人： Virender K. Sarin , Jack L. Fox , Shanker L. Gupta , Darryl R. Absolom
IPC分类号： A61K38/00 , A61K47/24 , A61K47/28 , A61P11/00 , C07K14/785 , A61K37/02 , C07K7/08 , C07K7/10
CPC分类号： C07K14/785 , A61K38/00
摘要： This invention discloses that certain fragments of a pulmonary surfactant protein exhibit unexpected surface activity. These protein fragments are useful in preparing formulations for the treatment of respiratory disease.
摘要翻译：本发明公开了肺表面活性蛋白的某些片段表现出意想不到的表面活性。这些蛋白质片段可用于制备用于治疗呼吸系统疾病的制剂。

9. 发明授权

US5294543A Inhibitor of platelet aggregation 失效
标题翻译：抑制血小板聚集
公开(公告)号：US5294543A
公开(公告)日：1994-03-15
申请号：US865166
申请日：1992-04-08
申请人： Ethan A. Lerner , Michael R. Lerner
发明人： Ethan A. Lerner , Michael R. Lerner
IPC分类号： A61K38/00 , C07K14/435 , C12N15/11 , C07K7/10 , C07K15/12 , C12N15/63
CPC分类号： C07K14/43581 , A61K38/00 , Y10S514/822 , Y10S514/824
摘要： Purified DNA comprising a sequence encoding chrysoptin.Chrysoptin can be used to alter the hemodynamic or hemostatic properties of an animal's blood by administering to the animal an effective amount of chrysoptin.
摘要翻译：纯化的DNA，其包含编码chrysoptin的序列。辣根素可用于通过向动物施用有效量的木霉素来改变动物血液的血液动力学或止血性质。

10. 发明授权

US5283320A Peptides for HTLV-2 infection diagnosis of, therapy for, vaccination against, for distinguishing between HTLV-1 and HTLV-2 infections and antibodies derived therefrom 失效
标题翻译：用于HTLV-2感染诊断的多肽，用于区分HTLV-1和HTLV-2感染的疫苗接种的治疗及其衍生的抗体
公开(公告)号：US5283320A
公开(公告)日：1994-02-01
申请号：US434239
申请日：1989-11-13
申请人： Anders Vahlne , Bo Svennerholm , Lars Rymo , Stig Jeansson , Peter Horal
发明人： Anders Vahlne , Bo Svennerholm , Lars Rymo , Stig Jeansson , Peter Horal
IPC分类号： A61K39/00 , C07K14/15 , C07K14/16 , C07K7/10 , A61K37/02
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/14022 , C12N2740/16122 , C12N2740/16222 , Y10S530/826
摘要： Peptides corresponding to epitopes of HTLV-2 proteins are provided. These peptides are immunologically reactive with HTLV-2 specific antibodies. Several of the peptides are sufficiently unreactive to antibodies to HTLV-1 to distinguish between antibodies which recognize HTLV-1 and those which recognize HTLV-2. Thus HTLV-1 infections can be distinguished from HTLV-2 infections. The peptides are useful in assays for detection of HTLV-2 infection or exposure. The peptides are also useful as vaccine compositions against HTLV-2. Antibodies generated in response to immunization by the peptides are also provided.
摘要翻译：提供了相应于HTLV-2蛋白表位的肽。这些肽与HTLV-2特异性抗体具有免疫反应性。几种肽对HTLV-1的抗体没有足够的反应性，以区分识别HTLV-1的抗体和识别HTLV-2的抗体。因此HTLV-1感染可以区别于HTLV-2感染。该肽可用于检测HTLV-2感染或暴露的测定中。肽也可用作抗HTLV-2的疫苗组合物。还提供了响应于肽的免疫产生的抗体。

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