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1. 发明授权

US5350764A Anticoccidial and growth promoting polycyclic ether antibiotic 失效
标题翻译：抗球虫和生长促进多环醚抗生素
公开(公告)号：US5350764A
公开(公告)日：1994-09-27
申请号：US30055
申请日：1993-03-12
申请人： John P. Dirlam , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Hiroshi Maeda , Junsuke Tone
IPC分类号： A23K1/16 , A61K31/35 , A61P31/04 , A61P33/02 , C07D407/04 , C12N1/20 , C12P17/16 , C12R1/03 , C12R1/465 , C07D315/00
CPC分类号： C07D407/04 , C12P17/162 , C12R1/03
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55027. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.
摘要翻译：通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 55027.这种新型抗生素可用作家禽中的抗球虫，预防和治疗猪痢疾以及作为牛和猪的生长促进剂。

2. 发明授权

US5091418A Novel alpha-glucosidase inhibitor, pradimicin Q 失效
标题翻译：新型α-葡萄糖苷酶抑制剂，普拉定霉素Q
公开(公告)号：US5091418A
公开(公告)日：1992-02-25
申请号：US589729
申请日：1990-09-28
申请人： Yosuke Sawada , Tomokazu Ueki , Takashi Tsuno , Toshikazu Oki
发明人： Yosuke Sawada , Tomokazu Ueki , Takashi Tsuno , Toshikazu Oki
IPC分类号： A61K31/19 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P43/00 , C07C65/40 , C12P15/00 , C12R1/03
CPC分类号： C07C65/40
摘要： The present invention relates to a novel .alpha.-glucosidase inhibitor, pradimicin Q, having the following formula ##STR1## and its pharmaceutically acceptable base salts.

3. 发明授权

US5043333A Zinc-lysocelling therapeutic and growth promoting agents 失效
标题翻译：锌溶血细胞治疗和生长促进剂
公开(公告)号：US5043333A
公开(公告)日：1991-08-27
申请号：US262138
申请日：1988-10-21
申请人： Jerome L. Martin
发明人： Jerome L. Martin
IPC分类号： A23K20/195 , A23K20060101 , A61K20060101 , A61K31/33 , A61K35/74 , A61P9/04 , A61P31/04 , A61P43/00 , C07D405/08 , C07D407/00 , C07D407/04 , C07D407/14 , C07D493/00 , C07D493/10 , C07D493/20 , C07F20060101 , C07G20060101 , C07G11/00 , C07H19/01 , C07H23/00 , C12P1/06 , C12P9/00 , C12P17/06 , C12P17/10 , C12P17/14 , C12P17/16 , C12R1/01 , C12R1/03 , C12R1/465 , C12R1/47 , C12R1/485 , C12R1/52 , C12R1/545 , C12R1/55
CPC分类号： C07H19/01 , A23K20/195 , C07H23/00
摘要： A zinc complex of lysocellin is provided. The complex acts as a coccidiostat and growth-promoting agent when administered to poultry.
摘要翻译：提供了溶素原的锌络合物。该复合物在被给予家禽时作为球虫抑制剂和生长促进剂。

4. 发明授权

US4870165A Antifungal antibiotics 失效
标题翻译：抗真菌抗生素
公开(公告)号：US4870165A
公开(公告)日：1989-09-26
申请号：US115273
申请日：1987-11-02
申请人： Toshikazu Oki , Kyoichiro Saitoh , Kozo Tomatsu , Koji Tomita , Masataka Konishi , Takeo Miyaki , Mitsuaki Tsunakawa , Maki Nishio
发明人： Toshikazu Oki , Kyoichiro Saitoh , Kozo Tomatsu , Koji Tomita , Masataka Konishi , Takeo Miyaki , Mitsuaki Tsunakawa , Maki Nishio
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P31/10 , A61P31/12 , C07C235/84 , C07H15/24 , C07H15/244 , C07H15/256 , C12N1/20 , C12P19/56 , C12R1/03
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56
摘要： Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.

5. 发明授权

US4868171A Antibiotic A 40926 N-acylaminoglucuronyl aglycons and antiobiotic A 40926 aglycon 失效
标题翻译：抗生素A 40926 N-酰氨基葡萄糖醛酸糖苷和抗生素A 40926糖苷配基
公开(公告)号：US4868171A
公开(公告)日：1989-09-19
申请号：US945639
申请日：1986-12-23
申请人： Enrico Selva , Ernesto Riva , Giovanni Cassani , Francesco Parenti
发明人： Enrico Selva , Ernesto Riva , Giovanni Cassani , Francesco Parenti
IPC分类号： C07K7/64 , A61K35/74 , A61K38/00 , A61P31/04 , C07K1/113 , C07K1/20 , C07K1/22 , C07K7/06 , C07K9/00 , C07K14/195 , C07K14/41 , C12P21/02 , C12R1/03
CPC分类号： C07K9/008 , Y10S930/19 , Y10S930/27
摘要： The present invention concerns new antibiotic substances denominated antibiotic A 40926 N-acylaminoglucuronyl aglycon complex AB, antibiotic A 40926 N-acylaminoglucuronyl aglycon factor A, antibiotic A 40926 N-acylaminoglucuronyl aglycon factor B, antibiotic A 40926 N-acylaminoglucuronyl aglycon factor B.sub.0, antibiotic A 40926 N-acylaminoglucuronyl aglycon factor B.sub.1, antibiotic A 40926 aglycon and the addition salts thereof, a process for their preparation starting from antibiotic A 40926 complex or a factor thereof, and their use in the treatment of infectious diseases involving microorganisms susceptible to them.
摘要翻译：本发明涉及新型抗生素物质A 40926 N-酰氨基葡萄糖醛酸糖苷配基AB，抗生素A40926 N-酰氨基葡糖苷酸糖苷配基因子A，抗生素A40926 N-酰氨基葡糖苷酸糖苷配基因子B，抗生素A40926 N-酰氨基葡糖苷酸糖苷配基因子B0，抗生素A 40926 N-酰氨基葡糖苷酸糖苷配基因子B1，抗生素A 40926糖苷配基及其加成盐，从抗生素A40926复合物或其因素开始制备其制备方法，以及它们在治疗涉及对其敏感的微生物的感染性疾病中的用途。

6. 发明授权

US4683204A Process for producing antibiotic A80190 失效
标题翻译：生产抗生素A80190的方法
公开(公告)号：US4683204A
公开(公告)日：1987-07-28
申请号：US658977
申请日：1984-10-09
申请人： LaVerne D. Boeck
发明人： LaVerne D. Boeck
IPC分类号： A23K20/195 , C07H19/01 , C12P19/44 , C12P19/60 , C12P13/00 , C12N1/20 , C12R1/03
CPC分类号： C07H19/01 , A23K20/195 , C12P19/445 , C12P19/60 , C12R1/03 , Y10S435/825
摘要： Improved fermentation process for producing the polyether antibiotic A80190 which comprises cultivating a new strain of Actinomodura Oligospora, NRRL 15878, and the biologically purified culture of this microorganism are provided.
摘要翻译：提供了用于生产聚醚抗生素A80190的改进的发酵方法，其包括培养新的放线杆菌寡核苷酸NRRL 15878和该微生物的生物纯化培养物。

7. 发明授权

US4554162A CL-1724 Antibiotic compounds, their production and use 失效
标题翻译： CL-1724抗生素，其生产和使用
公开(公告)号：US4554162A
公开(公告)日：1985-11-19
申请号：US607056
申请日：1984-05-04
申请人： Cynthia A. Young , John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac
发明人： Cynthia A. Young , John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , A61P35/00 , C07H11/00 , C12P1/06 , C12R1/03
CPC分类号： C07H11/00 , C12P1/06
摘要： A strain of actinomycete, NRRL 15758, is capable of producing the CL-1724 complex of compounds under conditions of aerobic fermentation in the presence of assimilable sources of carbon and nitrogen. The compound CL-1724B-2 exhibiting antimicrobial and antitumor activity, is claimed together with pharmaceutical compositions and methods of treating microbial infections and tumors in mammals employing these pharmaceutical compositions.
摘要翻译：放线菌菌株NRRL 15758能够在需氧发酵的条件下在可同化的碳源和氮源的情况下生产化合物的CL-1724复合物。表现出抗微生物和抗肿瘤活性的化合物CL-1724B-2与使用这些药物组合物的哺乳动物中治疗微生物感染和肿瘤的药物组合物和方法一起是要求的。

8. 发明授权

US4546076A Enzymatic process for the determination of beta-lactam antibiotics 失效
标题翻译：用于测定β-内酰胺抗生素的酶法
公开(公告)号：US4546076A
公开(公告)日：1985-10-08
申请号：US462233
申请日：1983-01-31
申请人： Jacques Degelaen , Albert Loffet , Jean-Pierre Durieux
发明人： Jacques Degelaen , Albert Loffet , Jean-Pierre Durieux
IPC分类号： G01N33/50 , C12N9/52 , C12N11/08 , C12Q1/04 , C12Q1/18 , C12Q1/34 , C12Q1/37 , C12R1/03 , C12Q1/36
CPC分类号： C12Q1/34 , C12N11/08 , G01N2415/00
摘要： An enzymatic process for the determination of beta-lactam antibiotics in a biological liquid, comprising the steps of: (1) incubating the liquid with soluble D-alanyl-D-alanine-carboxypeptidase produced by Actinomadura R 39, said enzyme being immobilized on a water-insoluble support, the beta-lactam antibiotic reacting with the immobilized enzyme to form an inactive and equimolecular enzyme-antibiotic complex; (2) separating the immobilized enzyme from the liquid and washing it; (3) incubating the immobilized enzyme with a substrate solution to hydrolyze it and form an amount of D-alanine corresponding to the residual enzymatic activity; (4) determining the amount of D-alanine formed; and (5) comparing the determination of step (4) with a standard to obtain the concentration of the antibiotic in the biological liquid; as well as a test set for carrying out this process and comprising the necessary reagents.
摘要翻译：一种用于测定生物液体中β-内酰胺抗生素的酶促方法，包括以下步骤：（1）将该液体与由Actinomadura R 39产生的可溶性D-丙氨酰-D-丙氨酸 - 羧肽酶一起孵育，所述酶固定在水不溶性载体，β-内酰胺抗生素与固定化酶反应形成无活性和等分子酶 - 抗生素复合物; （2）将固定化酶与液体分离并洗涤; （3）将固定化酶与底物溶液一起温育以使其水解并形成一定数量的对应于残留的酶活性的D-丙氨酸; （4）确定形成的D-丙氨酸的量; 和（5）将步骤（4）的测定与标准进行比较以获得生物液体中抗生素的浓度; 以及用于进行该方法并包含必要试剂的试验组。

9. 发明授权

US5843679A Method for selectively enhancing the production of factors A or B.sub.0 of antibiotic A 40926 complex 失效
标题翻译：选择性增强抗生素A 40926复合物因子A或B0生成的方法
公开(公告)号：US5843679A
公开(公告)日：1998-12-01
申请号：US460024
申请日：1995-06-02
申请人： Enrico Selva , Luciano Gastaldo , Maurizio Denaro , Giovanni Cassani , Francesco Parenti
发明人： Enrico Selva , Luciano Gastaldo , Maurizio Denaro , Giovanni Cassani , Francesco Parenti
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/04 , C12P1/06 , C12P21/02 , C12R1/03 , C12P21/04
CPC分类号： C12R1/03 , C12P1/06
摘要： The present invention is directed to a method for selectively enhancing the production of factors A, and/or B.sub.0 of antibiotic A 40926 either to isolate these single components in better yields or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A 40926 producing culture during fermentation.
摘要翻译：本发明涉及一种用于选择性增强抗生素A 40926的因子A和/或B0的产生的方法，以便以更好的产率分离这些单一组分或富集上述组分的一种或两种中的复合物，其包括加入在发酵期间产生A 40926的培养物的所需抗生素因子的合适前体。

10. 发明授权

US5602012A Microbiological process for making UK-61,689 失效
标题翻译：制造英国的微生物过程61,689
公开(公告)号：US5602012A
公开(公告)日：1997-02-11
申请号：US344313
申请日：1994-11-22
申请人： Edward J. Tynan, III
发明人： Edward J. Tynan, III
IPC分类号： C12N1/20 , C07H19/01 , C12P17/16 , C12P19/00 , C12P19/44 , C12P19/58 , C12R1/01 , C12R1/03
CPC分类号： C07H19/01 , C12P17/16 , C12P17/162 , C12P19/445 , C12R1/03
摘要： Actinomadura roseorufa mutants characterized by the ability to produce by fermentation UK-61,689, an acidic polycyclic ether anticoccidial antibiotic previously available only by selective acid hydrolysis of UK-58,852; and Actinomadura roseorufa having the identifying characteristics of ATCC 53,666, ATCC 53,665, ATCC 53,664 and ATCC 53,674.
摘要翻译： Actinomadura roseorufa突变体，其特征在于通过发酵UK-61,689（一种仅通过UK-58,852的选择性酸水解获得的酸性多环醚抗球虫抗生素）产生的能力; 和具有ATCC 53,666，ATCC 53,665，ATCC 53,664和ATCC 53,674的鉴定特征的Actinomadura roseorufa。

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