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1. 发明授权

US06472543B2 Lactone compounds having alicyclic structure and their manufacturing method 有权
标题翻译：具有脂环结构的内酯化合物及其制造方法
公开(公告)号：US06472543B2
公开(公告)日：2002-10-29
申请号：US09897985
申请日：2001-07-05
申请人： Takeshi Kinsho , Takeru Watanabe , Koji Hasegawa , Tsunehiro Nishi , Mutsuo Nakashima , Seiichiro Tachibana , Jun Hatakeyama
发明人： Takeshi Kinsho , Takeru Watanabe , Koji Hasegawa , Tsunehiro Nishi , Mutsuo Nakashima , Seiichiro Tachibana , Jun Hatakeyama
IPC分类号： C07D40700
CPC分类号： C07D315/00 , G03F7/0395
摘要： Lactone compounds of formula (1) are novel and useful as monomers to form base resins for use in chemically amplified resist compositions adapted for micropatterning lithography. Letter k is 0 or 1 and m is an integer of 1-8.
摘要翻译：式（1）的内酯化合物是新颖的并且可用作单体以形成适用于微图案光刻的化学放大抗蚀剂组合物的基础树脂。引发剂k为0或1，m为1-8的整数。

2. 发明授权

US06506910B1 Process for preparing discodermolide and analogues thereof 失效
标题翻译：制备discodermolide及其类似物的方法
公开(公告)号：US06506910B1
公开(公告)日：2003-01-14
申请号：US09922055
申请日：2001-08-03
申请人： Frederick Ray Kinder, Jr.
发明人： Frederick Ray Kinder, Jr.
IPC分类号： C07D40700
CPC分类号： C07D309/30 , C07F7/1804
摘要： A more practical synthesis for preparing discodermolide and structurally related analogues, novel compounds useful in the process and novel compounds prepared by the process.
摘要翻译：用于制备discodermolide和结构相关类似物的更实用的合成物，用于该方法的新化合物和通过该方法制备的新化合物。

3. 发明授权

US06800767B2 Method for purifying cyclic esters 失效
标题翻译：环酯的纯化方法
公开(公告)号：US06800767B2
公开(公告)日：2004-10-05
申请号：US10239584
申请日：2003-01-13
申请人： Frédéric Van Gansberghe , Philippe Coszach , Patricia Di Salvatore , Jean-Christophe Bogaert
发明人： Frédéric Van Gansberghe , Philippe Coszach , Patricia Di Salvatore , Jean-Christophe Bogaert
IPC分类号： C07D40700
CPC分类号： C07D319/12
摘要： The invention concerns a method for purifying the dimeric cyclic esters of lactic (or glycolic) acid starting from a raw lactide (or glycolide) comprising impurities, the method consisting in: extractive and controlled crystallization of the raw lactide, in aqueous medium, controlling the geometry of the formed crystals and carrying out a separation of phases into lactide and impurities; separation of the resulting suspension of crystals, into a phase poor in lactide and loaded with impurities, and a wet cake rich in lactide crystals; drying the resulting wet cake; and recrystallization in melted medium of the resulting dried impure lactide and recuperating the purified lactide.
摘要翻译：本发明涉及从含有杂质的原料丙交酯（或乙交酯）开始纯化乳酸（或乙醇酸）的二聚环状酯的方法，该方法包括：在水性介质中萃取和控制结晶，控制形成晶体的几何形状，并进行相分离为丙交酯和杂质; 将所得结晶悬浮液分离成丙交酯相不良并装载杂质，富含丙交酯晶体的湿滤饼; 干燥所得湿饼; 并在所得干燥的不纯的丙交酯的熔融介质中重结晶并使纯化的丙交酯恢复。

4. 发明授权

US06509480B2 Glucose and lipid lowering compounds 失效
标题翻译：葡萄糖和降脂化合物
公开(公告)号：US06509480B2
公开(公告)日：2003-01-21
申请号：US10047182
申请日：2001-10-23
申请人： Dilip R. Wagle , Sheng Ding Fang , Ihor Terleckyj , John Resek , John J. Egan
发明人： Dilip R. Wagle , Sheng Ding Fang , Ihor Terleckyj , John Resek , John J. Egan
IPC分类号： C07D40700
CPC分类号： A61K31/34
摘要： Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: wherein the dotted line between carbons 5 and 6, the dotted line between carbon 4 and R2, and the dotted line between carbon 11 and R3 each independently represent an optional double bond from the respective numbered carbon to a linked carbon, and wherein X is hydroxy or, together with Y is oxy linking carbon 8 and carbon 12.
摘要翻译：尤其提供具有如下的AB环结构的降脂或葡萄糖降低方法和化合物，特别是降脂或葡萄糖降低化合物，其中碳5和6之间的虚线是虚线碳4和R 2之间的虚线，碳11和R 3之间的虚线各自独立地表示从相应的编号的碳到连接的碳的任选的双键，并且其中X是羟基，或者与Y一起是氧连接碳8和碳12。

5. 发明授权

US06689891B2 2-bromomethyl-6-methyl-benzoic acid and a process for the preparation thereof 有权
标题翻译： 2-溴甲基-6-甲基 - 苯甲酸及其制备方法
公开(公告)号：US06689891B2
公开(公告)日：2004-02-10
申请号：US10437996
申请日：2003-05-15
申请人： Paolo Farina , Maurizia Guidetti
发明人： Paolo Farina , Maurizia Guidetti
IPC分类号： C07D40700
CPC分类号： C07D307/88 , C07C51/363 , C07C63/70 , C07C67/14 , C07C69/76
摘要： A process for the preparation of 2-bromomethyl-6-methyl-benzoic acid (I) and derivatives thereof by selective bromination of 2,6-dimethylbenzoic acid (II) with sodium bromate and hydrobromic acid in the presence of light.
摘要翻译：通过在光存在下用溴酸钠和氢溴酸选择性溴化2,6-二甲基苯甲酸（II），制备2-溴甲基-6-甲基 - 苯甲酸（I）及其衍生物的方法。

6. 发明授权

US06500962B1 Production method of &agr;-methylene-&ggr;-butyrolactones 有权
标题翻译： α-亚甲基-γ-丁内酯的制备方法
公开(公告)号：US06500962B1
公开(公告)日：2002-12-31
申请号：US10097588
申请日：2002-03-15
申请人： Suk-Koo Kang , Kwang-Jin Kim
发明人： Suk-Koo Kang , Kwang-Jin Kim
IPC分类号： C07D40700
CPC分类号： C07D307/935 , C07D307/83 , C07D491/04 , C07D493/04
摘要： The present invention relates to a method for producing an &agr;-methylene-&ggr;-butyrolactone which is one of basic structures often shown in drugs such as an anti-cancer agent by reacting an alene compound having an aldehyde or ketone group with carbon monoxide via cyclization in a single step in the presence of a catalyst containing ruthenium, thereby improving total yield of the entire reaction and achieving effects of cost reduction.
摘要翻译：本发明涉及一种制备α-亚甲基-γ-丁内酯的方法，该方法是通常在药物如抗癌剂中通过使具有醛或酮基的烯化合物与一氧化碳通过环化反应而显示的碱性结构之一在含有钌的催化剂的存在下的一个步骤，从而提高整个反应的总产率并实现成本降低的效果。

7. 发明授权

US06365759B1 Intermediate compounds for preparing macrocylcic analogs 有权
标题翻译：用于制备大环类似物的中间体化合物
公开(公告)号：US06365759B1
公开(公告)日：2002-04-02
申请号：US09677485
申请日：2000-10-02
申请人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
发明人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
IPC分类号： C07D40700
CPC分类号： C07D493/22
摘要： Intermediate compounds of the formulas for use in the preparation of macrocyclic analogs.
摘要翻译：用于制备大环类似物的式的中间体化合物

8. 发明授权

US06348603B1 Process for the preparation of isochroman-3-ones 失效
标题翻译：异苯并二氢吡喃-3-酮的制备方法
公开(公告)号：US06348603B1
公开(公告)日：2002-02-19
申请号：US09668915
申请日：2000-09-25
申请人： Holger Geissler , Ralf Pfirmann
发明人： Holger Geissler , Ralf Pfirmann
IPC分类号： C07D40700
CPC分类号： C07D311/76
摘要： The present invention relates to a process for the preparation of an isochroman-3-one of the formula (I) by reaction of a 1,2-bishalomethylbenzene of the formula (II) in which X is chlorine, bromine or iodine, with carbon monoxide and a compound of the formula (III) R5R6R7C—OH (III) at a CO pressure of 0.1 to 50 MPa and a temperature of 20 to 200° C. in the presence or absence of an ionic halide, in the presence of a palladium catalyst and of a dipolar aprotic solvent, with addition of water or without addition of water, where in the formulae (I) and (II) the radicals R1, R2, R3 and R4 independently of one another are: a hydrogen or fluorine atom; an NC or F3C group; an alkyl, alkoxy or acyloxy radical, in each case having 1 to 18 carbon atoms; or a C6-C18-aryloxy, aryl or heteroaryl radical, where 1 to 3 atoms from the group consisting of O, N and/or S are present as heteroatoms; or in which at least two of the radicals R1, R2, R3 and R4 are linked to one another and form at least one aliphatic or aromatic ring having 5 to 18 carbon atoms, and in formula (III) the radicals R5, R6 and R7 are identical or different and are a C1-C18-alkyl, an HOC(═O)—, H3CC(═O)CH2— or (C6-C18-aryl)-CH2— radical or at least two of the radicals R5, R6 and R7 are linked to one another and form at least one aliphatic or aromatic ring having 5 to 18 carbon atoms.
摘要翻译：本发明涉及一种制备式（I）的异苯并二氢吡喃-3-酮的方法，其中X为氯，溴或碘的式（Ⅱ）的1,2-二沙甲基苯与碳一氧化碳和式（III）化合物在CO 2压力为0.1〜50MPa，温度为20〜200℃的条件下，在钯催化剂存在或不存在下，在钯催化剂和偶极非质子溶剂，加入水或不加入水，其中在式（I）和（II）中，基团R 1，R 2，R 3和R 4彼此独立地为：氢或氟原子; NC或F3C组; 烷基，烷氧基或酰氧基，每种情况具有1至18个碳原子; 或C 6 -C 18芳氧基，芳基或杂芳基，其中以O，N和/或S为基的1至3个原子作为杂原子存在;或其中至少两个基团R 1，R 2，R 3和 R4彼此连接并形成至少一个具有5至18个碳原子的脂族或芳族环，并且在式（III）中，基团R 5，R 6和R 7相同或不同，为C 1 -C 18烷基，HOC （= O） - ，H 3 C（= O）CH 2 - 或（C 6 -C 18 - 芳基）-CH 2 - 基或基团R 5，R 6和R 7中的至少两个彼此连接并形成至少一个脂族或芳族具有5至18个碳原子的环。

9. 发明授权

US06586606B2 Process for the preparation of 3-aryl-benzofuran-2-ones 有权
标题翻译： 3-芳基 - 苯并呋喃-2-酮的制备方法
公开(公告)号：US06586606B2
公开(公告)日：2003-07-01
申请号：US09899450
申请日：2001-07-05
申请人： Michèle Gerster , Paul Dubs
发明人： Michèle Gerster , Paul Dubs
IPC分类号： C07D40700
CPC分类号： C07D307/82 , C07D307/83 , C07D405/06 , C07D409/06
摘要： The instant invention discloses a process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises hydrolyzing a compound of formula V wherein the general symbols are as defined in claim 1, in an aqueous solvent in the presence of an acid. The compounds of the formula V are new and useful as stabilizers for protecting organic materials, in particular polymers and lubricants, against oxidative, thermal or light-induced degradation.
摘要翻译：本发明公开了一种制备式I化合物的方法，其中一般符号如权利要求1所定义，该方法包括在一般符号如权利要求1所定义的水溶液中水解式V化合物，的酸。式V的化合物是新的并且可用作保护有机材料，特别是聚合物和润滑剂以防止氧化，热或光诱导的降解的稳定剂。

10. 发明授权

US06579992B2 Method for producing chiral dihydrotagetone, and its conversion to chiral 5-isobutyl-3-methyl-4,5-dihydro-2(3H)-furanone 失效
标题翻译：制备手性二氢吉他酮的方法及其转化为手性5-异丁基-3-甲基-4,5-二氢-2（3H） - 呋喃酮
公开(公告)号：US06579992B2
公开(公告)日：2003-06-17
申请号：US09815335
申请日：2001-03-23
申请人： Arun Kumar Sinha , Bhupendra Prasad Joshi , Ruchi Dogra
发明人： Arun Kumar Sinha , Bhupendra Prasad Joshi , Ruchi Dogra
IPC分类号： C07D40700
CPC分类号： C07C51/29 , C07C59/347
摘要： A natural inexpensive acyclic monoterpene ketone (dihydrotagetone) of formula (4), isolated from the oil of Tagetes sp., was smoothly oxidized with meta-periodate/potassium permanganate into 2,6-dimethyl-4-oxo-heptanoic acid of formula (3), the reduction of 3 with metal hydride such as sodium borohydride or lithium aluminium hydride provided 4-hydroxyacid of formula (2) which on without isolation undergone lactonization in acidic medium furnished two chiral centered 5-isobutyl-3-methyl-4,5-dihydro-2(3H)-furanone of formula (1) as an analogue of whisky lactone 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1a) responsible for high quality of alcoholic beverage (whisky, wine, brandy and scotch), in addition, coconut flavored 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1) is also as an analogue of coconut aldehyde (&ggr;-nonalactone, F.E.M.A. No. 2751) of formula (1b) which is responsible for flavoring a wide range of food stuffs including baked goods and confectionery.
摘要翻译：从Tagetes sp。油中分离得到的式（4）的天然廉价的无环单萜酮（二氢t酮）用高碘酸钾/高锰酸钾被平滑地氧化成式（4）的2,6-二甲基-4-氧代 - 庚酸 3）中，用金属氢化物如硼氢化钠或氢化铝锂还原3，得到式（2）的4-羟基酸，其在酸性介质中经过内酯化而没有分离，提供了两个手性中心的5-异丁基-3-甲基-4- （1）的5-二氢-2（3H） - 呋喃酮作为负责高品质的式（1a）的威士忌内酯5-丁基-4-甲基-4,5-二氢-2（3H） - 呋喃酮的类似物的酒精饮料（威士忌，葡萄酒，白兰地和苏格兰威士忌），此外，式（1）的椰子风味的5-丁基-4-甲基-4,5-二氢-2（3H） - 呋喃酮也是椰子的类似物式（1b）的醛（γ-非内酯，FEMA No.2751），其负责调味各种食品，包括烘焙食品和糖果 y。

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