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1. 发明授权

US07417040B2 Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 有权
标题翻译：稠合三环化合物作为17β-羟基类固醇脱氢酶3的抑制剂
公开(公告)号：US07417040B2
公开(公告)日：2008-08-26
申请号：US11066373
申请日：2005-02-25
申请人： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Wen-Ching Han , Raj N. Misra , Hai-Yun Xiao , Derek J. Norris , John S. Tokarski
发明人： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Wen-Ching Han , Raj N. Misra , Hai-Yun Xiao , Derek J. Norris , John S. Tokarski
IPC分类号： A61K31/33 , C07D225/04 , C07D267/22 , C07D281/18 , C07D291/00 , C07D337/16 , A01N43/00
CPC分类号： C07D225/02 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/04
摘要： Disclosed are fused tricyclic compounds of the following formula I, or an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof. The disclosed compounds are useful as inhibitors of 17β-hydroxysteriod dehydrogenase 3 (17βHSD3). Also disclosed are methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer and pharmaceutical compositions comprising such compounds.
摘要翻译：公开了下式I的稠合三环化合物或其对映体，非对映异构体，互变异构体或其药学上可接受的盐。所公开的化合物可用作17β-羟基二氢脱氢酶3（17βHSD3）的抑制剂。还公开了使用这些化合物治疗激素敏感性疾病如前列腺癌的方法和包含这些化合物的药物组合物。

2. 发明申请

US20050137249A1 1-or 3-thia-benznaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof 审中-公开
标题翻译：作为肿瘤坏死因子产生抑制剂的1-或3-硫苯并萘并薁类及其制备中间体
公开(公告)号：US20050137249A1
公开(公告)日：2005-06-23
申请号：US10510867
申请日：2003-04-09
申请人： Mladen Mercep , Milan Mesic , Dijana Pesic , Ivana Ozimec , Rudolf Trojko
发明人： Mladen Mercep , Milan Mesic , Dijana Pesic , Ivana Ozimec , Rudolf Trojko
IPC分类号： C07D495/04 , A61K31/38 , A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/5377 , A61P1/04 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P37/02 , A61P37/08 , A61P43/00 , C07D333/80 , C07D337/16 , C07D413/02 , C07D495/02
CPC分类号： C07D333/80 , C07D495/04 , Y02P20/55
摘要： The present invention relates to 1- or 3-thiabenzonaphthoazulene derivafives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
摘要翻译：本发明涉及1-或3-噻吩并苯并薁衍生物与其药理学上可接受的盐和溶剂合物，其制备方法和中间体以及它们的抗炎作用，特别是抑制肿瘤坏死因子-α（TNF-α ）生产和抑制白细胞介素-1（IL-1）生产以及其止痛作用。

3. 发明申请

US20020022717A1 Rapamycin assay 有权
标题翻译：雷帕霉素测定
公开(公告)号：US20020022717A1
公开(公告)日：2002-02-21
申请号：US09757212
申请日：2001-01-09
发明人： Richard Sedrani , Valerie Quesniaux Ryffel
IPC分类号： G01N033/53 , G01N033/537 , G01N033/543 , C07K016/00 , C12P021/08 , C07D267/22 , C07D281/18 , C07D291/00 , C07D337/16 , C07D487/00
CPC分类号： C07K16/1292
摘要： Monoclonal antibodies to rapamycin and to 40-O-alkylated derivatives of rapamycin are provided, together with novel haptens, immunogenic conjugates, and processes for making them and assay kits for using them.
摘要翻译：提供雷帕霉素的单克隆抗体和雷帕霉素的40-O-烷基化衍生物，以及新型的半抗原，免疫原性缀合物及其制备方法以及使用它们的试剂盒。

4. 发明授权

US6043361A Polymerisable monomers and polymers 失效
标题翻译：可聚合单体和聚合物
公开(公告)号：US6043361A
公开(公告)日：2000-03-28
申请号：US849529
申请日：1997-08-26
申请人： Richard Alexander Evans , Ezio Rizzardo , Graeme Moad
发明人： Richard Alexander Evans , Ezio Rizzardo , Graeme Moad
IPC分类号： G02B1/04 , A61K6/083 , A61K6/087 , C07D281/18 , C07D327/00 , C07D327/02 , C07D337/16 , C07D339/00 , C07D339/08 , C07F7/18 , C08F28/06 , C08G75/02 , C07D337/00
CPC分类号： A61K6/0017 , A61K6/0023 , A61K6/083 , C07D281/18 , C07D327/00 , C07D337/16 , C07D339/00 , C07D339/08 , C07F7/184 , C08F28/06 , C08G75/02
摘要： The invention relates to compounds of the formulae: processes for their preparation, polymers, co-polymers or block co-polymers containing them or their use as monomers or co-monomers in free radical polymerisation and in the manufacture of adhesives, dental composites or optical lenses.
摘要翻译： PCT No.PCT / AU95 / 00859 Sec。 371日期：1997年8月26日 102（e）日期1997年8月26日PCT 1995年12月18日PCT PCT。 WO96 / 19471 PCT公开号日期1996年6月27日本发明涉及下式的化合物：其制备方法，含聚合物的聚合物，共聚物或嵌段共聚物或其作为单体或共聚单体在自由基聚合中的用途和粘合剂的制备，牙科复合材料或光学镜片。

5. 发明授权

US5348965A N-substituted azaheterocyclic carboxylic acids 失效
标题翻译： N-取代的氮杂环羧酸
公开(公告)号：US5348965A
公开(公告)日：1994-09-20
申请号：US882788
申请日：1992-05-14
申请人： Knud E. Andersen , Lars J. S. Knutsen , Per O. Sorensen , Behrend F. Lundt , Jesper Lau , Hans Petersen
发明人： Knud E. Andersen , Lars J. S. Knutsen , Per O. Sorensen , Behrend F. Lundt , Jesper Lau , Hans Petersen
IPC分类号： A61K31/395 , A61K31/4427 , A61K31/445 , A61K31/455 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/554 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , C07D207/08 , C07D207/16 , C07D211/36 , C07D211/60 , C07D279/22 , C07D281/02 , C07D281/16 , C07D281/18 , C07D335/10 , C07D337/14 , C07D337/16 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D211/14 , C07D211/70
CPC分类号： C07D401/12 , C07D211/60 , C07D403/12 , C07D413/10 , C07D417/12
摘要： The invention relates to therapeutically active azaheterocyclic compounds and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.
摘要翻译：本发明涉及治疗活性的氮杂环化合物和包含该化合物的药物组合物。新化合物可用于治疗与GABA摄取相关的中枢神经系统疾病。

6. 发明授权

US4070373A Tricyclic aminoalkyl derivatives 失效
标题翻译：三环氨基烷基衍生物
公开(公告)号：US4070373A
公开(公告)日：1978-01-24
申请号：US291426
申请日：1972-09-22
申请人： Werner Winter , Max Thiel , Kurt Stach, deceased , by Werner Plattner, administrator , Wolfgang Schaumann , Karl Dietmann
发明人： Werner Winter , Max Thiel , Kurt Stach, deceased , by Werner Plattner, administrator , Wolfgang Schaumann , Karl Dietmann
IPC分类号： C07D311/90 , C07D313/12 , C07D337/12 , C07D337/16
CPC分类号： C07D337/16 , C07D311/90 , C07D313/12 , C07D337/12 , C07C2103/18
摘要： Novel tricyclic aminoalkyl derivatives are disclosed which are characterized by valuable pharmacological activities and namely by cardiac and circulatory activities. The tricyclic aminoalkyl derivatives are compounds of the formula: ##STR1## wherein X is an oxygen or a sulfur atom, a saturated or unsaturated, straight chain or branched alkylene group containing up to 3 carbon atoms, an oxymethylene, thiamethylene or thiaethylene group or a valency bond, R.sub.1 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen or hydroxyl, R.sub.3 is hydrogen or together with R.sub.2 represents a further valency bond, R.sub.4 and R.sub.5 which may be the same or different are each hydrogen or lower alkyl, A is alkylene which is substituted by an optionally acylated hydroxyl group, Y is an oxygen or sulfur atom or an optionally alkylated imino group and Z is aryl, aralkyl, cycloalkyl or cycloalkyl-alkyl which may be substituted by halogen, hydroxyl, nitro, amino, alkoxy, aralkoxy, alkyl, trifluoromethyl, alkylamino or alkylsulfonyl group, and the acid addition salts thereof with pharmacologically acceptable acids.
摘要翻译：公开了新颖的三环氨基烷基衍生物，其特征在于有价值的药理活性，即通过心脏和循环活性。三环氨基烷基衍生物是下式的化合物：其中X是氧或硫原子，含有至多3个碳原子的饱和或不饱和的直链或支链亚烷基，亚甲基，亚亚甲基或亚硫代亚乙基或化合键，R 1是氢，卤素，烷基，烷氧基或三氟甲基，R 2是氢或羟基，R 3是氢或与R 2一起代表另外的价键，可以相同或不同的R 4和R 5各自是氢或低级烷基 A是被任意酰化的羟基取代的亚烷基，Y是氧或硫原子或任选烷基化的亚氨基，Z是可以被卤素，羟基，硝基取代的芳基，芳烷基，环烷基或环烷基 - 烷基，氨基，烷氧基，芳烷氧基，烷基，三氟甲基，烷基氨基或烷基磺酰基，及其与药理学上可接受的酸的酸加成盐。

7. 发明申请

US20090239169A1 OXIDIZED MIXED CYCLIC PHENOL SULFIDES, AND CHARGE CONTROL AGENTS AND TONERS USING THE SAME 有权
标题翻译：氧化的混合循环硫醇，以及充电控制剂和使用它的调色剂
公开(公告)号：US20090239169A1
公开(公告)日：2009-09-24
申请号：US12481112
申请日：2009-06-09
申请人： Masateru Yasumura , Masami Ito , Naohiro Tarumoto , Yoshikazu Aoki , Masafumi Umekawa , Masaki Okubo , Hideyuki Otsuka , Jun Watanabe
发明人： Masateru Yasumura , Masami Ito , Naohiro Tarumoto , Yoshikazu Aoki , Masafumi Umekawa , Masaki Okubo , Hideyuki Otsuka , Jun Watanabe
IPC分类号： G03G9/097 , C07D337/16
CPC分类号： G03G9/09775 , C07D341/00 , G03G9/08748 , G03G9/08771
摘要： The present invention discloses an oxidized mixed cyclic phenol sulfide which is a mixture of the oxidized cyclic phenol sulfide wherein m is 8 and the oxidized cyclic phenol sulfide wherein m is an integer other than 8, the oxidized cyclic phenol sulfide being represented by the following formula (1): wherein R is a straight or branched alkyl group having 1 to 6 carbon atoms, m is an integer from 4 to 9, and n is 1 or 2; or an oxidized cyclic phenol sulfide of formula (1) wherein m is 8. The present invention also discloses a charge control agent which comprises the above sulfide(s) as the active ingredient; and a toner which comprises the charge control agent, a coloring agent and a binder resin. This charge control agent is particularly useful for color toners, and it speeds up charging risetime, and has a high charge amount and charging characteristics excellent in environmental stability. Further, the charge control agent is safe since it does not have any problem with the waste regulations.
摘要翻译：本发明公开了氧化型环状苯酚硫化物，其为m为8的氧化型环状苯酚硫化物和m为8以外的整数的氧化型环状苯酚硫化物的混合物，氧化型环状苯酚硫化物由下式（1）表示：其中R是具有1-6个碳原子的直链或支链烷基，m是4至9的整数，n是1或2; 或式（1）的氧化环状苯酚硫化物，其中m为8.本发明还公开了一种电荷控制剂，其包含上述硫化物作为活性成分; 以及包含电荷控制剂，着色剂和粘合剂树脂的调色剂。该电荷控制剂对于彩色调色剂特别有用，并且其加速时间上升，并且具有高的电荷量和环境稳定性优良的充电特性。此外，充电控制剂是安全的，因为废物规定没有任何问题。

8. 发明授权

US07087765B2 Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 失效
公开(公告)号：US07087765B2
公开(公告)日：2006-08-08
申请号：US10797355
申请日：2004-03-09
申请人： Alan L. Mueller , Scott T. Moe
发明人： Alan L. Mueller , Scott T. Moe
IPC分类号： C07D337/16 , C07D495/00 , C07D313/00 , C07D311/82 , C07C211/03
CPC分类号： C07D207/08 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/165 , A61K31/381 , A61K31/40 , A61K31/4409 , A61K31/4462 , A61K31/4465 , C07B2200/07 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/32 , C07C211/40 , C07C211/42 , C07C211/54 , C07C211/55 , C07C215/28 , C07C215/54 , C07C217/10 , C07C217/48 , C07C217/58 , C07C217/60 , C07C217/62 , C07C233/11 , C07C233/13 , C07C233/22 , C07C235/34 , C07C237/06 , C07C237/22 , C07C257/14 , C07C279/14 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/32 , C07D207/12 , C07D207/20 , C07D209/42 , C07D211/18 , C07D213/30 , C07D213/32 , C07D213/38 , C07D231/20 , C07D311/90 , C07D313/12 , C07D333/20 , C07D335/20
摘要： Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits due to ischemia or hypoxia such as those that frequently occur as a consequence of cardiac surgery under cardiopulmonary bypass, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).

9. 发明申请

US20040014803A1 Novel benzothiepines having activity as inhibitors of lleal bile acid transport and taurocholate uptake 失效
标题翻译：具有作为胆汁酸运输抑制剂和牛磺胆酸摄取的活性的新型苯并噻庚英
公开(公告)号：US20040014803A1
公开(公告)日：2004-01-22
申请号：US10068297
申请日：2002-02-08
申请人： G.D. Searle & Co.
发明人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC分类号： C07D337/16 , A61K031/38
CPC分类号： A61K31/38 , B24B5/18 , B24B21/12 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329 , C07C323/12 , C07C323/18
摘要： Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
摘要翻译：提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。

10. 发明申请

US20010021423A1 Ferulic acid derivative, and liquid crystal material, cation detecting element , anion detecting element, ion conducting material and electrolyte, each using the ferulic acid derivative 失效
标题翻译：阿魏酸衍生物和液晶材料，阳离子检测元件，阴离子检测元件，离子导电材料和电解质，各自使用阿魏酸衍生物
公开(公告)号：US20010021423A1
公开(公告)日：2001-09-13
申请号：US09750171
申请日：2000-12-29
申请人： Agency of Industrial Science and Technology
发明人： Takushi Sugino , Yo Shimizu , Hirosato Monobe
IPC分类号： C09K019/12 , C07D281/18 , C07D337/16
CPC分类号： C09K19/40 , C09K19/2014 , Y10T428/1036
摘要： A ferulic acid derivative represented by the general formula: 1 wherein R denotes a polyethylene glycol group, a crown ether group, or a azacrown ether group.
摘要翻译：由以下通式表示的阿魏酸衍生物：其中R表示聚乙二醇基，冠醚基或偶氮染料醚基

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