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1. 发明授权

US08314258B2 Method for producing acrylate derivative, acrylate derivative, and intermediate thereof 有权
标题翻译：丙烯酸酯衍生物，丙烯酸酯衍生物及其中间体的制造方法
公开(公告)号：US08314258B2
公开(公告)日：2012-11-20
申请号：US12918527
申请日：2009-02-20
申请人： Osamu Nakayama , Takashi Fukumoto
发明人： Osamu Nakayama , Takashi Fukumoto
IPC分类号： C07D339/00
CPC分类号： C07D339/08 , C07D339/00 , C08F220/28 , C08F220/38 , G03F7/0397
摘要： Provided are 1) a production process for an acrylic ester derivative capable of being a raw material of a polymer for obtaining a photoresist composition capable of forming a photoresist film which is excellent in a reactivity to acid and a heat stability and is less swollen in developing and which has a refractive index of preferably 1.72 or more in 193 nm and can be patterned, 2) an acrylic ester derivative obtained by the above production process and 3) alcohol and ester which are synthetic intermediates for the above acrylic ester derivative.
摘要翻译： 1）一种丙烯酸酯衍生物的生产方法，其能够作为获得能够形成光致抗蚀剂的聚合物的原料，所述光致抗蚀剂组合物具有优异的反应性和热稳定性，并且在显影中的溶胀性较小并且其在193nm中的折射率优选为1.72以上，并且可以被图案化，2）通过上述制备方法获得的丙烯酸酯衍生物和3）作为上述丙烯酸酯衍生物的合成中间体的醇和酯。

2. 发明申请

US20110009643A1 METHOD FOR PRODUCING ACRYLATE DERIVATIVE, ACRYLATE DERIVATIVE, AND INTERMEDIATE THEREOF 有权
标题翻译：生产丙烯酸酯衍生物，丙烯酸酯衍生物及其中间体的方法
公开(公告)号：US20110009643A1
公开(公告)日：2011-01-13
申请号：US12918527
申请日：2009-02-20
申请人： Osamu Nakayama , Takashi Fukumoto
发明人： Osamu Nakayama , Takashi Fukumoto
IPC分类号： C07D339/00 , C07D339/08
CPC分类号： C07D339/08 , C07D339/00 , C08F220/28 , C08F220/38 , G03F7/0397
摘要： Provided are 1) a production process for an acrylic ester derivative capable of being a raw material of a polymer for obtaining a photoresist composition capable of forming a photoresist film which is excellent in a reactivity to acid and a heat stability and is less swollen in developing and which has a refractive index of preferably 1.72 or more in 193 nm and can be patterned, 2) an acrylic ester derivative obtained by the above production process and 3) alcohol and ester which are synthetic intermediates for the above acrylic ester derivative.
摘要翻译： 1）一种丙烯酸酯衍生物的生产方法，其能够作为获得能够形成光致抗蚀剂的聚合物的原料，所述光致抗蚀剂组合物具有优异的反应性和热稳定性，并且在显影中的溶胀性较小并且其在193nm中的折射率优选为1.72以上，并且可以被图案化，2）通过上述制备方法获得的丙烯酸酯衍生物和3）作为上述丙烯酸酯衍生物的合成中间体的醇和酯。

3. 发明申请

US20100331508A1 (METH)ACRYLATE DERIVATIVE, INTERMEDIATE THEREOF, AND POLYMER COMPOUND 有权
标题翻译：（METH）丙烯酸酯衍生物，其中间体和聚合物化合物
公开(公告)号：US20100331508A1
公开(公告)日：2010-12-30
申请号：US12918675
申请日：2009-02-20
申请人： Junko Sato , Osamu Nakayama , Takashi Fukumoto
发明人： Junko Sato , Osamu Nakayama , Takashi Fukumoto
IPC分类号： C08F228/06 , C07D339/08 , C07D327/06 , C07D319/12 , C07D339/00 , C07D327/00 , C07D323/00 , C08F224/00
CPC分类号： C07D327/06 , C07D339/08 , C08F220/28 , C08F220/38 , G03F7/0395 , G03F7/0397 , C08F220/18 , C08F222/06 , C08F232/08
摘要： Provided are a polymerizable compound shown below which is useful as a raw material for a polymer having less swelling in developing, a polymer obtained by polymerizing a raw material containing the above polymerizable compound, a photoresist composition which contains the above polymer and which is improved in LWR and an efficient production process for the polymerizable compound described above: wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or trifluoromethyl; R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like; W represents an alkylene group having 1 to 10 carbon atoms or the like; and Y1 and Y2 represent an oxygen atom or a sulfur atom.
摘要翻译：提供下述可聚合化合物，其可用作显影时溶胀较小的聚合物的原料，通过聚合含有上述可聚合化合物的原料获得的聚合物，含有上述聚合物的光致抗蚀剂组合物， LWR和上述可聚合化合物的有效制备方法：其中n表示0至2的整数; R1表示氢原子，甲基或三氟甲基; R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和R 10表示氢原子，碳原子数1〜6的烷基等; W表示碳原子数1〜10的亚烷基等; Y 1和Y 2表示氧原子或硫原子。

4. 发明申请

US20090175812A1 Novel Skin Lightening Agents, Compositions and Methods 审中-公开
标题翻译：新型皮肤发光剂，组合物和方法
公开(公告)号：US20090175812A1
公开(公告)日：2009-07-09
申请号：US12406643
申请日：2009-03-18
申请人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko , Victor De Florio , Jose Guillermo Rosa , Michael Tallman
发明人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko , Victor De Florio , Jose Guillermo Rosa , Michael Tallman
IPC分类号： A61K8/49 , C07D339/06 , C07D339/08 , C07D339/00 , A61Q19/02
CPC分类号： A61Q19/02 , A61K8/4986 , C07D339/00 , C07D339/06 , C07D339/08
摘要： Compounds of formula I, process for making same, and cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Where each A1 and/or A2 independently is ═H or COR, CO2R, CONHR, the latter three having the following formula A: where R═C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is H; C1-C18 saturated or unsaturated hydrocarbon; or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1═C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; X is Carbon, Nitrogen, Sulfur, or Oxygen; and N is in integer between 0 and 2.
摘要翻译：式I的化合物，其制备方法，以及使用式I化合物作为皮肤增亮剂的化妆品组合物和皮肤发白的方法：其中每个A1和/或A2独立地为-H或COR，CO 2 R，CONHR，后者三个具有下式A：其中R-C1-C18饱和或不饱和的直链或支链烃; 并且每个Y1和/或Y2独立地为H; C1-C18饱和或不饱和烃; 或OZ，其中Z = H或COR1，式B的CO 2 R 1，CONHR：其中R 1 -C 1 -C 18饱和或不饱和的直链或支链烃; X是碳，氮，硫或氧; 并且N在0和2之间的整数。

5. 发明授权

US07348441B2 Methyl 2,4,9-trithiaadamantane-7-carboxylate 失效
标题翻译： 2,4,9-三硫代金刚烷-7-羧酸甲酯
公开(公告)号：US07348441B2
公开(公告)日：2008-03-25
申请号：US10562090
申请日：2004-07-01
申请人： Jun Hu
发明人： Jun Hu
IPC分类号： C07D339/00
CPC分类号： C07D495/18 , C07D495/22
摘要： Methyl 2,4,9-trithiaadamantane-7-carboxylate and a method for its manufacture is disclosed. The method reacts oxidized methyl triallyl acetate with a Lewis acid and a sulphuring agent.
摘要翻译：公开了2,4,9-三硫杂金刚烷-7-羧酸甲酯及其制备方法。该方法使氧化甲基三烯丙基酯与路易斯酸和硫化剂反应。

6. 发明授权

US5824484A RXR homodimer formation 失效
标题翻译： RXR同二聚体形成
公开(公告)号：US5824484A
公开(公告)日：1998-10-20
申请号：US589528
申请日：1996-01-22
申请人： Magnus Pfahl , Xiao-kun Zhang , Jurgen M. Lehmann , Marcia I. Dawson , James F. Cameron , Peter D. Hobbs , Ling Jong
发明人： Magnus Pfahl , Xiao-kun Zhang , Jurgen M. Lehmann , Marcia I. Dawson , James F. Cameron , Peter D. Hobbs , Ling Jong
IPC分类号： A61K31/19 , A61K31/36 , A61K38/00 , C07C63/49 , C07C63/66 , C07C69/738 , C07C69/76 , C07D317/30 , C07D319/06 , C07D327/04 , C07D333/38 , C07D339/06 , C07D339/08 , C07D409/04 , C07K14/705 , G01N33/68 , G01N33/74 , G01N33/53 , C07D317/00 , C07D339/00 , C07D69/76
CPC分类号： C07D409/04 , A61K31/19 , A61K31/36 , C07C63/49 , C07C63/66 , C07C69/738 , C07C69/76 , C07D317/30 , C07D319/06 , C07D327/04 , C07D333/38 , C07D339/06 , C07D339/08 , C07K14/70567 , G01N33/6875 , G01N33/74 , A61K38/00 , C07K2319/00 , G01N2500/00
摘要： The invention provides a method of screening a substance for the ability to effect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the presence of homodimer formation. Also provided is a method of screening a substance for an effect on a retinoid X receptor homodimer's ability to bind DNA comprising combining the substance with the homodimer and determining the effect of the compound on the homodimer's ability to bind DNA. A method of inhibiting an activity of a retinoid X receptor heterodimer comprising increasing the formation of a retinoid X receptor homodimer, thereby preventing the retinoid X receptor from forming a heterodimer and preventing the resulting heterodimer activity is also provided. A method of inhibiting an activity of a retinoid X receptor homodimer is also provided. A method of determining an increased probability of a pathology associated with retinoid X receptor homodimer formation and treating such pathology are further provided. In addition, a method of screening a response element for binding with a retinoid X receptor homodimer is provided. Finally, the invention provides methods of activating retinoid X receptor homodimer formation.
摘要翻译：本发明提供了筛选物质以形成类视黄醇X受体同二聚体的能力的方法，其包括将该物质与含有类视色素X受体的溶液组合并测定同型二聚体形成的存在。还提供了筛选对视黄酸X受体同二聚体结合DNA的能力的物质的筛选方法，包括将该物质与同型二聚体组合并确定化合物对同二聚体结合DNA的能力的影响。一种抑制类视黄醇X受体异二聚体活性的方法包括增加类视黄醇X受体同二聚体的形成，从而防止类视黄醇X受体形成异源二聚体并防止所得的异二聚体活性。还提供了抑制类视黄醇X受体同二聚体的活性的方法。还提供了确定与类视黄醇X受体同二聚体形成和治疗这种病理学相关的病理学增加概率的方法。此外，提供了筛选与类视黄醇X受体同二聚体结合的响应元件的方法。最后，本发明提供活化类视黄醇X受体同二聚体形成的方法。

7. 发明授权

US5767274A Prenyl transferase inhibitors 失效
标题翻译：丙烯酰转移酶抑制剂
公开(公告)号：US5767274A
公开(公告)日：1998-06-16
申请号：US675439
申请日：1996-06-28
申请人： Sun H. Kim
发明人： Sun H. Kim
IPC分类号： C12N9/99 , A61K31/17 , A61K31/33 , A61K31/395 , A61K38/00 , A61P9/10 , A61P13/08 , A61P35/00 , A61P43/00 , C07C323/60 , C07D241/04 , C07D285/00 , C07D285/36 , C07D285/38 , C07D339/00 , C07D513/04 , C07D513/14 , C07K5/06 , C07K5/08 , C07K5/083 , A61K31/385
CPC分类号： C07D513/04 , C07C323/60 , C07D217/26 , C07D241/04 , C07D285/36 , C07D285/38 , C07D339/00 , C07D417/06 , C07D417/14 , C07D513/14 , C07K5/0606 , C07K5/081 , A61K38/00
摘要： A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by either of the two following formulas ##STR1## Each of the R groups is defined in the disclosure.
摘要翻译：能够抑制异戊烯基转移酶活性的化合物家族。这些化合物被以下两个下式中的任一个所覆盖：在本公开内容中定义了每个R基团。

8. 再颁专利

USRE33778E 1,3-dithietane-2-carboxylic acid penicillin and cephalosporin derivatives 失效
公开(公告)号：USRE33778E
公开(公告)日：1991-12-24
申请号：US449114
申请日：1989-12-08
申请人： Masaru Iwanami , Tetsuya Maeda , Yoshinobu Nagano , Masaharu Fujimoto , Noriaki Nagano , Atsuki Yamazaki , Kasaharu Tamazawa , Kiyoshi Murase , Tadao Shibanuma
发明人： Masaru Iwanami , Tetsuya Maeda , Yoshinobu Nagano , Masaharu Fujimoto , Noriaki Nagano , Atsuki Yamazaki , Kasaharu Tamazawa , Kiyoshi Murase , Tadao Shibanuma
IPC分类号： C07D339/00 , C07D499/76 , C07D501/06 , C07D501/20 , C07D501/36 , C07D501/57
CPC分类号： C07D339/00
摘要： Substituted 1,3-dithietane-2-carboxylic acid derivatives useful as intermediates for the preparation of highly effective penicillin and cephalosporin derivatives and the preparation thereof.

9. 发明授权

US4680303A Thioformamide derivatives and use in inhibiting gastric secretion 失效
标题翻译：硫代甲酰胺衍生物，用于抑制胃分泌
公开(公告)号：US4680303A
公开(公告)日：1987-07-14
申请号：US798846
申请日：1985-11-18
申请人： Jean C. Aloup , Jean Bouchaudon , Daniel Farge , Claude James
发明人： Jean C. Aloup , Jean Bouchaudon , Daniel Farge , Claude James
IPC分类号： C07D213/30 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61P1/04 , C07D213/34 , C07D335/00 , C07D339/00 , C07D405/04 , C07D409/04 , C07D409/00 , C07D401/00
CPC分类号： C07D405/04 , C07D409/04
摘要： Thioformamide derivatives of formula: ##STR1## in which R is hydrogen or alkyl (1 to 4 C), R.sub.1 is alkyl (1 to 4 C), and X denotes sulphur or oxygen and Y is sulphur, oxygen, methylene radical, or, when X is oxygen, a valency bond, are inhibitors of gastric secretion and therefore useful in the treatment of gastric ulcers. They may be made by reaction of an amine R--NH.sub.2 with a corresponding thioester or, when R is alkyl, by reaction of an alkyl isothiocyanate with the product of reacting a base with a compound of formula: ##STR2##
摘要翻译：式（Ⅰ）的硫代甲酰胺衍生物，其中R为氢或烷基（1-4），R 1为烷基（1-4），X为硫或氧，Y为硫，氧，亚甲基，或当X是氧时，价键是胃分泌的抑制剂，因此可用于治疗胃溃疡。它们可以通过胺R-NH 2与相应的硫酯反应制得，或者当R是烷基时，通过异硫氰酸烷基酯与碱与下式化合物反应的产物：

10. 发明授权

US4529721A Vinylthioacetamido oxacephalosporin derivatives 失效
标题翻译：乙烯基硫代乙酰氨基氧杂环孢菌素衍生物
公开(公告)号：US4529721A
公开(公告)日：1985-07-16
申请号：US534147
申请日：1983-09-21
申请人： Wataru Nagata , Mitsuru Yoshioka , Yasuhiro Nishitani , Tsutomu Aoki , Toshiro Konoike , Tadatoshi Kubota
发明人： Wataru Nagata , Mitsuru Yoshioka , Yasuhiro Nishitani , Tsutomu Aoki , Toshiro Konoike , Tadatoshi Kubota
IPC分类号： A01N43/90 , C07D241/08 , C07D339/00 , C07D505/00 , C07D519/00 , C07F9/535 , A01N59/06 , C07D498/04
CPC分类号： C07F9/5352 , C07C309/00 , C07C323/00 , C07D241/08 , C07D339/00 , C07D505/00 , Y02P20/55
摘要： A compound of the formula: ##STR1## wherein u represents hydrogen, carboxamido, N-hydroxycarboxamido, carboxy, azido, an aryl, an acylamino, a protected carboxy or an N-alkoxycarboxamido, or, together with v, can represent --S-- or --CH.sub.2 S--; v represents hydrogen, halogen, cyano or an alkylthio, or, together with u, can represent --S-- or --CH.sub.2 S--, or, together with w, can represent --(CH.sub.2).sub.3 CO--; w represents hydrogen, carboamoyl, cyano, carboxy, an N-alkylcarbamoyl, an alkyl, an aryl, a protected carboxy or a heterocycle, or, together with v, can represents --(CH.sub.2).sub.3 CO--; x represents halogen, trifluoromethyl, an alkylthio or an arylthio; y represents hydrogen, a light metal or a carboxylic acid protecting group; and z represents an acyloxy or a heterocycle-thio, each of the above radicals represented by the symbols u, v, w, x, y and z being optionally substituted by halogen or a carbon-, nitrogen-, oxygen- or sulfur-containing functional group, a process for preparing the compound, a pharmaceutical composition containing the compound, and a therapeutical use of the compound.A compound of the formula: ##STR2## wherein u, v, w and x are as defined above, useful as a starting compound for preparing the compound (I) is also provided.
摘要翻译：下式的化合物：其中u表示氢，甲酰氨基，N-羟基羧甲酰氨基，羧基，叠氮基，芳基，酰氨基，被保护的羧基或N-烷氧基羧酰胺基，或与v一起可代表 -S-或-CH2S-; v表示氢，卤素，氰基或烷硫基，或与u一起可以表示-S-或-CH 2 S-，或者与w一起可以表示 - （CH 2）3 CO-; w表示氢，氨甲酰基，氰基，羧基，N-烷基氨基甲酰基，烷基，芳基，保护的羧基或杂环，或与v一起可以表示 - （CH 2）3 CO-; x表示卤素，三氟甲基，烷硫基或芳硫基; y表示氢，轻金属或羧酸保护基; 和z表示酰氧基或杂环硫基，由符号u，v，w，x，y和z表示的上述基团中的每一个任选被卤素或含碳，氮，氧或硫的官能团，制备该化合物的方法，含该化合物的药物组合物和该化合物的治疗用途。还提供了下式化合物：其中u，v，w和x如上定义，可用作制备化合物（I）的起始化合物。

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