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1. 发明授权

US09884046B1 Method of treating lung cancer 有权
公开(公告)号：US09884046B1
公开(公告)日：2018-02-06
申请号：US15632406
申请日：2017-06-26
申请人： Macau University of Science and Technology
发明人： Xiao Jun Yao , Lai Han Elaine Leung , Liang Liu , Xing Xing Fan , Chun Xie
IPC分类号： A61K31/428 , C07D277/72 , G01N33/574 , C07K14/47 , C12Q1/68 , G01N33/68 , A61K38/00
CPC分类号： A61K31/428 , A61K38/00 , C07D277/72 , C07K14/47 , C07K2319/00 , C12Q1/6886 , C12Q2600/112 , G01N33/574 , G01N33/57423 , G01N33/57484 , G01N33/68
摘要： One embodiment relates to a method of treating lung cancer by administering a compound of formula I to a patient. Another embodiment relates to a method of treating cancer with a KRAS mutation that includes administering to a patient the compound with the following formula I:

2. 发明授权

US09499501B2 2-Mercaptobenzothiazole manganese zinc, preparation method therefor and application thereof 有权
标题翻译： 2-巯基苯并噻唑锰锌，其制备方法及其应用
公开(公告)号：US09499501B2
公开(公告)日：2016-11-22
申请号：US14653654
申请日：2013-11-30
申请人： Henan Xinxiang Academy of Agriculture Sciences
发明人： Zhenjun Wang , Xu Zhang , Limin Wang , Hongyan Liu , Senxiang Cheng , Mengjiao Li
IPC分类号： C07D277/72 , C07D277/70 , A01N43/78 , A01N59/16
CPC分类号： C07D277/72 , A01N43/78 , A01N59/16 , C07D277/70 , Y02A50/359 , A01N2300/00
摘要： The present invention belongs to the technical field of agricultural fungicides and discloses a 2-mercaptobenzothiazole manganese zinc, preparation method therefor and application thereof. The chemical structure of the 2-mercaptobenzothiazole manganese zinc is shown as the above formula. Wherein m, n and n′ are positive integers, m=2(n+n′), n≧n′, n:n′=1:1˜9:1. Materials are prepared according to the stoichiometric ratio of the target products; 2-mercaptobenzothiazole is dissolved in sodium hydroxide solution. The aqueous solution of water-soluble manganese salts and water-soluble zinc salts solution are successively added to 2-mercaptobenzothiazole sodium solution under stirring, followed by stirring for mixing well, then the solution being allowed to stand, filtered and washed with water to obtain filter cake, and then dried in vacuum to obtain 2-mercaptobenzothiazole manganese zinc. The present 2-mercaptobenzothiazole manganese zinc may be used as an agricultural fungicide. The present invention coordinates the surface of solid particles of 2-mercaptobenzothiazole manganese with zinc to form a stable clathrate of 2-mercaptobenzothiazole manganese and zinc. Tests show that the clathrate has excellent effect for controlling a plurality of diseases including apple alternaria leaf spot, pear scab, apple ring rot, apple anthracnose and the like.
摘要翻译：本发明属于农药杀菌剂的技术领域，公开了2-巯基苯并噻唑锰锌，其制备方法及应用。 2-巯基苯并噻唑锰锌的化学结构如上式所示。其中m，n和n'为正整数，m = 2（n + n'），n≥n'，n：n'= 1：1〜9：1。材料根据目标产品的化学计量比制备; 将2-巯基苯并噻唑溶解在氢氧化钠溶液中。将水溶性锰盐和水溶性锌盐溶液的水溶液在搅拌下依次加入到2-巯基苯并噻唑钠溶液中，搅拌均匀，然后静置，过滤并用水洗涤，得到滤饼，然后真空干燥，得到2-巯基苯并噻唑锰锌。本发明的2-巯基苯并噻唑锰锌可用作农业杀真菌剂。本发明用锌与2-巯基苯并噻唑锰的固体颗粒表面配位，形成稳定的2-巯基苯并噻唑锰和锌的包合物。试验结果表明，包合物对苹果叶斑病，梨痂病，苹果腐烂，苹果炭疽病等多种疾病的控制效果优异。

3. 发明授权

US5436346A Process for the preparation of benzothiazolyl-2-sulphenamides 失效
标题翻译：苯并噻唑基-2-磺基苯胺的制备方法
公开(公告)号：US5436346A
公开(公告)日：1995-07-25
申请号：US240780
申请日：1994-06-21
申请人： Ludwig Eisenhuth , Manfred Bergfeld
发明人： Ludwig Eisenhuth , Manfred Bergfeld
IPC分类号： C07D277/80 , A61K31/425 , C07D277/72
CPC分类号： C07D277/80
摘要： The process for the preparation of benzothiazolyl-2-sulphenamides, by reacting a 2-mercaptobenzothiazole or dibenzothiazolyl 2,2'-disulphide with a primary or secondary aliphatic or cycloaliphatic amine in the presence of hydrogen peroxide as oxidizing agent in an aqueous medium is distinguished in that an aqueous hydrogen peroxide solution is metered at a temperature in the range from 30.degree. to 70.degree. C. into an aqueous suspension of the respective amine and the 2-mercaptobenzothiazole or dibenzothiazolyl 2,2'-disulphide in a ratio in the range between 1.0 and 1.5 mol of amine per mole of 2-mercaptobenzothiazole or per equivalent of dibenzothiazolyl 2,2'-disulphide, preferably in a quantity of below 1.35 mol per mole of 2-mercaptobenzothiazole or per equivalent of dibenzothiazolyl 2,2'-disulphide over a period of at least 60 minutes. The total quantity of water in the reaction mixture should not exceed 1500 g per mole of 2-mercaptobenzothiazole. An environmentally friendly and economic process is provided for the preparation of benzothiazolyl-2-sulphenamides in high yield and with high selectivity.
摘要翻译： PCT No.PCT / EP92 / 02917 371日期：1994年6月21日 102（e）日期1994年6月21日PCT提交1992年12月16日PCT公布。公开号WO93 / 13084 日期：1993年7月8日。在过氧化氢作为氧化剂存在下，通过使2-巯基苯并噻唑或二苯并噻唑基2,2'-二硫化物与伯或仲脂族或脂环族胺反应制备苯并噻唑-2-磺酰胺的方法在水性介质中的试剂的特征在于，将过氧化氢水溶液在30℃至70℃的温度下计量加入到相应的胺和2-巯基苯并噻唑或二苯并噻唑基的水悬浮液中，以每摩尔2-巯基苯并噻唑或每当量二苯并噻唑基2,2'-二硫化物的1.0至1.5摩尔胺之间的比例的二硫化物，优选以低于1.35摩尔/摩尔2-巯基苯并噻唑或每当量的二苯并噻唑基2,2'-二硫化物，至少60分钟。反应混合物中的水的总量不应超过每摩尔2-巯基苯并噻唑1500克。提供了一种环保经济的方法，以高产率和高选择性制备苯并噻唑-2-磺酰胺。

4. 发明授权

US5198550A Process for the purification of crude 2-mercaptobenzothiazole 失效
标题翻译：纯化2-巯基苯并噻唑的方法
公开(公告)号：US5198550A
公开(公告)日：1993-03-30
申请号：US890764
申请日：1992-06-01
申请人： Klaus Reinartz , Harro Schlesmann , Stefan Dietl
发明人： Klaus Reinartz , Harro Schlesmann , Stefan Dietl
IPC分类号： C07B63/00 , C07D277/72
CPC分类号： C07D277/72
摘要： Crude 2-mercaptobenzothiazole is purified by a process in which the crude 2-mercaptobenzothiazole is dissolved in relatively high-boiling aliphatic or cycloaliphatic alcohols or in mixtures of the alcohols mentioned or azeotropes thereof with water at temperatures of 60.degree. to 200.degree. C., optionally under elevated pressure, or is suspended in relatively high-boiling aliphatic or cycloaliphatic alcohols, aliphatic or cycloaliphatic ethers, organic acids or esters thereof at temperatures of 10.degree. to 100.degree. C., the solution or suspension is subsequently cooled and the product precipitating is filtered off and optionally washed.
摘要翻译：粗2-巯基苯并噻唑通过其中粗2-巯基苯并噻唑溶解在相对高沸点的脂肪族或脂环族醇中或在所述醇或其共沸物与水的混合物中在60至200℃的温度下进行纯化，任选地在升高的压力下，或者在10℃至100℃的温度下悬浮在相对高沸点的脂族或脂环族醇，脂族或脂环族醚，有机酸或酯中，随后将溶液或悬浮液冷却并使产物沉淀过滤并任选地洗涤。

5. 发明授权

US5069805A Phenolic benzothiazole derivatives and their use as corrosion inhibitors 失效
标题翻译：苯酚苯并噻唑衍生物及其作为腐蚀抑制剂的用途
公开(公告)号：US5069805A
公开(公告)日：1991-12-03
申请号：US583775
申请日：1990-09-14
申请人： Adalbert Braig , Hans-Rudolf Meier , David G. Leppard , Robert C. Wasson , Emyr Phillips
发明人： Adalbert Braig , Hans-Rudolf Meier , David G. Leppard , Robert C. Wasson , Emyr Phillips
IPC分类号： C07D277/70 , C07D277/72 , C07D417/06 , C08K5/46 , C09D5/08 , C09D181/00 , C09K15/30 , C10M135/36 , C10N30/10 , C10N30/12
CPC分类号： C07D277/70 , C07D277/72 , C08K5/46 , C09D5/086 , C09K15/30 , C10M135/36 , C10M2207/16 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10M2223/045 , C10N2210/02 , C10N2230/12
摘要： Compounds of the formula I ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meaning given in claim 1 are formed by thermal rearrangement of the isomers of formula V ##STR2## especially in the presence of basic catalysts. The compounds are corrosion inhibitors for organic materials, in particular coating materials and lubricants. In these substrates they also act as antioxidants and light-stabilizers and are very stable to heat.

6. 发明授权

US4978756A Compound and use 失效
标题翻译：复合使用
公开(公告)号：US4978756A
公开(公告)日：1990-12-18
申请号：US301785
申请日：1989-01-25
申请人： John R. Lawson
发明人： John R. Lawson
IPC分类号： C07C51/00 , C07C57/60 , C07C67/00 , C07C67/08 , C07C69/78 , C07D249/18 , C07D251/22 , C07D251/46 , C07D277/70 , C07D277/72 , C07D403/12 , C07D417/12 , C08J5/06 , C23F11/00 , C23F11/14 , C23F11/16
CPC分类号： C07D277/70 , C07D249/18 , C07D251/46 , C07D403/12 , C07D417/12 , C08J5/06 , C23F11/149 , C23F11/16 , C08J2321/00
摘要： A compound contains a ligand group and at least one group of the general formula --XR.sub.n where X is a linking group which contains at least one hetero-atom, R is a saturated hydrocarbyl group containing at least six carbon atoms or is an unsaturated hydrocarbyl group containing at least three carbon atoms. The ligand group can be a polyhydroxyhydrocarbyl, a triazole, an imidazole, an indazole, a thiazole, an oxazole, a carbamate, an xanthate or a phthalazine. The compounds can be used to improve bonding between a metal and a coating material in contact with the metal surface. The metal may be a tire cord and the coating material rubber or a rubber composition.

7. 发明授权

US4894091A Phenolic benzothiazole derivatives and their use as corrosion inhibitors 失效
标题翻译：酚苯并噻唑衍生物及其作为腐蚀抑制剂的用途
公开(公告)号：US4894091A
公开(公告)日：1990-01-16
申请号：US86337
申请日：1987-08-17
申请人： Adalbert Braig , Hans-Rudolf Meier , David G. Leppard , Robert C. Wasson , Emyr Phillips
发明人： Adalbert Braig , Hans-Rudolf Meier , David G. Leppard , Robert C. Wasson , Emyr Phillips
IPC分类号： C07D277/70 , C07D277/72 , C07D417/06 , C08K5/46 , C09D5/08 , C09D181/00 , C09K15/30 , C10M135/36 , C10N30/10 , C10N30/12
CPC分类号： C07D277/70 , C07D277/72 , C08K5/46 , C09D5/086 , C09K15/30 , C10M135/36 , C10M2207/16 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10M2223/045 , C10N2210/02 , C10N2230/12
摘要： Compounds of the formula I ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meaning given in claim 1 are formed by thermal rearrangement of the isomers of formula V ##STR2## especially in the presence of basic catalysts. The compounds are corrosion inhibitors for organic materials, in particular coating materials and lubricants. In these substrates they also act as antioxidants and light-stabilizers and are very stable to heat.
摘要翻译：其中R，R 1，R 2，R 3，R 4和R 5具有权利要求1中给出的含义的式I化合物（I）通过式V（V）异构体的热重排形成，特别是在存在碱性催化剂。这些化合物是有机材料的腐蚀抑制剂，特别是涂料和润滑剂。在这些基材中，它们也起到抗氧化剂和光稳定剂的作用，对热量非常稳定。

8. 发明授权

US4764299A Anti-oxidant compositions 失效
公开(公告)号：US4764299A
公开(公告)日：1988-08-16
申请号：US60183
申请日：1987-06-09
申请人： Mary F. Salomon
发明人： Mary F. Salomon
IPC分类号： C07D277/72 , C07C321/14 , C07C321/28 , C07C323/12 , C10M135/22 , C10M135/24 , C10M135/28 , C10M135/30 , C10M135/36 , C10M151/04 , C10M159/12 , C10M173/02 , C10N30/10 , C10N40/04 , C10N40/08
CPC分类号： C10M135/30 , C10M135/24 , C10M135/36 , C10M151/04 , C10M173/02 , C10M2201/02 , C10M2215/064 , C10M2219/084 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10M2219/108 , C10M2221/02 , C10M2221/04 , C10M2221/041 , C10M2221/043 , C10N2240/04 , C10N2240/042 , C10N2240/044 , C10N2240/046 , C10N2240/08 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106 , C10N2250/02
摘要： The present invention deals with compositions containing sulfur and oxygen which are useful in lubricants and automatic transmission fluids.

9. 发明授权

US4647669A Process for the purification of mercaptobenzothizaole 失效
标题翻译：巯基苯并噻唑纯化方法
公开(公告)号：US4647669A
公开(公告)日：1987-03-03
申请号：US745397
申请日：1985-06-14
申请人： Michel Alicot
发明人： Michel Alicot
IPC分类号： C07D277/72
CPC分类号： C07D277/72
摘要： A process for purifying crude synthetic mercaptobenzothiazole according to the invention, which comprises treating the crude mercaptobenzothiazole with aniline, filtering and washing the crystallized mercaptobenzothiazole with aniline and, if desired, recycling the liquid organic phases of the purification medium, wherein the crystallization of mercaptobenzothiazole, the filtration and the washing are carried out at a temperature of from 40.degree. to 120.degree. C.
摘要翻译：一种纯化本发明粗制合成巯基苯并噻唑的方法，其包括用苯胺处理粗制巯基苯并噻唑，用苯胺过滤和洗涤结晶的巯基苯并噻唑，如果需要，再循环纯化介质的液态有机相，其中巯基苯并噻唑，过滤和洗涤在40℃至120℃的温度下进行。

10. 发明授权

US4427436A N-Substituted xanthate benzothiazoline and related derivatives 失效
标题翻译： N-取代的黄原酸酯苯并噻唑啉及相关衍生物
公开(公告)号：US4427436A
公开(公告)日：1984-01-24
申请号：US397617
申请日：1982-07-12
申请人： John J. D'Amico
发明人： John J. D'Amico
IPC分类号： A01N47/06 , C07D263/58 , C07D277/68 , C07D277/72 , A01N9/12
CPC分类号： C07D263/58 , A01N47/06 , C07D277/68 , C07D277/72
摘要： The present invention relates to compounds represented by the formula ##STR1## wherein R represents an alkyl radical having from 1 to 3 carbon atoms, and X and Y represent oxygen or sulfur, and T represents a radical selected from hydrogen and C.sub.1-3 alkoxy. Those compounds have been found useful in a method for regulating plant growth and in plant growth regulant compositions.
摘要翻译：本发明涉及由下式表示的化合物：其中R表示具有1至3个碳原子的烷基，X和Y表示氧或硫，T表示选自氢和C 1-3烷氧基的基团。已经发现这些化合物可用于调节植物生长和植物生长调节剂组合物的方法。

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