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1. 发明授权

US11433061B2 Heteroaryl sulfonamides and CCR2/CCR9 有权
公开(公告)号：US11433061B2
公开(公告)日：2022-09-06
申请号：US16739204
申请日：2020-01-10
申请人： ChemoCentryx, Inc.
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/444 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K45/06
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

2. 发明授权

US09884826B2 Sulfonamide compounds and uses as TNAP inhibitors 有权
公开(公告)号：US09884826B2
公开(公告)日：2018-02-06
申请号：US15241905
申请日：2016-08-19
申请人： Sanford-Burnham Medical Research Institute
发明人： Anthony B. Pinkerton , Russell Dahl , Nicholas D. P. Cosford , Jose Luis Millan
IPC分类号： C07D213/58 , C07D401/12 , A61K31/44 , C07D213/74 , A61P19/00 , C07D213/76 , C07D215/38 , A61K31/50 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D213/80 , C07D213/82 , C07D231/42 , C07D333/36 , C07D237/20 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D271/113 , C07D277/52 , C07D285/135 , C07D213/79 , C07D213/81 , C07D215/48
CPC分类号： C07D213/76 , A61K31/44 , A61K31/50 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/38 , C07D215/48 , C07D231/42 , C07D237/20 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D271/113 , C07D277/52 , C07D285/135 , C07D333/36 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04
摘要： Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

3. 发明申请

US20110237584A1 KYNURENINE PRODUCTION INHIBITOR 有权
标题翻译：吉非宁生产抑制剂
公开(公告)号：US20110237584A1
公开(公告)日：2011-09-29
申请号：US13128516
申请日：2009-11-09
申请人： Nobuyoshi Amishiro , Yuichi Fukuda , Keisuke Kinpara , Motoya Mie , Hisashi Tagaya , Takeshi Takahashi
发明人： Nobuyoshi Amishiro , Yuichi Fukuda , Keisuke Kinpara , Motoya Mie , Hisashi Tagaya , Takeshi Takahashi
IPC分类号： A61K31/4965 , C07D401/12 , A61K31/497 , C07D241/22 , C07D471/04 , A61K31/4985 , C07D409/12 , C07D405/14 , C07D413/14 , C07D405/12 , A61K31/5377 , C07D417/12 , C07D417/14 , C07D403/12 , A61P35/00
CPC分类号： C07D241/22 , A61K31/4965 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/5377 , C07D241/20 , C07D241/44 , C07D401/12 , C07D403/12 , C07D407/12 , C07D407/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D453/02 , C07D471/04
摘要： Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein R50 and R51 may be the same or different and each represent a hydrogen atom or the like, G1 and G2 may be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein m1 and m2 may be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and R6 and R7 may be the same or different and each represent a hydrogen atom or the like), R1 represents optionally substituted lower alkyl or the like, R2 represents a hydrogen atom or the like, and R3 represents optionally substituted lower alkyl or the like), and the like.
摘要翻译：本发明提供了含有由式（I）表示的含氮杂环化合物的犬尿氨酸生产抑制剂：其中R50和R51可以相同或不同，各自表示氢原子等，G1和G2可以相同或不同各自表示氮原子等，X表示式（III）：（其中，m1和m2可以相同或不同，表示0或1的整数，Y表示氧原子等，R6和 R 7可以相同或不同，各自表示氢原子等），R 1表示任选取代的低级烷基等，R 2表示氢原子等，R 3表示任选取代的低级烷基等），和类似。

4. 发明申请

US20080293742A1 Novel N-(Fluoro-Pyrazinyl)-Phenylsulfonamides as Modulators of Chemokine Receptor Ccr4 审中-公开
标题翻译：新型N-（氟 - 吡嗪基） - 苯磺酰胺作为趋化因子受体Ccr4的调节剂
公开(公告)号：US20080293742A1
公开(公告)日：2008-11-27
申请号：US12096513
申请日：2006-12-11
申请人： David Cheshire , Nicholas Kindon , Antonio Mete , Bryan Roberts
发明人： David Cheshire , Nicholas Kindon , Antonio Mete , Bryan Roberts
IPC分类号： A61K31/4965 , C07D241/22 , A61P11/06
CPC分类号： C07D241/22
摘要： The invention provides N-(fluoro-pyrazinyl)-phenylsulfonamides of formula (I) wherein R1-R5 are as defined in the specification; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy
摘要翻译：本发明提供式（I）的N-（氟 - 吡嗪基） - 苯基磺酰胺，其中R 1 -R 5如说明书中所定义; 制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途

5. 发明授权

US06943254B2 Synthesis of pyrazinyl pyridine-3-sulfonamide compounds 失效
标题翻译：吡嗪基吡啶-3-磺酰胺化合物的合成
公开(公告)号：US06943254B2
公开(公告)日：2005-09-13
申请号：US10348229
申请日：2003-01-22
申请人： Philip John Hogan
发明人： Philip John Hogan
IPC分类号： C07D213/71 , C07B45/04 , C07C303/02 , C07C309/86 , C07C309/89 , C07D401/12 , C07D241/22
CPC分类号： C07D401/12 , C07C303/02 , Y02P20/55 , C07C309/86 , C07C309/89
摘要： A process for the manufacture of: wherein R is (1-4C)alkyl, carboxyl(1-4C)alkyl or 1,3,4-oxadiazol-2-yl comprises: (a) reaction of the diazonium salt of 3-amino-2-chloropyridine with thionyl chloride in water and an electron transfer catalyst; (b) reaction with isobutyl-(3-methoxy-5-methylpyrazin-2-yl)carbamate and an alkali metal hydride in inert solvent; and (I) where R is (1-4C)alkyl, carboxy(1-4C)alkyl: (c) reaction with a boronic acid: (or an anhydride or ester therof) in the presence of a base and a palladium or nickel catalyst in solvent; and removal of the isobutoxy carbonyl group; or (ii) where R is 1,3,4-oxadiazol-2-yl (c) reaction with 4-methoxycarbonylphenylboronic acid (or an anhydride or ester thereof) with a source fluoride ion under aqueous conditions; (d) removal of the isobutoxycarbonyl protecting group; (e) conversion of the methyl ester group to the hydrazide; and (f) conversion to a 1,3,4-oxadiazol-2-yl moiety.
摘要翻译：一种制备方法：其中R是（1-4C）烷基，羧基（1-4C）烷基或1,3,4-恶二唑-2-基包括：（a）3-氨基的重氮盐 -2-氯吡啶与亚硫酰氯在水中的电子转移催化剂; （b）与惰性溶剂中的异丁基 - （3-甲氧基-5-甲基吡嗪-2-基）氨基甲酸酯和碱金属氢化物反应; 和（I）其中R是（1-4C）烷基，羧基（1-4C）烷基：（c）在碱和钯或镍的存在下与硼酸（或酸酐或酯基）反应：溶剂中的催化剂; 并除去异丁氧基羰基; 或（ii）其中R是1,3,4-恶二唑-2-基（c）在含水条件下与4-氟甲基羰基苯基硼酸（或其酸酐或酯）与源氟离子反应; （d）除去异丁氧羰基保护基; （e）甲酯转化为酰肼; 和（f）转化为1,3,4-恶二唑-2-基部分。

6. 发明授权

US2444012A Method of preparing 2-sulfanilamidopyrazine 失效
标题翻译： 2-磺胺酰吡嗪的制备方法
公开(公告)号：US2444012A
公开(公告)日：1948-06-22
申请号：US53587844
申请日：1944-05-16
申请人： AMERICAN CYANAMID CO
发明人： NORTHEY ELMORE H , WEBB JOHN S
IPC分类号： C07D241/22
CPC分类号： C07D241/22

7. 发明申请

US20200147066A1 Heteroaryl Sulfonamides and CCR2/CCR9 审中-公开
公开(公告)号：US20200147066A1
公开(公告)日：2020-05-14
申请号：US16739204
申请日：2020-01-10
申请人： ChemoCentryx, Inc.
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M.K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/444 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K45/06
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

8. 发明授权

US10532044B2 Heteroaryl sulfonamides and CCR2/CCR9 有权
公开(公告)号：US10532044B2
公开(公告)日：2020-01-14
申请号：US16272401
申请日：2019-02-11
申请人： ChemoCentryx, Inc.
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/444 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K45/06
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

9. 发明授权

US10206912B2 Heteroaryl sulfonamides and CCR2/CCR9 有权
公开(公告)号：US10206912B2
公开(公告)日：2019-02-19
申请号：US15383788
申请日：2016-12-19
申请人： ChemoCentryx, Inc.
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： C07C311/21 , A61K31/444 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K45/06
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

10. 发明申请

US20190010126A1 SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS 审中-公开
公开(公告)号：US20190010126A1
公开(公告)日：2019-01-10
申请号：US15888736
申请日：2018-02-05
申请人： Sanford-Burnham Medical Research Institute
发明人： Anthony B. PINKERTON , Russell DAHL , Nicholas D.P. COSFORD , Jose Luis MILLAN
IPC分类号： C07D213/76 , C07D215/48 , A61K31/44 , C07D213/81 , C07D417/04 , C07D285/135 , C07D277/52 , C07D271/113 , C07D263/50 , C07D261/16 , C07D241/22 , C07D239/69 , C07D237/20 , C07D231/42 , C07D213/82 , C07D213/80 , C07D333/36 , C07D409/12 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , A61K31/50 , C07D401/12 , C07D215/38 , C07D213/79
CPC分类号： C07D213/76 , A61K31/44 , A61K31/50 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/38 , C07D215/48 , C07D231/42 , C07D237/20 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D271/113 , C07D277/52 , C07D285/135 , C07D333/36 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04
摘要： Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

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