专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09884826B2 Sulfonamide compounds and uses as TNAP inhibitors 有权
公开(公告)号：US09884826B2
公开(公告)日：2018-02-06
申请号：US15241905
申请日：2016-08-19
申请人： Sanford-Burnham Medical Research Institute
发明人： Anthony B. Pinkerton , Russell Dahl , Nicholas D. P. Cosford , Jose Luis Millan
IPC分类号： C07D213/58 , C07D401/12 , A61K31/44 , C07D213/74 , A61P19/00 , C07D213/76 , C07D215/38 , A61K31/50 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D213/80 , C07D213/82 , C07D231/42 , C07D333/36 , C07D237/20 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D271/113 , C07D277/52 , C07D285/135 , C07D213/79 , C07D213/81 , C07D215/48
CPC分类号： C07D213/76 , A61K31/44 , A61K31/50 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/38 , C07D215/48 , C07D231/42 , C07D237/20 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D271/113 , C07D277/52 , C07D285/135 , C07D333/36 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04
摘要： Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

2. 发明申请

US20160024004A1 NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION 有权
标题翻译：抗HBV感染的新型抗病毒药物
公开(公告)号：US20160024004A1
公开(公告)日：2016-01-28
申请号：US14759385
申请日：2013-12-27
申请人： DREXEL UNIVERSITY , BARUCH S. BLUMBERG INSTITUTE , ENANTIGEN THERAPEUTICS, INC.
发明人： XIAODONG XU , JU-TAO GUO , TONG XIAO , YANMING DU , TIMOTHY BLOCK , SIMON DAVID PETER BAUGH , HONG YE
IPC分类号： C07C311/16 , C07C317/14 , C07D319/16 , C07C311/20 , C07D213/76 , C07D205/04 , C07D231/42 , C07D277/52 , C07D211/96 , C07D239/26 , C07D295/32 , C07C311/17 , C07D263/50
CPC分类号： C07C311/16 , C07B2200/07 , C07C233/66 , C07C309/89 , C07C311/17 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/48 , C07C317/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D203/26 , C07D205/04 , C07D211/96 , C07D213/40 , C07D213/75 , C07D213/76 , C07D215/38 , C07D215/42 , C07D217/24 , C07D231/40 , C07D231/42 , C07D239/26 , C07D261/14 , C07D263/48 , C07D263/50 , C07D263/58 , C07D277/46 , C07D277/52 , C07D295/26 , C07D295/30 , C07D295/32 , C07D305/08 , C07D309/04 , C07D319/16 , C07D319/18
摘要： The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as nucleocapsid assembly inhibitors. In other embodiments, the compounds of the invention are useful as pregenomic RNA encapsidation inhibitors of Hepatitis B virus (HBV). In yet other embodiments, the compounds of the invention are useful for the treatment of viral infection, including HBV and related viral infections.
摘要翻译：本发明提供新的式（I）化合物及其使用方法。在某些实施方案中，本发明的化合物可用作核衣壳组装抑制剂。在其它实施方案中，本发明的化合物可用作乙型肝炎病毒（HBV）的前基因组RNA包封抑制剂。在其它实施方案中，本发明的化合物可用于治疗病毒感染，包括HBV和相关病毒感染。

3. 发明授权

US06949654B2 N-alkyl-N-phenylhydroxylamine compounds containing metal chelating groups, their preparation and their therapeutic uses 失效
标题翻译：含有金属螯合基团的N-烷基-N-苯基羟胺化合物，其制备及其治疗用途
公开(公告)号：US06949654B2
公开(公告)日：2005-09-27
申请号：US10456024
申请日：2003-06-05
申请人： Eu-Gene Oh , Sung-Bo Ko , Won-Yeob Kim , Kyung-Hwa Kim , Dennis W. Choi , Laura L. Dugan , Tae-Cheon Kang , Jae-Young Koh , Kyung-Mi Kim , In-Jae Shin
发明人： Eu-Gene Oh , Sung-Bo Ko , Won-Yeob Kim , Kyung-Hwa Kim , Dennis W. Choi , Laura L. Dugan , Tae-Cheon Kang , Jae-Young Koh , Kyung-Mi Kim , In-Jae Shin
IPC分类号： C07C239/18 , C07D213/75 , C07D215/38 , C07D231/42 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D263/48 , C07D277/46 , C07D277/48 , C07D307/66 , C07D333/36 , C07D277/44 , A61K31/425 , A61K31/44
CPC分类号： C07D213/75 , C07C239/18 , C07D215/38 , C07D231/42 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/14 , C07D251/42 , C07D257/06 , C07D263/48 , C07D277/46 , C07D307/66 , C07D333/36
摘要： The present invention provides novel N-alkyl-N-phenylhydroxylamine derivatives containing metal chelating groups, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species (ROS) and/or excess Zn ions, in particular stroke, Parkinson's disease and Alzheimer's disease. The compounds of the invention possess similar or superior LPO inhibition activity to the reference compounds of Trolox and Ebselen. While showing lower toxicity, they also effectively inhibit the cerebral neuronal cell death caused by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.
摘要翻译：本发明提供了含有金属螯合基团的新型N-烷基-N-苯基羟胺衍生物及其制备方法，该新化合物用作治疗和/或预防各种医学功能障碍和由活性氧产生的疾病的用途（ ROS）和/或过量的Zn离子，特别是中风，帕金森病和阿尔茨海默病。本发明的化合物对Trolox和依布硒林的参考化合物具有相似或优异的LPO抑制活性。虽然毒性较低，但也有效地抑制由ROS和/或锌离子引起的脑神经元细胞死亡，并显示对缺血性神经元变性的神经保护作用。

4. 发明授权

US4685956A 1-aryl-5-hydrazino-pyrazoles, compositions containing them, and herbicidal method of using them 失效
标题翻译： 1-芳基-5-肼基 - 吡唑，含有它们的组合物和使用它们的除草方法
公开(公告)号：US4685956A
公开(公告)日：1987-08-11
申请号：US885051
申请日：1986-07-14
申请人： Reinhold Gehring , Otto Schallner , Jorg Stetter , Hans-Joachim Santel , Robert R. Schmidt
发明人： Reinhold Gehring , Otto Schallner , Jorg Stetter , Hans-Joachim Santel , Robert R. Schmidt
IPC分类号： A01N43/40 , A01N43/56 , A01N47/02 , A01N47/24 , A01N47/34 , C07D231/16 , C07D231/38 , C07D231/40 , C07D231/42 , C07D401/04
CPC分类号： C07D231/38 , A01N43/56 , A01N47/02 , A01N47/24 , A01N47/34 , C07D231/16 , C07D401/04
摘要： Herbicidally active 1-aryl-5-hydrazinopyrazoles of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents cyano or nitro,R.sup.3 represents hydrogen, or represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, or represents a radical ##STR2## or represents a radical --SO.sub.2 --R.sup.7, R.sup.4 represents hydrogen, or represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, or represents a radical ##STR3## or represents a radical --SO.sub.2 --R.sup.7, R.sup.5 represents hydrogen: or, in the case where R.sup.4 represents hydrogen, also represents a radical ##STR4## or represents a radical --SO.sub.2 --R.sup.7, or represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, wherein, in each case,X represents oxygen or sulphur,R.sup.6 represents hydrogen, alkyl, alkoxy, alkoxyalkyl, alkylthio, alkylthioalkyl, alkylamino, dialkylamino, halogenoalkyl, alkenyl or alkinyl, or represents optionally substituted cycloalkyl, or represents in each case optionally substituted aryl, aryloxy, arylthio or arylamino andR.sup.7 represents alkyl, hydroxyalkyl, alkoxyalkyl, halogenoalkyl, alkenyl, alkinyl or cycloalkyl, or represents in each case optionally substituted aralkyl or aryl andAr represents substituted phenyl, or represents optionally substituted pyridyl.
摘要翻译：其中R1代表氢或烷基，R2代表氰基或硝基，R3代表氢或在各种情况下代表任选取代的烷基，链烯基，炔基或环烷基，或代表（甲基）丙烯酸或者代表基团-SO 2 -R 7，R 4代表氢，或在各种情况下表示任选取代的烷基，链烯基，炔基或环烷基，或表示基团-SO 2 -R 7，R 5 表示氢;或者，在R4表示氢的情况下也表示基团，或表示基团-SO 2 -R 7，或表示在各种情况下为任选取代的烷基，烯基，炔基或环烷基，其中，在每种情况下， X表示氧或硫，R6表示氢，烷基，烷氧基，烷氧基烷基，烷硫基，烷硫基烷基，烷基氨基，二烷基氨基，卤代烷基，烯基或炔基，或表示任意取代的环烷基，芳基，芳硫基或芳基氨基，R 7表示烷基，羟基烷基，烷氧基烷基，卤代烷基，烯基，炔基或环烷基，或在各种情况下表示任选取代的芳烷基或芳基，Ar表示取代的苯基，或表示任意取代的吡啶基。

5. 发明授权

US4025614A Substituted 2H-pyran-2,6 (3H)-dione derivatives useful in treatment of allergic reactions 失效
标题翻译：用于治疗过敏反应的取代的2H-吡喃-2,6（3H） - 二酮衍生物
公开(公告)号：US4025614A
公开(公告)日：1977-05-24
申请号：US681945
申请日：1976-04-30
申请人： Kenneth M. Snader , Chester R. Willis
发明人： Kenneth M. Snader , Chester R. Willis
IPC分类号： A61K31/35 , A61K31/351 , A61P37/08 , C07D309/36 , A01N9/28 , A61L9/04 , C07D231/42 , C07D309/22
CPC分类号： C07D309/36
摘要： Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.
摘要翻译：通过3,5-二乙酰基-4,6-二羟基-2H-吡喃-2-酮与合适的苯胺的反应制备可用于治疗过敏病症的取代的2H-吡喃-2,6（3H） - 二酮衍生物。

6. 发明授权

US3374227A Sulfonamides 失效
标题翻译：磺胺类
公开(公告)号：US3374227A
公开(公告)日：1968-03-19
申请号：US33367563
申请日：1963-12-26
申请人： CIBA GEIGY CORP
发明人： PAUL SCHMIDT , ERNST SCHWEIZER , KURT EICHENBERGER , MAX WILHELM
IPC分类号： C07D231/42
CPC分类号： C07D231/42

7. 发明授权

US3028382A Sulfanilamido pyrazole compounds 失效
标题翻译：磺酰氨基吡唑化合物
公开(公告)号：US3028382A
公开(公告)日：1962-04-03
申请号：US282360
申请日：1960-01-18
申请人： C F BOEHRINGER & SOCHNE G M B
发明人： DANIEL ACHELIS JOHANN , RUDI GALL , ERICH HAACK , RUTH HEERDT , WOLFGANG VOEMEL
IPC分类号： C07D231/42
CPC分类号： C07D231/42

9. 发明申请

US20220388957A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY 有权
公开(公告)号：US20220388957A1
公开(公告)日：2022-12-08
申请号：US17422397
申请日：2020-01-16
申请人： IFM Due, Inc.
发明人： Hans Martin Seidel , William R. Roush , Shankar Venkatraman
IPC分类号： C07D209/40 , A61K31/404 , C07D471/04 , A61K31/437 , A61K31/415 , C07D231/42 , C07D498/04 , A61K31/5383 , A61K31/4439 , A61K31/4545 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12
摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

10. 发明申请

US20210317076A9 COMPOUNDS WITH ANTIMICROBIAL ACTIVITY 有权
公开(公告)号：US20210317076A9
公开(公告)日：2021-10-14
申请号：US16959142
申请日：2019-01-08
申请人： The Hong Kong Polytechnic University , The Chinese University of Hong Kong
发明人： Cong MA , Xiao YANG
IPC分类号： C07C251/86 , C07C251/24 , C07C217/58 , C07C255/59 , C07D249/12 , C07D231/20 , C07D231/42 , C07D403/12 , C07D307/90 , A61P31/04 , C07C311/44 , C07C215/50 , C07C311/39 , C07C255/61 , C07D257/04 , C07C255/58 , C07C255/53
摘要： This invention relates to compounds of formula 1, 2 or 3 a pharmaceutically acceptable salt, or solvate thereof, wherein X1, Y, R1, R2, R3, R4, and R5 are as defined herein. The compounds are antimicrobial agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1, 2 or 3.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式