
基本信息:
- 专利标题: Heteroaryl sulfonamides and CCR2/CCR9
- 申请号:US15383788 申请日:2016-12-19
- 公开(公告)号:US10206912B2 公开(公告)日:2019-02-19
- 发明人: Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
- 申请人: ChemoCentryx, Inc.
- 申请人地址: US CA Mountain View
- 专利权人: ChemoCentryx, Inc.
- 当前专利权人: ChemoCentryx, Inc.
- 当前专利权人地址: US CA Mountain View
- 代理机构: Brinks Gilson & Lione
- 代理人: Ryan L. Marshall; Jonathan M. Hartley
- 主分类号: C07C311/21
- IPC分类号: C07C311/21 ; A61K31/444 ; C07D213/75 ; C07D241/22 ; C07D401/06 ; C07D401/10 ; C07D407/04 ; C07D409/12 ; C07D413/06 ; C07D417/12 ; C07D471/04 ; C07D498/04 ; A61K31/437 ; A61K31/4439 ; A61K45/06
摘要:
Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
公开/授权文献:
- US20170095458A1 HETEROARYL SULFONAMIDES AND CCR2/CCR9 公开/授权日:2017-04-06
信息查询:
EspacenetIPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C311/00 | 磺酰胺,即磺基的单键氧原子被不属于硝基或亚硝基的氮原子取代的化合物 |
--------C07C311/15 | .磺酰胺基的硫原子连接在六元芳环碳原子上的磺酰胺 |
----------C07C311/21 | ..有至少1个磺酰胺基的氮原子连接在六元芳环的碳原子上 |