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    • 3. 发明授权
    • Process for the manufacture of steroid epoxides
    • 类固醇环氧化物的制造方法
    • US3929769A
    • 1975-12-30
    • US45126174
    • 1974-03-14
    • CIBA GEIGY CORP
    • KAUFMANN HEINZWETTSTEIN ALBERT
    • C07J17/00
    • wherein X1 is chlorine or fluorine, X2 is chlorine, fluorine or trifluoromethyl and R and R'' are alkyl groups or together with the nitrogen atom form a heterocyclic radical. There are preferably used compounds in which R and R'' are lower alkyl groups, such as for instance N- (2-chloro-1,1,2-trifluoroethyl)diethylamine, and the reaction is performed in an inert solvent e.g. ethylene chloride, at room temperature or elevated temperature, if desired, in the presence of another organic nitrogen base. The compounds of the process are intermediates for the preparation of therapeutically useful 6-fluoro-steroids, such as 6-fluoro-corticoids. In particular, the epoxides can be further reacted with the same fluorinated amine used in their preparation to give the 6 Beta ,5 Alpha -fluorohydrins.

      The invention is directed to a process for the manufacture of 5 Alpha ,6 Alpha -oxido-steroids starting from corresponding 5 Alpha ,6 Beta -dihydroxy steroids. The starting steroids are treated with a fluorinated amine of the formula
    • 本发明涉及从相应的5α,6β-二羟基类固醇开始制备5α,6α-氧代 - 类固醇的方法。 起始类固醇用式R FX1 || ANGLE NCCH(I)|| R'FX2的氟化胺处理,其中X1是氯或氟,X2是氯,氟或三氟甲基,R和R'是烷基或一起 与氮原子形成杂环基团。 优选使用其中R和R'是低级烷基的化合物,例如N-(2-氯-1,1,2-三氟乙基) - 二乙胺,并且该反应在惰性溶剂如 如果需要,在室温或升高的温度下,在另一有机氮碱存在下进行。 该方法的化合物是制备治疗上有用的6-氟类固醇如6-氟皮质激素的中间体。 特别地,环氧化物可以与其制备中使用的相同的氟化胺进一步反应,得到6β,5α-氟代醇。
    • 7. 发明授权
    • Process for deodorising waste or exhaust gases
    • 废物或废气除臭工艺
    • US3923955A
    • 1975-12-02
    • US49236674
    • 1974-07-29
    • CIBA GEIGY CORP
    • FATTINGER VOLKER
    • B01D53/14B01D53/34
    • B01D53/1475B01D53/1406B01D53/1493B01D53/34Y02C10/06
    • A process for deodorising waste or exhaust gases, preferably containing CO2, in at least two washing stages with introduction of active chlorine, wherein a stream of the waste gas to be deodorised is subjected in an initial chlorine washing stage to the action of a washing liquid containing active chlorine and in a subsequent chlorine washing operation to the action of a washing liquid, likewise containing active chlorine, of alkaline pH is described. This process is improved by the following features: A. THE SUPPLIED ACTIVE CHLORINE IS PRACTICALLY FREE FROM CHLORINE DIOXIDE; B. A CONTENT OF AT LEAST 0.02 G OF ACTIVE CHLORINE PER LITRE OF WASHING LIQUID IS MAINTAINED IN AT LEAST ONE OF THE WASHING STAGES; C. THE PH-value of the washing liquid in the first washing stage, through which the waste gas to be purified, is flowing, is kept to between 4 and 9, and D. THE PH-value of the washing liquid in the subsequent washing stage is kept between 7 and 11, with the pH-value in the said subsequent washing stage being adjusted to remain higher by 0.3 to 4 than the pH-value in the first stage; E. ACTIVE ALKALI IS ADDED IN AN APPROXIMATELY STOICHIOMETRIC AMOUNT, CALCULATED ON TOTAL ACTIVE CHLORINE SUPPLIED, IN A SUBSEQUENT WASHING STAGE.
    • 一种用于在至少两个洗涤阶段中引入活性氯除臭废物或废气(优选含有CO 2)的方法,其中将要除臭的废气流在初始氯洗涤阶段中经受洗涤液的作用 描述了含有活性氯并且在随后的氯洗涤操作中对同样含有活性氯的碱性pH的洗涤液的作用。 通过以下功能改进此过程: