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1. 发明授权

US06359014B1 Polyoxypropylene/polyoxyethylene copolymers with improved biological activity 失效
标题翻译：具有改善生物活性的聚氧丙烯/聚氧乙烯共聚物
公开(公告)号：US06359014B1
公开(公告)日：2002-03-19
申请号：US09368855
申请日：1999-08-05
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K3108
CPC分类号： A61K45/06 , A61K31/765 , A61K31/77 , A61K47/56 , A61K47/60 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
摘要翻译：本发明包括保留商业制剂的治疗活性但基本上没有现有技术制剂固有的不良作用的聚氧丙烯/聚氧乙烯共聚物的制剂。由于包含本发明的聚氧丙烯/聚氧乙烯共聚物的制备是比现有技术的聚氧丙烯/聚氧乙烯共聚物更少的多分散分子群，所以共聚物的生物活性被更好地定义并且更可预测。

2. 发明授权

US06288127B1 Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid 有权
标题翻译：氟醚组合物和在路易斯酸存在下抑制其降解的方法
公开(公告)号：US06288127B1
公开(公告)日：2001-09-11
申请号：US09447853
申请日：1999-11-23
申请人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorate A. Stelmach
发明人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorate A. Stelmach
IPC分类号： A61K3108
CPC分类号： A61K47/02 , A61K9/0019 , A61K31/08 , A61K47/10 , A61K47/12 , A61K47/14 , Y10S514/816
摘要： The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.
摘要翻译：本发明涉及含有氟醚化合物和生理上可接受的路易斯酸抑制剂的麻醉组合物。该组合物表现出改进的稳定性，并且在路易斯酸存在下不容易降解。

3. 发明授权

US06417146B1 Aqueous liquid detergent compositions having a surfactant, fatty acid glycol ester and a glyceryl ether 失效
标题翻译：具有表面活性剂，脂肪酸乙二醇酯和甘油醚的水性液体洗涤剂组合物
公开(公告)号：US06417146B1
公开(公告)日：2002-07-09
申请号：US09685083
申请日：2000-10-11
申请人： Tetsuya Miyajima , Kennichi Kasuga
发明人： Tetsuya Miyajima , Kennichi Kasuga
IPC分类号： A61K3108
CPC分类号： C11D1/83 , C11D1/146 , C11D1/29 , C11D1/523 , C11D1/74 , C11D1/825 , C11D1/90 , C11D1/94
摘要： An aqueous liquid detergent composition comprises: (A) 1 to 50 wt. % of a surfactant selected from an anionic surfactant, a nonionic surfactant or an amphoteric surfactant; (B) 0.3 to 5 wt. % of a long-chain fatty acid glycol ester represented by the following formula (1): wherein R1 represents a linear or branched, C13-23 alkyl or alkenyl group, n stands for an integer of 1 to 3, and A represents H and (C) 0.1 to 10 wt.% of a glyceryl ether having one or more linear or branched, C4-12 alkyl or alkenyl groups.
摘要翻译：含水液体洗涤剂组合物包含：（A）1至50wt。％的表面活性剂，选自阴离子表面活性剂，非离子表面活性剂或两性表面活性剂;（B）0.3〜5重量％％的由下式（1）表示的长链脂肪酸二醇酯：其中R1表示直链或支链的C13-23烷基或烯基，n表示1〜3的整数，A表示H和（C）0.1〜10重量％的具有一个或多个直链或支链C 4-12烷基或链烯基的甘油醚。

4. 发明授权

US06362233B1 Methoxy capped alkoxylated glycerin compounds 失效
标题翻译：甲氧基封端的烷氧基化甘油化合物
公开(公告)号：US06362233B1
公开(公告)日：2002-03-26
申请号：US09751965
申请日：2001-01-02
申请人： John Imperante , Anthony J. O'Lenick, Jr.
发明人： John Imperante , Anthony J. O'Lenick, Jr.
IPC分类号： A61K3108
CPC分类号： A61K31/08
摘要： The present invention is directed to a series of methoxy capped water-soluble emollient products that exhibit resistance to hydrolysis with water. The present invention also provides a process for treating skin, which comprises contacting the skin with an effective emollient amount of the compounds of the present invention.
摘要翻译：本发明涉及一系列具有抗水解水解性的甲氧基封端水溶性软化剂产品。本发明还提供了一种治疗皮肤的方法，其包括使皮肤与有效润肤剂量的本发明化合物接触。

5. 再颁专利

USRE37285E1 Polyoxypropylene/polyoxyethylene copolmers with improved biological activity 失效
标题翻译：具有改善的生物活性的聚氧丙烯/聚氧乙烯共聚物
公开(公告)号：USRE37285E1
公开(公告)日：2001-07-17
申请号：US09444417
申请日：1999-11-19
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K3108
CPC分类号： A61K45/06 , A61K31/765 , A61K31/77 , A61K47/56 , A61K47/60 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior an polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
摘要翻译：本发明包括保留商业制剂的治疗活性但基本上没有现有技术制剂固有的不良作用的聚氧丙烯/聚氧乙烯共聚物的新型制剂。由于包含本发明的聚氧丙烯/聚氧乙烯共聚物的制备是比以前的聚氧丙烯/聚氧乙烯共聚物少的多分散分子群，所以共聚物的生物活性被更好地定义和更可预测。

6. 发明授权

US06177476B1 Nutritional supplements for replenishing plasmalogens 失效
标题翻译：营养补充剂补充等离子体发生剂
公开(公告)号：US06177476B1
公开(公告)日：2001-01-23
申请号：US09141061
申请日：1998-08-27
申请人： Andrew C. Peterson , Thaddeus P. Pruss
发明人： Andrew C. Peterson , Thaddeus P. Pruss
IPC分类号： A61K3108
CPC分类号： A61K31/08
摘要： A method of replenishing plasmalogens in mammals comprising treatment with a plasmalogen-replenishing-effective amount of one or more stantially pure monoethers of glycerols and their carboxylic acid ester derivatives of Formula I: wherein R is a C12-C22 linear or branched alkyl or alkenyl group; and R1 and R2 are, each independently, hydrogen or an acyl moiety {—C(═O)—R3} wherein R3 is a linear or branched C1-C30 alkyl or alkenyl; and pharmaceutically-acceptable salts thereof, is disclosed. Nutritional supplements, dietary supplements and food additives comprising one or more substantially pure compounds of Formula I is also disclosed.
摘要翻译：一种补充哺乳动物中的等离子体发生剂的方法，其包括用补充有效量的甘油的一种或多种常规纯的单醚及其式I的羧酸酯衍生物进行处理：其中R是C 12 -C 22直链或支链烷基或链烯基 ; 并且R 1和R 2各自独立地为氢或酰基部分{-C（= O）-R 3}，其中R 3为直链或支链C 1 -C 30烷基或烯基; 及其药学上可接受的盐。还公开了营养补充剂，膳食补充剂和包含一种或多种基本上纯的式I化合物的食品添加剂。

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