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1. 发明授权

US5645849A Hemostatic patch 失效
标题翻译：止血补片
公开(公告)号：US5645849A
公开(公告)日：1997-07-08
申请号：US487659
申请日：1995-06-07
申请人： Thaddeus P. Pruss , James A. Will
发明人： Thaddeus P. Pruss , James A. Will
IPC分类号： A61F13/00 , A61F13/02 , A61L15/44 , A61L15/58 , A61L15/64 , A61L24/00 , A61L26/00 , A61K9/70
CPC分类号： A61L26/009 , A61F13/0203 , A61L15/44 , A61L15/64 , A61L24/0015 , A61L24/0042 , A61F2013/00221 , A61F2013/00472 , A61L2300/418 , A61L2300/434 , A61L2400/04
摘要： A fibrogen-free substrate having as a hemostatic agent on a surface thereof a mixture of a clot-promoting amount of thrombin and an amount of epsilon aminocaproic acid (EACA) effective to accelerate the rate of blood clotting induced by the thrombin is useful as a hemostatic patch which is safe, inexpensive and which rapidly controls bleeding from a wound. A patch which rapidly stanches the flow of blood from a lesion on a parenchymal organ by pressing it against the surface of the organ for 3-5 minutes, is produced by applying thrombin, EACA and CaCl.sub.2 to a rigid sheet of biodegradable foam, such as an absorbable gelatin sponge, and compressing the dry sheet to produce a flexible sheet which conforms to the contour of the organ without the necessity of pre-moistening. The EACA raises the pH of the acidic fluid associated with the wound and thereby accelerates the activation of the thrombin.
摘要翻译：在其表面具有止血剂作为止血剂的无纤维素底物可有效促进由凝血酶引起的血液凝固速度的促凝血量的凝血酶与ε氨基己酸（EACA）的量的混合物，作为止血补片是安全，便宜，并快速控制伤口出血。通过将凝血酶，EACA和CaCl 2施用于可生物降解的泡沫塑料的刚性片材，例如可吸收的明胶海绵，并压缩干燥片材以产生符合器官轮廓的柔性片材，而不需要预润湿。 EACA提高与伤口相关的酸性流体的pH值，从而加速凝血酶的活化。

2. 发明授权

US6022560A Pharmaceutical compositions, novel uses, and novel form of .alpha.-tocopherylphosphocholine 失效
标题翻译：药物组合物，新用途和α-生育酚磷酸胆碱的新形式
公开(公告)号：US6022560A
公开(公告)日：2000-02-08
申请号：US93129
申请日：1998-06-08
申请人： Parvin T. Yazdi , Thaddeus P. Pruss
发明人： Parvin T. Yazdi , Thaddeus P. Pruss
IPC分类号： A61K9/127 , A61K31/355 , A61K31/685
CPC分类号： A61K31/685 , A61K9/1272
摘要： .alpha.-Tocopherylphosphocholine and salts thereof have been discovered to possess antiviral, anti-fungal, anti-inflammatory, PAF-antagonist, and ultra-violet radiation-blocking activities. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal .alpha.-tocopherylphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising .alpha.-tocopherylphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise .alpha.-tocopherylphosphocholine or a salt thereof as a structural component of the liposome bilayer.
摘要翻译：已经发现α-生育酚基磷酸胆碱及其盐具有抗病毒，抗真菌，抗炎，PAF拮抗剂和紫外线辐射阻断活性。化合物和盐也被发现能够形成脂质体。因此，本发明提供了通过向哺乳动物α-生育酚磷酰胆碱或其药学上可接受的盐施用而在哺乳动物中治疗由于PAF活性引起的病毒和真菌感染，炎性疾病和病理生理状况的方法。本发明还提供包含α-生育酚磷酰胆碱或其药学上可接受的盐和药学上可接受的载体的药物组合物。此外，本发明提供包含α-生育酚磷酰胆碱或其盐作为脂质体双层结构成分的脂质体。

3. 发明授权

US5883084A Treatment of respiratory diseases utilizing .alpha.-tocopheryl-phosphocholine 失效
标题翻译：用α-生育酚 - 磷酸胆碱治疗呼吸系统疾病
公开(公告)号：US5883084A
公开(公告)日：1999-03-16
申请号：US93128
申请日：1998-06-08
申请人： Andrew C. Peterson , Thaddeus P. Pruss
发明人： Andrew C. Peterson , Thaddeus P. Pruss
IPC分类号： A61K31/355 , A61K31/685
CPC分类号： A61K31/685
摘要： Disclosed is a method of treating respiratory diseases comprising treating the lungs with an therapeutically-effective amount of .alpha.-tocopheryl-phosphocholine or a pharmaceutically-acceptable salt thereof, wherein the amount is administered is effective to make breathing easier.
摘要翻译：公开了一种治疗呼吸系统疾病的方法，包括用治疗有效量的α-生育酚 - 磷酸胆碱或其药学上可接受的盐治疗肺，其中所施用的量对于呼吸更容易是有效的。

4. 发明授权

US5731354A Treatment for the inhibition of neuro-degenerative disease states 失效
标题翻译：治疗抑制神经退行性疾病状态
公开(公告)号：US5731354A
公开(公告)日：1998-03-24
申请号：US643567
申请日：1996-05-06
申请人： Thaddeus P. Pruss
发明人： Thaddeus P. Pruss
IPC分类号： A61K31/08
CPC分类号： A61K31/08
摘要： A method of inhibiting degeneration of neural cells comprising treating the cells with an effective degeneration-inhibiting amount of one or more compounds of Formula I: ##STR1## wherein R is a C.sub.12 to C.sub.22 linear or branched alkyl group, or pharmaceutically-acceptable salts thereof is disclosed.
摘要翻译：一种抑制神经细胞变性的方法，包括以有效的变性抑制量的一种或多种式I化合物治疗细胞：其中R是C 12至C 22直链或支链烷基或药学上可接受的公开了其盐。

5. 发明授权

US5730157A Method for treating viral infection 失效
标题翻译：治疗病毒感染的方法
公开(公告)号：US5730157A
公开(公告)日：1998-03-24
申请号：US749417
申请日：1996-11-15
申请人： Thaddeus P. Pruss
发明人： Thaddeus P. Pruss
IPC分类号： A61K31/675 , A61B19/00
CPC分类号： A61K31/675
摘要： The present invention relates to the treatment and prophylaxis of viral infections with fatty alkyl and alkenyl ether glycerophosphoethanolamines bearing a 3-(2-imidazolinyl)-2-imidazolinyl or 2-imidazolinyl substituent on the ethanolamine nitrogen.
摘要翻译：本发明涉及在乙醇胺氮上带有3-（2-咪唑啉基）-2-咪唑啉基或2-咪唑啉基取代基的脂肪烷基和链烯基醚甘油磷酸乙醇胺治疗和预防病毒感染。

6. 发明授权

US5698537A Method of lowering the viscosity of mucus 失效
标题翻译：降低粘液粘度的方法
公开(公告)号：US5698537A
公开(公告)日：1997-12-16
申请号：US666631
申请日：1996-06-18
申请人： Thaddeus P. Pruss
发明人： Thaddeus P. Pruss
IPC分类号： A61K31/685
CPC分类号： A61K31/685 , Y10S514/826 , Y10S514/851 , Y10S514/855
摘要： The use of phospholipids of the following formula to reduce the viscosity of mucus in a patient is described: ##STR1## wherein one of X, Y, or Z represent: ##STR2## in which each R represents hydrogen or methyl, and each of the other two of X, Y, or Z represents --CO--R.sup.1 in which R.sup.1 represents linear or branched C.sub.11-21 alkyl or C.sub.11-21 alkenyl, unsubstituted or substituted with one or more substituents selected from the group consisting of halo, C.sub.1-6 linear or branched alkoxy or cyano.
摘要翻译：描述了使用下式的磷脂来降低患者中粘液的粘度，其描述如下：其中X，Y或Z之一表示：其中每个R代表氢或甲基， X，Y或Z中的另外两个表示-CO-R 1，其中R 1表示直链或支链C 11-21烷基或C 11-21链烯基，未取代或被一个或多个选自卤素，C 1-6 直链或支链烷氧基或氰基。

7. 发明授权

US5643596A Hemostatic patch 失效
标题翻译：止血补片
公开(公告)号：US5643596A
公开(公告)日：1997-07-01
申请号：US474127
申请日：1995-06-07
申请人： Thaddeus P. Pruss , James A. Will
发明人： Thaddeus P. Pruss , James A. Will
IPC分类号： A61F13/00 , A61F13/02 , A61L15/44 , A61L15/58 , A61L15/64 , A61L24/00 , A61L26/00 , A61K9/70
CPC分类号： A61L26/009 , A61F13/0203 , A61L15/44 , A61L15/64 , A61L24/0015 , A61L24/0042 , A61F2013/00221 , A61F2013/00472 , A61L2300/418 , A61L2300/434 , A61L2400/04
摘要： A fibrogen-free substrate having as a hemostatic agent on a surface thereof a mixture of a clot-promoting amount of thrombin and an amount of epsilon aminocaproic acid (EACA) effective to accelerate the rate of blood clotting induced by the thrombin is useful as a hemostatic patch which is safe, inexpensive and which rapidly controls bleeding from a wound. A patch which rapidly stanches the flow of blood from a lesion on a parenchymal organ by pressing it against the surface of the organ for 3-5 minutes, is produced by applying thrombin, EACA and CaCl.sub.2 to a rigid sheet of biodegradable foam, such as an absorbable gelatin sponge, and compressing the dry sheet to produce a flexible sheet which conforms to the contour of the organ without the necessity of pre-moistening. The problem associated with thrombin-fibrinogen glues of adhesion of the wounded surface of the organ to adjacent tissue is avoided by applying the hemostatic agent to only the wound-contacting face of the sheet.
摘要翻译：在其表面具有止血剂作为止血剂的无纤维素底物可有效促进由凝血酶引起的血液凝固速度的促凝血量的凝血酶与ε氨基己酸（EACA）的量的混合物，作为止血补片是安全，便宜，并快速控制伤口出血。通过将凝血酶，EACA和CaCl 2施用于可生物降解的泡沫塑料的刚性片材，例如可吸收的明胶海绵，并压缩干燥片材以产生符合器官轮廓的柔性片材，而不需要预润湿。通过将止血剂仅施加到片材的伤口接触面上来避免与器官的受伤表面对相邻组织的粘附的凝血酶 - 纤维蛋白原胶粘剂相关的问题。

8. 发明授权

US06177476B1 Nutritional supplements for replenishing plasmalogens 失效
标题翻译：营养补充剂补充等离子体发生剂
公开(公告)号：US06177476B1
公开(公告)日：2001-01-23
申请号：US09141061
申请日：1998-08-27
申请人： Andrew C. Peterson , Thaddeus P. Pruss
发明人： Andrew C. Peterson , Thaddeus P. Pruss
IPC分类号： A61K3108
CPC分类号： A61K31/08
摘要： A method of replenishing plasmalogens in mammals comprising treatment with a plasmalogen-replenishing-effective amount of one or more stantially pure monoethers of glycerols and their carboxylic acid ester derivatives of Formula I: wherein R is a C12-C22 linear or branched alkyl or alkenyl group; and R1 and R2 are, each independently, hydrogen or an acyl moiety {—C(═O)—R3} wherein R3 is a linear or branched C1-C30 alkyl or alkenyl; and pharmaceutically-acceptable salts thereof, is disclosed. Nutritional supplements, dietary supplements and food additives comprising one or more substantially pure compounds of Formula I is also disclosed.
摘要翻译：一种补充哺乳动物中的等离子体发生剂的方法，其包括用补充有效量的甘油的一种或多种常规纯的单醚及其式I的羧酸酯衍生物进行处理：其中R是C 12 -C 22直链或支链烷基或链烯基 ; 并且R 1和R 2各自独立地为氢或酰基部分{-C（= O）-R 3}，其中R 3为直链或支链C 1 -C 30烷基或烯基; 及其药学上可接受的盐。还公开了营养补充剂，膳食补充剂和包含一种或多种基本上纯的式I化合物的食品添加剂。

9. 发明授权

US5827836A Retinoid glycerol phospholipid conjugates 失效
标题翻译：类视黄醇甘油磷脂共轭物
公开(公告)号：US5827836A
公开(公告)日：1998-10-27
申请号：US749512
申请日：1996-11-15
申请人： Andrew C. Peterson , Thaddeus P. Pruss , Parvin T. Yazdi
发明人： Andrew C. Peterson , Thaddeus P. Pruss , Parvin T. Yazdi
IPC分类号： C07F9/10 , A61K31/66
CPC分类号： C07F9/10
摘要： Retinoyl substituted glycerophosphoethanolamines are disclosed having the general Formula I: ##STR1## wherein one of A, B or C is a fatty ether substituent, one is a natural or synthetic retinoid ester substituent, and one is a phosphoethanolamine substituent, provided that A, B and C are each a different substituent. The optical and geometric isomers of compounds of Formula I and the pharmaceutically acceptable salts of the compounds, including the isomers, are also disclosed. The compounds (including the isomers thereof) and salts of the invention exhibit anti-tumor, anti-psoriatic and anti-inflammatory activities.
摘要翻译：公开了具有通式I的视黄酰取代的甘油磷酸乙醇胺：其中A，B或C之一是脂肪醚取代基，一个是天然或合成的类视色素酯取代基，一个是磷酸乙醇胺取代基，条件是 A，B和C各自是不同的取代基。还公开了式I化合物的光学和几何异构体和化合物的药学上可接受的盐，包括异构体。本发明的化合物（包括其异构体）和盐表现出抗肿瘤，抗牛皮癣和抗炎活性。

10. 发明授权

US5763423A Pharmaceutical compositions, novel uses, and novel form of tocopherylphosphocholine 失效
标题翻译：药物组合物，新用途和生物基磷酸胆碱的新形式
公开(公告)号：US5763423A
公开(公告)日：1998-06-09
申请号：US703446
申请日：1996-08-27
申请人： Parvin T. Yazdi , Thaddeus P. Pruss
发明人： Parvin T. Yazdi , Thaddeus P. Pruss
IPC分类号： A61K9/127 , A61K31/685 , A61K31/355
CPC分类号： A61K31/685 , A61K9/1272
摘要： .alpha.-tocopherolphosphocholine and salts thereof have been discovered to possess anti-viral, anti-fungal, anti-inflammatory and PAF-antagonist activities. The compound and salts have also been discovered to be capable of forming liposomes. The present invention thus provides methods of treating viral and fungal infections, inflammatory disorders and pathophysiological conditions due to PAF activity in a mammal by administering to the mammal .alpha.-tocopherolphosphocholine or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions comprising .alpha.-tocopherolphosphocholine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Further, the invention provides liposomes which comprise .alpha.-tocopherolphosphocholine or a salt thereof as a structural component of the liposome bilayer.
摘要翻译：已经发现α-生育酚磷酰胆碱及其盐具有抗病毒，抗真菌，抗炎和PAF拮抗剂活性。化合物和盐也被发现能够形成脂质体。因此，本发明提供了通过向哺乳动物α-生育酚磷酰胆碱或其药学上可接受的盐施用而在哺乳动物中治疗由于PAF活性引起的病毒和真菌感染，炎性病症和病理生理状况的方法。本发明还提供包含α-生育酚磷酰胆碱或其药学上可接受的盐和药学上可接受的载体的药物组合物。此外，本发明提供了包含α-生育酚磷酸胆碱或其盐作为脂质体双层结构成分的脂质体。

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