专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06677492B2 Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid 有权
标题翻译：氟醚组合物和在路易斯酸存在下抑制其降解的方法
公开(公告)号：US06677492B2
公开(公告)日：2004-01-13
申请号：US10190271
申请日：2002-07-03
申请人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorats A. Stelmach
发明人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorats A. Stelmach
IPC分类号： C07C4312
CPC分类号： A61K47/02 , A61K9/0019 , A61K31/08 , A61K47/10 , A61K47/12 , A61K47/14 , Y10S514/816
摘要： The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.
摘要翻译：本发明涉及含有氟醚化合物和生理上可接受的路易斯酸抑制剂的麻醉组合物。该组合物表现出改进的稳定性，并且在路易斯酸存在下不容易降解。

2. 发明授权

US06444859B1 Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid 有权
公开(公告)号：US06444859B1
公开(公告)日：2002-09-03
申请号：US09924573
申请日：2001-08-08
申请人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorate A. Stelmach
发明人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorate A. Stelmach
IPC分类号： C07C4312
摘要： The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

3. 发明授权

US5922754A Pharmaceutical compositions containing paclitaxel 失效
标题翻译：含有紫杉醇的药物组合物
公开(公告)号：US5922754A
公开(公告)日：1999-07-13
申请号：US165930
申请日：1998-10-02
申请人： Mark K. Burchett , Cynthia A. Coddington , Rajagopalan Raghavan , Earl R. Speicher
发明人： Mark K. Burchett , Cynthia A. Coddington , Rajagopalan Raghavan , Earl R. Speicher
IPC分类号： C07D305/14 , A61K9/00 , A61K9/08 , A61K31/337 , A61K47/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/32 , A61K47/36 , A61P35/00 , A61K31/335
CPC分类号： A61K9/0019 , A61K31/337 , A61K47/14 , A61K47/10 , A61K47/12
摘要： The present invention provides novel paclitaxel formulations which may be terminally sterilized and show long term stability in water containing admixtures.
摘要翻译：本发明提供了新型紫杉醇制剂，其可以终末灭菌并在含水混合物中表现出长期的稳定性。

4. 发明授权

US4857552A Stable pharmaceutical composition 失效
标题翻译：稳定的药物组成
公开(公告)号：US4857552A
公开(公告)日：1989-08-15
申请号：US203836
申请日：1988-06-08
申请人： Leonard S. Rosenberg , Cheryl Black , Earl R. Speicher , Dietmar Wagenknecht
发明人： Leonard S. Rosenberg , Cheryl Black , Earl R. Speicher , Dietmar Wagenknecht
IPC分类号： A61K9/00 , A61K9/08 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K47/12 , A61P9/12 , A61P25/02
CPC分类号： A61K9/0019 , A61K31/195 , A61K31/215 , A61K47/12
摘要： An injectable, aqueous pharmaceutical composition for the treatment of cardiac conditions comprising an effective amount of methyl 3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride (esmolol) for treating such a cardiac condition, said composition comprising about 1 mg to 250 mg of esmolol per milliliter of said injectable pharmaceutical composition; 0.01 to 0.02M buffer; said composition having a pH range of 4.5 to 5.5, the esmolol degrading in aqueous solution to produce 3-[4-(3-propionic acid)phenoxy]-1-isopropylamino-2-propanol hydrochloride, said 3-[4-(3-propionic acid)-phenoxyl]-1-isopropylamino-2-propanol hydrochloride having a pK in the pH range of said composition to thereby act as a secondary buffer to increase the buffer capacity and minimize the change in pH as degradation occurs, whereby the stability of esmolol in an aqueous composition is enhanced.
摘要翻译：一种用于治疗心脏病症的可注射的水性药物组合物，其包含有效量的用于治疗这种心脏病症的3- [4-（2-羟基-3-异丙基氨基）丙氧基]苯丙酸甲酯（艾司洛尔），所述组合物包含约每毫升所述可注射药物组合物1mg至250mg艾司洛尔; 0.01〜0.02M缓冲液; 所述组合物的pH范围为4.5至5.5，艾司洛尔在水溶液中降解以产生3- [4-（3-丙酸）苯氧基] -1-异丙基氨基-2-丙醇盐酸盐，所述3- [4-（3 - 丙酸） - 苯氧基] -1-异丙基氨基-2-丙醇盐酸盐，其在所述组合物的pH范围内具有pK，从而充当二级缓冲液，以增加缓冲能力，并且随着劣化发生使pH的变化最小化，由此艾司洛尔在水性组合物中的稳定性得到提高。

5. 发明授权

US6140374A Propofol composition 有权
标题翻译：丙泊酚组成
公开(公告)号：US6140374A
公开(公告)日：2000-10-31
申请号：US354017
申请日：1999-07-15
申请人： Thomas May , John Hofstetter , Kathleen L. Olson , Sukumaran K. Menon , Bernard A. Mikrut , Clayton S. Ovenshire , Lawrence John Rhodes , Earl R. Speicher , James R. Waterson
发明人： Thomas May , John Hofstetter , Kathleen L. Olson , Sukumaran K. Menon , Bernard A. Mikrut , Clayton S. Ovenshire , Lawrence John Rhodes , Earl R. Speicher , James R. Waterson
IPC分类号： A61K9/107 , A61K31/05 , A61K47/10 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/24 , A61K47/34 , A61P23/00
CPC分类号： A61K31/05 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/186 , A61K9/0019 , A61K9/1075 , Y10S514/836
摘要： The present invention is directed to a sterile pharmaceutical composition comprising a propofol containing oil-in-water emulsion formulation having as an antimicrobial agent, a member selected from the group consisting of benzyl alcohol and sodium ethylene diamine tetraacetate; benzethonium chloride; and benzyl alcohol and sodium benzoate.
摘要翻译：本发明涉及一种无菌药物组合物，其包含含有作为抗微生物剂的含水包油乳液制剂的丙泊酚，选自苄醇和乙二胺四乙酸钠的成员; 苄索氯铵; 和苯甲醇和苯甲酸钠。

6. 发明授权

US06558679B2 Container for an inhalation anesthetic 有权
公开(公告)号：US06558679B2
公开(公告)日：2003-05-06
申请号：US09740463
申请日：2000-12-19
申请人： Mary Jane Flament-Garcia , Keith R. Cromack , David Loffredo , Rajagopalan Raghavan , George M. Ramsay , Earl R. Speicher
发明人： Mary Jane Flament-Garcia , Keith R. Cromack , David Loffredo , Rajagopalan Raghavan , George M. Ramsay , Earl R. Speicher
IPC分类号： A61K700
CPC分类号： B65D1/0207 , A61J1/00
摘要： A pharmaceutical product. The pharmaceutical product includes a container constructed from a material containing one or more of polypropylene, polyethylene, and ionomeric resins. The container defines an interior space. A volume of a fluoroether-containing inhalation anesthetic is contained in the interior space defined by the container.

7. 发明授权

US06288127B1 Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid 有权
标题翻译：氟醚组合物和在路易斯酸存在下抑制其降解的方法
公开(公告)号：US06288127B1
公开(公告)日：2001-09-11
申请号：US09447853
申请日：1999-11-23
申请人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorate A. Stelmach
发明人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorate A. Stelmach
IPC分类号： A61K3108
CPC分类号： A61K47/02 , A61K9/0019 , A61K31/08 , A61K47/10 , A61K47/12 , A61K47/14 , Y10S514/816
摘要： The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.
摘要翻译：本发明涉及含有氟醚化合物和生理上可接受的路易斯酸抑制剂的麻醉组合物。该组合物表现出改进的稳定性，并且在路易斯酸存在下不容易降解。

8. 发明授权

US6140373A Propofol composition 有权
标题翻译：丙泊酚组成
公开(公告)号：US6140373A
公开(公告)日：2000-10-31
申请号：US178347
申请日：1998-10-23
申请人： Thomas May , John Hofstetter , Kathleen L. Olson , Sukumaran K. Menon , Bernard A. Mikrut , Clayton S. Ovenshire , Lawrence John Rhodes , Earl R. Speicher , James R. Waterson
发明人： Thomas May , John Hofstetter , Kathleen L. Olson , Sukumaran K. Menon , Bernard A. Mikrut , Clayton S. Ovenshire , Lawrence John Rhodes , Earl R. Speicher , James R. Waterson
IPC分类号： A61K9/107 , A61K31/05 , A61K47/10 , A61K47/12 , A61K47/18 , A61K31/55
CPC分类号： A61K31/05 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/186 , A61K9/0019 , A61K9/1075
摘要： The present invention is directed to a sterile pharmaceutical composition comprising a propofol containing oil-in-water emulsion formulation having as an antimicrobial agent, a member selected from the group consisting of benzyl alcohol and ethylene diamine tetra acetic acid; benzethonium chloride; and benzyl alcohol and sodium benzoate.
摘要翻译：本发明涉及一种无菌药物组合物，其包含含有作为抗微生物剂的选自含有苯甲醇和乙二胺四乙酸的成员的含异丙酚的水包油乳液制剂; 苄索氯铵; 和苯甲醇和苯甲酸钠。

9. 发明授权

US6162443A Container for an inhalation anesthetic 有权
公开(公告)号：US6162443A
公开(公告)日：2000-12-19
申请号：US205460
申请日：1998-12-04
申请人： Mary Jane Flament-Garcia , Keith R. Cromack , David Loffredo , Rajagopalan Raghavan , George M. Ramsay , Earl R. Speicher
发明人： Mary Jane Flament-Garcia , Keith R. Cromack , David Loffredo , Rajagopalan Raghavan , George M. Ramsay , Earl R. Speicher
IPC分类号： B65D1/00 , A61J1/00 , A61J1/05 , A61K9/48 , B65D1/02
CPC分类号： B65D1/0207 , A61J1/00
摘要： A pharmaceutical product. The pharmaceutical product includes a container constructed from a material containing one or more of polypropylene, polyethylene, and ionomeric resins. The container defines an interior space. A volume of a fluoroether-containing inhalation anesthetic is contained in the interior space defined by the container.

10. 发明授权

US5990176A Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid 失效
公开(公告)号：US5990176A
公开(公告)日：1999-11-23
申请号：US789679
申请日：1997-01-27
申请人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorate A. Stelmach
发明人： Christopher Bieniarz , Steve H. Chang , Keith R. Cromack , Shuyen L. Huang , Toshikazu Kawai , Manami Kobayashi , David Loffredo , Rajagopalan Raghavan , Earl R. Speicher , Honorate A. Stelmach
IPC分类号： A61J1/00 , A61J3/00 , A61K9/08 , A61K31/08 , A61K47/02 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/14 , A61P23/00 , C07C63/04 , C09K3/00 , C07C43/12
CPC分类号： A61K47/02 , A61K31/08 , A61K47/10 , A61K47/12 , A61K47/14 , A61K9/0019 , Y10S514/816
摘要： The present invention relates to an anesthetic composition containing a fluoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式