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1. 再颁专利

USRE38558E1 Polyoxypropylene/polyoxyethylene copolymers with improved biological activity 失效
标题翻译：具有改善生物活性的聚氧丙烯/聚氧乙烯共聚物
公开(公告)号：USRE38558E1
公开(公告)日：2004-07-20
申请号：US09460298
申请日：1999-12-09
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： C07C4302
CPC分类号： A61K45/06 , A61K31/765 , A61K31/77 , A61K47/56 , A61K47/60 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.

2. 发明授权

US06359014B1 Polyoxypropylene/polyoxyethylene copolymers with improved biological activity 失效
标题翻译：具有改善生物活性的聚氧丙烯/聚氧乙烯共聚物
公开(公告)号：US06359014B1
公开(公告)日：2002-03-19
申请号：US09368855
申请日：1999-08-05
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K3108
CPC分类号： A61K45/06 , A61K31/765 , A61K31/77 , A61K47/56 , A61K47/60 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
摘要翻译：本发明包括保留商业制剂的治疗活性但基本上没有现有技术制剂固有的不良作用的聚氧丙烯/聚氧乙烯共聚物的制剂。由于包含本发明的聚氧丙烯/聚氧乙烯共聚物的制备是比现有技术的聚氧丙烯/聚氧乙烯共聚物更少的多分散分子群，所以共聚物的生物活性被更好地定义并且更可预测。

3. 发明授权

US5990241A Polyoxypropylene/polyoxyethylene copolymers with improved biological activity 失效
公开(公告)号：US5990241A
公开(公告)日：1999-11-23
申请号：US889342
申请日：1997-07-08
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48 , A61P7/02 , C07C43/11 , C08G65/02 , C08G65/08 , C08G65/26 , C08G65/28 , C08G65/30 , A61K47/32
CPC分类号： A61K47/48215 , A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48169 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.

4. 发明授权

US5523492A Polyoxypropylene/polyoxyethylene copolymers with improved biological activity 失效
公开(公告)号：US5523492A
公开(公告)日：1996-06-04
申请号：US87136
申请日：1993-07-02
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48 , A61P7/02 , C07C43/11 , C08G65/02 , C08G65/08 , C08G65/26 , C08G65/28 , C08G65/30
CPC分类号： A61K47/48215 , A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48169 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.

5. 再颁专利

USRE37285E1 Polyoxypropylene/polyoxyethylene copolmers with improved biological activity 失效
标题翻译：具有改善的生物活性的聚氧丙烯/聚氧乙烯共聚物
公开(公告)号：USRE37285E1
公开(公告)日：2001-07-17
申请号：US09444417
申请日：1999-11-19
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K3108
CPC分类号： A61K45/06 , A61K31/765 , A61K31/77 , A61K47/56 , A61K47/60 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior an polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
摘要翻译：本发明包括保留商业制剂的治疗活性但基本上没有现有技术制剂固有的不良作用的聚氧丙烯/聚氧乙烯共聚物的新型制剂。由于包含本发明的聚氧丙烯/聚氧乙烯共聚物的制备是比以前的聚氧丙烯/聚氧乙烯共聚物少的多分散分子群，所以共聚物的生物活性被更好地定义和更可预测。

6. 再颁专利

USRE36665E Polyoxypropylene/polyoxyethylene copolymers with improved biological activity 失效
公开(公告)号：USRE36665E
公开(公告)日：2000-04-18
申请号：US089043
申请日：1998-06-02
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48 , A61P7/02 , C07C43/11 , C08G65/02 , C08G65/08 , C08G65/26 , C08G65/28 , C08G65/30
CPC分类号： A61K47/48215 , A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48169 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.

7. 发明授权

US06747064B2 Polyoxypropylene/polyoxyethylene copolymers with improved biological activity 失效
标题翻译：具有改善生物活性的聚氧丙烯/聚氧乙烯共聚物
公开(公告)号：US06747064B2
公开(公告)日：2004-06-08
申请号：US10017223
申请日：2001-12-14
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K3608
CPC分类号： A61K45/06 , A61K31/765 , A61K31/77 , A61K47/56 , A61K47/60 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
摘要翻译：本发明包括保留商业制剂的治疗活性但基本上没有现有技术制剂固有的不良作用的聚氧丙烯/聚氧乙烯共聚物的新型制剂。由于包含本发明的聚氧丙烯/聚氧乙烯共聚物的制备是比现有技术的聚氧丙烯/聚氧乙烯共聚物更少的多分散分子群，所以共聚物的生物活性被更好地定义并且更可预测。

8. 发明授权

US5696298A Polyoxypropylene/polyoxyethylene copolymers with improved biological activity 失效
标题翻译：具有改善生物活性的聚氧丙烯/聚氧乙烯共聚物
公开(公告)号：US5696298A
公开(公告)日：1997-12-09
申请号：US460192
申请日：1995-06-02
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48 , C08G65/08 , C08G65/26 , C08G65/30 , C07C43/02 , C07C43/04 , C07C43/11
CPC分类号： C08G65/30 , A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48169 , C08G65/08 , C08G65/2609 , C08G65/2624
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
摘要翻译：本发明包括保留商业制剂的治疗活性但基本上没有现有技术制剂固有的不良作用的聚氧丙烯/聚氧乙烯共聚物的新型制剂。由于包含本发明的聚氧丙烯/聚氧乙烯共聚物的制备是比现有技术的聚氧丙烯/聚氧乙烯共聚物更少的多分散分子群，所以共聚物的生物活性被更好地定义并且更可预测。

9. 发明授权

US5691387A Polyoxypropylene/polyoxyethylene copolmers with improved biological activity 失效
标题翻译：具有改善的生物活性的聚氧丙烯/聚氧乙烯共聚物
公开(公告)号：US5691387A
公开(公告)日：1997-11-25
申请号：US657161
申请日：1996-06-03
申请人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
发明人： R. Martin Emanuele , Robert L. Hunter , Paula H. Culbreth
IPC分类号： A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48 , A61P7/02 , C07C43/11 , C08G65/02 , C08G65/08 , C08G65/26 , C08G65/28 , C08G65/30 , A61K31/08
CPC分类号： A61K47/48215 , A61K31/765 , A61K31/77 , A61K45/06 , A61K47/48169 , C08G65/08 , C08G65/2609 , C08G65/2624 , C08G65/30
摘要： The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but are substantially free from the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior an polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable.
摘要翻译：本发明包括保留商业制剂的治疗活性但基本上没有现有技术制剂固有的不良作用的聚氧丙烯/聚氧乙烯共聚物的新型制剂。由于包含本发明的聚氧丙烯/聚氧乙烯共聚物的制备是比以前的聚氧丙烯/聚氧乙烯共聚物少的多分散分子群，所以共聚物的生物活性被更好地定义和更可预测。

10. 发明授权

US5811088A Antiinfective compounds and methods of use 失效
标题翻译：抗感染剂及其使用方法
公开(公告)号：US5811088A
公开(公告)日：1998-09-22
申请号：US457808
申请日：1995-06-01
申请人： Robert L. Hunter , R. Martin Emanuele , Hameedsulthan S. Allaudeen
发明人： Robert L. Hunter , R. Martin Emanuele , Hameedsulthan S. Allaudeen
IPC分类号： A61K31/765 , A61K31/77 , A61K45/06 , C08G65/30 , A61K31/74
CPC分类号： C08G65/30 , A61K31/765 , A61K31/77 , A61K45/06
摘要： In accordance with the present invention, a composition and method is provided that is effective in treating infections caused by microorganisms including, but not limited to, bacteria, viruses, and fungi. The present invention is effective in inhibiting the growth of bacteria such as Mycobacterium species including, but not limited to, Mycobacterium avium-intracellulare complex and M. tuberculosis. The present invention comprises a surface active copolymer, preferably an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C.sub.3 H.sub.6 O) has a molecular weight of approximately 1200 to 15,000, and b is an integer such that the hydrophile portion represented by (C.sub.2 H.sub.4 O) constitutes approximately 1% to 50% by weight of the compound.
摘要翻译：根据本发明，提供了有效治疗由微生物引起的感染的组合物和方法，包括但不限于细菌，病毒和真菌。本发明有效地抑制细菌如分枝杆菌属的生长，包括但不限于分枝杆菌 - 胞内分枝杆菌复合体和结核分枝杆菌。本发明包括表面活性共聚物，优选具有以下通式的环氧乙烷 - 环氧丙烷缩合产物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H，其中a是整数，使得由（C 3 H 6 O）具有约1200至15,000的分子量，b是使由（C 2 H 4 O）表示的亲水部分构成化合物的约1重量％至50重量％的整数。

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