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1. 发明授权

US08603739B2 Inhibitors of Rv0256c 有权
标题翻译： Rv0256c抑制剂
公开(公告)号：US08603739B2
公开(公告)日：2013-12-10
申请号：US12551115
申请日：2009-08-31
申请人： Sangita Mukhopadhyay , Khalid Hussaid Bhat , Nooruddin Khan
发明人： Sangita Mukhopadhyay , Khalid Hussaid Bhat , Nooruddin Khan
IPC分类号： C12Q1/68 , C12Q1/02 , C12Q1/18
CPC分类号： G01N33/566 , G01N2333/35 , G01N2333/90254 , G01N2500/00
摘要： Described herein are methods for identifying inhibitors of Rv0256c functions, e.g., inhibitors of Rv0256c expression, DNA binding, nuclear localization and iNOS inhibition.
摘要翻译：本文描述了用于鉴定Rv0256c功能的抑制剂的方法，例如Rv0256c表达的抑制剂，DNA结合，核定位和iNOS抑制。

2. 发明申请

US20180224465A1 Endothelial Cell Derived Exosomes and Uses Thereof 审中-公开
公开(公告)号：US20180224465A1
公开(公告)日：2018-08-09
申请号：US15703955
申请日：2017-09-13
申请人： Edward Goetzl
发明人： Edward Goetzl
IPC分类号： G01N33/68 , G01N33/573 , G01N33/86
CPC分类号： G01N33/6893 , G01N33/573 , G01N33/86 , G01N2333/49 , G01N2333/60 , G01N2333/70503 , G01N2333/70542 , G01N2333/70596 , G01N2333/755 , G01N2333/90254 , G01N2800/2871 , G01N2800/32 , G01N2800/52
摘要： The present invention relates to endothelial cell biomarkers and diagnostic and prognostic methods for vascular diseases, including cardiovascular and cerebrovascular diseases. The invention also provides compositions for detecting endothelial cell biomarkers (e.g., endothelial cell-derived exosome biomarkers) as well as compositions and methods useful for treating vascular diseases (e.g., atherosclerotic cerebrovascular disease).

3. 发明授权

US09696309B2 Methods of measuring levels of phosphorylated neuronal nitric oxide synthase 有权
公开(公告)号：US09696309B2
公开(公告)日：2017-07-04
申请号：US14408393
申请日：2012-12-07
申请人： THE JOHNS HOPKINS UNIVERSITY , KENNEDY KRIEGER INSTITUTE, INC.
发明人： Irina Burd , Talaibek Borbiev , Elisabeth Nigrini , Michael Johnston
IPC分类号： G01N33/535 , G01N33/573 , G01N33/68
CPC分类号： G01N33/573 , G01N33/535 , G01N33/6896 , G01N2333/90254 , G01N2440/14 , G01N2800/28
摘要： The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. In a specific embodiment, a method for diagnosing perinatal brain injury in a patient comprises the steps of (a) determining the ratio of phosphorylated nNOS to unphosphorylated nNOS in a sample collected from the patient using an ELISA; and (b) comparing the ratio with predefined ratios of the same proteins that correlate to a patient having perinatal brain injury and predefined ratios of the same proteins that correlate to a patient not having perinatal brain injury, wherein a correlation to one of the predefined ratios provides the diagnosis.

4. 发明授权

US08709743B2 Inhibitors of bacterial nitric oxide synthase, and related screening methods 有权
标题翻译：细菌一氧化氮合酶抑制剂及相关筛选方法
公开(公告)号：US08709743B2
公开(公告)日：2014-04-29
申请号：US12808889
申请日：2008-12-17
申请人： Stephen J. Lippard , Lindsey E. McQuade , Evgeny A. Nudler
发明人： Stephen J. Lippard , Lindsey E. McQuade , Evgeny A. Nudler
IPC分类号： C12Q1/02
CPC分类号： C12Q1/26 , C07D401/14 , C07D405/12 , C07D405/14 , C12Q1/025 , G01N2333/90254 , G01N2500/10
摘要： The invention relates in part to compounds that act as highly nitric oxide (NO)-specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS.
摘要翻译：本发明部分地涉及作为高度一氧化氮（NO）特异性开启荧光探针的化合物。本发明还涉及这些基于荧光素的传感器选择性筛选细菌一氧化氮合酶（bNOS）抑制剂的用途。本发明的化合物容易检测体内产生的一氧化氮。因此，它们可用于通过bNOS测量NO产生的测定。使用本发明的传感器，可以筛选用于bNOS抑制剂的小分子的文库。

5. 发明申请

US20130131161A1 METHODS AND COMPOSITIONS FOR CARDIOVASCULAR DISEASES AND CONDITIONS 审中-公开
标题翻译：心血管疾病和病症的方法和组成
公开(公告)号：US20130131161A1
公开(公告)日：2013-05-23
申请号：US13518471
申请日：2010-12-23
申请人： Michael R. Bristow , Jonathan David Port
发明人： Michael R. Bristow , Jonathan David Port
IPC分类号： A61K31/34
CPC分类号： A61K31/34 , A61K31/345 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N33/573 , G01N2333/90254 , G01N2800/52
摘要： Embodiments of the invention are directed to identifying or treating a patient that would benefit from phosphodiesterase inhibitor therapy.
摘要翻译：本发明的实施方案涉及鉴定或治疗将受益于磷酸二酯酶抑制剂治疗的患者。

6. 发明授权

US09629892B2 Treatment of penetrative injury to the brain 有权
公开(公告)号：US09629892B2
公开(公告)日：2017-04-25
申请号：US13816663
申请日：2011-08-12
申请人： Michael Tymianski , Peter S. Lu , Jonathan David Garman
发明人： Michael Tymianski , Peter S. Lu , Jonathan David Garman
IPC分类号： A61K38/07 , A61K38/08 , C07K7/06 , A61K47/48 , G01N33/573 , G01N33/68 , C12N9/02 , A61K38/17
CPC分类号： A61K38/07 , A61K38/08 , A61K38/1709 , A61K38/1787 , A61K47/645 , C07K7/06 , C07K2319/10 , C12N9/0075 , C12Y114/13039 , G01N33/573 , G01N33/6872 , G01N2333/70571 , G01N2333/90254 , G01N2500/02
摘要： The invention provides methods of treatment or prophylaxis of damaging effects of penetrative injury to the brain or other part of the central nervous system. The methods are based in part on results in a rodent model of penetrative ballistic injury showing that an inhibitor of PDF-95 NMDAR interaction is effective in inhibiting neurological deficits resulting from such injury. The methods are useful for treating subjects having or at risk of penetrative brain injury, including subjects who have been shot in the head or at risk of such injury (e.g., military or law enforcement personnel).

7. 发明申请

US20150232576A1 ENDOTHELIAL NITRIC OXIDE SYNTHASE 审中-公开
标题翻译：内氧化氮氧化物合成酶
公开(公告)号：US20150232576A1
公开(公告)日：2015-08-20
申请号：US14672642
申请日：2015-03-30
申请人： John C. Salerno , Carol A. Chrestensen
发明人： John C. Salerno , Carol A. Chrestensen
IPC分类号： C07K16/40 , G01N33/573
CPC分类号： C07K16/40 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C12N9/0075 , C12N9/99 , C12Y114/13039 , G01N33/573 , G01N2333/90254 , G01N2440/14
摘要： Endothelial nitric oxide synthase (eNOS) activity was modulated by contact with an effective amount of a mitogen-activated protein (MAP) kinase, resulting in phosphorylation of S602, T46, and/or S58. Kinetics and stoichiometry are disclosed. The contact strongly reduced nitric oxide (NO) synthesis, and inhibited the cytochrome c reductase activity of eNOS reductase domains. Three sites of phosphorylation were determined that matched the serine-proline (SP) and threonine-proline (TP) motifs of typical MAP kinase phosphorylation sites.
摘要翻译：通过与有效量的丝裂原活化蛋白（MAP）激酶接触调节内皮一氧化氮合酶（eNOS）活性，导致S602，T46和/或S58的磷酸化。公开了动力学和化学计量。接触强烈地减少一氧化氮（NO）合成，并抑制eNOS还原酶结构域的细胞色素c还原酶活性。测定三个磷酸化位点，其与典型的MAP激酶磷酸化位点的丝氨酸 - 脯氨酸（SP）和苏氨酸 - 脯氨酸（TP）基序相匹配。

8. 发明申请

US20140193369A1 ANTI-INFLAMMATORY FOOD PRODUCT 审中-公开
标题翻译：抗炎食品
公开(公告)号：US20140193369A1
公开(公告)日：2014-07-10
申请号：US13735547
申请日：2013-01-07
申请人： WHITEWAVE SERVICES, INC.
发明人： Neal Allan Bringe
IPC分类号： C12Q1/02 , G01N33/68 , G01N33/573
CPC分类号： C12Q1/025 , G01N33/573 , G01N33/6863 , G01N33/6869 , G01N33/88 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/90254 , G01N2800/7095
摘要： According to some embodiments, a method selects one or more inflammatory markers to evaluate. The one or more inflammatory markers selected from the group consisting of iNOS, COX-2, TNF-alpha, NO, PGE2, IL-6, and IL-1β. The method determines a first expression level and a second expression level of the one or more inflammatory markers. The first expression level is associated with a positive control sample comprising a type of human macrophages. The second expression level is associated with a test sample obtained by exposing a food product to a digest, the type of human macrophages, and a pro-inflammatory compound. The method performs a comparison between the first expression level and the second expression level and designates the food product according to an anti-inflammatory standard based on the comparison.
摘要翻译：根据一些实施方案，一种方法选择一种或多种炎性标志物进行评估。选自iNOS，COX-2，TNF-α，NO，PGE2，IL-6和IL-1和bgr的一种或多种炎性标志物。该方法确定一种或多种炎性标志物的第一表达水平和第二表达水平。第一表达水平与包含一种人类巨噬细胞的阳性对照样品相关。第二表达水平与通过将食物暴露于消化物，人类巨噬细胞的类型和促炎症化合物而获得的测试样品相关联。该方法在第一表达水平和第二表达水平之间进行比较，并且基于比较来指定根据抗炎标准的食品。

9. 发明申请

US20110201042A1 Inhibitors of Bacterial Nitric Oxide Synthase, and Related Screening Methods 有权
标题翻译：细菌一氧化氮合酶抑制剂及相关筛选方法
公开(公告)号：US20110201042A1
公开(公告)日：2011-08-18
申请号：US12808889
申请日：2008-12-17
申请人： Stephen J. Lippard , Lindsey E. McQuade , Evgeny A. Nudler
发明人： Stephen J. Lippard , Lindsey E. McQuade , Evgeny A. Nudler
IPC分类号： C12Q1/02 , G01N33/00 , C07D311/82 , C07D221/06
CPC分类号： C12Q1/26 , C07D401/14 , C07D405/12 , C07D405/14 , C12Q1/025 , G01N2333/90254 , G01N2500/10
摘要： The invention relates in part to compounds that act as highly nitric oxide (NO)-specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS.
摘要翻译：本发明部分地涉及作为高度一氧化氮（NO）特异性开启荧光探针的化合物。本发明还涉及这些基于荧光素的传感器选择性筛选细菌一氧化氮合酶（bNOS）抑制剂的用途。本发明的化合物容易检测体内产生的一氧化氮。因此，它们可用于通过bNOS测量NO产生的测定。使用本发明的传感器，可以筛选用于bNOS抑制剂的小分子的文库。

10. 发明申请

US20060127385A1 Method for sustaining enos activity 审中-公开
标题翻译：维持enos活动的方法
公开(公告)号：US20060127385A1
公开(公告)日：2006-06-15
申请号：US10537599
申请日：2003-12-04
申请人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
发明人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
IPC分类号： A61K38/54
CPC分类号： G01N33/86 , A61K31/05 , A61K31/27 , C12Q1/26 , G01N2333/90254
摘要： The present invention is directed to methods for sustaining eNOS activity to inhibit platelet aggregation, clot retraction, and enhance fibrinolysis. One embodiment of the invention provides methods of treating thrombosis by inhibiting the activity of the syk kinase. Another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by screening for compounds which sustain eNOS activity. Yet another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by identifying inhibitors of calpain and IIbIIIa by screening for compounds which act through calpain or IIbIIIa to sustain eNOS activity. Yet another embodiment provides for enhancing fibrinolysis, by inhibiting the activity of the syk kinase or calpain.
摘要翻译：本发明涉及维持eNOS活性以抑制血小板聚集，凝块缩回和增强纤维蛋白溶解的方法。本发明的一个实施方案提供了通过抑制syk激酶的活性来治疗血栓形成的方法。另一个实施方案提供了通过筛选维持eNOS活性的化合物来发现用于治疗血栓形成的改进化合物的测定。另一个实施方案提供了通过筛选通过钙蛋白酶或IIbIIIa作用以维持eNOS活性的化合物来鉴定钙蛋白酶和IIbIIIa的抑制剂来发现治疗血栓形成的改进化合物的测定。另一个实施方案通过抑制syk激酶或钙蛋白酶的活性来提供增强纤维蛋白溶解。

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