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1. 发明申请

US20130224827A1 ENDOTHELIAL NITRIC OXIDE SYNTHASE 审中-公开
标题翻译：内氧化氮氧化物合成酶
公开(公告)号：US20130224827A1
公开(公告)日：2013-08-29
申请号：US13773721
申请日：2013-02-22
申请人： John C. Salerno , Carol A. Chrestensen
发明人： John C. Salerno , Carol A. Chrestensen
IPC分类号： C12N9/99 , C07K16/40 , C12N9/96 , C12N9/00
CPC分类号： C12N9/99 , C07K16/40 , C12N9/0075 , C12N9/96 , C12Y114/13039
摘要： The activity of endothelial nitric oxide synthase (eNOS) was modulated by contact with an effective amount of a mitogen-activated protein (MAP) kinase, resulting in phosphorylation of S602, T46, and/or S58. Kinetics and stoichiometry are disclosed. The contact strongly reduced nitric oxide (NO) synthesis, and also inhibited the cytochrome c reductase activity of eNOS reductase domains. Three sites of phosphorylation were determined that matched the serine-proline (SP) and threonine-proline (TP) motifs of typical MAP kinase phosphorylation sites.
摘要翻译：通过与有效量的丝裂原活化蛋白（MAP）激酶接触调节内皮一氧化氮合酶（eNOS）的活性，导致S602，T46和/或S58的磷酸化。公开了动力学和化学计量。接触强烈地减少一氧化氮（NO）合成，并且还抑制eNOS还原酶结构域的细胞色素c还原酶活性。测定三个磷酸化位点，其与典型的MAP激酶磷酸化位点的丝氨酸 - 脯氨酸（SP）和苏氨酸 - 脯氨酸（TP）基序相匹配。

2. 发明授权

US06750197B1 Activators of endothelial nitric oxide synthase 失效
标题翻译：内皮一氧化氮合酶的激活剂
公开(公告)号：US06750197B1
公开(公告)日：2004-06-15
申请号：US09398405
申请日：1999-09-16
申请人： John C. Salerno
发明人： John C. Salerno
IPC分类号： A61K3800
CPC分类号： C12N9/0075 , A61K38/00 , C07K14/4702
摘要： The regulatory peptides for constitutive nitric oxide synthase enzymes, and a peptide specific to inducible nitric oxide synthase, as well as derivatives of the peptides, homologous peptides, nucleic acids encoding the peptides, derivatives, and homologous peptides, and antibodies to the peptides, derivatives, and homologous peptides, are disclosed. The peptides, derivatives, homologous peptides, antibodies, and nucleic acids, as well as peptidomimetics, can be used in methods of modulating the activity of nitric oxide synthase enzymes, and also in methods of treating diseases or conditions modulated by production of nitric oxide by nitric oxide synthases. Assays for identifying agents which modulate the activity of the nitric oxide synthase enzymes are also described.
摘要翻译：用于组成型一氧化氮合成酶的调节肽和可诱导的一氧化氮合酶特异性肽，以及肽的衍生物，同源肽，编码肽，衍生物和同源肽的核酸，以及针对肽，衍生物的抗体和同源肽。肽，衍生物，同源肽，抗体和核酸以及肽模拟物可用于调节一氧化氮合酶活性的方法，以及用于治疗由一氧化氮生成调节的疾病或病症的方法一氧化氮合酶。还描述了用于鉴定调节一氧化氮合酶的活性的试剂的测定。

3. 发明申请

US20150232576A1 ENDOTHELIAL NITRIC OXIDE SYNTHASE 审中-公开
标题翻译：内氧化氮氧化物合成酶
公开(公告)号：US20150232576A1
公开(公告)日：2015-08-20
申请号：US14672642
申请日：2015-03-30
申请人： John C. Salerno , Carol A. Chrestensen
发明人： John C. Salerno , Carol A. Chrestensen
IPC分类号： C07K16/40 , G01N33/573
CPC分类号： C07K16/40 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C12N9/0075 , C12N9/99 , C12Y114/13039 , G01N33/573 , G01N2333/90254 , G01N2440/14
摘要： Endothelial nitric oxide synthase (eNOS) activity was modulated by contact with an effective amount of a mitogen-activated protein (MAP) kinase, resulting in phosphorylation of S602, T46, and/or S58. Kinetics and stoichiometry are disclosed. The contact strongly reduced nitric oxide (NO) synthesis, and inhibited the cytochrome c reductase activity of eNOS reductase domains. Three sites of phosphorylation were determined that matched the serine-proline (SP) and threonine-proline (TP) motifs of typical MAP kinase phosphorylation sites.
摘要翻译：通过与有效量的丝裂原活化蛋白（MAP）激酶接触调节内皮一氧化氮合酶（eNOS）活性，导致S602，T46和/或S58的磷酸化。公开了动力学和化学计量。接触强烈地减少一氧化氮（NO）合成，并抑制eNOS还原酶结构域的细胞色素c还原酶活性。测定三个磷酸化位点，其与典型的MAP激酶磷酸化位点的丝氨酸 - 脯氨酸（SP）和苏氨酸 - 脯氨酸（TP）基序相匹配。

4. 发明授权

US6150500A Activators of endothelial nitric oxide synthase 失效
标题翻译：内皮一氧化氮合酶的激活剂
公开(公告)号：US6150500A
公开(公告)日：2000-11-21
申请号：US679006
申请日：1996-07-12
申请人： John C. Salerno
发明人： John C. Salerno
IPC分类号： A61K38/00 , C07K14/47 , C12N9/02 , C12N15/53
CPC分类号： C12N9/0075 , C07K14/4702 , A61K38/00
摘要： The regulatory peptides for constitutive nitric oxide synthase enzymes, and a peptide specific to inducible nitric oxide synthase, as well as derivatives of the peptides, homologous peptides, nucleic acids encoding the peptides, derivatives, and homologous peptides, and antibodies to the peptides, derivatives, and homologous peptides, are disclosed. The peptides, derivatives, homologous peptides, antibodies, and nucleic acids, as well as peptidomimetics, can be used in methods of modulating the activity of nitric oxide synthase enzymes, and also in methods of treating diseases or conditions modulated by production of nitric oxide by nitric oxide synthases. Assays for identifying agents which modulate the activity of the nitric oxide synthase enzymes are also described.
摘要翻译：用于组成型一氧化氮合成酶的调节肽和可诱导的一氧化氮合酶特异性肽，以及肽的衍生物，同源肽，编码肽，衍生物和同源肽的核酸，以及针对肽，衍生物的抗体和同源肽。肽，衍生物，同源肽，抗体和核酸以及肽模拟物可用于调节一氧化氮合酶活性的方法，以及用于治疗由一氧化氮生成调节的疾病或病症的方法一氧化氮合酶。还描述了用于鉴定调节一氧化氮合酶的活性的试剂的测定。

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