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1. 发明申请

US20060127385A1 Method for sustaining enos activity 审中-公开
标题翻译：维持enos活动的方法
公开(公告)号：US20060127385A1
公开(公告)日：2006-06-15
申请号：US10537599
申请日：2003-12-04
申请人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
发明人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
IPC分类号： A61K38/54
CPC分类号： G01N33/86 , A61K31/05 , A61K31/27 , C12Q1/26 , G01N2333/90254
摘要： The present invention is directed to methods for sustaining eNOS activity to inhibit platelet aggregation, clot retraction, and enhance fibrinolysis. One embodiment of the invention provides methods of treating thrombosis by inhibiting the activity of the syk kinase. Another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by screening for compounds which sustain eNOS activity. Yet another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by identifying inhibitors of calpain and IIbIIIa by screening for compounds which act through calpain or IIbIIIa to sustain eNOS activity. Yet another embodiment provides for enhancing fibrinolysis, by inhibiting the activity of the syk kinase or calpain.
摘要翻译：本发明涉及维持eNOS活性以抑制血小板聚集，凝块缩回和增强纤维蛋白溶解的方法。本发明的一个实施方案提供了通过抑制syk激酶的活性来治疗血栓形成的方法。另一个实施方案提供了通过筛选维持eNOS活性的化合物来发现用于治疗血栓形成的改进化合物的测定。另一个实施方案提供了通过筛选通过钙蛋白酶或IIbIIIa作用以维持eNOS活性的化合物来鉴定钙蛋白酶和IIbIIIa的抑制剂来发现治疗血栓形成的改进化合物的测定。另一个实施方案通过抑制syk激酶或钙蛋白酶的活性来提供增强纤维蛋白溶解。

2. 发明授权

US08586292B2 Methods for identifying compounds for treatment of thrombotic condition 有权
标题翻译：鉴定用于治疗血栓形成症状的化合物的方法
公开(公告)号：US08586292B2
公开(公告)日：2013-11-19
申请号：US12979753
申请日：2010-12-28
申请人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
发明人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
IPC分类号： C12Q1/00
CPC分类号： G01N33/86 , A61K31/05 , A61K31/27 , C12Q1/26 , G01N2333/90254
摘要： The present invention is directed to methods for sustaining eNOS activity to inhibit platelet aggregation, clot retraction, and enhance fibrinolysis. One embodiment of the invention provides methods of treating thrombosis by inhibiting the activity of the syk kinase. Another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by screening for compounds which sustain eNOS activity. Yet another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by identifying inhibitors of calpain and IIbIIIa by screening for compounds which act through calpain or IIbIIIa to sustain eNOS activity. Yet another embodiment provides for enhancing fibrinolysis, by inhibiting the activity of the syk kinase or calpain.
摘要翻译：本发明涉及维持eNOS活性以抑制血小板聚集，凝块缩回和增强纤维蛋白溶解的方法。本发明的一个实施方案提供了通过抑制syk激酶的活性来治疗血栓形成的方法。另一个实施方案提供了通过筛选维持eNOS活性的化合物来发现用于治疗血栓形成的改进化合物的测定。另一个实施方案提供了通过筛选通过钙蛋白酶或IIbIIIa作用以维持eNOS活性的化合物来鉴定钙蛋白酶和IIbIIIa的抑制剂来发现治疗血栓形成的改进化合物的测定。另一个实施方案通过抑制syk激酶或钙蛋白酶的活性来提供增强纤维蛋白溶解。

3. 发明申请

US20110124512A1 METHODS AND KITS FOR SUSTAINING eNOS ACTIVITY TO INHIBIT PLATELET AGGREGATION, AND CLOT RETRACTION, AND PROMOTE FIBRINOLYSIS 有权
标题翻译：用于保持eNOS活性以抑制平板聚集和粘滞回缩和促进纤维蛋白溶解的方法和工具
公开(公告)号：US20110124512A1
公开(公告)日：2011-05-26
申请号：US12979753
申请日：2010-12-28
申请人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
发明人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
IPC分类号： C40B30/00 , C12Q1/48 , C12Q1/37
CPC分类号： G01N33/86 , A61K31/05 , A61K31/27 , C12Q1/26 , G01N2333/90254
摘要： The present invention is directed to methods for sustaining eNOS activity to inhibit platelet aggregation, clot retraction, and enhance fibrinolysis. One embodiment of the invention provides methods of treating thrombosis by inhibiting the activity of the syk kinase. Another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by screening for compounds which sustain eNOS activity. Yet another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by identifying inhibitors of calpain and IIbIIIa by screening for compounds which act through calpain or IIbIIIa to sustain eNOS activity. Yet another embodiment provides for enhancing fibrinolysis, by inhibiting the activity of the syk kinase or calpain.
摘要翻译：本发明涉及维持eNOS活性以抑制血小板聚集，凝块缩回和增强纤维蛋白溶解的方法。本发明的一个实施方案提供了通过抑制syk激酶的活性来治疗血栓形成的方法。另一个实施方案提供了通过筛选维持eNOS活性的化合物来发现用于治疗血栓形成的改进化合物的测定。另一个实施方案提供了通过筛选通过钙蛋白酶或IIbIIIa作用以维持eNOS活性的化合物来鉴定钙蛋白酶和IIbIIIa的抑制剂来发现治疗血栓形成的改进化合物的测定。另一个实施方案通过抑制syk激酶或钙蛋白酶的活性来提供增强纤维蛋白溶解。

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