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1. 发明公开

US20240353406A1 INNOVATIVE BIOTECHNOLOGICAL SYSTEMS FOR THE DETECTION OF CELLULAR OR MOLECULAR ANALYTES 审中-公开
公开(公告)号：US20240353406A1
公开(公告)日：2024-10-24
申请号：US18693672
申请日：2022-09-21
申请人： UNIVERSITA' DEGLI STUDI DI MESSINA , ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA
发明人： Sabrina CONOCI , Salvatore GUGLIELMINO , Matteo CALVARESI , Alberto DANIELLI , Luca PRODI , Enza FAZIO , Annapaola PETROSINO , Matteo DI GIOSIA
IPC分类号： G01N33/569 , G01N21/64 , G01N33/543
CPC分类号： G01N33/56911 , G01N21/6486 , G01N33/54326 , G01N2333/01 , G01N2333/21
摘要： A method for detecting cellular or molecular analytes is provided. The method uses two types of engineered phages: a “capture” phage (bait phage) and a “signal” phage (reporter phage). Through this method it is possible to selectively bind a target analyte and thus recognize said target analyte.

2. 发明授权

US12006355B2 Nanobodies against cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) 有权
公开(公告)号：US12006355B2
公开(公告)日：2024-06-11
申请号：US17544377
申请日：2021-12-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE TRUSTEES OF DARTMOUTH COLLEGE
发明人： Bruce D. Hammock , Natalia Vasylieva , Jiexian Dong , Christophe Morisseau , Dean R. Madden
IPC分类号： C07K16/12 , C07K16/40 , G01N33/569
CPC分类号： C07K16/1214 , C07K16/40 , G01N33/56911 , C07K2317/22 , C07K2317/569 , C07K2317/76 , C07K2317/92 , G01N2333/21
摘要： Provided are VHH or nanobodies that specifically bind to cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif), and uses thereof for diagnosis and treatment of Pseudomonas infection.

3. 发明申请

US20180208962A1 MEDICINAL OROBANCHEACE EXTRACTS 审中-公开
公开(公告)号：US20180208962A1
公开(公告)日：2018-07-26
申请号：US15933477
申请日：2018-03-23
申请人： Mohamed Fakhr EL-Din EL-SAWY , Sherine Hassan Abbas HELMY , Layla M.F. El-Din EL-SAWY , Maha Adel EL DEMELLAWY , Shefaa M.F. EL-SAWY
发明人： Mohamed Fakhr EL-Din EL-SAWY , Sherine Hassan Abbas HELMY , Layla M.F. El-Din EL-SAWY , Maha Adel EL DEMELLAWY , Shefaa M.F. EL-SAWY
IPC分类号： C12Q1/18
CPC分类号： C12Q1/18 , A61J3/00 , A61K36/64 , G01N2333/21 , G01N2800/26 , G01N2800/52
摘要： Pharmaceutical extracts from Egyptian broomrape have proven efficacy against HCV and NAFLD. Compositions and method of making and using same are provided.

4. 发明申请

US20170216380A1 BENEFICIAL EFFECTS OF BACTERIOPHAGE TREATMENTS 审中-公开
公开(公告)号：US20170216380A1
公开(公告)日：2017-08-03
申请号：US15400786
申请日：2017-01-06
申请人： AmpliPhi Biosciences Corporation
发明人： David Harper
IPC分类号： A61K35/76 , A61K31/546 , A61K31/496 , C12N7/00 , A61K31/431 , A61K38/12 , A61K31/427 , C12Q1/02 , A61K31/7036 , A61K31/407
CPC分类号： C12Q1/18 , A61K31/407 , A61K31/427 , A61K31/431 , A61K31/496 , A61K31/546 , A61K31/7036 , A61K35/76 , A61K38/12 , C12N7/00 , C12N2795/00032 , C12Q1/025 , G01N2333/21 , G01N2800/26 , G01N2800/52 , A61K2300/00
摘要： The invention elates to use of one or more bacteriophages in vivo in a human or animal in order to induce sensitivity to chemical antibiotics in bacterial cells, where such susceptibility is heritable, independent of continuing bacteriophage metabolism within those cells, and does not relate to the destruction of a biofilm to induce such sensitivity.

5. 发明申请

US20170205426A1 RAPID MASS SPECTROMETRY METHODS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING USING TOP-DOWN MASS SPECTROMETRY 审中-公开
公开(公告)号：US20170205426A1
公开(公告)日：2017-07-20
申请号：US15411814
申请日：2017-01-20
申请人： Thermo Finnigan LLC
发明人： James STEPHENSON, JR. , Roger GRIST , William McGEE , Jason NEIL , David SARRACINO
IPC分类号： G01N33/68 , C12Q1/18 , G06F19/18 , G06F19/24
CPC分类号： G01N33/6848 , C12Q1/18 , G01N2333/21 , G01N2333/26 , G01N2333/31 , G01N2333/32 , G01N2800/52 , G16B20/00 , G16B40/00
摘要： Methods and systems for rapid prediction and/or confirmation of antimicrobial susceptibility of a microorganism using top-down mass spectrometry, ion-ion chemistry, and a database with susceptibility, pathogenicity and antimicrobial resistance markers for sample characterization.

6. 发明申请

US20160237145A1 BINDING MOIETIES FOR BIOFILM REMEDIATION 审中-公开
标题翻译：生物技术补救的绑定机制
公开(公告)号：US20160237145A1
公开(公告)日：2016-08-18
申请号：US15144681
申请日：2016-05-02
申请人： Trellis Bioscience, LLC
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Reyna J. SIMON
IPC分类号： C07K16/12 , A01N63/02 , G01N33/577 , A61K49/00 , C07K14/31 , G01N33/569 , A61K39/40 , A61K45/06
CPC分类号： C07K16/1271 , A01N63/02 , A61K39/00 , A61K39/40 , A61K45/06 , A61K49/00 , A61K2039/505 , C07K14/31 , C07K16/1214 , C07K16/1228 , C07K16/1242 , C07K16/1275 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12Q1/18 , G01N33/566 , G01N33/56911 , G01N2333/195 , G01N2333/21 , G01N2333/245 , G01N2333/26 , G01N2333/285 , G01N2469/10 , A61K2300/00
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
摘要翻译：描述了能够破坏不同来源的细菌生物膜的结合剂，包括适合于给予所选物种的单克隆抗体，以及包括适体核酸的抗体模拟物。还描述了防止用这些结合剂形成或溶解生物膜的方法。还描述了用于引发抗体破坏生物膜的免疫原。

7. 发明授权

US09366673B2 Porphyromonas gingivalis polypeptides 有权
标题翻译：牙龈卟啉单胞菌多肽
公开(公告)号：US09366673B2
公开(公告)日：2016-06-14
申请号：US13388042
申请日：2010-07-30
申请人： Jacqueline McCluskey , Robert Charlebois , Laurence Quemeneur , Jeremy Yethon , Michael Leach
发明人： Jacqueline McCluskey , Robert Charlebois , Laurence Quemeneur , Jeremy Yethon , Michael Leach
IPC分类号： A61K39/02 , A61P31/04 , C07K14/195 , C07K16/12 , A61K39/395 , A61P37/04 , G01N33/569 , A61K39/00
CPC分类号： G01N33/56955 , A61K39/00 , A61K39/0216 , A61K2039/55505 , A61K2039/55566 , C07K16/1257 , G01N2333/21
摘要： Provided herein are compositions and methods for eliciting an immune response against Porphyromonas gingivalis. The compositions and methods relate to P. gingivalis polypeptides and fragments and variants thereof and the corresponding polynucleotides which are useful in the diagnosis, prevention and therapy of P. gingivalis infections (e.g. periodontitis). Antibodies against the polypeptides and compositions and methods including these antibodies are also disclosed. The disclosure also describes methods for the detection, prevention and treatment of P. gingivalis infection (e.g. periodontitis).
摘要翻译：本文提供了用于引发针对牙龈卟啉单胞菌的免疫应答的组合物和方法。组合物和方法涉及牙龈卟啉单胞菌多肽及其片段和变体，以及可用于诊断，预防和治疗牙龈卟啉菌感染（例如牙周炎）的相应多核苷酸。还公开了针对多肽的抗体以及包括这些抗体的组合物和方法。本公开还描述了牙龈卟啉菌感染（例如牙周炎）的检测，预防和治疗方法。

8. 发明申请

US20150231165A1 TREATMENT AND PREVENTION OF P. AERUGINOSA INFECTIONS USING COFORMYCIN ANALOGS 有权
标题翻译：治疗和预防使用联合胰蛋白酶类似物的阿维菌素感染
公开(公告)号：US20150231165A1
公开(公告)日：2015-08-20
申请号：US14426775
申请日：2013-09-10
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , Victoria Link Limited
发明人： Vern L. Schramm , Peter Charles Tyler , Richard Fröhlich
IPC分类号： A61K31/7056 , A61L29/16 , C12Q1/34 , A61L31/16
CPC分类号： A61K31/7056 , A61K31/706 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/406 , C07H19/23 , C12Q1/18 , C12Q1/34 , G01N2333/21 , G01N2333/978
摘要： Methods and devices are disclosed for treating or preventing infections in a subject due to Pseudomonas aeruginosa using coformycin analogs and inhibitors of Pseudomonas aeruginosa 5′-methylthioadenosine deaminase (MTADA).
摘要翻译：公开了用于治疗或预防由铜绿假单胞菌引起的受试者感染的方法和装置，其使用铜绿假单胞菌5'-甲硫基腺苷脱氨酶（MTADA）的共转霉素类似物和抑制剂。

9. 发明申请

US20150197558A1 BINDING MOIETIES FOR BIOFILM REMEDIATION 审中-公开
标题翻译：生物技术补救的绑定机制
公开(公告)号：US20150197558A1
公开(公告)日：2015-07-16
申请号：US14668767
申请日：2015-03-25
申请人： TRELLIS BIOSCIENCE, LLC
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Robert STEPHENSON , Reyna J. SIMON , Omar NOURZAIE
IPC分类号： C07K16/12 , A61K39/40 , C12N15/115 , A61K45/06
CPC分类号： C07K16/1271 , A61K39/40 , A61K45/06 , C07K16/1214 , C07K16/1228 , C07K16/1242 , C07K16/1275 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92 , C12N15/115 , C12N2310/16 , C12N2310/3181 , C12N2330/00 , C12Q1/18 , G01N33/566 , G01N33/56911 , G01N2333/21 , G01N2333/245 , G01N2333/26 , G01N2333/285 , Y02A50/57
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species and decoy nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
摘要翻译：描述了能够破坏不同来源的细菌生物膜的结合剂，包括适合于施用于选定物种和诱饵核酸的单克隆抗体。还描述了防止用这些结合剂形成或溶解生物膜的方法。还描述了用于引发抗体破坏生物膜的免疫原。

10. 发明授权

US08980566B2 Biomarkers for respiratory infection 有权
标题翻译：呼吸道感染的生物标志物
公开(公告)号：US08980566B2
公开(公告)日：2015-03-17
申请号：US14345994
申请日：2012-09-19
申请人： Aseptika Ltd
发明人： Kevin Andrew Auton
IPC分类号： G01N33/53 , G01N33/569 , G01N21/64 , C12Q1/04
CPC分类号： G01N33/56911 , C12Q1/04 , G01N21/6428 , G01N2021/6421 , G01N2333/21
摘要： Methods of determining levels of activity of bacteria in the lungs of patients are described, in which levels of a marker of a bacterial iron scavenging processes (for example, siderophores) and levels of a secreted bacterial protein are measured over time. Changes in the measured levels over time allow levels of bacterial activity to be determined, and exacerbations of bacterial infection to be predicted and/or monitored. Additional markers may also be used. The methods of the invention may also be used for monitoring effectiveness of antibiotic treatment of lung infection. The invention is particularly useful for monitoring P. aeruginosa levels in lungs of cystic fibrosis patients. Kits for use in the methods are also described.
摘要翻译：描述了确定患者肺中细菌活性水平的方法，其中测量细菌铁清除过程的标记物（例如铁载体）和分泌的细菌蛋白的水平随时间的水平。随着时间的推移，测量水平的变化可以确定细菌活性的水平，并预测和/或监测细菌感染的恶化。也可以使用附加的标记。本发明的方法也可用于监测肺部感染的抗生素治疗的有效性。本发明对于监测囊性纤维化患者肺中铜绿假单胞菌水平特别有用。还描述了用于该方法的试剂盒。

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