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1. 发明申请

US20220348934A1 NON-RIBOSOMAL PEPTIDES AND SYNTHETASES AND METHODS OF PREPARATION AND USE THEREOF 有权
公开(公告)号：US20220348934A1
公开(公告)日：2022-11-03
申请号：US17642492
申请日：2020-09-11
申请人： VICTORIA LINK LIMITED
发明人： David ACKERLEY , Mark CALCOTT
IPC分类号： C12N15/52 , C12N15/62 , C12P21/02
摘要： The present invention encompasses non-ribosomal peptides and non-ribosomal peptide synthetases, and the preparation and use thereof. Specifically encompassed are methods for preparing non-ribosomal peptide synthetases, methods for preparing non-ribosomal peptides from these enzymes, as well as polynucleotides used for producing these enzymes, libraries comprising these polynucleotides, and microbial strains comprising these polynucleotides.

2. 发明授权

US11055830B2 Rendering process and system 有权
公开(公告)号：US11055830B2
公开(公告)日：2021-07-06
申请号：US16345927
申请日：2016-11-22
申请人： Victoria Link Limited
发明人： Tae Hyun Rhee , Andrew Chalmers , Benjamin Peter Allen , Thomas Manu Iorns , Lohit Dev Petikam
IPC分类号： G06T15/20 , G06T5/00 , G06T15/50 , G06T15/55 , G06T15/60 , H04N5/232
摘要： A rendering process and system that may be used to composite virtual objects in panoramic video to provide a virtual reality and augmented reality experience. The process includes receiving low dynamic range (LDR) video data, e.g. 360° video; generating radiance maps, such as diffuse and specular maps, from the LDR data; inverse tone mapping the LDR data of the maps to generate high dynamic range (HDR) data for the maps; and receiving at least one virtual object and applying image based lighting (IBL) to the virtual object using the HDR data of the maps. A perceptually based threshold is also applied to radiance maps to detect prominent pixels, and using the prominent pixels as salient lights for image based shadowing (IBS) associated the virtual object. Objects are composited 360° video in real time using IBL and IBS without precomputation allowing user interaction with the objects.

3. 发明申请

US20210139338A1 AMMONIA PRODUCTION METHOD AND APPARATUS FOR AMMONIA PRODUCTION 有权
公开(公告)号：US20210139338A1
公开(公告)日：2021-05-13
申请号：US16628214
申请日：2018-07-02
申请人： VICTORIA LINK LIMITED
发明人： Franck NATALI , Benjamin John RUCK , Harry Joseph TRODAHL
IPC分类号： C01C1/04
摘要： The present invention concerns an ammonia production method comprising the steps of: providing at least one rare earth nitride material or layer in a chamber; creating a vacuum or an inert atmosphere in the chamber; and providing hydrogen H2 to react with nitrogen N released at an external surface of the at least one rare earth nitride material or layer to produce ammonia.

4. 发明申请

US20210032635A1 MODULAR DNA ASSEMBLY SYSTEM 有权
公开(公告)号：US20210032635A1
公开(公告)日：2021-02-04
申请号：US16651043
申请日：2018-09-28
申请人： VICTORIA LINK LIMITED
发明人： Emily Jane Parker , Matthew Joseph Nicholson , Craig John Van Dolleweerd
IPC分类号： C12N15/64 , C12N15/52 , C12N15/66 , C12N15/70 , C12P17/18
摘要： A modular and hierarchical DNA assembly platform for synthetic biology is described. This enabling technology, termed MIDAS (for Modular Idempotent DNA Assembly System), can precisely assemble multiple DNA fragments in a single reaction using a standardised assembly design. It can be used to build genes from libraries of sequence-verified, reusable parts and to assemble multiple genes in a single vector. We describe the design and use of MIDAS, and its application in the reconstruction of the metabolic pathway for production of paspaline, a key intermediate in the biosynthesis of a range of indole diterpenes—a class of economically important secondary metabolites produced by several species of filamentous fungi.

5. 发明申请

US20200333684A1 OPTICAL SYSTEM FOR NARROWING THE BANDWIDTH OF RADIATION 审中-公开
公开(公告)号：US20200333684A1
公开(公告)日：2020-10-22
申请号：US16769554
申请日：2018-11-29
申请人： Victoria Link Limited
发明人： Shyamal Kush Kanchan Prasad , Nicholas Richard Monahan , Karen Elisabeth Thorn , Kai Chen , Justin Mark Hodgkiss
IPC分类号： G02F1/35 , H01S3/00 , G02B27/10 , G02F1/355 , G02B27/30
摘要： An optical system for narrowing the bandwidth of a beam of incident radiation includes an optical mixing unit configured to receive a first beam of radiation and a second beam of radiation. The first and second beams are spatially chirped and the first beam is inverted relative to the second beam. The optical mixing unit includes an optical mixing member, which includes a nonlinear optical medium to mix the first and second beams into an output beam having a narrower bandwidth than the beam of incident radiation.

6. 发明申请

US20190272626A1 A RENDERING PROCESS AND SYSTEM 审中-公开
公开(公告)号：US20190272626A1
公开(公告)日：2019-09-05
申请号：US16345927
申请日：2016-11-22
申请人： Victoria Link Limited
发明人： Tae Hyun Rhee , Andrew Chalmers , Benjamin Peter Allen , Thomas Manu Iorns , Lohit Dev Petikam
IPC分类号： G06T5/00 , G06T15/50 , G06T15/20 , G06T15/55 , G06T15/60
摘要： A rendering process and system that may be used to composite virtual objects in panoramic video to provide a virtual reality and augmented reality experience. The process includes receiving low dynamic range (LDR) video data, e.g. 360° video; generating radiance maps, such as diffuse and specular maps, from the LDR data; inverse tone mapping the LDR data of the maps to generate high dynamic range (HDR) data for the maps; and receiving at least one virtual object and applying image based lighting (IBL) to the virtual object using the HDR data of the maps. A perceptually based threshold is also applied to radiance maps to detect prominent pixels, and using the prominent pixels as salient lights for image based shadowing (IBS) associated the virtual object. Objects are composited 360° video in real time using IBL and IBS without precomputation allowing user interaction with the objects.

7. 发明申请

US20190257745A1 A SPECTROMETER APPARATUS FOR MEASURING SPECTRA OF A LIQUID SAMPLE USING AN INTEGRATING CAVITY 审中-公开
公开(公告)号：US20190257745A1
公开(公告)日：2019-08-22
申请号：US16340550
申请日：2017-10-11
申请人： VICTORIA LINK LIMITED
发明人： Brendan Liam DARBY , Eric LE RU , Matthias MEYER
IPC分类号： G01N21/25 , G01J3/02 , G01J3/08 , G01J3/42 , G01J3/44
摘要： A spectrometer apparatus (1) is provided for measuring spectra of a liquid sample, such as a beverage such as wine. The apparatus (1) comprises an integrating cavity (3) comprising a reflective inner wall or walls (5), configured to receive a cuvette (7) containing the liquid sample within the integrating cavity (5). A combination of light inlet ports P1, P2 and light outlet ports P3, P4 are provided to receive light from at least one light source (9) and to deliver light to a spectrometer (11). A light path adjuster (13, 13B) is configured to selectively adjust a light path through the integrating cavity (5) such that at least two distinct light paths are provided; wherein when the light path adjuster (13, 13B) is in a first configuration, the apparatus (1) is in a transmission mode in which light from the light source follows a first light path (15) from the or one of the light inlet port(s) to the liquid sample such that the light from the light source irradiates the liquid sample directly before the light transmitted by the sample is transmitted through the or one of the light outlet port(s) and received by the spectrometer (11) for wavelength analysis of the light to provide an extinction spectrum of the liquid sample; and when the light path adjuster (13, 13B) is in a second configuration, the apparatus is in a diffusely reflecting mode in which light from the light source follows a second light path (17) from the or one of the inlet port(s) into the integrating cavity, is incident onto the reflective inner wall or walls of the integrating cavity and is diffusely reflected within the integrating cavity, such that the light from the light source irradiates the liquid sample before being transmitted through the or one of the light outlet port(s) and received by the spectrometer (11) for wavelength analysis of the light to provide an absorbance spectrum of the liquid sample contained in the liquid sample.

8. 发明授权

US10227351B2 Salt and polymorphic forms of (3R,4S)-L-((4-amino-5H-pyrrolo[3,2,-D]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(MTDIA) 有权
公开(公告)号：US10227351B2
公开(公告)日：2019-03-12
申请号：US15993669
申请日：2018-05-31
申请人： VICTORIA LINK LIMITED
发明人： Gary Brian Evans , Peter Michael Kelly , Peter Charles Tyler
IPC分类号： C07D207/50 , C07D487/04 , C07D207/44 , C07D207/12 , C07D207/34 , C07C55/07 , C07C53/06 , C07C269/04 , A61K31/519 , A61P35/00 , A61P35/02
摘要： The invention relates to salt forms of (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methyl-thiomethyl)pyrrolidin-3-ol, as well as polymorphic forms of the salts. The invention further relates to processes for preparing the salt forms and to the use of the salt forms in the treatment of diseases and disorders where it is desirable to inhibit 5′-methylthioadenosine phosphorylase (MTAP).

9. 发明授权

US10118928B2 Treatment of H. pylori infections using MTAN inhibitors 有权
公开(公告)号：US10118928B2
公开(公告)日：2018-11-06
申请号：US15118113
申请日：2015-02-06
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. , VICTORIA LINK LIMITED
发明人： Vern L. Schramm , Keith Clinch , Shivali Ashwin Gulab
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61P31/04
摘要： Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering inhibitors of H. pylori MTAN (5′-methylthioadenosine nucleosidase) to the subject, where the inhibitors have the structure

10. 发明授权

US10023869B2 Bio-sensor for the detection of small molecules 有权
公开(公告)号：US10023869B2
公开(公告)日：2018-07-17
申请号：US14765728
申请日：2014-02-05
申请人： VICTORIA LINK LIMITED
发明人： Omar Ahmed Alsager , Justin Mark Hodgkiss , Shalen Kumar , Kenneth Patrick McNatty
IPC分类号： C12N15/115 , C12Q1/6811 , G01N33/53 , G01N33/543
摘要： This present invention provides methods for the detection of small molecules in samples comprising the steps a) coupling a nanoparticle (NP) or microparticle (MP) to an aptamer specific for the small molecule to be detected to form a NP-aptamer conjugate b) contacting the NP-aptamer conjugate with the sample; and c) detecting a change in the size, surface potential, or mobility of the NP-aptamer conjugate, wherein the change is indicative of the presence of the small molecule. The present invention also provides for and a biosensor comprising nanoparticles coupled to aptamers to provide nanoparticle aptamer-conjugates (NP-aptamer).

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