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1. 发明授权

US09562254B2 Anti-biofilm screening assays 有权
标题翻译：抗生物膜筛选试验
公开(公告)号：US09562254B2
公开(公告)日：2017-02-07
申请号：US14770866
申请日：2013-03-19
申请人： Colgate-Palmolive Company
发明人： Shashank Potnis , Navin Lewis
IPC分类号： C12Q1/18 , G01N33/569
CPC分类号： C12Q1/18 , G01N33/56955
摘要： Procedures are provided to evaluate the effectiveness of slow-acting antibacterial agents such as metal salts on reduction of bacterial oral biofilm. In the modified process, the exposure time of the agent is increased from the usual 3 minutes to 7-15 minutes, e.g., about 10 minutes, and the duration increased to 5-12 days, e.g., about 8 days instead of the conventional 3 days.
摘要翻译：提供程序来评估缓慢作用的抗菌剂如金属盐对减少细菌口腔生物膜的有效性。在改性方法中，试剂的暴露时间从通常的3分钟增加到7-15分钟，例如约10分钟，持续时间增加到5-12天，例如约8天，而不是常规3 天。

2. 发明授权

US09500649B2 Analytical tool and method for determining a condition of an oral cavity 有权
标题翻译：用于确定口腔状况的分析工具和方法
公开(公告)号：US09500649B2
公开(公告)日：2016-11-22
申请号：US13976643
申请日：2011-12-27
申请人： Eiji Nishinaga , Akira Uchiyama , Naho Suzuki , Tetsu Fukasawa , Riichi Maki , Akio Okubo , Isao Fukuta
发明人： Eiji Nishinaga , Akira Uchiyama , Naho Suzuki , Tetsu Fukasawa , Riichi Maki , Akio Okubo , Isao Fukuta
IPC分类号： G01N33/569 , G01N33/543 , G01N33/68 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/56955 , C12Q1/689 , C12Q2600/118 , C12Q2600/16 , G01N33/5302 , G01N33/54386 , G01N33/6893 , G01N2800/18 , G01N2800/50
摘要： A method of determining the condition of the oral cavity in a subject is provided by using an analytical tool comprising the following (A), (B), and (C): (A) a reagent for measuring one or more parameters that reflect the dental caries risk for a test sample obtained from the oral cavity, (B) a reagent for measuring one or more parameters that reflect the periodontal disease risk for the test sample obtained from the oral cavity, and (C) a reagent for measuring one or more parameters that reflect the degree of oral cleanliness for the test sample obtained from the oral cavity.

3. 发明授权

US08975032B2 Test kit for plasma or serum antibody titer against periodontal disease-causing bacteria 有权
标题翻译：血浆或血清抗体滴定对牙周病致病细菌的试剂盒
公开(公告)号：US08975032B2
公开(公告)日：2015-03-10
申请号：US13994005
申请日：2011-10-18
申请人： Mikio Nozoe
发明人： Mikio Nozoe
IPC分类号： G01N33/68 , G01N33/569 , C07K14/195 , G01N33/543
CPC分类号： G01N33/6893 , C07K14/195 , G01N33/54366 , G01N33/56955 , G01N33/6854 , G01N2800/18 , Y10S435/81
摘要： The object of the present invention is to provide: a test kit for an antibody titer or an antibody against a periodontal disease-causing bacterium in a blood sample, which enables the testing on a periodontal disease in patients having a wide scope of immunotypes with high accuracy and can be treated by an automated device at a high speed; a periodontal disease-causing bacterium antigen protein which can be suitably used in the kit; a method for testing an antibody titer or the presence of an antibody in a blood sample using the kit; and a kit for typing strains of Porphyromonas gingivalis. The present invention discloses: a test kit comprising a set of polypeptides respectively having the acid sequences represented by SEQ ID NOs: 1, 3, 9, 15, 19, 31, 41, 43, 63, 65 and 67; a modified polypeptide having the amino acid sequence represented by SEQ ID NO: 67; and a method for determining an antibody titer or the presence of an antibody against a periodontal disease-causing bacterium in a blood sample separated from a human body, comprising bringing the blood sample into contact with the above-mentioned set of polypeptides.
摘要翻译：本发明的目的是提供：用于血液样品中抗体滴度或针对牙周病致细菌的抗体的测试试剂盒，其能够在具有高度免疫型的广泛范围的患者中对牙周病进行测试精度高，可以通过自动化设备高速处理; 可以适用于试剂盒的牙周病致细菌抗原蛋白; 使用试剂盒测试血液样品中抗体滴度或抗体存在的方法; 以及用于分类牙龈卟啉单胞菌的试剂盒。本发明公开了一种测试试剂盒，其包含分别具有由SEQ ID NO：1,3,9,15,19,31,41,43,63,65和67表示的酸序列的一组多肽; 具有由SEQ ID NO：67表示的氨基酸序列的经修饰的多肽; 以及用于测定从人体分离的血液样品中抗体滴度或抗牙周病致细菌的抗体的存在的方法，包括使血液样品与上述多肽组合接触。

4. 发明授权

US08871213B2 Prevention, treatment and diagnosis of P. gingivalis infection 有权
标题翻译：牙龈卟啉菌感染的预防，治疗和诊断
公开(公告)号：US08871213B2
公开(公告)日：2014-10-28
申请号：US13060653
申请日：2009-08-28
申请人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J Cross , Nada Slakeski
发明人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J Cross , Nada Slakeski
IPC分类号： A61K38/00 , A61K39/00 , A61K39/38 , A61K39/02 , A61K39/385 , C07K14/195 , C07K16/12 , G01N33/569
CPC分类号： C07K14/195 , A61K39/0216 , A61K2039/505 , A61K2039/53 , A61K2039/55566 , C07K16/1203 , C07K16/1257 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C12N9/14 , C12N9/52 , C12Y304/21 , C12Y304/21004 , C12Y306/05002 , G01N33/56955 , G01N2333/95
摘要： The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
摘要翻译：本发明涉及细胞和体液应答的生成和使用，用于预防和治疗牙龈卟啉单胞菌相关病症和疾病。

5. 发明申请

US20130236915A1 METHOD OF INSPECTING PERIODONTAL DISEASE CAUSING BACTERIA USING OUTER MEMBRANE VESICLE AND MEASURING APPLIANCE OF THE SAME 审中-公开
标题翻译：使用外膜检测周边疾病引起细菌的方法及其测量仪器
公开(公告)号：US20130236915A1
公开(公告)日：2013-09-12
申请号：US13788287
申请日：2013-03-07
申请人： Director-Gen. of Nat. Inst. of Infectious Diseases , GC CORPORATION
发明人： Ryoma NAKAO , Hidenobu SENPUKU , Makoto ONISHI , Kazuto TAKAYAMA , Hiroki NAITO , Tetsuo SAKUMA
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N33/56955 , G01N2469/20
摘要： The invention provides a method of inspecting bacteria by using an outer membrane vesicle of the bacteria, which is useful for easily diagnosing a periodontopathic bacteria with high precision. An outer membrane vesicle of bacteria to be detected is previously arranged in a measuring portion of a measuring appliance, a specimen material collected from a test subject is brought into contact with the measuring portion, and an anti-outer membrane vesicle antibody corresponding to the outer membrane vesicle in the specimen material is detected on the basis of an antigen antibody reaction. A measuring appliance for executing the inspecting method of the bacteria is structured such that the outer membrane vesicle of the bacteria to be detected is previously arranged in the measuring portion.
摘要翻译：本发明提供了通过使用细菌的外膜囊泡检查细菌的方法，其可用于以高精度容易地诊断牙周病细菌。预先将待检测细菌的外膜泡囊设置在测量仪器的测量部分中，将从受检对象收集的样本材料与测量部分接触，并且与外部对应的抗外膜囊泡抗体基于抗原抗体反应检测样品中的膜泡。用于执行细菌检查方法的测量装置被构造成使得要检测的细菌的外膜泡囊预先布置在测量部分中。

6. 发明申请

US20130230462A1 METHOD FOR PREDICTING AND PREVENTING CARDIOVASCULAR DISEASE 有权
标题翻译：预防和预防心血管疾病的方法
公开(公告)号：US20130230462A1
公开(公告)日：2013-09-05
申请号：US13818405
申请日：2011-08-22
申请人： Jacqueline Abranches , José A. Lemos , Robert A. Burne
发明人： Jacqueline Abranches , José A. Lemos , Robert A. Burne
IPC分类号： G01N33/569 , C12Q1/02 , G01N33/50 , C12Q1/68
CPC分类号： G01N33/56955 , C12Q1/025 , C12Q1/6883 , C12Q1/689 , C12Q2600/136 , C12Q2600/158 , G01N33/5085
摘要： Disclosed are methods of identifying an individual having a predisposition to the development of a cardiovascular disease, and administering a suitable prophylactic agent to the identified individual to prevent disease. Methods of screening and identifying agents that inhibit bacterial collagen binding protein (CBP)-mediated cell invasion are also disclosed.
摘要翻译：公开了鉴定具有心血管疾病发展倾向的个体的方法，以及向所鉴定的个体施用合适的预防剂以预防疾病。还公开了筛选和鉴定抑制细菌胶原结合蛋白（CBP）介导的细胞侵袭的试剂的方法。

7. 发明申请

US20120107843A1 ANTI BONE-LOSS AND ANTI ATTACHMENT-LOSS EFFECTS OF AN ORAL COMPOSITION 有权
标题翻译：口服组合物的抗骨折和抗附着损伤作用
公开(公告)号：US20120107843A1
公开(公告)日：2012-05-03
申请号：US13262027
申请日：2010-04-01
申请人： Virginia Barnes , Harsh M. Trivedi , Wei Wang , Tao Xu , Emi Shimizu , Nicola C. Partridge
发明人： Virginia Barnes , Harsh M. Trivedi , Wei Wang , Tao Xu , Emi Shimizu , Nicola C. Partridge
IPC分类号： G01N33/573 , C12Q1/37
CPC分类号： G01N33/56955 , G01N2333/96486
摘要： Methods for identifying compounds useful for treating diseases and conditions of the oral cavity are described herein.
摘要翻译：本文描述了用于鉴定可用于治疗口腔疾病和病症的化合物的方法。

8. 发明授权

US08133720B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US08133720B2
公开(公告)日：2012-03-13
申请号：US12235336
申请日：2008-09-22
申请人： Shizuko Ono , Yayoi Takahashi
发明人： Shizuko Ono , Yayoi Takahashi
IPC分类号： C12M1/34 , A61K39/09 , G01N33/543
CPC分类号： G01N33/56944 , G01N33/5438 , G01N33/56955 , G01N2333/335
摘要： The invention provides a biosensor comprising a microbe-binding aptamer(s) in the substrate recognition element. It is possible to obtain a stabilized biosensor wherein the detection sensitivity for target microbe (target bacterium) is not impaired depending on the storage condition or measuring sample, and target bacterium in a body fluid can be directly measured by insertion of the substrate recognition element of the biosensor.
摘要翻译：本发明提供了一种生物传感器，其包含基底识别元件中的微生物结合适体。可以获得稳定的生物传感器，其中根据储存条件或测量样品不会损害目标微生物（靶细菌）的检测灵敏度，并且可以通过插入基质识别元件直接测量体液中的靶细菌生物传感器。

9. 发明申请

US20160138089A1 ASSAY AND METHOD 审中-公开
标题翻译：测定方法
公开(公告)号：US20160138089A1
公开(公告)日：2016-05-19
申请号：US14898149
申请日：2014-06-13
申请人： MARS, INCORPORATED
发明人： Stephen James Harris , Matthew Coates , Matthew Ronald Gibbs
IPC分类号： C12Q1/68 , A61Q11/00 , A61K8/02 , G06F19/18 , G06F19/24
CPC分类号： C12Q1/689 , A23K50/40 , A61K8/0204 , A61K2800/70 , A61Q11/00 , C12Q2600/112 , G01N33/56955 , G16B20/00 , G16B40/00
摘要： The present invention relates to an assay for use in a method of determining the oral health status of a canine animal by identifying certain bacteria present or absent in a sample taken from the animal, and applying the information set out herein for each identified bacteria to statistical models in order to determine the oral health status of the animal.
摘要翻译：本发明涉及一种用于确定犬动物口腔健康状况的方法的方法，其通过鉴定取自动物的样品中存在或不存在的某些细菌，并将针对每个鉴定的细菌应用于本文所列的信息至统计学模型以确定动物的口腔健康状况。

10. 发明申请

US20160010137A1 Anti-Biofilm Screening Assays 有权
标题翻译：抗生物膜筛选试验
公开(公告)号：US20160010137A1
公开(公告)日：2016-01-14
申请号：US14770866
申请日：2013-03-19
申请人： Shashank POTNIS , Navin LEWIS , COLGATE-PALMOLIVE COMPANY
发明人： Shashank Potnis , Navin Lewis
IPC分类号： C12Q1/18
CPC分类号： C12Q1/18 , G01N33/56955
摘要： Procedures are provided to evaluate the effectiveness of slow-acting antibacterial agents such as metal salts on reduction of bacterial oral biofilm. In the modified process, the exposure time of the agent is increased from the usual 3 minutes to 7-15 minutes, e.g., about 10 minutes, and the duration increased to 5-12 days, e.g., about 8 days instead of the conventional 3 days.
摘要翻译：提供程序来评估缓慢作用的抗菌剂如金属盐对减少细菌口腔生物膜的有效性。在改性方法中，试剂的暴露时间从通常的3分钟增加到7-15分钟，例如约10分钟，持续时间增加到5-12天，例如约8天，而不是常规3 天。

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