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1. 发明公开

US20230384204A1 Linear Variable Optical Filter Systems for Flow Cytometry and Methods for Using the Same 审中-公开
公开(公告)号：US20230384204A1
公开(公告)日：2023-11-30
申请号：US18142767
申请日：2023-05-03
申请人： Becton, Dickinson and Company
发明人： Geoffrey Osborne
IPC分类号： G01N15/14 , G02B5/28 , G02B5/20 , G01J1/58
CPC分类号： G01N15/1434 , G02B5/288 , G02B5/203 , G01J1/58 , G01N2015/1037
摘要： Aspects of the present disclosure include systems for detecting light from a particle in a flow stream by spectral discrimination. Light detection systems according to certain embodiments include a wavelength separator component configured to propagate light between a first set of linear variable optical filters and a second set of linear variable optical filters where each set of linear variable optical filters is configured to pass light having predetermined sub-spectral ranges and a plurality of photodetectors positioned to detect light from each sub-spectral range across the linear variable optical filters. Systems having a light source for irradiating a particle in a flow stream and a photodetector modulator component for binning data signals generated in a plurality of photodetector channels of the light detection system are also described. Methods for detecting light with the subject systems and kits having one or more components for detecting light according to the subject methods are also provided.

2. 发明授权

US09952135B2 Microfluidic interrogation device 有权
公开(公告)号：US09952135B2
公开(公告)日：2018-04-24
申请号：US15006332
申请日：2016-01-26
申请人： E. I. SPECTRA, LLC
发明人： Harold E. Ayliffe
IPC分类号： G01N15/14 , H01J49/00 , G01N35/00 , G01N27/00 , B01L3/00 , G01N15/12 , G06F17/40 , G06F19/00 , B01L99/00 , G01N15/10 , G01N33/49
CPC分类号： G01N15/1404 , B01L3/502715 , B01L3/502761 , B01L99/00 , B01L2300/0645 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , G01N15/1056 , G01N15/12 , G01N15/1209 , G01N15/1456 , G01N15/1463 , G01N27/00 , G01N33/49 , G01N35/00 , G01N2015/1037 , G01N2015/1062 , G01N2015/1087 , G01N2035/00306 , G06F17/40 , G06F19/00 , H01J49/0013 , H01J49/0022
摘要： A portable, stand-alone microfluidic interrogation device including a microprocessor and a touch-screen display. The touch-screen display can receive one or more user input to select a particular particle interrogation procedure, and subsequently show interrogation results. A microfluidic path extending through the interrogation device includes alignment structure that defines an interrogation zone in which particles carried in a fluid are urged toward single-file travel. Operable alignment structure may define sheath-, or non-sheath fluid flow. Desirably, a portion of the alignment structure is removable from the device in a tool-free procedure. The device may operate under the Coulter principle, and/or detect Stokes' shift phenomena, and/or other optically-based signal(s).

3. 发明授权

US09861984B2 Microchip and channel structure for the same 有权
公开(公告)号：US09861984B2
公开(公告)日：2018-01-09
申请号：US15221261
申请日：2016-07-27
申请人： Sony Corporation
发明人： Masataka Shinoda , Toru Takashimizu
IPC分类号： B01L3/00 , G05D7/06 , F15C1/04 , B07C3/02 , G01N15/14 , B01J19/00 , G01N15/10 , G01N35/10
CPC分类号： B01L3/502776 , B01J19/0093 , B01J2219/00853 , B01J2219/00889 , B01J2219/00891 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0645 , B01L2300/0861 , B01L2400/02 , G01N15/1404 , G01N35/10 , G01N2015/1037 , G01N2015/1406 , G01N2015/149 , Y10T137/0324 , Y10T137/2191
摘要： A microchip includes a channel permitting a sheath liquid to flow therethrough; and a microtube for introducing a sample liquid into a laminar flow of the sheath liquid flowing through the channel; wherein liquid feeding is performed in the condition where a laminar flow of the sample liquid introduced through the microtube is surrounded by the laminar flow of the sheath liquid.

4. 发明授权

US09719924B1 Wideband antenna structure with optics reflector as ground plane and associated methods 有权
公开(公告)号：US09719924B1
公开(公告)日：2017-08-01
申请号：US14550407
申请日：2014-11-21
申请人： Raytheon Company
发明人： Glafkos K. Stratis , David J. Knapp , Douglas Mills , Raymond A. Graffam , Michael S. Smith
IPC分类号： G01N21/00 , G01N21/64 , G01N21/68 , G01N15/10 , G01J3/02
CPC分类号： G01N21/64 , F41G7/008 , F41G7/2246 , F41G7/2253 , F41G7/2286 , F41G7/2293 , G01J3/02 , G01N21/68 , G01N2015/1037 , G01S3/42 , H01Q1/281 , H01Q1/405 , H01Q1/42 , H01Q1/528 , H01Q3/2617 , H01Q5/22 , H01Q5/30 , H01Q5/48 , H01Q9/30 , H01Q15/0086 , H01Q21/065 , H01Q21/08 , H01Q21/205 , H01Q21/28 , H01Q21/30
摘要： A compact transducer system includes both an antenna subsystem and an optical transducer subsystem. The antenna subsystem may include multiple radio frequency (RF) radiating elements disposed adjacent to a ground plane. The ground plane may also serve as an optical reflector within an optical path of the optical transducer subsystem. A secondary reflector may also be provided within the optical path of the optical transducer subsystem. The secondary reflector may be formed of dielectric material (e.g., meta-material) in some embodiments to prevent undesired coupling with RF circuitry.

5. 发明授权

US09470618B2 Sheath fluid systems and methods for particle analysis in blood samples 有权
公开(公告)号：US09470618B2
公开(公告)日：2016-10-18
申请号：US15064129
申请日：2016-03-08
申请人： IRIS International, Inc.
发明人： Gregory A. Farrell , Bart J. Wanders , Thomas H. Adams , Warren Groner , Xiaodong Zhao
IPC分类号： G01N33/48 , G01B11/00 , G01N15/14 , G01N33/50 , G01N15/00 , G01N15/10 , G01N21/05
CPC分类号： G01N33/4915 , G01N15/1404 , G01N15/1434 , G01N15/1436 , G01N15/1459 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/05 , G01N33/5091 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1037 , G01N2015/1409 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058 , G01N2201/12
摘要： Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer.

6. 发明申请

US20160109353A1 ANALYZING SYSTEM AND ANALYZING APPARATUS 审中-公开
标题翻译：分析系统和分析装置
公开(公告)号：US20160109353A1
公开(公告)日：2016-04-21
申请号：US14885432
申请日：2015-10-16
申请人： NIHON KOHDEN CORPORATION
发明人： Yutaka NAGAI
IPC分类号： G01N15/14 , G01N27/06
CPC分类号： G01N15/1434 , G01N15/1031 , G01N15/1468 , G01N27/06 , G01N2015/1037
摘要： An analyzing system includes an imaging cytometer having a first imaging section configured to perform an imaging of particles contained in an analyte sample to generate images, the imaging cytometer being configured to analyze the images generated by the first imaging section, and a blood cell analyzing apparatus configured to analyze particles contained in the analyte sample by at least one of an electrical resistance method and an optical analyzing method. One of the imaging cytometer and the blood cell analyzing apparatus has an analyzing section configured to produce a report of an analysis of the analyte sample based on particle information acquired by the imaging cytometer and particle information acquired by the blood cell analyzing apparatus.
摘要翻译：分析系统包括具有第一成像部分的成像细胞计数器，所述第一成像部分被配置为对分析物样品中包含的颗粒进行成像以产生图像，所述成像细胞计数器被配置为分析由第一成像部分生成的图像，以及血细胞分析装置被配置为通过电阻方法和光学分析方法中的至少一种来分析包含在分析物样品中的颗粒。成像细胞仪和血细胞分析装置中的一个具有分析部，其被配置为基于由成像细胞仪获取的粒子信息和由血细胞分析装置获取的粒子信息来生成分析物样品的分析报告。

7. 发明授权

US09316635B2 Sheath fluid systems and methods for particle analysis in blood samples 有权
标题翻译：护套流体系统和血液样品中颗粒分析方法
公开(公告)号：US09316635B2
公开(公告)日：2016-04-19
申请号：US14215834
申请日：2014-03-17
申请人： IRIS International, Inc.
发明人： Gregory A. Farrell , Bart J. Wanders , Thomas H. Adams , Warren Groner , Xiaodong Zhao
IPC分类号： G01N33/50 , G01N15/14 , G01N15/00 , G01N15/10 , G01N21/05
CPC分类号： G01N33/4915 , G01N15/1404 , G01N15/1434 , G01N15/1436 , G01N15/1459 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/05 , G01N33/5091 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1037 , G01N2015/1409 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058 , G01N2201/12
摘要： Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer.
摘要翻译：本公开的方面和实施方案提供用于分析样品中包含的颗粒的颗粒分析仪的颗粒和/或细胞内细胞器取向剂。示例性的颗粒和/或细胞内细胞器取向剂包括水溶液，粘度调节剂和/或缓冲液。

8. 发明申请

US20150377763A1 MICROPARTICLE ANALYSIS APPARATUS AND MICROPARTICLE ANALYSIS SYSTEM 有权
标题翻译：微波分析仪器和微波分析系统
公开(公告)号：US20150377763A1
公开(公告)日：2015-12-31
申请号：US14763980
申请日：2013-12-26
申请人： SONY CORPORATION
发明人： Marcaurele Brun , Kazumasa Sato , Shinji Omori , Yoichi Katsumoto
IPC分类号： G01N15/10 , G01N33/487 , G01N27/22
CPC分类号： G01N15/1031 , G01N15/1218 , G01N27/221 , G01N33/48728 , G01N2015/0065 , G01N2015/1006 , G01N2015/1037 , G01N2015/1081 , G01N2015/1087 , G01N2015/1254 , G01N2015/129
摘要： There is provided a microparticle analysis apparatus including a sample channel configured to receive liquid containing a plurality of microparticles, a first pair of electrodes configured to form an alternating electric field in at least a part of the sample channel, a measuring part configured to measure impedance between the first pair of electrodes, an analyzing part configured to calculate property values of the microparticles from the impedance measured in the measuring part, and a determining part configured to determine whether data of the impedance measured in the measuring part is derived from the microparticles.
摘要翻译：提供了一种微粒分析装置，其包括被配置为接收含有多个微粒的液体的样品通道，第一对电极构造成在至少一部分样品通道中形成交变电场;测量部件，被配置为测量阻抗在第一对电极之间，分析部件被配置为根据在测量部件中测量的阻抗计算微粒的特性值，以及确定部件，被配置为确定在测量部件中测量的阻抗的数据是否从微粒导出。

9. 发明授权

US08616048B2 Reusable thin film particle sensor 失效
标题翻译：可重复使用的薄膜颗粒传感器
公开(公告)号：US08616048B2
公开(公告)日：2013-12-31
申请号：US12985536
申请日：2011-01-06
申请人： Harold E. Ayliffe
发明人： Harold E. Ayliffe
IPC分类号： G01N15/06 , G01N27/00
CPC分类号： G01N15/12 , B01L3/502715 , B01L3/502761 , B01L2300/0645 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , G01N15/1056 , G01N15/1463 , G01N33/49 , G01N2015/1037 , G01N2015/1062 , G01N2015/1087
摘要： A microfluidic sensor formed by stacking a plurality of substantially non-electrically conductive layers, typically formed from thin polymer films. Certain layers may carry patterned electrodes that are arranged to permit their connection to an electrical interrogation circuit. Electrodes may be disposed in a 3-dimensional array in the sensor. A fluid path through the sensor includes an orifice sized to promote single-file travel of particles. The orifice may be defined by a tunnel passing through at least one layer. Particles entrained in an electrolytic carrier fluid may be detected, or otherwise characterized, by interrogation circuitry connected to certain embodiments of the sensor. Sensors generally include portions of a fluid path disposed parallel to the layers. Sensors may operate under the Coulter principle, and/or Stokes' shift phenomena. In certain embodiments, the sensor may be carried by a cartridge, which is adapted to couple with an interrogation platform. In any case, coupling desirably places the sensor in-circuit with operable interrogation structure, as well as with a fluid-flow control device. Structure included in a cartridge may provide fluid sample loading, routing, and storage capabilities.
摘要翻译：通过层叠通常由薄聚合物膜形成的多个基本上非导电层形成的微流体传感器。某些层可以携带被布置成允许它们连接到电询问电路的图案化电极。电极可以设置在传感器中的3维阵列中。通过传感器的流体路径包括尺寸适于促进颗粒单文件行进的孔口。孔可以由穿过至少一层的隧道限定。携带在电解载体流体中的颗粒可以通过连接到传感器的某些实施例的询问电路来检测或以其它方式表征。传感器通常包括平行于层布置的流体路径的部分。传感器可以在库尔特原理和/或斯托克斯转移现象下运行。在某些实施例中，传感器可以由适于与询问平台耦合的卡盒携带。在任何情况下，耦合期望将传感器在线地具有可操作的询问结构以及流体流动控制装置。盒中包含的结构可提供流体样品加载，路由和存储功能。

10. 发明申请

US20130327957A1 FLUORESCENCE FLOW CYTOMETRY 有权
标题翻译：荧光细胞计数
公开(公告)号：US20130327957A1
公开(公告)日：2013-12-12
申请号：US13492805
申请日：2012-06-09
申请人： Harold E. Ayliffe
发明人： Harold E. Ayliffe
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N15/1056 , G01N15/12 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1037
摘要： A flow cytometer including a laser, indexing structure, adjustment structure, and sensor structure. The cytometer is conventionally used with a removable microfluidic cassette, which is installed at a first position that is enforced by the indexing structure. The adjustment structure changes a relative position between an interrogation aperture of the cassette and the laser beam. Feedback from the sensor structure is used to optimize propagation of the laser through the interrogation aperture to reduce (and hopefully eliminate) autofluorescence caused by beam impingement onto the cassette.
摘要翻译：包括激光，分度结构，调整结构和传感器结构的流式细胞仪。通常，细胞计数器使用可拆卸的微流控盒，其安装在由分度结构执行的第一位置。调整结构改变了盒的询问孔与激光束之间的相对位置。来自传感器结构的反馈用于优化激光通过询问孔的传播，以减少（并希望消除）由光束撞击到盒上引起的自发荧光。

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