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    • 2. 发明申请
    • AUTOFOCUS SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES
    • 自动分析系统及其在血液样品中的分析方法
    • US20140273068A1
    • 2014-09-18
    • US14216811
    • 2014-03-17
    • IRIS International, Inc.
    • Bart J. WandersBrett JordanGregory A. FarrellThomas H. AdamsWarren Groner
    • G01N33/50
    • Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. A contrast pattern for autofocusing is provided on the flowcell, for example at an edge of a rear illumination opening. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Blood cell images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.
    • 可以通过数字图像处理器对诸如血细胞的颗粒进行分类和计数。 数字显微镜照相机可以被引导到限定对称变窄的流动路径的流动池中,其中样品流在由鞘液层之间的流动和粘度参数平坦化的带中流动。 在流动池上提供用于自动聚焦的对比度图案,例如在后部照明开口的边缘。 图像处理器从像素数据对比度评估焦点精度。 定位电机沿着光轴移动显微镜和/或流动池,用于自动聚焦在对比度图案目标上。 然后,处理器将显微镜和流动池移位在对比度图案和样品流之间已知的距离,从而聚焦于样品流。 从该位置收集血细胞图像,直到通过输入信号周期性重新开始自动聚焦,或当检测图像数据中的温度变化或聚焦不准确时。