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1. 发明授权

US08497090B2 Fungal strains and a process for production of insecticide thereof 失效
标题翻译：真菌菌株及其杀虫剂的生产方法
公开(公告)号：US08497090B2
公开(公告)日：2013-07-30
申请号：US12739328
申请日：2008-10-22
申请人： Ram Rajasekharan , Chikkarasanahalli Shivegowda Vivekbabu
发明人： Ram Rajasekharan , Chikkarasanahalli Shivegowda Vivekbabu
IPC分类号： C12P1/00
CPC分类号： C12R1/66 , A01N63/04 , C12N1/14 , C12P19/62 , C12R1/685
摘要： The present invention relates to fungal strains capable of producing insecticide and a process for production of insecticide. It also relates to a method of cultivation of fungal strains and a fermentation medium for culturing the fungal strains.
摘要翻译：本发明涉及能够产生杀虫剂的真菌菌株和杀虫剂的生产方法。它还涉及真菌菌株的培养方法和培养真菌菌株的发酵培养基。

2. 发明授权

US5258297A Proteinase-resistant cellulase, microorganism producing the same and process for producing the same 失效
标题翻译：蛋白酶抗性纤维素酶，与其相同的微生物及其生产方法
公开(公告)号：US5258297A
公开(公告)日：1993-11-02
申请号：US692722
申请日：1991-04-29
申请人： Shun-ichi Akiba , Akira Takei , Hiroshi Hagihara , Tomomi Ota , Hiroshi Kodama , Yoshiharu Kimura
发明人： Shun-ichi Akiba , Akira Takei , Hiroshi Hagihara , Tomomi Ota , Hiroshi Kodama , Yoshiharu Kimura
IPC分类号： C11D3/386 , C12N1/14 , C12N9/42 , C12R1/685 , C12N9/24
CPC分类号： C12R1/685 , C11D3/38645 , C12N9/2437 , C12Y302/01004
摘要： A proteinase-resistant cellulase, a microorganism producing the same, and a process for producing such a proteinase-resistant cellulase is disclosed. The cellulase can be used as an additive to detergent compositions for washing clothes containing a proteinase, without immobilization or stabilization by chemical modification. The proteinase-resistant cellulase can be produced by a novel microorganism, Aspergillus niger KSM-24 [deposited with Fermentation Research Institute, Agency of Industrial Science and Technology (FERM BP-3359)].

3. 发明申请

US20180327795A1 METHOD FOR PREPARING ANTHOCYANIN OLIGOMERS BY USING COENZYME DERIVED FROM ASPERGILLUS SP. STRAIN 审中-公开
公开(公告)号：US20180327795A1
公开(公告)日：2018-11-15
申请号：US16046012
申请日：2018-07-26
申请人： Pyo-Jam Park , Tuk-Rai Jeong , Hyun-Pil Yang , Jin Woo Hwang
发明人： Pyo-Jam Park , Tuk-Rai Jeong , Hyun-Pil Yang , Jin Woo Hwang
IPC分类号： C12P17/16 , C12N1/16
CPC分类号： C12P17/162 , C12N1/16 , C12N9/24 , C12P17/06 , C12P19/60 , C12R1/685
摘要： The present invention relates to a method of preparing an anthocyanin oligomer using a coenzyme derived from an Aspergillus sp. strain, and more particularly to a method of preparing an anthocyanin oligomer by fermenting an anthocyanin monomer with a coenzyme of Aspergillus niger, which is a kind of Aspergillus sp. strain. According to the present invention, in order to overcome contamination problems during the culturing process using Aspergillus niger, a coenzyme of Aspergillus niger is extracted and the fermentation process is performed using the same, whereby an anthocyanin oligomer characterized by reduced concern of contamination and superior radical-scavenging effects, compared to existing anthocyanin monomers, can be produced. Also, an anthocyanin oligomer, obtained through fermentation using glucosidase as an enzyme contained in the coenzyme, can exhibit excellent fermentation efficiency and radical-scavenging ability, and polymerization of the anthocyanin oligomer can be confirmed even upon the fermentation of the enzyme including glucosidase.

4. 发明申请

US20170321235A1 TRANSFORMED FUNGUS HAVING ENHANCED ERGOTHIONEINE PRODUCTIVITY AND METHOD FOR PRODUCING ERGOTHIONEINE 审中-公开
公开(公告)号：US20170321235A1
公开(公告)日：2017-11-09
申请号：US15533215
申请日：2015-12-25
申请人： KIKKOMAN CORPORATION
发明人： Seiichi HARA , Keiko KUROSAWA , Keiichi ICHIKAWA
IPC分类号： C12P13/04 , C12N9/10
CPC分类号： C12P13/04 , C12N9/10 , C12N9/1007 , C12N9/13 , C12N15/09 , C12R1/66 , C12R1/665 , C12R1/685 , C12R1/69 , C12Y201/01 , C12Y208/01007
摘要： The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5′-phosphate as a coenzyme.

5. 发明申请

US20090239260A1 Fungal Transcriptional Activator Useful In Methods for Producing Polypeptides 失效
标题翻译：真菌转录激活剂可用于生产多肽的方法
公开(公告)号：US20090239260A1
公开(公告)日：2009-09-24
申请号：US12398554
申请日：2009-03-05
申请人： Carsten M. Hjort , Cees A.M.J.J. Van Den Hondel , Peter J. Punt , Frank H.J. Schuren , Tove Christensen
发明人： Carsten M. Hjort , Cees A.M.J.J. Van Den Hondel , Peter J. Punt , Frank H.J. Schuren , Tove Christensen
IPC分类号： C12P21/00 , C12N1/15
CPC分类号： C12R1/685 , C07K14/38 , C12N15/80
摘要： The present disclosure relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The disclosure also relates to nucleic acid constructs, vectors and host cells including the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides.
摘要翻译：本公开涉及编码具有转录活化活性的多肽的分离的核酸序列和多肽。本公开还涉及核酸构建体，载体和宿主细胞，包括核酸序列。本发明还涉及可用于产生已经改变转录激活物的产生或功能的多肽的宿主细胞，以及生产多肽的方法。

6. 发明申请

US20060127976A1 Use of oxalate deficient aspergillus niger strains for producing a polypeptide 审中-公开
标题翻译：使用草酸缺乏黑曲霉菌株产生多肽
公开(公告)号：US20060127976A1
公开(公告)日：2006-06-15
申请号：US10544207
申请日：2004-02-05
申请人： Thibaut Wenzel , Jean-Marc Ladriere , Rogier Meulenberg
发明人： Thibaut Wenzel , Jean-Marc Ladriere , Rogier Meulenberg
IPC分类号： C12P21/06 , C12N9/32 , C12N1/16 , C12N15/74
CPC分类号： C12R1/685 , C12N1/14 , C12N15/80 , C12P21/02
摘要： The invention relates to oxalate deficient A. niger strains for the production of a given enzyme, wherein the oxalate deficient strain produces at least the same amount of enzyme as the wild type strain it originates from under the same culture conditions. Preferably, the oxalate deficient A. niger strain produces more enzyme than the wild type strain it originates from under the same culture conditions. More preferably, the oxalate deficient A. niger strain is such that when the strain has been transformed with an expression construct comprising a gene coding for an enzyme, said strain produces at least the amount of the enzyme the wild type strain it originates from would produce under the same culture conditions, when the wild type strain has also been transformed with the same expression construct as the oxalate deficient strain. The invention also relates to method for obtaining such oxalate deficient A. niger strain. The present invention further relates to method for producing an enzyme, wherein an oxalate deficient A. niger strain that produces at least the same amount of enzyme as the wild type strain it originates from under the same culture conditions is used.
摘要翻译：本发明涉及用于生产给定酶的草酸盐缺乏的黑曲霉菌株，其中草酸盐缺乏菌株在相同培养条件下产生与野生型菌株至少相同量的酶。优选地，草酸缺乏的黑曲霉菌株比在相同培养条件下产生的野生型菌株产生更多的酶。更优选地，草酸缺乏的黑曲霉菌株使得当菌株已经用包含编码酶的基因的表达构建体转化时，所述菌株至少产生其产生的野生型菌株的产生量在相同的培养条件下，当野生型菌株也用与草酸盐缺乏菌株相同的表达构建体转化时。本发明还涉及获得这种草酸不足的黑曲霉菌株的方法。本发明还涉及生产酶的方法，其中使用与相同培养条件下产生的与野生型菌株至少相同量的酶的草酸不足的黑曲霉菌株。

7. 发明授权

US09410175B2 Process for microbial production of a valuable compound 有权
标题翻译：微生物生产有价值化合物的方法
公开(公告)号：US09410175B2
公开(公告)日：2016-08-09
申请号：US11886582
申请日：2006-03-23
申请人： Philippe Thierry François Gaudin , Rogier Meulenberg
发明人： Philippe Thierry François Gaudin , Rogier Meulenberg
IPC分类号： C12P21/00 , C12N9/16 , C12C5/00 , A23K1/165 , C12N15/80 , C12P19/14 , C07K14/37 , C12R1/685 , C07K14/38
CPC分类号： C12P21/00 , A23K20/189 , C07K14/37 , C07K14/38 , C12C5/004 , C12N9/16 , C12N15/80 , C12P19/14 , C12R1/685 , C12Y301/03008 , C12Y301/03026 , G01N2333/914
摘要： The present invention relates to a process for the production of a valuable compound by cultivation of a microorganism comprising cultivating the microorganism in a medium wherein all nutrients are provided in excess over the whole cultivation period and wherein a suitable amount of oxygen is fed to the culture to maintain the culture under conditions of oxygen limitation.
摘要翻译：本发明涉及通过培养微生物来生产有价值化合物的方法，包括在培养基中培养微生物，其中在整个培养期间过量提供所有营养物，并且其中向培养物中加入适量的氧气在氧气限制条件下维持文化。

8. 发明授权

US09297001B2 Preparation method conducive to enhancing enzymatic activity of cellulase 有权
标题翻译：制备方法有利于提高纤维素酶的酶活性
公开(公告)号：US09297001B2
公开(公告)日：2016-03-29
申请号：US14471080
申请日：2014-08-28
申请人： INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
发明人： Chun-An Wang , Sheng-Hsin Chou , Gia-Luen Guo
IPC分类号： C12N9/42 , C12P39/00 , C12P21/00 , C12R1/885 , C12R1/685
CPC分类号： C12N9/2437 , C12P21/00 , C12P39/00 , C12R1/685 , C12R1/885 , Y02P20/52
摘要： A preparation method conducive to enhancing enzymatic activity of cellulase includes the steps of preparing a first inducer, preparing preculture hyphae, producing enzymes by a single strain, feeding a second inducer, and producing enzymes by co-culture strains. Main ingredients of the first inducer and the second inducer are cellulose and lactose, respectively. The enzymatic activity of the cellulase produced is enhanced by induction of cellulose and lactose and co-culture of Trichoderma and Aspergillus.
摘要翻译：有利于提高纤维素酶的酶活性的制备方法包括制备第一诱导剂，制备预培养菌丝，通过单一菌株产生酶，喂养第二诱导物和通过共培养菌株产生酶的步骤。第一诱导剂和第二诱导剂的主要成分分别是纤维素和乳糖。所产生的纤维素酶的酶活性通过诱导纤维素和乳糖以及木霉属和曲霉共培养来增强。

9. 发明授权

US08426164B2 Fungal transcriptional activator useful in methods for producing polypeptides 失效
标题翻译：可用于生产多肽的方法中的真菌转录激活物
公开(公告)号：US08426164B2
公开(公告)日：2013-04-23
申请号：US12398554
申请日：2009-03-05
申请人： Carsten M. Hjort , Cees A. M. J. J. Van den Hondel , Peter J. Punt , Frank H. J. Schuren , Tove Christensen
发明人： Carsten M. Hjort , Cees A. M. J. J. Van den Hondel , Peter J. Punt , Frank H. J. Schuren , Tove Christensen
IPC分类号： C12P21/02
CPC分类号： C12R1/685 , C07K14/38 , C12N15/80
摘要： The present disclosure relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The disclosure also relates to nucleic acid constructs, vectors and host cells including the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in which the production or function of the transcriptional activator has been altered, as well as to methods for producing the polypeptides.
摘要翻译：本公开涉及编码具有转录活化活性的多肽的分离的核酸序列和多肽。本公开还涉及核酸构建体，载体和宿主细胞，包括核酸序列。本发明还涉及可用于产生已经改变转录激活物的产生或功能的多肽的宿主细胞，以及生产多肽的方法。

10. 发明申请

US20100304441A1 FUNGAL STRAINS AND A PROCESS FOR PRODUCTION OF INSECTICIDE THEREOF 失效
标题翻译：真菌菌株及其生产杀虫剂的方法
公开(公告)号：US20100304441A1
公开(公告)日：2010-12-02
申请号：US12739328
申请日：2008-10-22
申请人： Ram Rajasekharan , Chikkarasanahalli Shivegowda Vivekbabu
发明人： Ram Rajasekharan , Chikkarasanahalli Shivegowda Vivekbabu
IPC分类号： C12P19/62 , C12N1/14 , C12P1/02
CPC分类号： C12R1/66 , A01N63/04 , C12N1/14 , C12P19/62 , C12R1/685
摘要： The present invention relates to fungal strains capable of producing insecticide and a process for production of insecticide. It also relates to a method of cultivation of fungal strains and a fermentation medium for culturing the fungal strains.
摘要翻译：本发明涉及能够产生杀虫剂的真菌菌株和杀虫剂的生产方法。它还涉及真菌菌株的培养方法和培养真菌菌株的发酵培养基。

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