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1. 发明授权

US08511289B2 Intake manifolds 失效
标题翻译：进气歧管
公开(公告)号：US08511289B2
公开(公告)日：2013-08-20
申请号：US12780024
申请日：2010-05-14
申请人： Hironori Tanikawa , Yukihiro Doko , Kenji Kusuda , Tomomi Ota , Xiaomin Pan , Ichiro Hisada
发明人： Hironori Tanikawa , Yukihiro Doko , Kenji Kusuda , Tomomi Ota , Xiaomin Pan , Ichiro Hisada
IPC分类号： F02M35/104
CPC分类号： F02M35/112 , F02M35/10039 , F02M35/10052 , F02M35/10085 , F02M35/10111 , F02M35/10144 , F02M35/10222 , F02M35/10262 , F02M35/10321 , F02M35/10347 , Y02T10/146
摘要： An intake manifold includes a surge tank chamber, a plurality of branch passages and a gas tank chamber capable of introducing a gas and distributing the gas into the plurality of branch passages. The gas is to be refluxed to an engine.
摘要翻译：进气歧管包括缓冲罐室，多个分支通道和能够引入气体并将气体分配到多个分支通道中的气罐室。气体将回流到发动机。

2. 发明申请

US20110269960A1 TRIAZOLE DERIVATIVE 审中-公开
标题翻译：三唑衍生物
公开(公告)号：US20110269960A1
公开(公告)日：2011-11-03
申请号：US13180011
申请日：2011-07-11
申请人： Naoya ONO , Tetsuo Takayama , Fumiyasu Shiozawa , Hironori Katakai , Tetsuya Yabuuchi , Tomomi Ota , Makoto Yagi , Masakazu Sato
发明人： Naoya ONO , Tetsuo Takayama , Fumiyasu Shiozawa , Hironori Katakai , Tetsuya Yabuuchi , Tomomi Ota , Makoto Yagi , Masakazu Sato
IPC分类号： C07D249/12 , C07D413/12 , C07D487/04 , C07D491/113 , C07D401/12 , C07D417/14 , C07D249/08 , C07D403/12 , C07D409/12 , C07D405/12 , C07D409/14 , C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14
CPC分类号： C07D249/08
摘要： An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P1), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula —SO—, a group represented by Formula —SO2—, or the like, R1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, R1A represents a hydrogen atom or the like, R2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, R3 represents an aryl group, R4 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and R5 represents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).
摘要翻译：本发明的目的是提供具有抑制S1P与其受体Edg-1（S1P1）结合的作用的化合物，可用作药物化合物。化合物或其药学上可接受的盐，其化合物由下式表示（其中A表示氧原子，硫原子，由式-SO-表示的基团，由式-SO2-表示的基团等） R1表示氢原子，具有1-6个碳原子的烷基等，R1A表示氢原子等，R2表示具有1-6个碳原子的烷基，具有3-6个碳原子的环烷基原子等，R 3表示芳基，R 4表示氢原子或具有1-6个碳原子并且任选被羧基取代的烷基，R 5表示具有1-10个碳原子的烷基，环烷基具有3-8个碳原子的基团，任选取代的芳基等）。

3. 发明授权

US6156801A 2-phenoxyaniline derivatives 失效
标题翻译： 2-苯氧基苯胺衍生物
公开(公告)号：US6156801A
公开(公告)日：2000-12-05
申请号：US381039
申请日：1999-09-15
申请人： Tomomi Ota , Misa Nakanishi , Minoru Taguchi , Kazuyuki Tomisawa
发明人： Tomomi Ota , Misa Nakanishi , Minoru Taguchi , Kazuyuki Tomisawa
IPC分类号： C07C217/90 , C07C225/22 , C07C233/43 , C07C235/34 , C07C255/59 , A61K31/136 , A61K31/167 , A61K31/277 , C07C237/40 , C07C255/58
CPC分类号： C07C225/22 , C07C217/90 , C07C233/43 , C07C235/34 , C07C255/59 , C07C2101/02
摘要： A 2-phenoxyaniline derivative represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, an amino group or an NHCOR.sup.3 group, R.sup.2 is a halogen atom, an amino group, a cyano group, a C.sub.1-6 alkyl group, a C.sub.1-3 perfluoroalkyl group, an NHCOR.sup.3 group, a CH.sub.2 OR.sup.4 group, an OCH.sub.2 R.sup.5 group or a COR.sup.6 group, R.sup.3 is a C.sub.1-6 alkyl group, R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl group, R.sup.5 is a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.1-5 aminoalkyl group, a C.sub.2-7 alkoxy-carbonyl group or a carbamoyl group, and R.sup.6 is a C.sub.1-6 alkyl group or a C.sub.3-8 cycloalkyl group which is unsubstituted or substituted by a halogen atom, an amino group, a cyano group or a straight or branched C.sub.1-6 alkyl group; or a pharmaceutically acceptable salt thereof.
摘要翻译： PCT No.PCT / JP98 / 01367 Sec。 371日期1999年9月15日 102（e）1999年9月15日PCT 1998年3月26日PCT PCT。第WO98 / 43943号公报日期：1998年10月8日由下式表示的2-苯氧基苯胺衍生物：其中R1为氢原子，氨基或NHCOR3基，R2为卤素原子，氨基，氰基，C1-6烷基，C1-3全氟烷基，NHCOR3基，CH2OR4基，OCH2R5基或COR6基，R3是C1-6烷基，R4是氢原子或C1-6烷基，R5是氢原子，C1-6烷基，C1-5氨基烷基，C2-7烷氧基 - 羰基或氨基甲酰基，R6是未取代或取代的C1-6烷基或C3-8环烷基通过卤素原子，氨基，氰基或直链或支链C 1-6烷基; 或其药学上可接受的盐。

4. 发明授权

US6066672A Amino compounds and angiotensin IV receptor agonists 失效
标题翻译：氨基化合物和血管紧张素IV受体激动剂
公开(公告)号：US6066672A
公开(公告)日：2000-05-23
申请号：US101449
申请日：1998-07-16
申请人： Takeo Kobori , Kenichi Goda , Kikuo Sugimoto , Tomomi Ota , Kazuyuki Tomisawa
发明人： Takeo Kobori , Kenichi Goda , Kikuo Sugimoto , Tomomi Ota , Kazuyuki Tomisawa
IPC分类号： C07C237/20 , C07D213/40 , C07D215/12 , A61K31/165 , C07C233/05
CPC分类号： C07D213/40 , C07C237/20 , C07D215/12
摘要： The present invention provides an amino compound represented by Formula: ##STR1## wherein X is CH.sub.2 NH or CONH, Y is CH.sub.2 NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH.dbd.C(R.sup.4)R.sup.5, CH.sub.2 CH(R.sup.4)R.sup.5 or an alkoxycarbonyl group, R.sup.1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R.sup.2 and R.sup.3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R.sup.4 and R.sup.5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.
摘要翻译： PCT No.PCT / JP97 / 02716 Sec。 371日期：1998年7月16日 102（e）日期1998年7月16日PCT提交1997年8月5日PCT公布。第WO98 / 05624号公报日期：1998年2月12日本发明提供由下式表示的氨基化合物：其中X为CH 2 NH或CONH，Y为CH 2 NH或CONH，条件是X和Y不同时为CONH; Z是CH = C（R4）R5，CH2CH（R4）R5或烷氧基羰基，R1是氢原子; 低级烷基，环烷基，环烷基取代的烷基，芳烷基或芳基，其各自为取代或未取代的，R2和R3各自独立地为低级烷基或芳烷基，各基团其中R 4和R 5各自独立地为氢原子; 其各自为取代或未取代的烷基，芳烷基，芳基或杂芳基，或其药学上可接受的盐; 包含式（1）的氨基化合物或其药学上可接受的盐的药物; 和含有与有效组分相同的血管紧张素IV受体激动剂，其特别可用作血管紧张素IV参与的各种疾病的治疗药物（拮抗剂或激动剂），例如加速肾血流量，脑血管舒张，抑制细胞增殖和高血症。

5. 发明授权

US5635395A Optically active 1,4-dihydropyridine compounds and the microbial process for the stereoselection thereof 失效
标题翻译：光学活性的1,4-二氢吡啶化合物及其立体选择的微生物过程
公开(公告)号：US5635395A
公开(公告)日：1997-06-03
申请号：US387750
申请日：1995-02-21
申请人： Kunio Isshiki , Takashi Nakashima , Takeo Yoshioka , Hiroshi Tsunekawa , Takashi Adachi , Tomomi Ota
发明人： Kunio Isshiki , Takashi Nakashima , Takeo Yoshioka , Hiroshi Tsunekawa , Takashi Adachi , Tomomi Ota
IPC分类号： C07D211/90 , C12P17/12 , C12P41/00 , A01N43/40 , C07D213/803
CPC分类号： C07D211/90 , C12P17/12 , C12P41/005
摘要： (4R)-3-(Substituted aminoalkyl)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-5-carboxylic acids can be prepared efficiently, by reacting bis(substituted aminoalkyl) 1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-3,5-dicarboxylates with a microorganism capable of asymmetric hydrolysis and belonging to the genus Streptomyces, the genus Paecilomyces, the genus Botryodioplodia, the genus Alternaria or the genus Helminthosporium, or a treated product thereof. The compounds are extremely useful as important intermediates for preparation of pharmaceuticals useful for the prevention and treatment of angina pectoris, hypertension, etc.
摘要翻译： PCT No.PCT / JP93 / 01222 Sec。 371日期1995年2月21日 102（e）1995年2月21日PCT PCT 1993年8月31日PCT公布。公开号WO94 / 05637 日期：1994年3月17日（4R）-3-（取代氨基烷基）氧羰基-1,4-二氢-2,6-二甲基-4-（硝基苯基）吡啶-5-羧酸可以通过双取代的氨基烷基）1,4-二氢-2,6-二甲基-4-（硝基苯基）吡啶-3,5-二羧酸盐与能够不对称水解的微生物属于链霉菌属，拟青霉属，Botryodioplodia属，链格孢属或Helminthosporium属，或其处理产物。该化合物作为制备可用于预防和治疗心绞痛，高血压等的药物的重要中间体非常有用。

6. 发明申请

US20100041655A1 TRIAZOLE DERIVATIVE 失效
标题翻译：三唑衍生物
公开(公告)号：US20100041655A1
公开(公告)日：2010-02-18
申请号：US12278054
申请日：2007-02-05
申请人： Naoya Ono , Tetsuo Takayama , Fumiyasu Shiozawa , Hironori Katakai , Tetsuya Yabuuchi , Tomomi Ota , Makoto Yagi , Masakazu Sato
发明人： Naoya Ono , Tetsuo Takayama , Fumiyasu Shiozawa , Hironori Katakai , Tetsuya Yabuuchi , Tomomi Ota , Makoto Yagi , Masakazu Sato
IPC分类号： A61K31/5377 , C07D249/08 , A61K31/4196 , C07D403/12 , A61K31/497 , C07D413/14
CPC分类号： C07D249/08
摘要： An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P1), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula —SO—, a group represented by Formula —SO2— or the like, R1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, R1A represents a hydrogen atom or the like, R2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, represents an aryl group, R4 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and R5 represents an alkyl group having 1-carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).
摘要翻译：本发明的目的是提供具有抑制S1P与其受体Edg-1（S1P1）结合的作用的化合物，可用作药物化合物。一种化合物或其药学上可接受的盐，该化合物由下式表示（其中A表示氧原子，硫原子，由式-SO-表示的基团，由式-SO2-等表示的基团， R1表示氢原子，具有1-6个碳原子的烷基等，R1A表示氢原子等，R2表示具有1-6个碳原子的烷基，具有3-6个碳原子的环烷基等表示芳基，R 4表示氢原子或具有1-6个碳原子并且任选被羧基取代的烷基，R 5表示具有1个碳原子的烷基，环烷基具有3个 -8个碳原子，任选取代的芳基等）。

7. 发明申请

US20090182144A1 BINDING INHIBITOR OF SPHINGOSINE-1-PHOSPHATE 失效
标题翻译：丝氨酸1-磷酸酯的结合抑制剂
公开(公告)号：US20090182144A1
公开(公告)日：2009-07-16
申请号：US12278477
申请日：2007-02-06
申请人： Naoya Ono , Tetsuo Takayama , Fumiyasu Shiozawa , Hironori Katakai , Tetsuya Yabuuchi , Tomomi Ota , Takeshi Koami , Rie Nishikawa
发明人： Naoya Ono , Tetsuo Takayama , Fumiyasu Shiozawa , Hironori Katakai , Tetsuya Yabuuchi , Tomomi Ota , Takeshi Koami , Rie Nishikawa
IPC分类号： C07D401/02 , C07D233/00 , C07D231/10 , C07D413/02 , C07D417/02
CPC分类号： C07D233/70 , C07D233/84 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention aims to provide compounds which have an inhibitory effect on the binding between S1P and its receptor Edg-1(S1P1) and which are useful for pharmaceutical purposes.A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: [wherein Ar represents a monocyclic heterocyclic ring containing one or two nitrogen atoms, A represents an oxygen atom or the like, Y1, Y2 and Y3 each represent a carbon atom or a nitrogen atom, R1 represents a hydrogen atom, a C1-C6 alkyl group or the like, R2 represents a C1-C6 alkyl group, a C3-C8 cycloalkyl group or the like, R3 represents a C1-C18 alkyl group or the like, R4 represents a hydrogen atom or a C1-C6 alkyl group, and R5 represents a C1-C10 alkyl group or the like].
摘要翻译：本发明的目的是提供对S1P与其受体Edg-1（S1P1）之间的结合具有抑制作用并且可用于制药目的的化合物。由式（I）表示的化合物或其药学上可接受的盐：[其中Ar表示含有一个或两个氮原子的单环杂环，A表示氧原子等，Y1，Y2和Y3表示碳原子或氮原子，R1表示氢原子，C1-C6烷基等，R2表示C1-C6烷基，C3-C8环烷基等，R3表示C1-C18烷基等 R4代表氢原子或C1-C6烷基，R5代表C1-C10烷基等]。

8. 发明授权

US5047543A 1,4-dihydropyridine derivatives 失效
公开(公告)号：US5047543A
公开(公告)日：1991-09-10
申请号：US437636
申请日：1989-11-17
申请人： Toshihisa Ogawa , Tomomi Ota , Shuichi Sato , Takemi Sunaga , Yoshiaki Watanabe , Katsuo Hatayama
发明人： Toshihisa Ogawa , Tomomi Ota , Shuichi Sato , Takemi Sunaga , Yoshiaki Watanabe , Katsuo Hatayama
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： A 1,4-dihydropyridine derivative represented by the formula ##STR1## wherein X is a hydrogen atom or an alkoxy group having 1 to 4 carbon atoms, A and B are the same or different and are each an alkylene group having 1 to 4 carbon atoms, and a pharmaceutically acceptable salt thereof are useful as the preventive and therapeutical agents of ischemic heart disease and hypertension.

9. 发明申请

US20100288247A1 INTAKE MANIFOLDS 失效
标题翻译：吸入烟雾
公开(公告)号：US20100288247A1
公开(公告)日：2010-11-18
申请号：US12780024
申请日：2010-05-14
申请人： Hironori TANIKAWA , Yukihiro DOKO , Kenji KUSUDA , Tomomi OTA , Xiaomin PAN , Ichiro HISADA
发明人： Hironori TANIKAWA , Yukihiro DOKO , Kenji KUSUDA , Tomomi OTA , Xiaomin PAN , Ichiro HISADA
IPC分类号： F02M25/07 , F02M35/10 , F02B25/06
CPC分类号： F02M35/112 , F02M35/10039 , F02M35/10052 , F02M35/10085 , F02M35/10111 , F02M35/10144 , F02M35/10222 , F02M35/10262 , F02M35/10321 , F02M35/10347 , Y02T10/146
摘要： An intake manifold includes a surge tank chamber, a plurality of branch passages and a gas tank chamber capable of introducing a gas and distributing the gas into the plurality of branch passages. The gas is to be refluxed to an engine.
摘要翻译：进气歧管包括缓冲罐室，多个分支通道和能够引入气体并将气体分配到多个分支通道中的气罐室。气体将回流到发动机。

10. 发明授权

US5258297A Proteinase-resistant cellulase, microorganism producing the same and process for producing the same 失效
标题翻译：蛋白酶抗性纤维素酶，与其相同的微生物及其生产方法
公开(公告)号：US5258297A
公开(公告)日：1993-11-02
申请号：US692722
申请日：1991-04-29
申请人： Shun-ichi Akiba , Akira Takei , Hiroshi Hagihara , Tomomi Ota , Hiroshi Kodama , Yoshiharu Kimura
发明人： Shun-ichi Akiba , Akira Takei , Hiroshi Hagihara , Tomomi Ota , Hiroshi Kodama , Yoshiharu Kimura
IPC分类号： C11D3/386 , C12N1/14 , C12N9/42 , C12R1/685 , C12N9/24
CPC分类号： C12R1/685 , C11D3/38645 , C12N9/2437 , C12Y302/01004
摘要： A proteinase-resistant cellulase, a microorganism producing the same, and a process for producing such a proteinase-resistant cellulase is disclosed. The cellulase can be used as an additive to detergent compositions for washing clothes containing a proteinase, without immobilization or stabilization by chemical modification. The proteinase-resistant cellulase can be produced by a novel microorganism, Aspergillus niger KSM-24 [deposited with Fermentation Research Institute, Agency of Industrial Science and Technology (FERM BP-3359)].

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