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1. 发明申请

US20110217728A1 HIGH THROUGHPUT TEST METHOD FOR EVALUATION OF BIOCIDES AGAINST ANAEROBIC MICROORGANISMS 审中-公开
标题翻译：用于评估厌氧微生物的生物活性的高通量测试方法
公开(公告)号：US20110217728A1
公开(公告)日：2011-09-08
申请号：US12674975
申请日：2008-09-10
申请人： Bei Yin
发明人： Bei Yin
IPC分类号： C12Q1/18
CPC分类号： C12Q1/18 , C12Q1/12 , G01N2333/315 , G01N2333/33 , G01N2333/335 , G01N2333/36
摘要： Provided is a high-throughput method for determining the biocidal efficacy of biocidal agents against anaerobic organisms. The method includes the steps of: providing one or more anaerobe samples in a first set of multiple receptacles accessible to multi-channel pipettes; providing one or more biocidal samples at known concentration(s) in a second set of multiple receptacles accessible to multi-channel pipettes; forming mixtures of the one or more biocidal samples and the anaerobe samples via a multi-channel pipette; incubating the mixtures so as to allow reaction between the biocidal samples and the anaerobe samples; determining each of the one or more biocidal samples' killing (biocidal) effectiveness against the anaerobes at selected time interval(s), wherein each step, except for the step of providing one or more biocidal samples, is conducted under anaerobic conditions.
摘要翻译：提供了一种用于测定杀生物剂对厌氧生物的杀生物效力的高通量方法。该方法包括以下步骤：在多通道移液器可接近的第一组多个容器中提供一个或多个厌氧样品; 在多通道移液器可接近的第二组多个容器中提供已知浓度的一种或多种杀生物样品; 通过多通道移液管形成一种或多种杀生物样品和厌氧菌样品的混合物; 孵育混合物以允许杀生物样品和厌氧菌样品之间的反应; 确定所述一种或多种杀生物样品在选定的时间间隔内对厌氧菌的杀灭（杀生物）效力的每一个，其中除了提供一种或多种杀生物样品的步骤之外，每个步骤都是在厌氧条件下进行的。

2. 发明授权

US4351761A Purified antigen to test for Neisseria gonorrhoeae antibodies 失效
标题翻译：纯化抗原检测淋病奈瑟氏球菌抗体
公开(公告)号：US4351761A
公开(公告)日：1982-09-28
申请号：US231891
申请日：1981-02-05
申请人： Hassan A. Gaafar
发明人： Hassan A. Gaafar
IPC分类号： A61K39/095 , C12Q1/12 , G01N33/571 , A61K35/74 , A61K39/385 , A61K39/40
CPC分类号： A61K39/095 , C12Q1/12 , G01N33/571 , Y10S530/806 , Y10S530/825
摘要： Serological method for determining the presence of Neisseria gonorrhoeae antibodies in human sera and products utilized in such testing.
摘要翻译：用于确定淋巴球菌抗体在人类血清和产品中的存在的血清学方法。

3. 发明授权

US4241045A Purified antigen to test for Neisseria gonorrheae antibodies 失效
标题翻译：纯化抗原检测淋病奈瑟氏球菌抗体
公开(公告)号：US4241045A
公开(公告)日：1980-12-23
申请号：US905954
申请日：1978-05-15
申请人： Hassan A. Gaafar
发明人： Hassan A. Gaafar
IPC分类号： A61K39/095 , C12Q1/12 , G01N33/571 , G01N33/16 , A61K43/00
CPC分类号： G01N33/571 , A61K39/095 , C12Q1/12 , Y10S435/961 , Y10S530/806 , Y10S530/825
摘要： Serological method for determining the presence of Neisseria gonorrhoeae antibodies in human sera and products utilized in such testing.
摘要翻译：用于确定淋巴球菌抗体在人类血清和产品中的存在的血清学方法。

4. 发明授权

US4229530A Methods and media for rapid detection of pathogenic neisseria 失效
标题翻译：用于快速检测病原性脑炎奈瑟氏球菌的方法和培养基
公开(公告)号：US4229530A
公开(公告)日：1980-10-21
申请号：US937881
申请日：1978-08-29
申请人： Richard A. Finkelstein , Shelley M. Payne
发明人： Richard A. Finkelstein , Shelley M. Payne
IPC分类号： C12N1/20 , C12N1/38 , C12Q1/12
CPC分类号： C12N1/38 , C12N1/20 , C12Q1/12 , Y10S435/871
摘要： A microbial growth medium for the isolation and rapid detection of Neisseria gonorrhoeae and Neisseria meningitidis, having incorporated therein an iron-dextran complex in a quantity sufficient to stimulate maximum colony growth.
摘要翻译：用于分离和快速检测淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌的微生物生长培养基，其中掺入了足以刺激最大菌落生长的量的铁 - 葡聚糖复合物。

5. 发明授权

US4111752A Comparative test for Neisseria 失效
标题翻译： NEISSERIA的比较测试
公开(公告)号：US4111752A
公开(公告)日：1978-09-05
申请号：US837365
申请日：1977-09-28
申请人： Howard H. Weetall
发明人： Howard H. Weetall
IPC分类号： C12Q1/12 , C12K1/04
CPC分类号： C12Q1/12
摘要： Bacteria of the genus Neisseria can be detected in a sample by separating a lysate of the sample into two parts, incubating one part with a solution of nicotinamide-adenine-dinucleotide (NAD) and 1,2-propanediol, incubating the other part with a solution of only the NAD, and then comparing the products of each incubation for reduction of NAD to NADH. A difference in NADH concentration indicates the presence of any enzyme specific to Neisseria, this enzyme having the capability of oxidizing 1,2-propanediol and reducing NAD. The structure of the enzyme is not completely understood but, because of those two characterizing properties, the nomenclature 1,2-propanediol dehydrogenase therefor is proposed herein.

6. 发明授权

US3359180A Diagnostic preparation for the detection of acetylmethylcarbinol 失效
标题翻译：检测乙酰甲基甲酚的诊断准备
公开(公告)号：US3359180A
公开(公告)日：1967-12-19
申请号：US62838567
申请日：1967-04-04
申请人： WARNER LAMBERT PHARMACEUTICAL
发明人： EVANS GEORGE L , HELLER CHARLES I , SCHWARTZ BENJAMIN S
IPC分类号： C12Q1/12
CPC分类号： C12Q1/12 , Y10S435/805 , Y10S435/828 , Y10S435/849 , Y10S435/852 , Y10S435/881

7. 发明申请

US20180258459A1 NITRATE BIOSENSOR 审中-公开
公开(公告)号：US20180258459A1
公开(公告)日：2018-09-13
申请号：US15760957
申请日：2016-09-16
申请人： William Marsh Rice University
发明人： Jeffrey J. TABOR , Brian LANDRY , Nikola DYULGYAROV
IPC分类号： C12Q1/12 , C12Q1/6897 , C12N9/12 , C12N9/02
CPC分类号： C12Q1/12 , C07K2319/80 , C12N9/0004 , C12N9/12 , C12Q1/02 , C12Q1/68 , C12Q1/6897 , C12Y207/13003
摘要： A nitrate sensing biosensor and bacteria and applications relating to the use of same are described. The nitrate biosensor comprises a two component sensor system (TCS) comprising: a nitrate-sensing sensor kinase (SK) gene comprising a ligand binding domain operably coupled to a kinase domain, and, a cognate response regulator (RR) gene comprising a receiver domain operably coupled to an DNA binding domain (DBD), as well as an output promoter that binds said DBD that is operably coupled to a heterologous reporter gene.

8. 发明授权

US07214509B2 Methods and compositions for degradation of nitroaromatic and nitramine pollutants 失效
标题翻译：硝基芳香和硝胺污染物降解的方法和组成
公开(公告)号：US07214509B2
公开(公告)日：2007-05-08
申请号：US10873659
申请日：2004-06-22
申请人： Jerald L. Schnoor , Beniot Van Aken
发明人： Jerald L. Schnoor , Beniot Van Aken
IPC分类号： C12N1/20 , C12Q1/12 , C12P39/00 , A62D3/02 , B09B3/00
CPC分类号： C12R1/01 , A62D3/02 , A62D2101/06 , A62D2101/26 , A62D2101/28 , B09C1/002 , B09C1/10 , C02F3/34 , C02F2101/38 , C12N1/20 , C12Q1/12 , Y10S435/975
摘要： The invention relates to novel Methylobacterium species that are capable of degrading nitroaromatic and nitramine compounds. Compositions, kits and methods of using the Methylobacterium species for the degradation of nitroaromatic and nitramine pollutants are provided. More specifically, compositions and methods for the degradation or bioremediation of nitroaromatic and nitramine explosives and explosive residues are provided.
摘要翻译：本发明涉及能够降解硝基芳族和硝胺化合物的新型甲基杆菌属物种。提供了使用甲基杆菌物种降解硝基芳族和硝胺污染物的组合物，试剂盒和方法。更具体地，提供了硝基芳族和硝胺炸药和爆炸性残留物的降解或生物修复的组合物和方法。

9. 发明授权

US5902728A Diazodenitrification in manufacture of recombinant bacterial biosensors 失效
标题翻译：重组细菌生物传感器制造中的重氮化硝化
公开(公告)号：US5902728A
公开(公告)日：1999-05-11
申请号：US933561
申请日：1997-09-19
申请人： Jill E. Parker , John L. Alls , Jonathan L. Kiel
发明人： Jill E. Parker , John L. Alls , Jonathan L. Kiel
IPC分类号： C12N9/02 , C12P17/12 , C12Q1/12 , G01N33/58 , C12Q1/02 , C12N15/70
CPC分类号： C12P17/12 , C12N9/0036 , C12Q1/12 , G01N33/582
摘要： E. coli strain JM109 transfected with nitrate reductase gene containing plasmid pIC20RNR1.1 produces diazoluminomelanin when cultured in a medium containing nitrate, 3-amino-L-tyrosine and luminol, under suitable metabolic conditions.
摘要翻译：用含有质粒pIC20RNR1.1的硝酸还原酶基因转染的大肠杆菌菌株JM109，在合适的代谢条件下，在含有硝酸盐，3-氨基-L-酪氨酸和鲁米诺的培养基中培养时，产生二叠氮木兰素。

10. 发明授权

US4696896A Gonococcal Pili processes for the preparation thereof and the use thereof for the detection of and prevention of infections caused by Neisseria gonorrhoeae 失效
标题翻译：用于其制备的淋球菌Pili方法及其用于检测和预防由淋病奈瑟氏球菌引起的感染的用途
公开(公告)号：US4696896A
公开(公告)日：1987-09-29
申请号：US590544
申请日：1984-03-19
申请人： Charles C. Brinton , John C. McMichael
发明人： Charles C. Brinton , John C. McMichael
IPC分类号： A61K39/00 , C07K14/22 , C07K16/12 , C12P1/04 , C12Q1/12 , G01N33/571 , G01N33/531 , G01N33/544 , G01N33/569 , A61K39/095
CPC分类号： G01N33/571 , C07K14/22 , C07K16/1217 , C12P1/04 , C12Q1/12 , A61K39/00 , Y10S435/82 , Y10S435/871 , Y10S530/825
摘要： There are provided a crystalline and single rod products derivable from the Pili of Type 1 and Type 2 Neisseria gonorrhoese organisms. There are provided methods of growing said organisms to produce the maximum yield of Pili and procedures for purifying said Pili to produce said crystalline material. There are further provided methods of utilizing said Pili to determine the presence, in a system infectable by N. gonorrhoese organisms, of antibodies to the Pili of said organisms, and methods of serotyping said Pili. There is also provided a mode of utilizing said crystalline material to provide a substantial degree of immunization infection by N. gonorrhoese in mammalian systems susceptible to such infection.
摘要翻译：提供了可从1型和2型淋病奈瑟氏球菌生物衍生的结晶和单杆产品。提供了使所述生物体生长以产生Pili的最大产量的方法和用于纯化所述Pili以产生所述结晶材料的方法。进一步提供了利用所述Pili来确定由淋病奈瑟氏球菌感染的系统中存在针对所述生物体的皮质的抗体的存在的方法和血清分型所述Pili的方法。还提供了一种利用所述结晶材料以在对这种感染敏感的哺乳动物系统中提供淋病奈瑟氏球菌的显着程度的免疫感染的方式。

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