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1. 发明授权

US5424287A Extract of bacterial macromolecules, a process for its preparation and a pharmaceutical composition containing the same 失效
标题翻译：细菌大分子的提取物，其制备方法和含有该大分子的药物组合物
公开(公告)号：US5424287A
公开(公告)日：1995-06-13
申请号：US119124
申请日：1993-09-20
申请人： Jacques Bauer , Pierre Hirt , Adrian Schulthess
发明人： Jacques Bauer , Pierre Hirt , Adrian Schulthess
IPC分类号： A61K35/74 , A61K38/00 , A61P35/00 , A61P37/00 , C07K1/16 , C07K1/34 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/245 , C07K14/41 , C12P1/00 , C12P21/00 , C12R1/19
CPC分类号： C07K14/245 , C12P1/00 , A61K38/00 , Y10S435/822 , Y10S435/849 , Y10S435/851 , Y10S435/852 , Y10S435/871 , Y10S435/885 , Y10S435/886
摘要： An extract based on modified bacterial proteins includes a mixture of acid bacterial polyanions having a molecular weight in the range from 10,000 to 1,000,000 and an isoelectric point in the range from 2.5 to 5.5, and in which the added weights of the constituent amino acids amount to at least 50% of the extract. The preparation or this protein extract includes a cultivation of bacteria in an aqueous medium and then the alkaline extraction of this bacterial suspension and the purification of the protein extract. The alkaline extraction is carried out in the presence of a dilute aqueous source of OH.sup.- ions and at a stable pH in the range from 11 to 13, the decrease of this pH during the acid extraction not exceeding 0.4. The protein extract thus obtained can be used as an active ingredient in a pharmaceutical composition.
摘要翻译： PCT No.PCT / CH93 / 00029 Sec。 371日期：1993年9月20日 102（e）1993年9月20日PCT 1993年2月3日提交PCT公布。出版物WO93 / 16190 日期为1993年8月19日。基于修饰的细菌蛋白质的提取物包括分子量在10,000至1,000,000范围内且等电点在2.5至5.5范围内的酸性细菌聚阴离子的混合物，其中添加重量的组成氨基酸达到提取物的至少50％。制备物或该蛋白质提取物包括在水性培养基中培养细菌，然后碱性提取该细菌悬浮液并纯化蛋白质提取物。碱性萃取在OH-离子水溶液的存在下进行，在11-13的稳定pH范围内，酸萃取时pH值的降低不超过0.4。由此获得的蛋白质提取物可以用作药物组合物中的活性成分。

2. 发明授权

US5387511A Extraction procedure for Chlamydia and Neisseria antigens 失效
标题翻译：衣原体和奈瑟氏球菌抗原的提取方法
公开(公告)号：US5387511A
公开(公告)日：1995-02-07
申请号：US911378
申请日：1992-07-13
申请人： Ian W. Davidson , Paul Sheard
发明人： Ian W. Davidson , Paul Sheard
IPC分类号： A61K39/118 , C07K14/195 , C07K14/21 , C07K14/295 , G01N33/569 , G01N33/571 , C12P19/04 , C12P21/04
CPC分类号： G01N33/56927 , A61K39/118 , C07K14/195 , C07K14/21 , C07K14/295 , Y10S435/871
摘要： Enhanced extraction of solubilized antigens is obtained from bacteria such as Chlamydia and Neisseri by the use of a buffer containing a zwitterionic surface active agent, especially CHAPS or CHAPSO, in the absence of divalent cations. The extraction is conducted at elevated temperature, and provides a sample useful in assays for the presence of the bacteria.
摘要翻译：通过在不存在二价阳离子的情况下，使用含有两性离子表面活性剂，特别是CHAPS或CHAPSO的缓冲液，从细菌如衣原体和奈瑟氏菌获得增溶的抗原的增强。提取在升高的温度下进行，并提供可用于测定细菌存在的样品。

3. 发明授权

US5132205A High pH extraction composition and its use to determine a chlamydial, gonococcal or herpes antigen 失效
标题翻译：高PH提取物组合物及其用于测定氯胺酮，甘露醇或其他抗生素
公开(公告)号：US5132205A
公开(公告)日：1992-07-21
申请号：US255928
申请日：1988-10-07
申请人： Allan D. Pronovost , John C. Mauck , Sheryl S. Sullivan , Catherine E. Greer , James H. Gilbert
发明人： Allan D. Pronovost , John C. Mauck , Sheryl S. Sullivan , Catherine E. Greer , James H. Gilbert
IPC分类号： G01N33/569 , A61K39/00 , A61K39/095 , A61K39/118 , A61K39/245 , C07K2/00 , C07K14/005 , C07K14/03 , C07K14/035 , C07K14/195 , C07K14/22 , C07K14/295 , C07K14/41 , C07K16/08 , C07K16/12 , C12P21/00 , C12R1/01 , C12R1/92 , G01N33/571
CPC分类号： C07K16/1203 , A61K39/095 , A61K39/118 , C07K14/005 , C07K14/22 , C07K14/295 , C07K16/085 , A61K39/00 , C12N2710/16622 , Y10S435/871 , Y10S436/825
摘要： An extraction composition is useful for lysing chlamydial, gonococcal or herpes organisms and extracting detectable antigen from the organisms. In particular, this composition has a high pH (at least about 8) and comprises an alcoholamine which is effective in extracting antigen. It is particularly useful for extracting either or both of the lipopolysaccharide and major outer membrane protein chlamydial antigens.

4. 发明授权

US5099011A Nucleic acid probe for detection of Neisseria gonorrhoea 失效
公开(公告)号：US5099011A
公开(公告)日：1992-03-24
申请号：US703361
申请日：1991-05-21
申请人： Derek Woods , M. Jane Madonna , Linda S. Mulcahy
发明人： Derek Woods , M. Jane Madonna , Linda S. Mulcahy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y10S435/822 , Y10S435/871
摘要： The invention discloses nucleic acid probes specific for Neisseria gonorrhoea useful in diagnostic methods to detect the presence of N. gonorrhoea in biological specimens.

5. 发明授权

US4755459A Detection of gonococcal infections using monoclonal antibodies 失效
标题翻译：使用单克隆抗体检测淋球菌感染
公开(公告)号：US4755459A
公开(公告)日：1988-07-05
申请号：US742853
申请日：1985-06-10
申请人： Terry W. Pearson , Malcolm B. Perry
发明人： Terry W. Pearson , Malcolm B. Perry
IPC分类号： C07K16/12 , C12Q1/04 , C12R1/36 , G01N33/53
CPC分类号： C07K16/1217 , Y10S435/871 , Y10S436/811
摘要： Monoclonal antibodies specific to Neisseria gonorrhoeae lipopolysaccharide components having no cross-reactivity with N. meningitidis have been produced and found useful in the diagnosis of the presence of N. gonorrhoeae.
摘要翻译：已经产生了与脑膜炎奈瑟氏球菌不具有交叉反应性的针对淋病奈瑟氏球菌的多糖组分特异的单克隆抗体，并且可用于诊断淋病奈瑟氏球菌的存在。

6. 发明授权

US4497900A Immunoassay for Neisseria gonorrhoeae antigens 失效
标题翻译：淋病奈瑟氏球菌抗原免疫测定
公开(公告)号：US4497900A
公开(公告)日：1985-02-05
申请号：US479413
申请日：1983-03-28
申请人： Dinah Abram , Alan S. Armstrong , John E. Herrmann , Chung-Mei Ling
发明人： Dinah Abram , Alan S. Armstrong , John E. Herrmann , Chung-Mei Ling
IPC分类号： G01N33/571 , G01N33/54 , G01N33/56
CPC分类号： G01N33/571 , Y10S435/871 , Y10S435/962 , Y10S436/804 , Y10S436/811 , Y10S436/815 , Y10S436/823 , Y10S436/825
摘要： The present disclosure relates to a solid phase immunoassay for the detection of Neisseria gonorrhoeae antigens in a clinical specimen, wherein the Neisseria gonorrhoeae antigens to be determined are coated or adsorbed on the solid phase.
摘要翻译：本公开涉及用于在临床标本中检测淋病奈瑟氏球菌抗原的固相免疫测定，其中待测定的淋病奈瑟氏球菌抗原被包被或吸附在固相上。

7. 发明授权

US4355113A Over the counter swab kit for self detection of gonorrhea in the male using saline ampule 失效
标题翻译：在计数器拭子套件中，用于使用盐水安瓿在男性中自我检测淋病
公开(公告)号：US4355113A
公开(公告)日：1982-10-19
申请号：US275170
申请日：1981-06-19
申请人： Frederick C. Mennen
发明人： Frederick C. Mennen
IPC分类号： A61B10/00 , C12M1/30 , C12Q1/12 , G01N33/50
CPC分类号： C12Q1/12 , C12M23/32 , A61B2010/0006 , B01L3/5029 , Y10S435/81 , Y10S435/871
摘要： An over the counter swab kit for self detection of gonorrhea in the male using saline ampul. A method wherein a pledget in the form of fibrous material is impregnated with a compound which reacts with Neisseria gonorrhea to produce a color change. The pledget, before the test, is in a dry condition and is activated by a wetting agent such as saline, when placed in contact with the pledget. The chemical compound used and incorporated into the pledget is selected from a group consisting of phenylenediamines. A sufficient amount of saline is held within a frangible ampul to wet the pledget and then to be drawn by capillary action through the swab on which a sample of exudate as a specimen is placed. The chemical compound is in the form of a mineral acid salt which dissolves in the saline and is transported by capillary action through the pledget into the swab. A purple color is created on the tip of the swab at the site of the bacteria and is a positive test for gonorrhea. There is also disclosed a novel method for the manufacture of the novel swab kit for self detection of gonorrhea in the male.
摘要翻译：在使用盐水安瓿的男性中用淋巴自检进行反对拭子试剂盒。一种方法，其中以纤维材料形式的绒毛浸渍有与淋病奈瑟氏球菌反应以产生颜色变化的化合物。在试验之前，试样处于干燥状态，并与润湿剂（如盐水）一起被活化，当与试剂接触时。所用的化合物和掺入到该物质中的化合物选自苯二胺。将足够量的盐水保持在易碎的安瓿内以润湿绒毛，然后通过毛细管作用通过其上放置作为样品的渗出物样品的棉签来拉伸。该化合物是无机酸盐的形式，其溶解在盐水中，并通过毛细管作用将其输送到拭子中。在细菌部位的棉签上产生紫色，是淋病的阳性检测。还公开了一种用于制造用于男性淋病自身检测的新型拭子试剂盒的新方法。

8. 发明授权

US4208480A Method, reagents and apparatus for the rapid identification of Neisseria gonorrhoeae and Neisseria meningitidis 失效
标题翻译：用于快速鉴定淋病奈瑟氏球菌和脑膜炎奈瑟菌的方法，试剂和仪器
公开(公告)号：US4208480A
公开(公告)日：1980-06-17
申请号：US936292
申请日：1978-08-23
申请人： Richard F. D'Amato , Louis A. Eriquez
发明人： Richard F. D'Amato , Louis A. Eriquez
IPC分类号： C12M1/20 , C12Q1/12 , C12Q1/04
CPC分类号： C12Q1/12 , Y10S435/871
摘要： The disclosure is directed to a method, reagents and apparatus for the rapid (one to four hours) identification of Neisseria gonorrhoeae and Neisseria meningitidis from cultures grown on a selective or a non-selective medium. One drop of growth suspended in sterile salt solution is placed in each of a plurality of miniature reaction chambers supported on a common base and incubated at 35.degree.-37.degree. C. for one to four hours. A dried substrate and buffer is contained in each chamber. A detector reagent such as a diazo dye in an aqueous solution with a polar solvent is added to each chamber after incubation. The color change in each chamber is noted and compared with a profile to identify N. gonorrhoeae and Neisseria meningitidis. Synthetic substrates rather than sugars are used in the reaction chambers. The substrates are naphthyl derivatives, .beta.-naphthyl or .beta.-naphthylamides, and are(1) .beta.-naphthyl-.beta.,D-galactopyranoside(2) N-L-.lambda.-glutamyl-.beta.-naphthylamide(3) L-hydroxyproline-.beta.-naphthylamide(4) L-serine-.beta.-naphthylamide(5) L-arginine-.beta.-naphthylamide(6) glycine-glycine-.beta.-naphthylamide(7) .beta.-naphthyl-phosphate(8) .beta.-naphthyl-valerate(9) 4 methoxy leucine-.beta.-naphthylamide(10) glycine-.beta.-naphthylamide.
摘要翻译：本公开涉及用于从在选择性或非选择性培养基上生长的培养物快速（一至四小时）鉴定淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌的方法，试剂和装置。将悬浮在无菌盐溶液中的一滴生长物置于支撑在共同碱基上的多个微型反应室中，并在35℃-37℃下孵育1-4小时。干燥的基材和缓冲液包含在每个室中。在温育后，向每个室中加入在具有极性溶剂的水溶液中的重氮染料等检测剂试剂。注意每个室中的颜色变化，并与一个轮廓进行比较，以鉴定淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌。合成底物而不是糖用于反应室。底物是萘衍生物，β-萘基或β-萘基酰胺，并且是（1）β-萘基-β，D-吡喃半乳糖苷（2）NL-λ-谷氨酰基-β-萘基酰胺（3）L-羟基脯氨酸-β-萘基酰胺（4）L-丝氨酸-β-萘基酰胺（5）L-精氨酸-β-萘基酰胺（6）甘氨酸 - 甘氨酸-β-萘基酰胺（7）β-萘基 - 磷酸酯（8）β-萘基 - 戊酸酯（9）4 甲氧基亮氨酸-β-萘基酰胺（10）甘氨酸-β-萘基酰胺。

9. 发明授权

US4049499A Microbial medium having fluorescent growth indicator 失效
标题翻译：具有荧光生长指示剂的微生物培养基
公开(公告)号：US4049499A
公开(公告)日：1977-09-20
申请号：US701894
申请日：1976-07-01
申请人： Cyrus A. Lepp , Robert D. Mason , William S. Ramsey
发明人： Cyrus A. Lepp , Robert D. Mason , William S. Ramsey
IPC分类号： C12Q1/04 , C12K1/06 , C12K1/10
CPC分类号： C12Q1/045 , Y10S435/808 , Y10S435/839 , Y10S435/849 , Y10S435/871 , Y10S435/876 , Y10S435/88 , Y10S435/883 , Y10S435/886
摘要： Solidified, polar, micorbial growth medium containing 8-anilino-1-naphthalenesulfonic acid or a salt thereof. Microbial colonies grown on the medium can be detected fluorimetrically.
摘要翻译：含有8-苯胺基-1-萘磺酸或其盐的固化，极性，微生物生长培养基。可以荧光测定在培养基上生长的微生物菌落。

10. 发明授权

US3846241A Medium for neisseria and method of cultivating neisseria 失效
标题翻译： NEISSERIA的中介和培养NEISSERIA的方法
公开(公告)号：US3846241A
公开(公告)日：1974-11-05
申请号：US29625372
申请日：1972-10-10
申请人： FAUR Y , WEISBURD M , MAY P , WILSON M
发明人： WEISBURD M , WILSON M , MAY P , FAUR Y
IPC分类号： C12M1/22 , C12Q1/12 , C12K1/10
CPC分类号： C12M23/38 , C12M23/10 , C12M25/14 , C12Q1/12 , Y10S435/80 , Y10S435/871
摘要： 1. THE MEDIUMS CONTAIN A FILTERED OR AUTOCLAVE YEAST DIALYSATE AS A SOURCE OF ESSENTIAL FACTORS THAT PROMOTE RAPID AND LUXURIANT GROWTH OF PATHOGENIC NEISSERIA, INCLUDING THE MOST FASTIDIOUS STRAINS THAT FAIL TO GROW OTHER AVAILABLE MEDIA. THE FILTERED YEAST DIALYSATE IN THE MEDIUM COMPOSITION MAY BE USED EITHER IN OPEN CONTAINERS OR CLOSED CONTAINERS WITH THE OPEN CONTAINERS INCUBATED UNDER OUTSIDE CO2 TENSION. ON THE OTHER HAND, THE AUTOCLAVED YEAST DIALYSATE CAN ONLY BE USED WHERE THE INCUBATION IS CARRIER OUT UNDER OUTSIDE INCREASED CO2 TENSION.

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