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    • 10. 发明申请
    • PARTICLE FOR MEDICAL USE, PARTICLE FOR ANLAYSIS AND METHOD OF PRODUCING THE SAME
    • 用于医疗用途的颗粒,用于环境的颗粒及其生产方法
    • US20100062475A1
    • 2010-03-11
    • US12448681
    • 2008-01-11
    • Yuzo HamaguchiSohei FunaokaYoshiaki FukunishiTayuki Matsumoto
    • Yuzo HamaguchiSohei FunaokaYoshiaki FukunishiTayuki Matsumoto
    • C12Q1/02B32B5/16B05D7/00
    • A61K47/32A61K9/167C08F230/08C08F257/02C08F265/00C08F265/04C08F289/00C08F291/00C08F292/00C08F2220/287C08F2220/306C08L51/003C08L51/10Y10T428/2995Y10T428/2996Y10T428/2998C08L2666/02
    • The object of the present invention is to provide a particle for medical use which has an excellent capability of fixing a biologically active substance and such a chemical/physical stability that the particle is less dissolved or deteriorated in a washing step, and a particle for analysis which has an excellent capability of capturing a biomolecule and such a chemical/physical stability that the particle is less dissolved or deteriorated in a washing step.The object of the present invention is achieved by a particle for medical use which has on the surface thereof a polymer-containing layer formed by introducing a polymerizable functional group or a chain-transfer group to the surface of a core particle, mixing the resultant particle with a polymerizable component containing a polymerizable monomer having a functional group for fixing a biologically active substance, and causing the mixture to develop polymerization reaction The object of the present invention is also achieved by a particle for analysis of the interaction of biomolecules, which particle having on the surface thereof a polymer-containing layer formed by introducing a polymerizable functional group or a chain-transfer group to the surface of a core particle, mixing the resultant particle with a polymerizable component containing a polymerizable monomer having a functional group for fixing a biologically active substance, and causing the mixture to develop, polymerization reaction, wherein the biologically active substance is fixed through the functional group for fixing a biologically active substance in the polymer-containing layer.
    • 本发明的目的是提供一种医疗用颗粒,其具有优异的固定生物活性物质的能力和在洗涤步骤中颗粒较少溶解或劣化的化学/物理稳定性和用于分析的颗粒 其具有捕获生物分子的优异能力和在洗涤步骤中颗粒较少溶解或劣化的化学/物理稳定性。 本发明的目的是通过一种用于医疗用途的颗粒来实现的,其表面上具有通过将可聚合官能团或链转移基团引入核心颗粒的表面而形成的含聚合物层,将所得颗粒 具有可聚合单体,其含有具有用于固定生物活性物质的官能团的可聚合单体,并使混合物产生聚合反应本发明的目的还通过用于分析生物分子的相互作用的颗粒来实现,该颗粒具有 在其表面上形成通过将可聚合官能团或链转移基团引入核心颗粒的表面而形成的含聚合物层,将所得颗粒与可聚合单元混合,所述可聚合组分含有用于固定生物学的官能团的可聚合单体 活性物质,并使混合物发生聚合 反应,其中通过用于将生物活性物质固定在含聚合物的层中的官能团固定生物活性物质。