专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09102667B2 N-arylaminomethylene benzothiophenones for treatment of cardiovascular disease 有权
标题翻译：用于治疗心血管疾病的N-芳基氨基亚甲基苯并噻吩酮
公开(公告)号：US09102667B2
公开(公告)日：2015-08-11
申请号：US13980057
申请日：2012-01-18
申请人： Enno Klussmann , Walter Rosenthal , Jelena Milic , Martin W. Bergmann
发明人： Enno Klussmann , Walter Rosenthal , Jelena Milic , Martin W. Bergmann
IPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , A61K31/135 , A61K31/343 , A61K31/381 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/4709 , C07D333/64 , C07D409/12
CPC分类号： C07D417/12 , A61K31/135 , A61K31/343 , A61K31/381 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/4709 , C07D333/64 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The invention relates to N-arylaminomethylenebenzothiophenones of General Formula (I) for use as a drug for the treatment of cardiovascular diseases: wherein E is S, O, or CH2, D is CH or NH, and Ar is a phenyl or naphtyl moiety substituted by an electron-withdrawing group, an unsubstituted heteroaryl residue, or a heteroaryl residue substituted by alkyl or an electron-withdrawing group.
摘要翻译：本发明涉及用作治疗心血管疾病的药物的通式（I）的N-芳基氨基亚甲基苯并苯乙酮：其中E是S，O或CH 2，D是CH或NH，Ar是取代的苯基或萘基部分通过吸电子基团，未取代的杂芳基残基或被烷基或吸电子基团取代的杂芳基。

2. 发明授权

US07863432B2 Nucleic acid molecules encoding AKAP18 delta, a splice variant of a protein kinase A anchor protein 失效
标题翻译：编码AKAP18δ的核酸分子，蛋白激酶A锚蛋白的剪接变体
公开(公告)号：US07863432B2
公开(公告)日：2011-01-04
申请号：US10526768
申请日：2003-09-05
申请人： Enno Klussmann , Alexander Oksche , Walter Rosenthal
发明人： Enno Klussmann , Alexander Oksche , Walter Rosenthal
IPC分类号： C07H21/04 , C12N15/63 , C12N1/20
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to polynucleotides which encode a protein kinase A anchor proteins (AKAP) and the use of such polynucleotides to generate AKAP polypeptides or fusion proteins containing AKAP proteins. The present invention also relates to methods of determining the interaction of AKAP proteins with regulatory subunits of protein kinase A and methods for identifying cell-permeable substances.
摘要翻译：本发明涉及编码蛋白激酶A锚蛋白（AKAP）的多核苷酸以及这种多核苷酸用于产生含有AKAP蛋白的AKAP多肽或融合蛋白的用途。本发明还涉及确定AKAP蛋白与蛋白激酶A的调控亚基的相互作用的方法以及用于鉴定细胞可渗透物质的方法。

3. 发明申请

US20090176773A1 Non-Peptidic Inhibitors of AKAP/PKA Interaction 审中-公开
标题翻译： AKAP / PKA相互作用的非肽抑制剂
公开(公告)号：US20090176773A1
公开(公告)日：2009-07-09
申请号：US11914591
申请日：2006-05-18
申请人： Enno Klussmann , Walter Rosenthal , Jorg Rademann , Frank Christian , Sina Meyer
发明人： Enno Klussmann , Walter Rosenthal , Jorg Rademann , Frank Christian , Sina Meyer
IPC分类号： A61K31/536 , C07D207/44 , A61K31/40 , C07K16/44 , A01K67/027 , C12N5/00 , C07D265/30 , C07D241/04 , A61K31/5375 , A61K31/495 , C07D319/12 , A61K31/357 , C07D413/06 , A61K31/421 , C07D257/06 , A61K31/41 , C07D233/96 , A61K31/4166 , C07D211/82 , A61K31/44 , C07D413/10 , C07D407/12 , A61K31/5355 , A61P3/04 , A61P3/10 , A61P9/00 , A61P11/00 , A61P9/04 , A61P25/18 , A61P11/06 , A61P29/00 , A61P31/18
CPC分类号： C07C335/32 , C07C31/137 , C07C50/24 , C07C69/017 , C07C69/94 , C07C211/50 , C07C211/61 , C07C215/76 , C07C215/80 , C07C225/22 , C07C233/09 , C07C233/47 , C07C233/56 , C07C237/40 , C07C245/08 , C07C251/08 , C07C251/24 , C07C251/46 , C07C271/28 , C07C279/04 , C07C279/26 , C07C281/18 , C07C311/08 , C07C311/20 , C07C311/51 , C07C317/44 , C07C335/12 , C07C335/16 , C07C337/06 , C07C2601/14 , C07C2603/18 , C07C2603/24 , C07C2603/74 , C07D213/42 , C07D231/12 , C07D277/40 , C07D277/54 , C07D277/68 , C07D295/135 , C07D333/64
摘要： The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism that comprises said non-peptidic compounds or recognition molecules directed to said compounds, such as e.g. antibodies or chelating agents. The invention also relates to a pharmaceutical agent, especially for use in the treatment of diseases that are associated with a disturbance of the cAMP signal path, especially insipid diabetes, hypertonia, pancreatic diabetes, duodenal ulcer, asthma, heart failure, obesity, AIDS, edema, hepatic cirrhosis, schizophrenia and others. The invention also relates to the use of the inventive molecules.
摘要翻译：本发明涉及调节，特别是抑制蛋白激酶A（PKA）和A激酶锚蛋白（AKAP）与包含所述非肽化合物或识别分子的宿主或靶生物的相互作用的非肽分子所述化合物，例如抗体或螯合剂。本发明还涉及药剂，特别是用于治疗与cAMP信号通路紊乱相关的疾病，特别是胰岛素性糖尿病，高渗，胰腺糖尿病，十二指肠溃疡，哮喘，心力衰竭，肥胖症，艾滋病，水肿，肝硬化，精神分裂症等。本发明还涉及本发明分子的用途。

4. 发明授权

US5041650A Allyl selenide, and method for making and using 失效
标题翻译：烯丙基硒化物，以及制备和使用方法
公开(公告)号：US5041650A
公开(公告)日：1991-08-20
申请号：US439328
申请日：1989-11-20
申请人： Walter Rosenthal
发明人： Walter Rosenthal
IPC分类号： C07C391/00
CPC分类号： C07C391/00
摘要： The new compound diallyl selenide, or 3.3'-bis(1-propene)selenide, having the formula(CH.sub.2 .dbd.CH--CH.sub.2).sub.2 Se.
摘要翻译：新的化合物二烯丙基硒化物或3.3'-双（1-丙烯）硒化物，具有式（CH2 = CH-CH2）2Se。

5. 发明授权

US4268493A Composition and method for improving meat production and quality as well as feed utilization by animals 失效
标题翻译：提高肉类生产和品质以及动物饲料利用的组成和方法
公开(公告)号：US4268493A
公开(公告)日：1981-05-19
申请号：US956853
申请日：1978-11-02
申请人： Walter Rosenthal
发明人： Walter Rosenthal
IPC分类号： A23K1/175 , A61K43/00 , A23K1/165
CPC分类号： A23K20/30 , Y10S426/807
摘要： Qualitative and quantitative meat production is improved considerably and decisively through administration of radio-active iodine isotope compounds, preferably the artificial iodine isotope I.sup.131. The glandular thyroid tissue is destroyed to any desirable degree by its administration. This method has the great advantage that in general a single administration suffices to achieve dramatic results. The method does not interfere with other measures used to improve meat production, such as early castration, or the use of feed additives like vitamins, antibiotics, and hormone preparations.
摘要翻译：通过施用放射性活性碘同位素化合物，优选人造碘同位素I131，定性和定量的肉类生产得到显着和决定性的改善。腺体组织通过其施用被破坏至任何所需的程度。这种方法具有很大的优点，一般来说，单一管理就足以实现显着的效果。该方法不会干扰用于改善肉类生产的其他措施，如早期去势，或使用饲料添加剂如维生素，抗生素和激素制剂。

6. 发明授权

US3021216A Animal feed compositions 失效
标题翻译：动物饲料组成
公开(公告)号：US3021216A
公开(公告)日：1962-02-13
申请号：US4426360
申请日：1960-07-21
申请人： WALTER ROSENTHAL , GERALD SCHORSCH
发明人： WALTER ROSENTHAL , GERALD SCHORSCH
IPC分类号： A23K1/16
CPC分类号： A23K20/132

7. 发明授权

US4889142A Smoking article and methods of making the same 失效
标题翻译：吸烟制品和制作方法
公开(公告)号：US4889142A
公开(公告)日：1989-12-26
申请号：US366203
申请日：1989-06-09
申请人： Walter Rosenthal
发明人： Walter Rosenthal
IPC分类号： A24B15/28
CPC分类号： A24B15/28 , A24B15/282
摘要： The invention is for a multi-fold improvement for tobacco, including cigarettes, cigars, pipe smoking and other smoking devices by decreasing the health hazards thereof by:1. Replacing and/or reducing substantially all of the nitrate in cigarette paper by use of an oxidizing agent such as potassium permanganate.2. Improving the completeness of burning of the relatively poisonous and undesirable components of tar and smoke of cigarette smoke through addition of an oxidizing agent such as potassium permanganate to the cigarette.Using an oxidizing agent to render non-poisonous certain toxic components in smoking devices and materials including cigarettes, cigars, pipe tobacco and other plant derived ingredients useful and used for smoking.
摘要翻译：本发明是为了通过以下方式减少其健康危害来对烟草进行多重改进，包括香烟，雪茄，烟斗和其他吸烟装置：1.通过使用卷烟纸来替代和/或减少卷烟纸中的大部分硝酸盐氧化剂如高锰酸钾。 2.通过向香烟加入氧化剂如高锰酸钾，提高香烟烟雾焦油和烟雾中相对有毒和不良成分燃烧的完整性。使用氧化剂在吸烟装置和材料中产生无毒的某些有毒成分，包括香烟，雪茄，管烟草和其他有用和用于吸烟的植物衍生成分。

8. 发明授权

US4205929A Slurry transport medium 失效
标题翻译：泥浆运输介质
公开(公告)号：US4205929A
公开(公告)日：1980-06-03
申请号：US888568
申请日：1978-03-20
申请人： Louis Schiffman , Walter Rosenthal
发明人： Louis Schiffman , Walter Rosenthal
IPC分类号： B65G53/30 , B65G53/04
CPC分类号： B65G53/30
摘要： This invention provides for an improvement in slurry transport systems, especially coal slurry lines. Instead of the usual use of fresh water resources which, in some geographic areas, are scarce for slurry transport, concentrated brine is used which is prepared from abundant salt water resources. Because of the higher density of this concentrated brine, it is a superior carrier of pulverized material. It dimishes the separation and settling tendency of slurry components during transport and particularly during shutdown. Other advantages in the use of concentrated brine include: freezing point depression which permits ease of transport during winter and at lower temperatures; dust suppression of stored coal; avoidance of spontaneous combustion of stored coal; inhibit freeze packing of dewatered pipeline coal; and diminished extent of corrosion in ferrous metal pipelines as compared to that which might occur with lower concentration brines. Important in the economy of the process is that the concentrated brine can be recycled. An inexpensive method for producing the concentrated brine is given.
摘要翻译：本发明提供了浆料输送系统，特别是煤浆管线的改进。而不是通常使用淡水资源，在某些地理区域稀缺的泥浆运输，使用浓缩的盐水，这是由丰富的盐水资源制成的。由于该浓缩盐水的密度较高，因此它是粉碎材料的优良载体。它在运输过程中特别是在关闭期间降低了浆料组分的分离和沉降趋势。使用浓缩盐水的其他优点包括：在冬季和较低温度下易于运输的凝固点凹陷; 贮存煤粉尘抑制; 避免储存煤的自燃; 抑制脱水管道煤的冷冻包装; 并且与较低浓度的盐水可能发生的情况相比，黑色金属管道的腐蚀程度减小。经济上重要的是浓缩的盐水可以回收利用。给出了生产浓缩盐水的廉价方法。

9. 发明授权

US2462556A Dropping funnel 失效
标题翻译：滴漏斗
公开(公告)号：US2462556A
公开(公告)日：1949-02-22
申请号：US76980547
申请日：1947-08-21
申请人： WALTER ROSENTHAL
发明人： WALTER ROSENTHAL
IPC分类号： B01L3/00 , B01L3/02
CPC分类号： B01L3/569 , B01L3/0241 , Y10T137/86187 , Y10T137/86292

10. 发明授权

US1281163A Adding mechanism. 失效
标题翻译：添加机制
公开(公告)号：US1281163A
公开(公告)日：1918-10-08
申请号：US1912680246
申请日：1912-02-27
申请人： LEON WALTER ROSENTHAL
发明人： HOPKINS MARCUS C
CPC分类号： G06C11/00

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式