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1. 发明申请

US20170233324A1 TRICYCLIC COMPOUNDS AND PROCESS FOR PREPARATION THEREOF 有权
公开(公告)号：US20170233324A1
公开(公告)日：2017-08-17
申请号：US15328425
申请日：2015-07-23
申请人： Council of Scientific and Industrial Research
发明人： Dumbala Srinivasa Reddy , Kishor Laxman Handore
IPC分类号： C07C49/643 , A01N35/06
CPC分类号： C07C49/643 , A01N35/06 , C07C2603/08 , C07C2603/10 , C07C2603/12
摘要： The present invention discloses tricyclic compounds of formula (I) or salt thereof and their process for synthesis. Further, the present invention relates to the use of these novel tricyclic compounds of formula (I) or salt thereof as insect repellents.

2. 发明申请

US20100113818A1 Photoacid generator containing aromatic ring 有权
标题翻译：含有芳香环的光酸发生剂
公开(公告)号：US20100113818A1
公开(公告)日：2010-05-06
申请号：US12384191
申请日：2009-04-01
申请人： Jung-Hoon Oh , Dong-Cheol Seo , Jin-Bong Shin
发明人： Jung-Hoon Oh , Dong-Cheol Seo , Jin-Bong Shin
IPC分类号： C07C69/76
CPC分类号： C07C25/18 , C07C309/08 , C07C309/12 , C07C313/04 , C07C323/52 , C07C381/12 , C07C2601/08 , C07C2603/08 , C07C2603/18 , C07C2603/24 , C07C2603/26 , C07D311/84 , G03F7/0045 , G03F7/0046 , G03F7/0397
摘要： An acid generator represented by the following formula (1) is provided: wherein X represents an alkylene group having 1 to 10 carbon atoms, —X1—O—X2—, or a heteroatom selected from the group consisting of nitrogen, sulfur and fluorine; X1 and X2 each independently represent an alkylene group having 1 to 10 carbon atoms; Y represents a cyclic hydrocarbon group having 5 to 30 carbon atoms and containing one or more aromatic rings, while one or more hydrogen atoms on the ring of the cyclic hydrocarbon group may be substituted by one or more members selected from the group consisting of —O—Y1, —CO—Y2, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a perfluoroalkyl group having 1 to 4 carbon atoms, a perfluoroalkoxy group having 1 to 4 carbon atoms, a hydroxyalkyl group having 1 to 6 carbon atoms, a halogen atom, a hydroxyl group and a cyano group; Y1 and Y2 each independently represent an alkyl group having 1 to 6 carbon atoms; n represents an integer of 0 or 5; and A+ represents an organic counterion.
摘要翻译：提供由下式（1）表示的酸发生剂：其中X表示碳原子数1〜10的亚烷基，-X 1 -O-X 2 - 或选自氮，硫和氟的杂原子; X1和X2各自独立地表示碳原子数1〜10的亚烷基。 Y表示碳原子数为5〜30的环状烃基，含有一个以上的芳香环，环状烃基的环上的一个以上的氢原子可以被选自-O〜 -Y1，-CO-Y2，碳原子数1〜6的烷基，碳原子数1〜6的烷氧基，碳原子数1〜4的全氟烷基，碳原子数1〜4的全氟烷氧基，具有1至6个碳原子的基团，卤素原子，羟基和氰基; Y1和Y2各自独立地表示碳原子数1〜6的烷基。 n表示0或5的整数; A +代表有机抗衡离子。

3. 发明授权

US07351825B2 Cyclopropane compounds and pharmaceutical use thereof 失效
标题翻译：环丙烷化合物及其药物用途
公开(公告)号：US07351825B2
公开(公告)日：2008-04-01
申请号：US11011773
申请日：2004-12-15
申请人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafumi Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
发明人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafumi Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
IPC分类号： C07D265/00 , C07D295/00 , C07D237/00 , C07D409/00 , C07D411/00 , C07D217/00 , C07D211/00 , C07D213/00 , C07D271/00 , C07D413/00 , C07D498/00 , C07D277/00 , C07D257/00 , C07D233/00 , C07D231/00 , C07D207/00 , C07D333/00 , C07D307/00 , C07D303/00 , C07D309/00 , C07D311/00
CPC分类号： C07C311/29 , C07C311/13 , C07C311/20 , C07C311/22 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07C2603/08 , C07C2603/18 , C07C2603/30 , C07D205/04 , C07D207/48 , C07D209/44 , C07D211/58 , C07D211/96 , C07D213/18 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/82 , C07D217/08 , C07D231/12 , C07D233/64 , C07D237/12 , C07D239/22 , C07D243/08 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/107 , C07D277/26 , C07D277/36 , C07D277/82 , C07D295/26 , C07D307/79 , C07D307/91 , C07D333/18 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/62 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）的环丙烷化合物：其中R 1 是 - （CH 2）2 -X-（CH 2）n - SUP> 1等，其中m和n相同或不同，并且各自为0至6，X为单键等，而A 1为取代的C _{3-14个烃环基等; R 2和R 3相同或不同，并且各自为氢原子， - （CH 2）2 N 其中p和q为 - （CH 2）2 - - - - CH 2 - 相同或不同，并且各自为0至6，X 1为单键等，而A 2为任选取代的C 3-14烷基，烃环等; R 4是-CO 2 R 9等，其中R 9是氢原子等。 ; 和R 20和R 21相同或不同，各自为氢原子， - （CH 2 CH 2）m 12 其中m12和m12（其中m12和m12）相同或不同，各自为0至6，X 12为单键等，R 30为氢原子等; 或其前药或其药学上可接受的盐。}

4. 发明申请

US20010025105A1 Certain substituted 1-aryl-3-piperazine-1'-yl propanones 审中-公开
标题翻译：某些取代的1-芳基-3-哌嗪-1'-基丙酮
公开(公告)号：US20010025105A1
公开(公告)日：2001-09-27
申请号：US09829336
申请日：2001-04-09
申请人： Molecular Geriatarics Corporation
发明人： John DeBernardis , Daniel Kerkman , Raymond Zinkowski
IPC分类号： C07D295/04
CPC分类号： C07D231/12 , C07C2602/10 , C07C2603/08 , C07D207/48 , C07D209/12 , C07D261/08 , C07D277/24 , C07D277/28 , C07D285/06 , C07D295/108 , C07D295/192 , C07D295/26 , C07D307/46 , C07D307/52 , C07D307/58 , C07D307/80 , C07D307/81 , C07D309/38 , C07D311/12 , C07D317/28 , C07D317/58 , C07D317/68 , C07D319/12 , C07D319/18 , C07D327/08 , C07D333/22 , C07D333/28 , C07D333/38 , C07D333/42 , C07D333/56 , C07D335/06 , C07D409/04
摘要： Disclosed are compounds of formula I: 1 wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydrogen; or Y and R1 or R2 together represent CH2;CH2CH2; CH2O; CH2S forming a five or six membered ring and such ring may be optionally substituted with loweralkyl or phenyl; or the pharmaceutically acceptable salts thereof, useful in the treatment of neoplastic diseases, and bacterial or fungal infections, and in preventing or decreasing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore, useful for treating Alzheimer's Disease.
摘要翻译：公开了式I的化合物：其中X是被任选取代的苯基取代的羰基，磺酰基，亚甲基或亚甲基; Z是氮或CH; Ar1和Ar2独立地表示芳基; Y为氢; 或Y和R 1或R 2一起表示CH 2; CH 2 CH 2; CH2O; 形成五或六元环的CH 2 S，并且这种环可以任选被低级烷基或苯基取代; 或其药学上可接受的盐，可用于治疗肿瘤疾病，细菌或真菌感染，以及预防或减少与阿尔茨海默病有关的异常磷酸化成对螺旋丝（PHF）表位的产生，因此可用于治疗阿尔茨海默病疾病。

5. 发明授权

US3694512A Tetrahydro-cyclopropa naphthalenes 失效
标题翻译：四氢环丙基萘磺酸盐
公开(公告)号：US3694512A
公开(公告)日：1972-09-26
申请号：US3694512D
申请日：1970-09-18
申请人： SQUIBB & SONS INC
发明人： NARAYANAN VENKATACHALA L
IPC分类号： C07C39/17 , C07C59/72 , C07D295/088 , C07C39/14
CPC分类号： C07D295/088 , C07C39/17 , C07C59/72 , C07C2603/08
摘要： Compounds are provided having the structure These compounds are useful as antiparasitic agents, antibacterial agents, and anti-inflammatory agents as well as surfact active agents.
摘要翻译：提供具有结构的化合物这些化合物可用作抗寄生虫剂，抗菌剂和抗炎剂以及表面活性剂。

6. 发明授权

US3483102A Photosensitized cycloadding process 失效
标题翻译：光敏循环过程
公开(公告)号：US3483102A
公开(公告)日：1969-12-09
申请号：US3483102D
申请日：1964-05-06
申请人： UNION CARBIDE CORP
发明人： ARNOLD DONALD R , TRECKER DAVID J , STEHR CHARLES E
IPC分类号： C07C2/42 , C07C17/281 , C07C271/02 , C07C271/24 , C07D303/06 , C08G18/42 , C08G18/48 , C08G59/22 , C08G59/24 , C08G59/50 , C08G59/66 , C08G63/199 , C08G65/26 , C08G69/26 , C08G75/30 , C07C3/24 , C07C13/54 , C07C13/62
CPC分类号： C08G75/30 , C07C2/42 , C07C17/281 , C07C271/02 , C07C271/24 , C07C2603/08 , C07C2603/62 , C07C2603/86 , C07C2603/90 , C07D303/06 , C08G18/423 , C08G18/4875 , C08G59/22 , C08G59/24 , C08G59/5026 , C08G59/66 , C08G63/199 , C08G65/2606 , C08G69/26 , Y10S204/905 , Y10S204/911 , Y10S204/912 , Y10S204/914 , C07C22/00

7. 发明申请

US20190127510A1 NOVEL INITIATORS FOR LIVING CARBOCATIONIC POLYMERIZATION 审中-公开
公开(公告)号：US20190127510A1
公开(公告)日：2019-05-02
申请号：US16069659
申请日：2017-01-20
申请人： Joseph KENNEDY , Turgut NUGAY
发明人： Joseph KENNEDY , Turgut NUGAY
IPC分类号： C08G18/62 , C08G81/02
CPC分类号： C08G18/6204 , C07C13/44 , C07C23/18 , C07C23/32 , C07C33/36 , C07C35/31 , C07C35/37 , C07C35/44 , C07C43/188 , C07C211/27 , C07C2602/06 , C07C2603/08 , C07C2603/40 , C08F2/48 , C08F8/06 , C08F8/30 , C08F210/10 , C08G81/024
摘要： In various embodiments, the present invention is directed to new low cost initiator compositions for use with the production of well-defined telechelic PIBs (by LC+P of isobutylene). In various other embodiments, the present invention is directed to methods for using these novel compositions as initiators for isobutylene (IB) and other cationically polymerizable monomers, such as styrene and its derivatives. In still other embodiments, the present invention is directed to structurally new, allyl (and chlorine) telechelic PIBs formed from these new initiator compositions and their derivatives (in particular, hydroxyl telechelic PIB and amine telechelic PIB). In yet other embodiments, the present invention is directed to structurally new polyurethanes, polyureas, and polyurethane ureas made using telechelic PIBs formed from these new initiator compositions.

8. 发明授权

US09493613B2 Organic light emitting composition, device and method 有权
标题翻译：有机发光组合物，装置及方法
公开(公告)号：US09493613B2
公开(公告)日：2016-11-15
申请号：US14130922
申请日：2012-07-03
申请人： Martin Humphries , Richard J. Wilson
发明人： Martin Humphries , Richard J. Wilson
IPC分类号： H01L51/00 , C08G73/02 , C08G61/12 , C08L65/00 , H01L51/50
CPC分类号： H01L51/0043 , C07C25/22 , C07C2602/06 , C07C2603/08 , C07F5/025 , C08G61/12 , C08G61/122 , C08G61/128 , C08G73/026 , C08G2261/12 , C08G2261/122 , C08G2261/135 , C08G2261/141 , C08G2261/1414 , C08G2261/1434 , C08G2261/148 , C08G2261/312 , C08G2261/3142 , C08G2261/3162 , C08G2261/3221 , C08G2261/3245 , C08G2261/374 , C08G2261/411 , C08G2261/512 , C08G2261/52 , C08G2261/76 , C08G2261/95 , C08L65/00 , C09K11/06 , C09K2211/1475 , H01L51/0003 , H01L51/0007 , H01L51/0039 , H01L51/0085 , H01L51/5004 , H01L51/5012 , H01L51/5016 , H01L51/5044 , H01L51/5056 , H01L51/5072 , H01L51/5088 , H01L51/5096 , H01L51/5206 , H01L51/5221 , H01L51/5253 , H01L2251/308 , H01L2251/552
摘要： Disclosed is a crosslinkable light-emitting composition comprising at least one host material, at least one phosphorescent light-emitting dopant, a first crosslinker comprising an unsaturated carbon-carbon bond group and a second crosslinker comprising a ring system capable of undergoing ring-opening crosslinking.
摘要翻译：公开了一种可交联发光组合物，其包含至少一种主体材料，至少一种磷光发光掺杂剂，包含不饱和碳 - 碳键基团的第一交联剂和包含能够进行开环交联的环系的第二交联剂。

9. 发明申请

US20160311791A1 NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTOGONISTS FOR THE TREATMENT OF OSTEOPOSOSIS 审中-公开
标题翻译：用于治疗骨质疏松症的新型TRICYCLIC感觉受体拮抗剂
公开(公告)号：US20160311791A1
公开(公告)日：2016-10-27
申请号：US15104394
申请日：2014-12-17
申请人： MERCK SHARP & DOHME CORP.
发明人： Gui-Bai Liang , Changyou Shou , Xianghong Huo , Haisheng Wang
IPC分类号： C07D307/93 , C07D409/12 , C07C323/32 , C07C217/28 , C07D307/79 , C07D333/54 , C07D407/12 , C07D405/12
CPC分类号： C07D307/93 , C07C217/28 , C07C323/32 , C07C2602/08 , C07C2603/08 , C07D307/79 , C07D333/54 , C07D405/12 , C07D407/12 , C07D409/12
摘要： Novel tricyclic compounds of Formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing osteoporosis and similar conditions. The compounds are effective as calcium sensing receptor antagonists. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了式（I）的新型三环化合物及其药学上可接受的盐可用于治疗或预防骨质疏松症和类似病症。这些化合物作为钙敏感受体拮抗剂是有效的。还包括药物组合物和治疗方法。

10. 发明申请

US20090069408A1 TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS 审中-公开
标题翻译：三氯化合物有效处理铁损
公开(公告)号：US20090069408A1
公开(公告)日：2009-03-12
申请号：US12044731
申请日：2008-03-07
申请人： Mikhail Chafeev , Nagasree Chakka , Jean-Jacques Cadieux , Jianmin Fu , Rajender Kamboj , Vishnumurthy Kodumuru , Jonathan Langille , Shifeng Liu , Jianyu Sun , Serguei Sviridov , Zaihui Zhang
发明人： Mikhail Chafeev , Nagasree Chakka , Jean-Jacques Cadieux , Jianmin Fu , Rajender Kamboj , Vishnumurthy Kodumuru , Jonathan Langille , Shifeng Liu , Jianyu Sun , Serguei Sviridov , Zaihui Zhang
IPC分类号： A61K31/381 , C07D333/76 , A61K31/343 , C07D307/91 , C07C257/10 , A61K31/155
CPC分类号： C07D337/10 , C07C335/32 , C07C2603/08 , C07C2603/18 , C07C2603/24 , C07D219/02 , C07D307/91 , C07D311/82 , C07D327/08 , C07D333/50
摘要： This invention is directed to, for example, compounds of formula (I): wherein n, m, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.
摘要翻译：本发明涉及例如式（I）的化合物：其中n，m，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义，为其立体异构体，对映异构体，互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药，用于治疗铁疾病。本发明还涉及包含该化合物的药物组合物和使用该化合物治疗铁疾病的方法。

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