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1. 发明授权

US09468890B2 Cycloalkylnorbornene monomers, polymers derived therefrom and their use in pervaporation 有权
标题翻译：环烷基降冰片烯单体，衍生自其的聚合物及其在全蒸发中的用途
公开(公告)号：US09468890B2
公开(公告)日：2016-10-18
申请号：US13959873
申请日：2013-08-06
申请人： Promerus, LLC
发明人： Andrew Bell , Leah Langsdorf , Oleksandr Burtovyy
IPC分类号： B01D15/00 , B01D39/00 , B01D39/14 , B01D63/00 , B01D71/82 , C07C13/42 , C07C13/465 , C07C13/50 , C07C13/547 , C07C13/573 , C07C13/605 , C07C13/61 , C07C13/615 , C07C13/64 , C07C13/68 , B01D67/00 , B01D69/02 , B01D69/08 , B01D69/12 , B01D71/44 , B01D71/76 , C08F232/08 , C07C13/40 , C07C13/54 , C07C29/76 , C07C37/82 , B01D61/36 , B01D71/26
CPC分类号： C08F232/08 , B01D61/362 , B01D67/0009 , B01D69/02 , B01D69/08 , B01D69/12 , B01D71/26 , B01D71/44 , B01D71/76 , B01D71/82 , B01D2325/20 , C07C13/40 , C07C13/42 , C07C13/465 , C07C13/47 , C07C13/50 , C07C13/54 , C07C13/547 , C07C13/573 , C07C13/605 , C07C13/61 , C07C13/615 , C07C13/64 , C07C13/68 , C07C29/76 , C07C37/82 , C07C2602/42 , C07C2603/10 , C07C2603/28 , C07C2603/62 , C07C2603/64 , C07C2603/66 , C07C2603/74 , C07C2603/90 , C07C2603/91 , Y02E50/17 , C07C31/12 , C07C39/04
摘要： Embodiments in accordance with the present invention provide forming various polycycloalkyl polynorbornene polymers and copolymers which are useful for forming pervaporation membranes, the membranes themselves and methods of making such membranes.
摘要翻译：根据本发明的实施方案提供形成各种聚环烷基聚降冰片烯聚合物和共聚物，其可用于形成渗透蒸发膜，膜本身和制备这种膜的方法。

2. 发明申请

US20130109777A1 DENTAL COMPOSITION, KIT OF PARTS AND USE THEREOF 有权
标题翻译：牙齿组合物，零件套件及其用途
公开(公告)号：US20130109777A1
公开(公告)日：2013-05-02
申请号：US13807553
申请日：2011-06-24
申请人： Adrian S. Eckert , Michael M. Cub , Bettina Hailand , Marion B. Kestel , Karsten Dede , Uwe H. Hoheisel , Gioacchino Raia , Christoph Thalacker , Reinhold Hecht , Thomas Luchterhandt , Peter Bissinger , Wolf Steiger
发明人： Adrian S. Eckert , Michael M. Cub , Bettina Hailand , Marion B. Kestel , Karsten Dede , Uwe H. Hoheisel , Gioacchino Raia , Christoph Thalacker , Reinhold Hecht , Thomas Luchterhandt , Peter Bissinger , Wolf Steiger
IPC分类号： A61K6/083
CPC分类号： A61K6/083 , A61K6/0023 , A61K6/09 , C07C271/16 , C07C2603/64 , C07C2603/66 , C08L33/00 , C08L75/16
摘要： The invention relates to a dental composition comprising a) a compound (A) with the following features: only one backbone unit (U) with 6 to 20 carbon atoms, at least 6 carbon atoms thereof forming an aromatic or an aliphatic cyclic moiety, the remaining carbon atoms either being part of substituents pending from the cyclic moiety or being part of bridging groups to spacer units, wherein one or more of the remaining carbon atoms can be replaced by an oxygen atom, the backbone unit not comprising a bisphenol structure and halogen atoms, one or two unit(s) (S) being connected to the backbone unit (U) via an ether linkage, at least one unit (S) comprising a —CH2-CH2-CH2-CH2-O—CH2-CH(Q)-OG moiety or a —CH2-CH(OG)-CH2-OM moiety or a mixture of these two types of moieties within one unit (S), with G comprising at least one polymerizable moiety and an urethane moiety, the urethane moiety acting as connecting element to unit(s) (S), and M comprising at least one group selected from acroyl, methacroyl, aryl, mixtures and combinations thereof, Q comprising at least one group selected from hydrogen, methyl, phenyl, phenoxymethyl, mixtures and combinations thereof, and with the proviso that onto the backbone unit (U) at least two substituents are attached, each bearing at least one group G, wherein in the case where only one unit (S) is present, the group G not being part of said unit (S) is located in the further substituent pending from unit (U), b) a filler (B) and c) an initiator (C).
摘要翻译：本发明涉及牙科用组合物，其包含a）具有以下特征的化合物（A）：只有一个具有6至20个碳原子的骨架单元（U），其至少6个碳原子形成芳族或脂族环状部分，剩余的碳原子是作为从环状部分悬挂的取代基的一部分或作为间隔基单元的桥连基团的一部分，其中一个或多个剩余的碳原子可被氧原子代替，所述主链单元不包含双酚结构和卤素原子，一个或两个单元（S）经由醚键连接至主体单元（U），至少一个包含-CH 2 -CH 2 -CH 2 -CH 2 -O-CH 2 -CH（CH 3） Q）-OG部分或-CH2-CH（OG）-CH2-OM部分或这些两种类型的部分在一个单位（S）内的混合物，其中G包含至少一个可聚合部分和氨基甲酸酯部分，氨基甲酸酯用作单元（S）的连接元件的部分，和M包含至少一个选自丙酰基，甲基的基团包括至少一个选自氢，甲基，苯基，苯氧基甲基，其混合物和组合的基团，并且条件是在主链单元（U）上连接至少两个取代基，每个具有至少一个基团G，其中在仅存在一个单元（S）的情况下，不是所述单元（S）的一部分的基团G位于从单元（U）悬挂的另外的取代基中，b）填料（B）和c）引发剂（C）。

3. 发明授权

US06689904B2 Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine 失效
标题翻译： 2-（羧基环丙基）甘氨酸的桥连三环类似物
公开(公告)号：US06689904B2
公开(公告)日：2004-02-10
申请号：US10185445
申请日：2002-06-27
申请人： Alexander Alexei Greenfield , John Anthony Butera
发明人： Alexander Alexei Greenfield , John Anthony Butera
IPC分类号： C07C6112
CPC分类号： C07D493/08 , C07C229/50 , C07C2603/64
摘要： This invention provides processes for preparing a group of novel bridged tricyclic compounds having the formula: wherein X is (CH2)n, O, S, SO, SO2 or CR1R2; n is 1 or 2; and R1 and R2 are, independently, hydrogen, halogen, hydroxy, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, or R1 and R2, taken together with the carbon to which they are attached, form cycloalkyl of three to six carbon atoms, an alkylidene of up to six carbon atoms or a carbonyl.
摘要翻译：本发明提供了制备一组具有下式的新型桥连三环化合物的方法：其中X是（CH 2）n，O，S，SO，SO 2或CR 1 R 2; n为1或2; R 1和R 2独立地是氢，卤素，羟基，1至6个碳原子的烷基，1至6个碳原子的烷氧基或R 1和R 2与它们所连接的碳形成3至6个碳原子的环烷基，最多6个碳原子的亚烷基或羰基。

4. 发明授权

US06472412B1 Compounds as PDE IV and TNF inhibitors 失效
标题翻译：化合物作为PDE IV和TNF抑制剂
公开(公告)号：US06472412B1
公开(公告)日：2002-10-29
申请号：US08592817
申请日：1996-01-26
申请人： Garry Fenton , Tahir Nadeem Majid , Malcolm Norman Palfreyman
发明人： Garry Fenton , Tahir Nadeem Majid , Malcolm Norman Palfreyman
IPC分类号： A61K3144
CPC分类号： C07D213/70 , C07C43/247 , C07C217/58 , C07C235/56 , C07C237/30 , C07C255/60 , C07C327/48 , C07C2601/08 , C07C2603/64 , C07C2603/66 , C07D213/65 , C07D213/69 , C07D213/75 , C07D213/79 , C07D213/81 , C07D213/82 , C07D213/89 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. The present invention is therefore directed to their pharmacological use for inhibiting TNF and/or cyclic AMP phosphodiesterase, pharmacological compositions comprising the compounds and methods for their preparation.
摘要翻译：本发明涉及[二（醚或硫醚）杂芳基或氟取代的芳基]化合物或其N-氧化物或其药学上可接受的盐，其可用于抑制TNF在治疗中的产生或生理作用患有与生理上有害的肿瘤坏死因子（TNF）过量相关的疾病状态的患者。本发明范围内的化合物还抑制环AMP磷酸二酯酶，并且可用于治疗与由下列疾病调节的病理状况相关的疾病状态：抑制环AMP磷酸二酯酶，这种疾病状态包括炎性和自身免疫疾病，特别是IV型环AMP磷酸二酯酶。因此，本发明涉及其用于抑制TNF和/或环AMP磷酸二酯酶的药理学用途，包含该化合物的药物组合物及其制备方法。

5. 发明授权

US08129537B2 Compounds as PDE IV and TNF inhibitors 失效
标题翻译：化合物作为PDE IV和TNF抑制剂
公开(公告)号：US08129537B2
公开(公告)日：2012-03-06
申请号：US12693791
申请日：2010-01-26
申请人： Garry Fenton , Tahir Nadeem Majid , Malcolm Norman Palfreyman
发明人： Garry Fenton , Tahir Nadeem Majid , Malcolm Norman Palfreyman
IPC分类号： C07D211/72 , A61K31/44
CPC分类号： C07D213/70 , C07C43/247 , C07C217/58 , C07C235/56 , C07C237/30 , C07C255/60 , C07C327/48 , C07C2601/08 , C07C2603/64 , C07C2603/66 , C07D213/65 , C07D213/69 , C07D213/75 , C07D213/79 , C07D213/81 , C07D213/82 , C07D213/89 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF).Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. The present invention is therefore directed to their pharmacological use for inhibiting TNF and/or cyclic AMP phosphodiesterase, pharmacological compositions comprising the compounds and methods for their preparation.
摘要翻译：本发明涉及[二（醚或硫醚）杂芳基或氟取代的芳基]化合物或其N-氧化物或其药学上可接受的盐，其可用于抑制TNF在治疗中的产生或生理作用患有与生理上有害的肿瘤坏死因子（TNF）过量相关的疾病状态的患者。本发明范围内的化合物还抑制环AMP磷酸二酯酶，并且可用于治疗与通过抑制环AMP磷酸二酯酶调节的病理状况相关的疾病状态，所述疾病状态包括炎性和自身免疫性疾病，特别是IV型环AMP 磷酸二酯酶。因此，本发明涉及其用于抑制TNF和/或环AMP磷酸二酯酶的药理学用途，包含该化合物的药物组合物及其制备方法。

6. 发明申请

US20080132706A1 Compounds as PDE IV and TNF Inhibitors 失效
标题翻译：化合物作为PDE IV和TNF抑制剂
公开(公告)号：US20080132706A1
公开(公告)日：2008-06-05
申请号：US11764317
申请日：2007-06-18
申请人： Garry FENTON , Tahir Nadeem MAJID , Malcolm Norman PALFREYMAN
发明人： Garry FENTON , Tahir Nadeem MAJID , Malcolm Norman PALFREYMAN
IPC分类号： C07D213/02 , C07C233/00
CPC分类号： C07D213/70 , C07C43/247 , C07C217/58 , C07C235/56 , C07C237/30 , C07C255/60 , C07C327/48 , C07C2601/08 , C07C2603/64 , C07C2603/66 , C07D213/65 , C07D213/69 , C07D213/75 , C07D213/79 , C07D213/81 , C07D213/82 , C07D213/89 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF).Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. The present invention is therefore directed to their pharmacological use for inhibiting TNF and/or cyclic AMP phosphodiesterase, pharmacological compositions comprising the compounds and methods for their preparation.
摘要翻译：本发明涉及[二（醚或硫醚）杂芳基或氟取代的芳基]化合物或其N-氧化物或其药学上可接受的盐，其可用于抑制TNF在治疗中的产生或生理作用患有与生理上有害的肿瘤坏死因子（TNF）过量相关的疾病状态的患者。本发明范围内的化合物还抑制环AMP磷酸二酯酶，并且可用于治疗与通过抑制环AMP磷酸二酯酶调节的病理状况相关的疾病状态，所述疾病状态包括炎性和自身免疫性疾病，特别是IV型环AMP 磷酸二酯酶。因此，本发明涉及其用于抑制TNF和/或环AMP磷酸二酯酶的药理学用途，包含该化合物的药物组合物及其制备方法。

7. 发明授权

US07138550B2 Bridged carbocyclic compounds and methods of making and using same 失效
标题翻译：桥联碳环化合物及其制备和使用方法
公开(公告)号：US07138550B2
公开(公告)日：2006-11-21
申请号：US10784377
申请日：2004-02-23
申请人： Richard Van Court Carr , Thomas John Markley , Atteye Houssein Abdourazak , John Anthony Marsella
发明人： Richard Van Court Carr , Thomas John Markley , Atteye Houssein Abdourazak , John Anthony Marsella
IPC分类号： C07C43/18 , C07C43/188 , G03C1/492
CPC分类号： G03F7/0046 , C07C31/42 , C07C41/01 , C07C43/196 , C07C2601/14 , C07C2602/42 , C07C2603/64 , C07D309/10 , G03F7/0395
摘要： Disclosed herein is a fluorinated bridged carbocyclic compound that can be polymerized by itself or with at least one other ethylenically unsaturated monomer to provide a polymer. The polymer may be used, for example, within a sub-300 nm photoresist composition. Also disclosed is a method to make the bridged carbocyclic compound.
摘要翻译：本文公开了氟化桥联的碳环化合物，其可以通过其本身或与至少一种其它烯属不饱和单体聚合以提供聚合物。聚合物可以用于例如300nm以下的光致抗蚀剂组合物中。还公开了制备桥连碳环化合物的方法。

8. 发明申请

US20030022930A1 Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport 失效
标题翻译： 2-（羧基环丙基）甘氨酸的桥连三环类似物作为谷氨酸转运抑制剂
公开(公告)号：US20030022930A1
公开(公告)日：2003-01-30
申请号：US10185489
申请日：2002-06-27
申请人： Wyeth
发明人： Gary Paul Stack , John Dunlop , Alexander Alexei Greenfield , Jonathan Laird Gross
IPC分类号： A61K031/403 , A61K031/381 , A61K031/343 , A61K031/198
CPC分类号： C07D493/08 , C07C229/50 , C07C2603/64
摘要： This invention provides compounds of the formula: 1 wherein X is (CH2)n, O, S, SO, SO2 or CR1R2; n is 1 or 2; R1 and R2 are H, halogen, hydroxy, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or R1 and R2, taken together form cycloalkyl of 3 to 6 carbon atoms, an alkylidene of up to 6 carbon atoms or a carbonyl; R3, R4 and R5 are H or alkyl of 1 to 6 carbon atoms; Z is H, alkyl of 1 to 6 carbon atoms, alkanoyl of 1 to 6 carbon atoms or alkoxycarbonyl of 2 to 7 carbon atoms; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods for their use in treating or preventing characterized by glutamate hypofunction, including schizophrenia, schizoaffective disorder and schizophreniform disorder, and for the treatment of cognitive deficits due to aging, stroke, Alzheimer's disease or other neurodegenerative diseases.
摘要翻译：本发明提供下式的化合物：其中X是（CH 2）n，O，S，SO，SO 2或CR 1 R 2; n为1或2; R 1和R 2为H，卤素，羟基，1至6个碳原子的烷基，1至6个碳原子的烷氧基，或者R 1和R 2一起形成3至6个碳原子的环烷基，最多6个碳原子的亚烷基或羰基; R3，R4和R5是H或1至6个碳原子的烷基; Z是H，1至6个碳原子的烷基，1至6个碳原子的烷酰基或2至7个碳原子的烷氧基羰基; 或其药学上可接受的盐，以及用于治疗或预防特征在于谷氨酸功能低下的药物组合物和方法，包括精神分裂症，分裂情感障碍和精神分裂症样疾病，以及用于治疗由于老化，中风，阿尔茨海默病引起的认知缺陷或其他神经变性疾病。

9. 发明授权

US3409644A Benzenesulfonyl ureas 失效
标题翻译：苯磺酰脲
公开(公告)号：US3409644A
公开(公告)日：1968-11-05
申请号：US46682165
申请日：1965-06-24
申请人： HOECHST AG
发明人： GERHARD MULLER , RUDOLF MERTEN , SOPHIE WIRTZ
IPC分类号： C07C311/54
CPC分类号： C07C311/59 , C07C2603/64

10. 发明授权

US08710113B2 Dental composition, kit of parts and use thereof 有权
标题翻译：牙科组成，零件套件及其用途
公开(公告)号：US08710113B2
公开(公告)日：2014-04-29
申请号：US13807553
申请日：2011-06-24
申请人： Adrian S. Eckert , Michael M. Cub , Bettina Hailand , Marion B. Kestel , Karsten Dede , Uwe H. Hoheisel , Gioacchino Raia , Christoph Thalacker , Reinhold Hecht , Thomas Luchterhandt , Peter Bissinger , Wolf Steiger
发明人： Adrian S. Eckert , Michael M. Cub , Bettina Hailand , Marion B. Kestel , Karsten Dede , Uwe H. Hoheisel , Gioacchino Raia , Christoph Thalacker , Reinhold Hecht , Thomas Luchterhandt , Peter Bissinger , Wolf Steiger
IPC分类号： A61K6/00 , B01F3/04 , C08F2/46 , C08G18/67 , C08G61/04
CPC分类号： A61K6/083 , A61K6/0023 , A61K6/09 , C07C271/16 , C07C2603/64 , C07C2603/66 , C08L33/00 , C08L75/16
摘要： The invention relates to a dental composition comprising a) a compound (A) with the following features: only one backbone unit (U) with 6 to 20 carbon atoms, at least 6 carbon atoms thereof forming an aromatic or an aliphatic cyclic moiety, the remaining carbon atoms either being part of substituents pending from the cyclic moiety or being part of bridging groups to spacer units, wherein one or more of the remaining carbon atoms can be replaced by an oxygen atom, the backbone unit not comprising a bisphenol structure and halogen atoms, one or two unit(s) (S) being connected to the backbone unit (U) via an ether linkage, at least one unit (S) comprising a —CH2-CH2-CH2-CH2-O—CH2-CH(Q)-OG moiety or a —CH2-CH(OG)-CH2-OM moiety or a mixture of these two types of moieties within one unit (S), with G comprising at least one polymerizable moiety and an urethane moiety, the urethane moiety acting as connecting element to unit(s) (S), and M comprising at least one group selected from acroyl, methacroyl, aryl, mixtures and combinations thereof, Q comprising at least one group selected from hydrogen, methyl, phenyl, phenoxymethyl, mixtures and combinations thereof, and with the proviso that onto the backbone unit (U) at least two substituents are attached, each bearing at least one group G, wherein in the case where only one unit (S) is present, the group G not being part of said unit (S) is located in the further substituent pending from unit (U), b) a filler (B) and c) an initiator (C).
摘要翻译：本发明涉及牙科用组合物，其包含a）具有以下特征的化合物（A）：只有一个具有6至20个碳原子的骨架单元（U），其至少6个碳原子形成芳族或脂族环状部分，剩余的碳原子是作为从环状部分悬挂的取代基的一部分或作为间隔基单元的桥连基团的一部分，其中一个或多个剩余的碳原子可被氧原子代替，所述主链单元不包含双酚结构和卤素原子，一个或两个单元（S）经由醚键连接至主体单元（U），至少一个包含-CH 2 -CH 2 -CH 2 -CH 2 -O-CH 2 -CH（CH 3） Q）-OG部分或-CH2-CH（OG）-CH2-OM部分或这些两种类型的部分在一个单位（S）内的混合物，其中G包含至少一个可聚合部分和氨基甲酸酯部分，氨基甲酸酯用作单元（S）的连接元件的部分，和M包含至少一个选自acroy的基团 Q，其包含至少一个选自氢，甲基，苯基，苯氧基甲基，其混合物和组合的基团，并且条件是在主链单元（U）上连接至少两个取代基各自具有至少一个基团G，其中在仅存在一个单元（S）的情况下，不是所述单元（S）的一部分的组G位于从单元（U）悬挂的另外的取代基中，b）填料（B）和c）引发剂（C）。

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