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1. 发明申请

US20170204037A1 Process for Making Cyclohexanone 有权
公开(公告)号：US20170204037A1
公开(公告)日：2017-07-20
申请号：US15324671
申请日：2015-08-03
申请人： ExxonMobil Chemical Patents Inc.
发明人： Christopher L. BECKER , Jason D. DAVIS , Jihad M. DAKKA , Kirk C. NADLER
IPC分类号： C07C45/82
CPC分类号： C07C45/006 , C07C7/005 , C07C7/04 , C07C7/12 , C07C37/74 , C07C37/82 , C07C45/79 , C07C45/82 , C07C2601/14 , Y02P20/52 , C07C49/403 , C07C39/04 , C07C13/28
摘要： Disclosed are processes for making cyclohexanone from a mixture comprising phenol, cyclohexanone, cyclohexylbenzene, and a catalyst poison component, comprising a step of removing at least a portion of the catalyst poison component to reduce poisoning of a hydrogenation catalyst used for hydrogenating phenol to cyclohexanone.

2. 发明授权

US09605203B2 Composition preventing the polymerization of ethylenically unsaturated monomers and the removal thereof before polymerization 有权
公开(公告)号：US09605203B2
公开(公告)日：2017-03-28
申请号：US15021994
申请日：2014-09-11
申请人： RHODIA OPERATIONS
发明人： Christelle Chretien , Lars Fischer , Stephan Verdier , Jacques Cavezzan
IPC分类号： C07C39/08 , C08F36/00 , C09K15/08 , C08F236/08 , C08F136/08 , C07C37/68 , C08F2/38 , C07C37/14 , C07C37/82 , C07C37/74
CPC分类号： C09K15/08 , C07C37/14 , C07C37/68 , C07C37/74 , C07C37/82 , C07C39/08 , C08F2/38 , C08F136/08 , C08F236/08 , C08F2/40
摘要： The invention describes a composition that inhibits the polymerization of ethylenically unsaturated monomers, including at least 98% by weight of 4-tert-butylcatechol (4-TBC), 0.03% to 0.2% by weight of catechol (PC), and at least one impurity selected among 3-tert-butylcatechol, tert-butylhydroquinone, 3,5-di-tert-butylcatechol and mixture thereof, the total quantity of said impurities and of the PC being 0.1% to 0.8% by weight of said composition. The invention also describes a method for removing said polymerization-inhibiting composition present in a mixture including at least one ethylenically unsaturated monomer.

3. 发明申请

US20160288090A1 MOLECULARLY IMPRINTED POLYMERS 审中-公开
标题翻译：分子印迹聚合物
公开(公告)号：US20160288090A1
公开(公告)日：2016-10-06
申请号：US15017737
申请日：2016-02-08
申请人： Commonwealth Scientific and Industrial Research Organisation , Monash University
发明人： Milton T. W. Hearn , Steven Langford , Kellie Louise Tuck , Simon Harris , Reinhard Ingemar Boysen , Victoria Tamara Perchyonok , Basil Danylec , Lachlan Schwarz , Jamil Chowdhury
IPC分类号： B01J20/26 , B01D15/38 , B01J20/30 , C07C37/82 , C08F226/06
CPC分类号： B01J20/268 , A23L5/273 , A23V2002/00 , A61K31/74 , B01D15/3852 , B01J20/26 , B01J20/3057 , C07B63/00 , C07C37/82 , C08F226/06 , Y10T442/10
摘要： The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.
摘要翻译：本发明提供了设计分子印迹聚合物（MIP）的方法，其可用于从一系列生物处理原料和废物中提取生物活性化合物。本发明还涉及通过本发明的方法设计的MIP。

4. 发明授权

US09452415B2 Sorbent comprising on its surface a cationic or protonizable aliphatic residue for the purification of organic molecules 有权
标题翻译：吸附剂在其表面上包含用于纯化有机分子的阳离子或可质子化的脂族残基
公开(公告)号：US09452415B2
公开(公告)日：2016-09-27
申请号：US14344718
申请日：2012-09-17
申请人： INSTRACTION GMBH
发明人： Markus Arendt , Björn Degel , Thomas Schwarz , Gerhard Stumm , Martin Welter
IPC分类号： B01J20/22 , B01J20/286 , B01D15/38 , B01J20/32 , C07D313/00 , C07B63/00 , C07D305/14 , C07H3/02 , C07H17/08 , C07D215/18 , C07D493/22 , C07C37/82 , A61K31/337 , A61K31/365 , A61K31/47 , A61K31/573 , A61K31/724 , C07C211/09 , C07C215/12 , C07C225/06 , C07D295/185
CPC分类号： B01J20/286 , A61K31/337 , A61K31/365 , A61K31/47 , A61K31/573 , A61K31/724 , B01D15/3804 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3255 , B01J20/328 , B01J20/3285 , B01J2220/80 , C07B63/00 , C07C37/82 , C07C211/09 , C07C215/12 , C07C225/06 , C07D215/18 , C07D295/185 , C07D305/14 , C07D313/00 , C07D493/22 , C07H3/02 , C07H17/08 , C07C39/30
摘要： The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic application.
摘要翻译：本发明涉及包含固体支持材料的吸附剂，其表面包含通式（I）的残基，其中所述残基通过共价单键连接到本体固体的表面上的官能团支撑材料本身或固体支撑材料表面上的聚合物膜。此外，本发明涉及根据本发明的吸着剂用于纯化有机分子，特别是药学活性化合物，优选在色谱应用中的用途。

5. 发明授权

US08884068B2 Phenol and cyclohexanone mixtures 有权
标题翻译：苯酚和环己酮混合物
公开(公告)号：US08884068B2
公开(公告)日：2014-11-11
申请号：US13814890
申请日：2011-08-16
申请人： Keith Holroyd Kuechler , Francisco Manuel Benitez
发明人： Keith Holroyd Kuechler , Francisco Manuel Benitez
IPC分类号： C07C49/403 , C07C39/04 , C07C37/86 , C07C45/85 , C07C37/08
CPC分类号： C07C49/403 , C07C37/08 , C07C37/82 , C07C37/86 , C07C39/04 , C07C45/85 , C07C407/00 , C07C2601/14 , Y02P20/52
摘要： Disclosed herein is a process for producing phenol. The process includes oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide. The oxidation composition may then be cleaved in the presence of an acid catalyst to produce a cleavage reaction mixture comprising the acid catalyst, phenol and cyclohexanone. At least a portion of the cleavage reaction mixture may be neutralized with a basic material to form a treated cleavage reaction mixture. In various embodiments, the cleavage reaction mixture contains 1 wt % to 30 wt % phenol, 1 wt % to 30 wt % cyclohexanone and a complexation product.
摘要翻译：本文公开了一种生产苯酚的方法。该方法包括氧化至少一部分包含环己基苯的进料以产生包含环己基-1-苯基-1-氢过氧化物的氧化组合物。然后可以在酸催化剂的存在下将氧化组合物切割，以产生包含酸催化剂，苯酚和环己酮的裂解反应混合物。裂解反应混合物的至少一部分可以用碱性物质中和以形成经处理的裂解反应混合物。在各种实施方案中，裂解反应混合物含有1重量％至30重量％的苯酚，1重量％至30重量％的环己酮和络合产物。

6. 发明申请

US20140094628A1 METHOD OF SEPARATING PHENOLIC COMPOUNDS IN SALIFIED FORM 有权
标题翻译：分解形式的酚醛化合物的方法
公开(公告)号：US20140094628A1
公开(公告)日：2014-04-03
申请号：US14099311
申请日：2013-12-06
申请人： Magali DESOUHANT-MASSACRET
发明人： Magali DESOUHANT-MASSACRET
IPC分类号： C07C41/34
CPC分类号： C07C41/34 , C07C37/82 , C07C41/36 , C07C43/23 , C07C39/04 , C07C39/07 , C07C39/06
摘要： The subject of the present invention is a method for separating phenolic compounds in salified form from a reaction medium comprising them. The method of the invention for separating phenolic compounds in salified form from an aqueous reaction medium resulting from the reaction of a phenolic compound and of glyoxylic acid in the presence of a base leading to a reaction medium comprising at least the excess of initial phenolic compound in salified form and the various mandelic compounds in salified form resulting from the reaction, is characterized by the fact that said reaction medium is brought into contact with a basic anion-exchange resin that leads to the selective attachment of the initial phenolic compound to said resin and to the recovery of an aqueous stream comprising the mandelic compounds in salified form resulting from the reaction, and that the phenolic compound in salified form attached to the resin is separated by a resin regeneration treatment.
摘要翻译：本发明的主题是从包含它们的反应介质中分离成盐形式的酚类化合物的方法。本发明的方法用于从碱性化合物与乙醛酸的反应产生的水性反应介质中分离成盐形式的酚类化合物，所述碱在导致至少包含过量的初始酚类化合物的反应介质的存在下进行，盐化形式和由反应产生的盐化形式的各种扁桃酸化合物的特征在于所述反应介质与碱性阴离子交换树脂接触，所述碱性阴离子交换树脂导致初始酚类化合物选择性连接到所述树脂上，回收包含由反应产生的盐化形式的扁桃酸化合物的水流，并且通过树脂再生处理分离与树脂附着的成盐形式的酚类化合物。

7. 发明授权

US08093302B2 Substituted tetralins as selective estrogen receptor-β agonists 失效
标题翻译：取代的四氢化萘作为选择性雌激素受体 - 激动剂
公开(公告)号：US08093302B2
公开(公告)日：2012-01-10
申请号：US11814806
申请日：2006-02-10
申请人： Elizabeth Marie Thomas , Bryan Hurst Norman , Julian Stanley Kroin
发明人： Elizabeth Marie Thomas , Bryan Hurst Norman , Julian Stanley Kroin
IPC分类号： A61K31/045 , A61K31/135 , A61K31/05 , A61K31/075 , C07C211/00 , C07C43/02 , C07C43/20 , C07C35/42 , C07C39/12
CPC分类号： C07C49/747 , C07B2200/07 , C07C37/82 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/1788 , C07C43/21 , C07C43/23 , C07C45/292 , C07C45/44 , C07C45/62 , C07C45/673 , C07C45/68 , C07C45/70 , C07C47/277 , C07C47/57 , C07C47/575 , C07C49/577 , C07C49/753 , C07C49/755 , C07C49/83 , C07C49/84 , C07C69/757 , C07C69/94 , C07C205/37 , C07C205/45 , C07C215/64 , C07C217/94 , C07C235/34 , C07C235/66 , C07C247/10 , C07C255/36 , C07C255/53 , C07C2603/16 , C07C2603/26 , C07D295/096 , C07D295/185 , C07D307/92 , C07D311/78 , C07C49/603
摘要： The present invention relates to novel tetralin ER-β agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-β mediated disease such as nocturia, obstructive uropathy, benign prostatic hypertrophy, obesity, dementia, hypertension, incontinence, colon cancer, prostate cancer, infertility, depression, leukemia, inflammatory bowel disease, and arthritis.
摘要翻译：本发明涉及新的四氢萘酮ER-＆bgr; 激动剂化合物，其药物组合物，以及这些化合物用于治疗ER- 介导性疾病如夜尿症，阻塞性尿失禁，良性前列腺肥大，肥胖症，痴呆，高血压，失禁，结肠癌，前列腺癌，不育症，抑郁症，白血病，炎性肠病和关节炎。

8. 发明申请

US20100258505A1 PROCESS AND APPARATUS FOR SIMULATED MOVING BED SEPARATION COMPRISING BYPASS LINES IN EVERY OTHER BED AND WITH A MODULATED BYPASS FLUID FLOW RATE 有权
标题翻译：用于模拟移动床分离的过程和装置，包括在任何其他床和旁路流体流量速率下的旁路线
公开(公告)号：US20100258505A1
公开(公告)日：2010-10-14
申请号：US12757101
申请日：2010-04-09
申请人： Xavier DECOODT , Gerard Hotier , Philibert Leflaive , Damien Leinekugel Le Cocq
发明人： Xavier DECOODT , Gerard Hotier , Philibert Leflaive , Damien Leinekugel Le Cocq
IPC分类号： B01D15/02
CPC分类号： B01D15/1828 , C07C7/13 , C07C37/82 , C07C15/08 , C07C9/00 , C07C15/073 , C07C39/07
摘要： A process for separating a feed F by simulated moving bed adsorption in a SMB device is described, the device comprising external bypass lines Li/i+1 which directly connect two successive plates Pi, Pi+1, the index i being either even or (exclusive of the foregoing) odd, along the whole length of the column, in order to flush said plates, in which each of the bypass lines Li/i+1 comprises automated means for regulating the flow rate in the bypass lines, the degree of opening of said regulating means being defined by the following three rules: a) establishing a flow rate corresponding to an oversynchronicity in the range 15% to 30% in all of the open bypass lines of zone 1; b) establishing a flow rate corresponding to the synchronicity to within plus or minus 8% in all of the open bypass lines of zones 2 and 3; c) establishing a flow rate corresponding to an oversynchronicity in the range 20% to 40% in all of the open bypass lines of zone 4.
摘要翻译：描述了一种通过SMB器件中的模拟移动床吸附分离进料F的方法，该装置包括直接连接两个连续的板Pi，Pi + 1的外部旁路管线Li / i + 1，索引i为偶数或（排除上述情况）奇数，为了冲洗所述板，其中每个旁路管线Li / i + 1包括用于调节旁路管线中的流量的自动装置，其程度所述调节装置的打开由以下三个规则定义：a）在区域1的所有开放旁路管线中建立对应于15％至30％范围内的超同步性的流量; b）在区域2和3的所有开放旁路管线中建立对应于同步性在±8％以内的流量; c）在区域4的所有开启旁路管线中建立对应于超时间差在20％至40％范围内的流量。

9. 发明申请

US20080188693A1 Mass Separation Method of Magnolol from Magnoliae Cortex Radix 有权
标题翻译：木兰木兰的大分离方法
公开(公告)号：US20080188693A1
公开(公告)日：2008-08-07
申请号：US11915721
申请日：2005-06-21
申请人： Jin Sook Kim , Yun Mi Lee , Dae Sik Jang
发明人： Jin Sook Kim , Yun Mi Lee , Dae Sik Jang
IPC分类号： C07C39/15
CPC分类号： C07C37/82 , C07C37/004 , C07C37/685 , C07C37/84 , C07C39/21
摘要： The present invention related to method for the mass separation of magnolol from Magnoliae cortex or Magnoliae radix. The method comprises the steps of: 1) crushing Magnoliae cortex or Magnoliae radix, extracting the crushed material with organic solvent, adding n-hexane to the extract so as to obtain a n-hexane layer; 2) concentrating the n-hexane layer in a water bath at a temperature of 30-40 ° C. and a revolution speed of 40-200 RPM under reduced pressure so as to form a crude crystal; and 3) removing the n-hexane from the crude crystal, completely dissolving the crude crystal in chloroform, adding n-hexane to the n-hexane-containing solution, and leaving the solution to stand at room temperature so as to recrystallize the solution. In the method, a column chromatography step which is necessarily carried out in the general separation process is omitted so that separation process steps are reduced, leading to a saving in separation time. Also, expensive equipment is not required, leading a reduction in separation cost. Accordingly, the method is effective for the mass separation of expensive magnolol.
摘要翻译：本发明涉及厚朴与厚朴与木兰质量分离的方法。该方法包括以下步骤：1）粉碎玉兰大麦或木兰，用有机溶剂萃取粉碎物，向提取液中加入正己烷，得到正己烷层; 2）将正己烷层在30-40℃的温度和40-200RPM的转速下在水浴中浓缩，以形成粗晶体; 3）从粗结晶中除去正己烷，将粗结晶完全溶解在氯仿中，向正己烷溶液中加入正己烷，使溶液在室温下静置，使溶液重结晶。在该方法中，省略了在一般的分离过程中必须进行的柱色谱步骤，从而减少了分离工艺步骤，从而节省了分离时间。此外，不需要昂贵的设备，导致分离成本的降低。因此，该方法对于昂贵的厚朴酚的质量分离是有效的。

10. 发明授权

US07112703B2 Production of bisphenol-A with reduced sulfur content 失效
标题翻译：生产具有降低硫含量的双酚A
公开(公告)号：US07112703B2
公开(公告)日：2006-09-26
申请号：US11043800
申请日：2005-01-26
申请人： Rainer Neumann , Ulrich Blaschke , Stefan Westernacher
发明人： Rainer Neumann , Ulrich Blaschke , Stefan Westernacher
IPC分类号： C07C39/16
CPC分类号： C07C37/20 , C07C37/70 , C07C37/82 , C07C37/84 , C08G64/06 , C07C39/16
摘要： A process for the production of bisphenol-A having low concentration of sulphur is disclosed. The process comprise a) reacting phenol with acetone in the presence of a sulfonic acid ion exchanger to form a product mixture containing water, bisphenol-A/phenol adduct, phenol and sulfurous particles, and b) filtering the product mixture to separate the sulfurous particles to obtain a purified product mixture that contains water, phenol and bisphenol-A/phenol adduct. In one embodiment of the process further comprise distilling the purified product mixture to remove the water to obtain a first material system that contains said adduct and phenol, crystallizing the adduct, and removing the phenol by filtration using a filtering apparatus to obtain crystalline adduct. In a yet additional embodiment the process comprise crystallizing the purified product mixture to obtain a second material system that contains crystalline adduct, water and phenol and removing the phenol and water by filtration using a filtering apparatus to obtain crystalline adduct.
摘要翻译：公开了一种生产低浓度硫的双酚A的方法。该方法包括a）在磺酸离子交换剂存在下使苯酚与丙酮反应，形成含有水，双酚A /苯酚加成物，苯酚和亚硫酸颗粒的产物混合物，和b）过滤产物混合物以分离出亚硫酸颗粒以获得含有水，苯酚和双酚A /苯酚加合物的纯化产物混合物。在该方法的一个实施方案中还包括蒸馏纯化的产物混合物以除去水以获得含有所述加合物和苯酚的第一材料体系，结晶加合物，并使用过滤装置通过过滤除去苯酚以获得结晶加合物。在另外的实施方案中，该方法包括使纯化的产物混合物结晶以获得含有结晶加合物，水和苯酚的第二材料体系，并使用过滤装置通过过滤除去苯酚和水以获得结晶加合物。

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