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1. 发明申请

US20060106017A1 NOVEL O-ACYLOXIME DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE 有权
标题翻译：新型O-亚氨基衍生物，其制备方法和含有其的药物组合物用于预防和治疗心血管疾病
公开(公告)号：US20060106017A1
公开(公告)日：2006-05-18
申请号：US11163383
申请日：2005-10-17
申请人： Tae-Sook JEONG , Woo-Song LEE , Hyung-Jae JEONG , Yong-Dae PARK , Jong-Min HAN , Hyoung-Chin KIM , Og-Sung MOON , Young-Suk WON
发明人： Tae-Sook JEONG , Woo-Song LEE , Hyung-Jae JEONG , Yong-Dae PARK , Jong-Min HAN , Hyoung-Chin KIM , Og-Sung MOON , Young-Suk WON
IPC分类号： A61K31/537 , A61K31/381 , A61K31/34 , A61K31/15 , C07C251/56 , C07D333/22 , C07D265/30
CPC分类号： C07C251/68 , C07C251/66 , C07D207/335 , C07D295/205 , C07D307/52 , C07D307/68 , C07D333/22 , C07D333/38
摘要： The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease. The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.
摘要翻译：本发明涉及新型O-酰氧基肟衍生物，其制备方法以及包含其的用于预防和治疗心血管疾病的药物组合物。根据本发明的O-酰氧基肟衍生物可以有价值地用于预防和治疗心血管疾病如高脂血症，冠状动脉心脏病，动脉粥样硬化和由Lp-PLA 2引起的心肌梗塞，因为它们具有优异的Lp-PLA 2的抑制作用。

2. 发明申请

US20050191567A1 Oxime ester photoinitiators 有权
公开(公告)号：US20050191567A1
公开(公告)日：2005-09-01
申请号：US11103194
申请日：2005-04-11
申请人： Kazuhiko Kunimoto , Hidetaka Oka , Masaki Ohwa , Junichi Tanabe , Hisatoshi Kura , Jean-Luc Birbaum
发明人： Kazuhiko Kunimoto , Hidetaka Oka , Masaki Ohwa , Junichi Tanabe , Hisatoshi Kura , Jean-Luc Birbaum
IPC分类号： G03F7/027 , A61K6/083 , B41M3/00 , C07C251/50 , C07C251/62 , C07C251/66 , C07C251/68 , C07C317/28 , C07C317/32 , C07C323/47 , C07C327/30 , C07D207/32 , C07D207/335 , C07D209/86 , C07D333/20 , C07D335/16 , C07D339/08 , C08F2/50 , G02B5/20 , G03F7/00 , G03F7/004 , G03F7/029 , G03F7/031 , G03F9/00
CPC分类号： C07D207/335 , A61K6/083 , B33Y70/00 , B41M3/003 , C07C251/66 , C07C251/68 , C07C317/32 , C07C323/47 , C07C327/30 , C07D209/86 , C07D333/20 , C07D335/16 , C07D339/08 , G03F7/0007 , G03F7/0045 , G03F7/031
摘要： Compounds of the formulae I, II, III, IV and V wherein R1 i.a. is C4-C9cycloalkanoyl, C1-C12alkanoyl, C4-C6alkenoyl, or benzoyl; R2 is for example phenyl, C1-C20alkyl, C3-C8cycloalkyl, C2-C20alkanoyl, or benzoyl; Ar1 is R4S-phenyl or NR5R6-phenyl, each of which optionally is substituted; or Ar1 i.a. is optionally substituted; or Ar1 is naphthyl or anthracyl each of which is unsubstituted or substituted; or Ar1 is benzoyl, naphthalenecarbonyl, phenanthrenecarbonyl, anthracenecarbonyl or pyrenecarbonyl, each of which is unsubstituted or substituted, or Ar1 is 3,4,5-trimethoxyphenyl, phenoxyphenyl or biphenyl; Ar2 i.a. is optionally substituted, or naphthyl or anthracyl, each of which is unsubstituted or substituted, x is 2 or 3; M1 when x is 2, for example is phenylene, naphthalene, anthracylene, each of which optionally is substituted; M1, when x is 3, is a trivalent radical; M2 for example is M3 is for example C1-C12alkylene, cyclohexylene, or phenylene; n is 1-20; R3 is for example hydrogen or C1-C12alkyl; R3′ i.a. is C1-C12alkyl; substituted or —O-interrupted C2-C6alkyl; R4 is for example hydrogen, or C1-C12alkyl; and R5 and R6 independently of each other i.a. are hydrogen, C1-C12alkyl, or phenyl; are suitable as photoinitiators in particular in resist applications.

3. 发明授权

US5180652A Light- and heat-sensitive composition, and recording material 失效
标题翻译：光和热敏组合物和记录材料
公开(公告)号：US5180652A
公开(公告)日：1993-01-19
申请号：US466906
申请日：1990-01-18
申请人： Jun Yamaguchi , Sadao Ishige , Kozo Sato , Shintaro Washizu , Isamu Itoh
发明人： Jun Yamaguchi , Sadao Ishige , Kozo Sato , Shintaro Washizu , Isamu Itoh
IPC分类号： G03F7/004 , B41M5/28 , C07C251/68 , G03F7/031 , G03F7/105
CPC分类号： G03F7/031 , B41M5/286 , C07C251/68 , G03F7/105 , Y10S430/116 , Y10S430/165
摘要： A light- and heat-sensitive composition which contains a photo-hardenable composition and at least one dye, a light- and heat-sensitive recording material which contains a support having the composition provided on at least one side thereof, and an image-forming process using the recording material are disclosed.
摘要翻译：一种光和热敏组合物，其含有光硬化组合物和至少一种染料，光敏和热敏记录材料，其含有在其至少一侧上提供的组合物的载体和成像公开了使用记录材料的方法。

4. 发明申请

US20120295904A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES 有权
标题翻译： HEMATOPOIETIC GROWTH FACTOR MIMETIC小分子化合物及其用途
公开(公告)号：US20120295904A1
公开(公告)日：2012-11-22
申请号：US13501622
申请日：2010-10-12
申请人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Bijan Pedram , Yixing Shen , Lino J. Valdez , Jillian Basinger , Virginia Heather Sharron Grant , Jason C. Pickens
发明人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Bijan Pedram , Yixing Shen , Lino J. Valdez , Jillian Basinger , Virginia Heather Sharron Grant , Jason C. Pickens
IPC分类号： C07D401/12 , C07D471/04 , A61K31/4545 , A61K31/454 , C07D403/12 , C12Q1/02 , C07D413/14 , A61K31/5377 , A61P7/00 , C12N5/078 , G01N21/76 , A61K31/506 , A61K31/496
CPC分类号： A61K31/15 , A61K31/167 , A61K31/18 , A61K31/245 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/421 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/438 , A61K31/4409 , A61K31/4418 , A61K31/4439 , A61K31/4468 , A61K31/4535 , A61K31/454 , A61K31/4747 , A61K31/495 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/541 , C07C233/78 , C07C233/80 , C07C235/56 , C07C237/40 , C07C237/42 , C07C243/38 , C07C247/18 , C07C251/48 , C07C251/66 , C07C251/68 , C07C251/86 , C07C271/28 , C07C311/08 , C07D207/12 , C07D207/27 , C07D207/273 , C07D207/32 , C07D207/327 , C07D207/34 , C07D207/416 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/24 , C07D209/34 , C07D209/42 , C07D211/46 , C07D211/58 , C07D213/12 , C07D213/53 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D231/26 , C07D231/40 , C07D231/56 , C07D233/60 , C07D233/61 , C07D233/90 , C07D235/06 , C07D235/14 , C07D235/20 , C07D235/24 , C07D235/30 , C07D237/24 , C07D239/28 , C07D241/04 , C07D241/24 , C07D249/04 , C07D261/18 , C07D263/04 , C07D263/16 , C07D263/57 , C07D265/36 , C07D277/56 , C07D285/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/68 , C07D317/62 , C07D317/68 , C07D333/24 , C07D333/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113
摘要： The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
摘要翻译：本实施方案涉及具有生理作用的化合物，例如造血生长因子受体的活化。本实施方案还涉及该化合物用于治疗多种病症，疾病和疾病如造血条件和病症的用途。

5. 发明授权

US07381842B2 Oxime ester photoinitiators 有权
公开(公告)号：US07381842B2
公开(公告)日：2008-06-03
申请号：US11103194
申请日：2005-04-11
申请人： Kazuhiko Kunimoto , Hidetaka Oka , Masaki Ohwa , Junichi Tanabe , Hisatoshi Kura , Jean-Luc Birbaum
发明人： Kazuhiko Kunimoto , Hidetaka Oka , Masaki Ohwa , Junichi Tanabe , Hisatoshi Kura , Jean-Luc Birbaum
IPC分类号： C07C251/60
CPC分类号： C07D207/335 , A61K6/083 , B33Y70/00 , B41M3/003 , C07C251/66 , C07C251/68 , C07C317/32 , C07C323/47 , C07C327/30 , C07D209/86 , C07D333/20 , C07D335/16 , C07D339/08 , G03F7/0007 , G03F7/0045 , G03F7/031
摘要： Compounds of the formulae I, II, III, IV and V wherein R1 i.a. is C4-C9cycloalkanoyl, C1-C12alkanoyl, C4-C6alkenoyl, or benzoyl; R2 is for example phenyl, C1-C20alkyl, C3-C8cycloalkyl, C2-C20alkanoyl, or benzoyl; Ar1 is R4S-phenyl or NR5R6-phenyl, each of which optionally is substituted; or Ar1 i.a. is optionally substituted; or Ar1 is naphthyl or anthracyl each of which is unsubstituted or substituted; or Ar1 is benzoyl, naphthalenecarbonyl, phenanthrenecarbonyl, anthracenecarbonyl or pyrenecarbonyl, each of which is unsubstituted or substituted, or Ar1 is 3,4,5-trimethoxyphenyl, phenoxyphenyl or biphenyl; Ar2 i.a. is optionally substituted, or naphthyl or anthracyl, each of which is unsubstituted or substituted, x is 2 or 3; M1 when x is 2, for example is phenylene, naphthalene, anthracylene, each of which optionally is substituted; M1, when x is 3, is a trivalent radical; M2 for example is M3 is for example C1-C12alkylene, cyclohexylene, or phenylene; n is 1-20; R3 is for example hydrogen or C1-C12alkyl; R3′ i.a. is C1-C12alkyl; substituted or —O-interrupted C2-C6alkyl; R4 is for example hydrogen, or C1-C12alkyl; and R5 and R6 independently of each other i.a. are hydrogen, C1-C12alkyl, or phenyl; are suitable as photoinitiators in particular in resist applications.

6. 发明授权

US06906121B2 4-nitrosodiphenylamine derivatives and their use as coupling agents for filled rubber compounds 失效
标题翻译： 4-亚硝基二苯胺衍生物及其作为填充橡胶化合物的偶联剂的用途
公开(公告)号：US06906121B2
公开(公告)日：2005-06-14
申请号：US10395591
申请日：2003-03-24
申请人： Joseph F. Stieber , Franklin H. Barrows
发明人： Joseph F. Stieber , Franklin H. Barrows
IPC分类号： B60C1/00 , C07D251/34 , C08K5/33 , C08K5/34 , C08K5/32
CPC分类号： C07C251/68 , B60C1/0016 , C07C251/66 , C07C2601/16 , C07D251/34 , C08K5/33 , C08L21/00
摘要： A composition of matter is disclosed that comprises a compound of the formula AnR, wherein: A is R1 is hydrocarbyl; m is 0 or 1; n is 1, 2, or 3; R is selected from the group consisting of: mono-, di-, and trivalent aliphatic groups; mono-, di-, and trivalent aromatic groups; five- and six-membered heterocyclic rings comprising n carbon atoms bonded to A, at least one nitrogen atom, and, optionally, at least one sulfur atom; and wherein R2 and R3 are independently selected from the group consisting of hydrogen and hydrocarbyl. These compounds are useful as coupling agents in filled elastomer compositions.
摘要翻译：公开了一种物质组合物，其包含式A N n R的化合物，其中：A为R 1为烃基; m为0或1; n为1,2或3; R选自：单 - ，二 - 和三价脂族基团; 单，二和三价芳基; 包含与A键合的n个碳原子，至少一个氮原子和任选地至少一个硫原子的五元和六元杂环; 并且其中R 2和R 3独立地选自氢和烃基。这些化合物可用作填充弹性体组合物中的偶联剂。

7. 发明授权

US4486601A Esters of 2-adamantanone oxime 失效
标题翻译： 2-金刚烷酮肟酯
公开(公告)号：US4486601A
公开(公告)日：1984-12-04
申请号：US524484
申请日：1983-08-19
申请人： C. Richard Kinsolving , Vassil St. Georgiev
发明人： C. Richard Kinsolving , Vassil St. Georgiev
IPC分类号： A61K31/19 , A61K31/215 , A61P29/00 , C07C251/44 , C07C131/02
CPC分类号： C07C251/66 , C07C251/68 , C07C255/57 , C07C2103/74
摘要： Esters of 2-adamantanone oxime are prepared and are disclosed as possessing anti-inflammatory activity and antiviral activity against murine hepatitis virus.
摘要翻译：制备2-金刚烷酮肟的酯，并公开为具有抗小鼠肝炎病毒的抗炎活性和抗病毒活性。

8. 发明授权

US08592081B2 Nonaqueous secondary battery and flame retardant for the same 有权
标题翻译：非水二次电池和阻燃剂相同
公开(公告)号：US08592081B2
公开(公告)日：2013-11-26
申请号：US13088666
申请日：2011-04-18
申请人： Hisayuki Utsumi
发明人： Hisayuki Utsumi
IPC分类号： H01M10/056
CPC分类号： H01M10/0525 , C07C239/22 , C07C251/68 , C07D207/404 , H01M10/0567
摘要： A nonaqueous secondary battery, comprising: a positive electrode; a negative electrode; and a nonaqueous electrolyte solution, the nonaqueous electrolyte solution containing as a flame retardant a compound of the general formula (I): wherein R1 and R2, which are the same or different, each represents a group that is selected from a hydrogen atom, a lower alkyl, lower alkenyl, lower alkoxy, lower alkoxycarbonyl, lower alkylcarbonyl, lower cycloalkyl or aryl group, and that may have a substituent, or R1 and R2 taken together are a methylene group that may have a substituent, or R1 and R2 taken together form a ring structure containing a nitrogen atom to which R1 and R2 are attached, the ring structure being a five-membered or six-membered hydrocarbon ring that may have one or two oxo groups, or a five-membered or six-membered heterocycle that may further contain a nitrogen atom; n is 0 or 1; when n is 0, R3 is a group that is selected from a hydrogen atom, a halogen atom, a lower alkyl, lower alkenyl, lower alkoxy, lower alkoxycarbonyl, lower alkylcarbonyl, lower cycloalkyl or aryl group, and that may have a substituent; and when n is 1, R3 and R4 are as defined for R1 and R2.
摘要翻译：一种非水二次电池，包括：正电极; 负极; 和非水电解液，所述非水电解质溶液含有通式（I）的化合物作为阻燃剂：其中相同或不同的R 1和R 2各自表示选自氢原子，低级烷基，低级烯基，低级烷氧基，低级烷氧基羰基，低级烷基羰基，低级环烷基或芳基，并且可以具有取代基，或者R 1和R 2一起是可以具有取代基的亚甲基，或者R 1和R 2一起形成含有R 1和R 2所连接的氮原子的环结构，所述环结构是可具有一个或两个氧代基的五元或六元烃环，或五元或六元杂环，其中可以进一步含有氮原子; n为0或1; 当n为0时，R 3为选自氢原子，卤素原子，低级烷基，低级烯基，低级烷氧基，低级烷氧基羰基，低级烷基羰基，低级环烷基或芳基，可以具有取代基的基团。当n为1时，R 3和R 4如对R 1和R 2所定义。

9. 发明授权

US08399662B2 O-acyloxime derivatives, preparation method thereof, and pharmaceutical composition containing the same for prevention and treatment of cardiovascular disease 有权
标题翻译： O-酰肟衍生物，其制备方法和含有该组合物的预防和治疗心血管疾病的药物组合物
公开(公告)号：US08399662B2
公开(公告)日：2013-03-19
申请号：US12614634
申请日：2009-11-09
申请人： Tae-Sook Jeong , Woo-Song Lee , Hyung-Jae Jeong , Yong-Dae Park , Jong-Min Han , Hyoung-Chin Kim , Og-Sung Moon , Young-Suk Won
发明人： Tae-Sook Jeong , Woo-Song Lee , Hyung-Jae Jeong , Yong-Dae Park , Jong-Min Han , Hyoung-Chin Kim , Og-Sung Moon , Young-Suk Won
IPC分类号： C07D295/10 , C07D333/38 , C07C229/00
CPC分类号： C07C251/68 , C07C251/66 , C07D207/335 , C07D295/205 , C07D307/52 , C07D307/68 , C07D333/22 , C07D333/38
摘要： The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease.The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.
摘要翻译：本发明涉及新型O-酰氧基肟衍生物，其制备方法以及包含其的用于预防和治疗心血管疾病的药物组合物。根据本发明的O-酰氧基肟衍生物可以用于预防和治疗由Lp-PLA2引起的高脂血症，冠状动脉心脏病，动脉粥样硬化和心肌梗塞等心血管疾病，因为它们具有优异的Lp- PLA2。

10. 发明申请

US20110256457A1 NONAQUEOUS SECONDARY BATTERY AND FLAME RETARDANT FOR THE SAME 有权
标题翻译：非等级二次电池及其阻燃剂
公开(公告)号：US20110256457A1
公开(公告)日：2011-10-20
申请号：US13088666
申请日：2011-04-18
申请人： Hisayuki UTSUMI
发明人： Hisayuki UTSUMI
IPC分类号： H01M10/056 , C07C251/68 , C07D403/12 , C07C259/06 , C07D207/46
CPC分类号： H01M10/0525 , C07C239/22 , C07C251/68 , C07D207/404 , H01M10/0567
摘要： A nonaqueous secondary battery, comprising: a positive electrode; a negative electrode; and a nonaqueous electrolyte solution, the nonaqueous electrolyte solution containing as a flame retardant a compound of the general formula (I): wherein R1 and R2, which are the same or different, each represents a group that is selected from a hydrogen atom, a lower alkyl, lower alkenyl, lower alkoxy, lower alkoxycarbonyl, lower alkylcarbonyl, lower cycloalkyl or aryl group, and that may have a substituent, or R1 and R2 taken together are a methylene group that may have a substituent, or R1 and R2 taken together form a ring structure containing a nitrogen atom to which R1 and R2 are attached, the ring structure being a five-membered or six-membered hydrocarbon ring that may have one or two oxo groups, or a five-membered or six-membered heterocycle that may further contain a nitrogen atom; n is 0 or 1; when n is 0, R3 is a group that is selected from a hydrogen atom, a halogen atom, a lower alkyl, lower alkenyl, lower alkoxy, lower alkoxycarbonyl, lower alkylcarbonyl, lower cycloalkyl or aryl group, and that may have a substituent; and when n is 1, R3 and R4 are as defined for R1 and R2.
摘要翻译：一种非水二次电池，包括：正电极; 负极; 和非水电解液，所述非水电解质溶液含有通式（I）的化合物作为阻燃剂：其中相同或不同的R 1和R 2各自表示选自氢原子，低级烷基，低级烯基，低级烷氧基，低级烷氧基羰基，低级烷基羰基，低级环烷基或芳基，并且可以具有取代基，或者R 1和R 2一起是可以具有取代基的亚甲基，或者R 1和R 2一起形成含有R 1和R 2所连接的氮原子的环结构，所述环结构是可具有一个或两个氧代基的五元或六元烃环，或五元或六元杂环，其中可进一步含有氮原子; n为0或1; 当n为0时，R 3为选自氢原子，卤原子，低级烷基，低级烯基，低级烷氧基，低级烷氧基羰基，低级烷基羰基，低级环烷基或芳基，可以具有取代基的基团。当n为1时，R 3和R 4如对R 1和R 2所定义。

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