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1. 发明授权

US09850268B2 Metathesis catalysts and methods thereof 有权
公开(公告)号：US09850268B2
公开(公告)日：2017-12-26
申请号：US14933741
申请日：2015-11-05
申请人： Massachusetts Institute of Technology , Trustees of Boston College
发明人： Amir H. Hoveyda , Hanmo Zhang , Ming Joo Koh , Richard Royce Schrock
IPC分类号： C07C17/275 , C07C45/63 , C07C37/62 , B01J31/22 , C07F11/00 , C07D333/54 , C07D209/10 , C07D209/48 , C07F5/02 , C07F7/18 , C07C17/266 , C07C17/269 , C07C17/278 , C07C17/10 , C07C17/14 , C07C17/361 , C07B37/04 , C07C17/02 , C07J9/00 , C07J51/00 , C07C67/307 , C07C67/333 , C07C41/30
CPC分类号： C07F11/00 , B01J31/2265 , B01J2231/543 , B01J2531/64 , B01J2531/66 , C07B37/04 , C07C17/02 , C07C17/10 , C07C17/14 , C07C17/266 , C07C17/269 , C07C17/275 , C07C17/278 , C07C17/361 , C07C21/14 , C07C21/18 , C07C22/08 , C07C37/62 , C07C41/30 , C07C45/63 , C07C67/307 , C07C67/333 , C07C69/753 , C07C2601/14 , C07C2603/26 , C07D209/10 , C07D209/48 , C07D333/54 , C07F5/025 , C07F7/1804 , C07J9/00 , C07J51/00 , C07C21/19 , C07C21/04 , C07C25/24 , C07C22/04 , C07C22/00 , C07C22/02 , C07C25/28 , C07C43/225 , C07C43/192 , C07C43/17 , C07C69/65 , C07C69/63
摘要： The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and Z-selectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and E-selectivity. In some embodiments, provided technologies are particularly useful for preparing alkenyl fluorides. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-a. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-b.

2. 发明申请

US20170087101A1 SEMIFLUORINATED COMPOUNDS 审中-公开
公开(公告)号：US20170087101A1
公开(公告)日：2017-03-30
申请号：US15280411
申请日：2016-09-29
申请人： NOVALIQ GMBH
发明人： Dieter SCHERER , Ralf GRILLENBERGER , Frank LÖSCHER , Hartmut VOSS
IPC分类号： A61K31/02 , A61K9/08 , A61F9/00 , A61K9/00
CPC分类号： A61K31/02 , A61F9/0008 , A61K9/0048 , A61K9/08 , A61K47/02 , C07C17/266 , C07C19/08 , A61K2300/00
摘要： The present invention is directed to certain semifluorinated compounds and to compositions comprising such compounds. The invention further provides the use of the compounds and of the compositions as medicaments for topical administration to the eye.

3. 发明授权

US09115043B2 Process for the preparation of benzonorbornenes 有权
标题翻译：制备苯并降冰片烯的方法
公开(公告)号：US09115043B2
公开(公告)日：2015-08-25
申请号：US13126380
申请日：2009-09-28
申请人： Denis Gribkov , Bjorn Antelmann , Fanny Giordano , Harald Walter , Alain De Mesmaeker
发明人： Denis Gribkov , Bjorn Antelmann , Fanny Giordano , Harald Walter , Alain De Mesmaeker
IPC分类号： C07C211/45 , C07C17/32 , C07C17/23 , C07C17/26 , C07C17/266 , C07C22/02 , C07C201/12 , C07C205/11 , C07C209/36 , C07C205/12
CPC分类号： C07C17/32 , C07C17/23 , C07C17/26 , C07C17/266 , C07C22/02 , C07C22/04 , C07C201/12 , C07C205/06 , C07C205/11 , C07C205/12 , C07C209/365 , C07C2601/10 , C07C2603/66 , C07C211/61
摘要： The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCI3, wherein X is chloro or bromo, to a compound of formula I1, or aa) reacting cyclopentadiene with CXCI3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula I1, wherein X is chloro, b) reacting the compound of formula I1 with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.
摘要翻译：本发明涉及一种制备9-二氯亚甲基-1,2,3,4-四氢-1,4-亚甲基 - 萘-5-基胺的新方法，该方法包括：a）使环戊二烯在自由基引发剂和其中X是氯或溴的CXCl 3，或aa）在金属催化剂存在下将环戊二烯与CXCl 3（其中X是氯）在式I化合物中反应，其中X是氯 b）使式I1化合物与碱在适当的溶剂存在下反应，得到式III化合物，c）并在1,2-脱氢-6-硝基苯存在下将式III化合物转化为式Ⅳ化合物，和d）在金属催化剂存在下氢化式Ⅳ化合物。

4. 发明授权

US08207381B2 Therapeutic compounds 有权
标题翻译：治疗化合物
公开(公告)号：US08207381B2
公开(公告)日：2012-06-26
申请号：US12027154
申请日：2008-02-06
申请人： Gerald B. Hammond , Bo Xu , Paula J. Bates
发明人： Gerald B. Hammond , Bo Xu , Paula J. Bates
IPC分类号： C07C33/42 , A61K31/45
CPC分类号： C07C69/007 , C07C17/266 , C07C17/269 , C07C33/42 , C07C33/426 , C07C33/483 , C07C43/225 , C07C69/78 , C07C271/14 , C07C2601/02 , C07C2601/14 , C07D317/20 , C07C21/22
摘要： The invention provides compounds of Formula (I): wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
摘要翻译：本发明提供式（I）化合物：其中R1和R2具有本文定义的任何值或具体值，以及包含这些化合物的组合物和包括施用这些化合物的治疗方法。

5. 发明申请

US20100197970A1 METHOD FOR PRODUCING NORBORNENE DERIVATIVE 失效
标题翻译：生产诺贝恩衍生物的方法
公开(公告)号：US20100197970A1
公开(公告)日：2010-08-05
申请号：US12669954
申请日：2008-07-29
申请人： Shinichi Komatsu , Toshikatsu Shoko , Tadahiro Kaminade
发明人： Shinichi Komatsu , Toshikatsu Shoko , Tadahiro Kaminade
IPC分类号： C07F9/28 , C07C4/24
CPC分类号： C07C13/605 , C07C2/86 , C07C2/861 , C07C17/266 , C07C2531/24 , C07C2602/42 , C07C2603/86 , C07C2603/90 , C07C13/42 , C07C13/68 , C07C13/64 , C07C25/24
摘要： A method for producing a norbornene derivative wherein, in the presence of palladium and at least one selected from phosphorus compounds represented by the following General Formulae (1) and (2): [in Formula (1), R1, R2, R3 and R4 each independently represent a hydrogen atom or the like, and R5 and R6 each independently represent a branched chain saturated hydrocarbon group having 3 to 10 carbon atoms or the like], and [in Formula (2), R7 represents a branched chain saturated hydrocarbon group having 3 to 10 carbon atoms], a norbornadiene derivative represented by the following General Formula (3): [in Formula (3), R8, R9, R10, R11 and R12 each independently represent a hydrogen atom or the like, l represents an integer of 0 or 1, m represents an integer of 0 or 1, and n represents an integer of 0 or 1], and a bromine compound represented by the following General Formula (4): [Chemical Formula 4] Br—Z—R13 (4) [in Formula (4), Z represents a phenylene group or the like, and R13 represents a hydrogen atom or the like] are reacted with each other, to thereby obtain a norbornene derivative represented by the following General Formula (5): [in Formula (5), R14, R15, R16, R17 and R18 each independently represent a hydrogen atom or the like, Z represents a phenylene group or the like, R19 represents a hydrogen atom or the like, l represents an integer of 0 or 1, m represents an integer of 0 or 1, and n represents an integer of 0 or 1], the norbornene derivative having a configuration of a substituent represented by Z in General Formula (5) that is an exo configuration.
摘要翻译：一种降冰片烯衍生物的制备方法，其中在钯和选自由以下通式（1）和（2）表示的磷化合物中的至少一种的存在下，[式（1）中，R 1，R 2，R 3和R 4 各自独立地表示氢原子等，R5和R6各自独立地表示碳原子数3〜10的支链饱和烃基等]，[式（2）中，R7表示支链饱和烃基具有3至10个碳原子]，由以下通式（3）表示的降冰片二烯衍生物：[式（3）中，R 8，R 9，R 10，R 11和R 12各自独立地表示氢原子等，l表示 0或1的整数，m表示0或1的整数，n表示0或1的整数]和由以下通式（4）表示的溴化合物：[化学式4] Br-Z-R13 （4）[式（4）中，Z表示亚苯基等，R 13表示亚苯基等代表氢原子等]彼此反应，从而得到由以下通式（5）表示的降冰片烯衍生物：[式（5）中，R 14，R 15，R 16，R 17和R 18各自独立地表示氢原子等，Z表示亚苯基等，R 19表示氢原子等，l表示0或1的整数，m表示0或1的整数，n表示0以上的整数， 1]表示的通式（5）中由Z表示的取代基的降冰片烯衍生物为外部构型。

6. 发明授权

US07282618B2 Method for the production of aryl alkenes 有权
标题翻译：芳基烯烃的制备方法
公开(公告)号：US07282618B2
公开(公告)日：2007-10-16
申请号：US10450379
申请日：2001-12-13
申请人： David Milstein , Haim Weissman , Xiao-Ping Song
发明人： David Milstein , Haim Weissman , Xiao-Ping Song
IPC分类号： C07C2/68
CPC分类号： C07C67/343 , C07C2/84 , C07C17/266 , C07C2527/13 , C07C2531/18 , C07C2531/20 , C07C2531/22 , C07C15/46 , C07C22/08 , C07C69/65 , C07C69/618 , C07C69/734
摘要： The present invention relates to a novel oxidative coupling arenes with olefins to yield aryl alkenes, which uses ruthenium (Ru) or Osmium (Os) compounds as catalysts.
摘要翻译：本发明涉及一种新型的具有烯烃的氧化偶联芳烃以产生芳基烯烃，其使用钌（Ru）或锇（Os）化合物作为催化剂。

7. 发明授权

US07125589B1 Liquid crystal compound having hydrogen as a terminal group, composition comprising the compound, and liquid crystal display element comprising the composition 有权
标题翻译：具有氢作为末端基的液晶化合物，包含该化合物的组合物和包含该组合物的液晶显示元件
公开(公告)号：US07125589B1
公开(公告)日：2006-10-24
申请号：US10409104
申请日：2003-04-09
申请人： Keiji Kimura , Shuichi Matsui
发明人： Keiji Kimura , Shuichi Matsui
IPC分类号： C09K19/12 , C09K19/32 , C09K19/30 , C09K19/34 , C07C25/13
CPC分类号： C07C17/263 , C07C17/2632 , C07C17/266 , C07C17/35 , C07C17/354 , C07C25/18 , C07C25/22 , C07C25/24 , C09K19/12 , C09K19/14 , C09K19/3001 , C09K19/322 , C09K19/3402 , C09K19/42 , C09K2019/124 , C09K2019/3422 , Y10T428/10
摘要： A compound represented by the following formula (1), a composition comprising the composition and an element comprising the composition: Ra is alkyl having 1 to 15 carbons and so forth; A1, A2 and A3 are 1,4-cyclohexylene and so forth; Z1, Z2 and Z3 are a single bond and so forth; n and m are 0 or 1; and phenyl having (F)p is phenyl, 2-fluorophenyl and so forth.
摘要翻译：由下式（1）表示的化合物，包含该组合物的组合物和包含该组合物的元素：Ra为碳原子数1〜15的烷基等; A 1，A 2和A 3是1,4-亚环己基等; Z 1，Z 2和Z 3是单键等等; n和m为0或1; 并且具有（F）P n的苯基是苯基，2-氟苯基等。

8. 发明授权

US06900285B2 Fluorene-containing polymers and compounds useful in the preparation thereof 失效
标题翻译：含有芴的聚合物和可用于其制备的化合物
公开(公告)号：US06900285B2
公开(公告)日：2005-05-31
申请号：US10318579
申请日：2002-12-13
申请人： Edmund P. Woo , William R. Shiang , Michael Inbasekaran , Gordon R. Roof , Mark T. Bernius , Weishi Wu
发明人： Edmund P. Woo , William R. Shiang , Michael Inbasekaran , Gordon R. Roof , Mark T. Bernius , Weishi Wu
IPC分类号： C07C17/26 , C07C17/266 , C07C25/22 , C07C25/24 , C07C43/225 , C07C69/00 , C07C211/48 , C07C211/52 , C08G61/00 , C08G61/02 , C08G61/10 , C09K11/06 , H01L51/00 , H01L51/30 , H01L51/42 , H01L51/50 , C08G75/00
CPC分类号： H01L51/0043 , C07C17/2637 , C07C17/266 , C07C25/22 , C07C25/24 , C07C211/48 , C07C2602/44 , C07C2603/18 , C08G61/00 , C08G61/02 , C08G61/10 , C09B69/105 , C09B69/109 , C09K11/06 , C09K2211/1408 , C09K2211/1416 , H01L51/0036 , H01L51/0037 , H01L51/0038 , H01L51/0039 , H01L51/0042 , H01L51/0052 , H01L51/0059 , H01L51/0062 , H01L51/007 , H01L51/0081 , H01L51/42 , H01L51/5012 , H01L2251/308 , Y10S428/917
摘要： A polymer comprising repeat units of the formula: wherein R1 is independently in each occurrence C1-20 hydrocarbyl or C1-20 hydrocarbyl containing one or more heteroatoms of S, N, O, P or Si or both R1 may form, with the 9-carbon of the fluorene ring, a C5-20 ring structure containing one or more heteroatoms of S, N, or O; R2 is independently in each occurrence C1-20 hydrocarbyl, C1-20 hydrocarbyloxy, C1-20 thioether, C1-20 hydrocarbyloxycarbonyl, hydrocarbylcarbonyloxy, or cyano; a is independently in each occurrence a number from about 0 to about 1; m is a number from about 1 to about 2; and n is a number from about 3 or greater.
摘要翻译：包含下式重复单元的聚合物：其中R 1在每次出现时独立地为含有一个或多个S，N的杂原子的烃基或C 1-20烃基，O，P或Si或两者R 1可以与芴环的9-碳形成含有一个或多个杂原子的C 5-20-20环结构， S，N或O; R 2在每次出现时独立地为C 1-20烃基，C 1-20烃氧基，C 1-20 >硫醚，C 1-20烃氧基羰基，烃基羰基氧基或氰基; a在每次出现时独立地为约0至约1的数; m为约1至约2的数; n为约3以上的数。

9. 发明申请

US20050010068A1 Use of microencapsulated transition metal reagents for reactions in supercritical fluids 审中-公开
标题翻译：使用微胶囊化的过渡金属试剂在超临界流体中的反应
公开(公告)号：US20050010068A1
公开(公告)日：2005-01-13
申请号：US10496662
申请日：2002-11-29
申请人： Andrew Holmes , Chandrashekar Ramarao , Richard Gordon , Steven Ley , Tessa Early
发明人： Andrew Holmes , Chandrashekar Ramarao , Richard Gordon , Steven Ley , Tessa Early
IPC分类号： B01J13/16 , B01J23/40 , B01J31/04 , B01J31/06 , B01J31/16 , B01J31/18 , B01J31/24 , B01J31/28 , B01J35/00 , C07B37/04 , C07B61/00 , C07C1/26 , C07C1/32 , C07C17/26 , C07C17/266 , C07C17/269 , C07C25/13 , C07C29/48 , C07C29/58 , C07C41/30 , C07C43/20 , C07C45/64 , C07C45/68 , C07C67/343 , C07C69/618 , C07C69/708 , C07C201/12 , C07C205/06 , C07C205/56 , C07C39/17
CPC分类号： B01J31/04 , B01J13/16 , B01J23/40 , B01J31/06 , B01J31/165 , B01J31/1805 , B01J31/24 , B01J31/28 , B01J35/0013 , B01J2231/4211 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2531/82 , B01J2531/922 , C07B37/04 , C07C1/26 , C07C1/321 , C07C1/325 , C07C17/263 , C07C17/266 , C07C17/269 , C07C29/48 , C07C41/30 , C07C45/64 , C07C45/68 , C07C67/343 , C07C201/12 , C07C2523/44 , C07C2531/04 , C07C2531/12 , Y02P20/544 , C07C15/14 , C07C25/18 , C07C69/734 , C07C69/618 , C07C69/65 , C07C205/06 , C07C205/56 , C07C43/205
摘要： There is provided processes for metal mediated reactions, particularly cross coupling and carbometallation reactions, wherein the metal is present as a catalyst system comprising a catalyst microencapsulated within a permeable polymer microcapsule shell and the reaction is carried out under super-critical or near super-critical conditions. Preferred metal-mediated cross coupling reactions include Heck, Suzuki, Sonogashira and Stille reactions. Preferred carbometallation reactions include hydroformylations.
摘要翻译：提供了用于金属介导的反应，特别是交叉偶联和金属金属化反应的方法，其中金属作为催化剂体系存在，该催化剂体系包含微囊化在可渗透的聚合物微胶囊壳内的催化剂，反应在超临界或接近超临界条件。优选的金属介导的交叉偶联反应包括Heck，Suzuki，Sonogashira和Stille反应。优选的金属化反应包括加氢甲酰化。

10. 发明申请

US20050004212A1 Aryl-substituted acyclic enediyne compounds 有权
标题翻译：芳基取代的无环烯烃化合物
公开(公告)号：US20050004212A1
公开(公告)日：2005-01-06
申请号：US10847667
申请日：2004-05-18
申请人： Ming-Jung Wu , Chi-Fong Lin
发明人： Ming-Jung Wu , Chi-Fong Lin
IPC分类号： C07C15/02 , C07C15/12 , C07C17/266 , C07C21/22 , C07C22/08 , C07C25/24 , C07C45/68 , C07C205/06 , C07C255/50 , C07C255/54 , C07C321/28 , C07C323/62 , C07D213/16 , C07D213/57 , C07D241/12 , C07D333/08 , C07D333/24 , C07C255/52 , A61K31/015 , C07C13/465 , C07C13/48
CPC分类号： C07D213/06 , C07C15/02 , C07C15/12 , C07C17/266 , C07C21/22 , C07C22/08 , C07C25/24 , C07C45/68 , C07C205/06 , C07C255/50 , C07C255/54 , C07C321/28 , C07C323/62 , C07D213/16 , C07D213/57 , C07D241/12 , C07D333/08 , C07D333/24 , C07C49/794
摘要： This invention provides aryl-substituted acyclic enediyne compounds of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1═R2═H; or R1 and R2 together form a moiety represented by the formula R3 represents a substituted or unsubstituted alkyl having 4-30 carbon atoms, or a substituted or unsubstituted aryl group having 3-30 carbon atoms; and R represents a substituted or unsubstituted aryl group having 3-30 carbon atoms; with the proviso that R3 is not butyl, pentyl, tetrahydropyranyloxymethyl, tetrahydropyranyloxypropyl or phenyl when R1═R2═H and R4 is o-cyanophenyl,; and with the proviso that R3 is not butyl when R1═R2═H and R4 is phenyl. The compounds of formula (I) are found to have inhibitory activities against topoisomerase I or act as a S phase or G2/M phase blocker.
摘要翻译：本发明提供式（I）的芳基取代的无环烯二炔化合物：或其药学上可接受的盐或溶剂合物，其中R1 = R2 = H; 或R 1和R 2一起形成由式R 3表示的部分表示取代或未取代的具有4-30个碳原子的烷基，或取代或未取代的具有3-30个碳原子的芳基; 并且R表示取代或未取代的具有3-30个碳原子的芳基; 条件是当R 1 = R 2 = H且R 4为邻 - 氰基苯基时，R 3不是丁基，戊基，四氢吡喃氧基甲基，四氢吡喃基氧基丙基或苯基; 并且条件是当R 1 = R 2 = H且R 4为苯基时，R 3不是丁基。发现式（I）化合物对拓扑异构酶I具有抑制活性或作为S期或G2 / M期阻滞剂。

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