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1. 发明申请

US20170173569A1 Fe-ppm Pd, Cu and/or Ni Nanoparticle-Catalyzed Reactions in Water 审中-公开
公开(公告)号：US20170173569A1
公开(公告)日：2017-06-22
申请号：US15379986
申请日：2016-12-15
申请人： Bruce H. Lipshutz , Sachin Handa
发明人： Bruce H. Lipshutz , Sachin Handa
IPC分类号： B01J23/89 , C07B31/00 , B01J37/00 , B01J23/745 , B01J35/00
CPC分类号： B01J23/8906 , B01J23/72 , B01J23/745 , B01J23/755 , B01J31/0202 , B01J31/0209 , B01J31/0225 , B01J31/04 , B01J31/068 , B01J31/2404 , B01J35/0013 , B01J37/009 , B01J37/16 , B01J2231/327 , B01J2231/4211 , B01J2231/4266 , B01J2231/64 , B01J2531/824 , B01J2531/842 , B01J2531/96 , C07B31/00 , C07B37/04 , C07C209/325 , C07C213/02 , C07C221/00 , C07C227/04 , C07C231/12 , C07C253/30 , C07C319/20 , C07C2601/14 , C07D209/12 , C07D211/90 , C07D213/30 , C07D213/61 , C07D215/40 , C07D235/18 , C07D249/04 , C07D249/06 , C07D277/48 , C07D295/192 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/12 , C07D471/04 , C07J41/0055 , C07C211/52 , C07C229/60 , C07C233/55 , C07C217/84 , C07C211/58 , C07C217/86 , C07C215/76 , C07C211/45 , C07C237/30 , C07C237/36 , C07C215/70 , C07C217/60 , C07C229/42 , C07C229/08 , C07C255/58 , C07C255/59 , C07C223/06 , C07C225/22 , C07C323/36
摘要： In one embodiment, the application discloses a composition for the reduction of an organic compound comprising a nitro group to form an organic compound comprising an amine group, the composition comprising: a) a transition metal salt; b) an iron salt; and c) a reducing agent; and methods for the use of such compositions, including Click chemistry and cross coupling reactions.

2. 发明申请

US20160347677A1 Surfactant-Enabled Transition Metal-Catalyzed Chemistry 审中-公开
标题翻译：表面活性剂的过渡金属催化化学
公开(公告)号：US20160347677A1
公开(公告)日：2016-12-01
申请号：US15167952
申请日：2016-05-27
申请人： MyCell Technologies, LLC
发明人： Volker Berl
IPC分类号： C07B37/00 , B01J31/24 , B01J31/18 , B01J31/28 , B01J31/02 , C07C1/32 , C07D211/02 , C07D223/04 , C07F7/18 , C07C67/343 , C07C41/30 , C07D213/74 , C07C209/10 , C07C17/26 , C07C209/18 , C07C209/08 , C07C221/00 , C07C231/12 , C07F7/08 , C07C273/18 , C07C253/30 , C07D249/06 , C07F5/02 , B01J31/22
CPC分类号： C07D311/72 , B01J31/0209 , B01J31/1805 , B01J31/22 , B01J31/2208 , B01J31/2278 , B01J31/24 , B01J31/2414 , B01J31/28 , B01J2231/4216 , B01J2231/4261 , B01J2231/4266 , B01J2231/44 , B01J2231/543 , B01J2531/824 , C07C1/321 , C07C2/861 , C07C17/26 , C07C41/30 , C07C67/343 , C07C209/08 , C07C209/10 , C07C209/16 , C07C209/18 , C07C221/00 , C07C227/18 , C07C231/12 , C07C253/30 , C07C273/1854 , C07C2531/24 , C07C2601/16 , C07C2603/74 , C07D211/02 , C07D213/74 , C07D223/04 , C07D249/06 , C07F7/1892 , C07C69/618 , C07C69/734 , C07C43/215 , C07C43/225 , C07C43/205 , C07C15/12 , C07C13/21
摘要： In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.
摘要翻译：在一个实施方案中，本申请公开了包含（a）至少1重量％/重量比混合物的水的混合物; （b）过渡金属催化剂; 和（c）一种或多种增溶剂; 以及使用这种混合物进行过渡金属介导的键形成反应的方法。

3. 发明申请

US20160038926A1 METAL NANO-CATALYSTS IN GLYCEROL AND APPLICATIONS IN ORGANIC SYNTHESIS 审中-公开
标题翻译：甘油中的金属纳米催化剂和有机合成中的应用
公开(公告)号：US20160038926A1
公开(公告)日：2016-02-11
申请号：US14654061
申请日：2013-12-20
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ PAUL SABATIER TOULOUSE 3
发明人： Montserrat GOMEZ , Emmanuelle TEUMA , Isabelle FAVIER , Faouzi CHAHDOURA
IPC分类号： B01J35/00 , B01J31/06 , B01J31/28 , B01J23/44 , B01J23/46 , B01J23/72 , C07C41/20 , C07C45/62 , C07C67/303 , C07D209/08 , C07D211/62 , C07C209/60 , C07D295/135 , C07D295/096 , C07C319/18 , C07D307/79 , C07D307/89 , C07D401/06 , C07C45/64 , C07D249/04 , C07D403/14 , C07D307/84 , C07D493/04 , C07D405/06 , C07D493/14 , C07D493/18 , C07D211/94 , C07D401/04 , C07C5/03 , B01J31/02
CPC分类号： B01J35/0013 , B01J23/44 , B01J23/464 , B01J23/72 , B01J31/0202 , B01J31/0267 , B01J31/0271 , B01J31/06 , B01J31/24 , B01J31/2404 , B01J31/28 , B01J35/023 , B01J2231/34 , B01J2231/4211 , B01J2231/4216 , B01J2231/4227 , B01J2231/4261 , B01J2231/4266 , B01J2231/4283 , B01J2231/4294 , B01J2231/641 , B01J2231/645 , B01J2531/16 , B01J2531/822 , B01J2531/824 , B01J2531/90 , B01J2540/32 , B22F1/0022 , B22F1/0062 , B22F9/26 , B82Y30/00 , B82Y40/00 , C07B37/04 , C07C5/03 , C07C41/20 , C07C45/62 , C07C45/64 , C07C67/303 , C07C209/60 , C07C319/18 , C07C2531/02 , C07C2531/28 , C07C2601/14 , C07D209/08 , C07D211/62 , C07D211/94 , C07D249/04 , C07D295/096 , C07D295/135 , C07D307/79 , C07D307/84 , C07D307/89 , C07D401/04 , C07D401/06 , C07D403/14 , C07D405/06 , C07D493/04 , C07D493/14 , C07D493/18
摘要： A catalytic system which is a suspension in glycerol of metal nanoparticles in at least one transition metal. The suspension also includes at least one compound stabilizing the metal nanoparticles, soluble in glycerol. The suspensions are obtained directly in glycerol. These are stable systems that can catalyse a reaction from an organic substrate, with high yields and activity, and excellent selectivity. Additionally, the use of the catalytic system for performing organic transformations such as hydrogenation or coupling reactions (formation of C—C, C—N, C—O, C—S . . . bonds), and for synthesizing polyfunctionnal molecules, in a single reactor, by multi-step, sequential or cascade reactions.
摘要翻译：催化体系，其是在至少一种过渡金属中的金属纳米颗粒的甘油中的悬浮液。悬浮液还包括至少一种稳定金属纳米颗粒的化合物，其可溶于甘油。悬浮液直接在甘油中获得。这些是可以以高产率和活性以及优异选择性催化有机底物的反应的稳定体系。另外，使用用于进行有机转化如氢化或偶联反应（形成C-C，C-N，C-O，C-S键）的催化体系，并用于合成多官能分子单反应器，通过多步，顺序或级联反应。

4. 发明授权

US08735630B2 Transition-metal-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions 有权
标题翻译：过渡金属催化的碳氮和碳 - 碳键形成反应
公开(公告)号：US08735630B2
公开(公告)日：2014-05-27
申请号：US13768124
申请日：2013-02-15
申请人： Massachusetts Institute of Technology
发明人： Stephen L. Buchwald , Kevin W. Anderson
IPC分类号： C07F9/50
CPC分类号： C07C51/367 , B01J31/2404 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2531/0266 , B01J2531/824 , B01J2531/847 , B01J2531/96 , C07B37/04 , C07B43/04 , C07C41/30 , C07C51/353 , C07C51/363 , C07C227/16 , C07C231/12 , C07C303/22 , C07C303/40 , C07D409/06 , C07F9/5022 , C07C65/105 , C07C63/331 , C07C63/72 , C07C311/16 , C07C229/60 , C07C233/65 , C07C309/30 , C07C43/215
摘要： One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.
摘要翻译：本发明的一个方面涉及过渡金属配体。本发明的第二方面涉及包含这些配体的催化剂在各种过渡金属催化的碳 - 杂原子和碳 - 碳键形成反应中的用途。本发明的方法提供了过渡金属催化反应的许多特征的改进，包括合适底物的范围，催化剂周转数，反应条件和效率。例如，在过渡金属催化下已经实现了改进：芳基胺化反应; 芳基酰胺化反应; 铃木联轴器和Sonogashira联轴器。在某些实施方案中，本发明涉及在含水溶剂系统中使用它们的催化剂和使用它们的方法。

5. 发明申请

US20130178632A1 Transition-Metal-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Forming Reactions 有权
公开(公告)号：US20130178632A1
公开(公告)日：2013-07-11
申请号：US13768124
申请日：2013-02-15
申请人： Massachusetts Institute of Technology
发明人： Stephen L. Buchwald , Kevin W. Anderson
IPC分类号： C07C51/367 , C07C41/30 , C07D409/06 , C07C51/353
CPC分类号： C07C51/367 , B01J31/2404 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2531/0266 , B01J2531/824 , B01J2531/847 , B01J2531/96 , C07B37/04 , C07B43/04 , C07C41/30 , C07C51/353 , C07C51/363 , C07C227/16 , C07C231/12 , C07C303/22 , C07C303/40 , C07D409/06 , C07F9/5022 , C07C65/105 , C07C63/331 , C07C63/72 , C07C311/16 , C07C229/60 , C07C233/65 , C07C309/30 , C07C43/215
摘要： One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

6. 发明授权

US08378145B2 Transition-metal-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions 有权
公开(公告)号：US08378145B2
公开(公告)日：2013-02-19
申请号：US12502749
申请日：2009-07-14
申请人： Stephen L. Buchwald , Kevin W. Anderson
发明人： Stephen L. Buchwald , Kevin W. Anderson
IPC分类号： C07F9/50
CPC分类号： C07C51/367 , B01J31/2404 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2531/0266 , B01J2531/824 , B01J2531/847 , B01J2531/96 , C07B37/04 , C07B43/04 , C07C41/30 , C07C51/353 , C07C51/363 , C07C227/16 , C07C231/12 , C07C303/22 , C07C303/40 , C07D409/06 , C07F9/5022 , C07C65/105 , C07C63/331 , C07C63/72 , C07C311/16 , C07C229/60 , C07C233/65 , C07C309/30 , C07C43/215
摘要： One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

7. 发明授权

US07847130B2 Ionic additive for catalysis in biphasic reaction systems 有权
标题翻译：用于双相反应体系催化的离子添加剂
公开(公告)号：US07847130B2
公开(公告)日：2010-12-07
申请号：US12438228
申请日：2007-08-21
申请人： David Cole-Hamilton , Simon Laurent Desset
发明人： David Cole-Hamilton , Simon Laurent Desset
IPC分类号： C07C45/28 , C07C5/03 , C09K3/00
CPC分类号： C07D233/58 , B01J31/0239 , B01J31/0244 , B01J31/0268 , B01J31/0284 , B01J31/2404 , B01J2231/321 , B01J2231/323 , B01J2231/4211 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2231/645 , B01J2231/72 , B01J2531/822 , B01J2531/985 , B01J2540/32 , C07B37/04 , C07C5/03 , C07C45/50 , C07C211/63 , C07D213/20 , C07D233/54 , C07C47/02
摘要： An additive for improving the rate of catalysis in biphasic reaction systems is disclosed. The additive is an ionic molecule comprising an organic cation such as a heterocyclic compound or a quaternary ammonium or phosphonium cation, and an anion which may be organic or inorganic. A process for improved catalysis in an aqueous biphasic system wherein the catalyst is substantially dissolved in the aqueous phase and the substrate is substantially contained in the non-aqueous phase is also described. A suitable additive is 1-octyl-3-methylimidazolium halide. Examples of suitable catalytic reactions include the hydrogenation, hydrosilation, hydroboration, hydrovinylation, hydroformylation, oxidation and hydroxycarbonylation of alkenes, and Heck, Suzuki, Stille, and Sonigashira coupling.
摘要翻译：公开了用于提高双相反应体系中催化速率的添加剂。添加剂是包含有机阳离子如杂环化合物或季铵或鏻阳离子的离子分子，以及可以是有机或无机的阴离子。还描述了在水相双相系统中改进催化的方法，其中催化剂基本上溶解在水相中，并且底物基本上包含在非水相中。合适的添加剂是1-辛基-3-甲基咪唑鎓卤化物。合适的催化反应的实例包括氢化，硅氢化，氢化，氢化，加氢甲酰化，烯烃的氧化和羟基羰基化，以及Heck，Suzuki，Stille和Sonigashira偶联。

8. 发明授权

US07847126B2 Process for preparing tertiary phosphines 有权
标题翻译：制备叔膦的方法
公开(公告)号：US07847126B2
公开(公告)日：2010-12-07
申请号：US11810374
申请日：2007-06-05
申请人： Florian Rampf , Hans-Christian Militzer
发明人： Florian Rampf , Hans-Christian Militzer
IPC分类号： C07F9/54 , C07F5/02 , C07F7/28
CPC分类号： C07B37/04 , B01J31/24 , B01J31/2404 , B01J31/2409 , B01J31/2414 , B01J31/2447 , B01J2231/4211 , B01J2231/4233 , B01J2231/4238 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2531/0205 , C07F9/5068 , C07F9/5442
摘要： The invention relates to a process for synthesizing tertiary phosphines by reacting halophosphines with organomagnesium compounds in the presence of copper compounds and optionally of salts.
摘要翻译：本发明涉及在铜化合物和任选的盐存在下使卤代膦与有机镁化合物反应合成叔膦的方法。

9. 发明申请

US20090318734A1 IONIC ADDITIVE FOR CATALYSIS IN BIPHASIC REACTION SYSTEMS 有权
标题翻译：用于催化反应体系的离子添加剂
公开(公告)号：US20090318734A1
公开(公告)日：2009-12-24
申请号：US12438228
申请日：2007-08-21
申请人： David Cole-Hamilton , Simon Laurent Desset
发明人： David Cole-Hamilton , Simon Laurent Desset
IPC分类号： C07C45/28 , C07C5/03 , C09K3/00
CPC分类号： C07D233/58 , B01J31/0239 , B01J31/0244 , B01J31/0268 , B01J31/0284 , B01J31/2404 , B01J2231/321 , B01J2231/323 , B01J2231/4211 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2231/645 , B01J2231/72 , B01J2531/822 , B01J2531/985 , B01J2540/32 , C07B37/04 , C07C5/03 , C07C45/50 , C07C211/63 , C07D213/20 , C07D233/54 , C07C47/02
摘要： An additive for improving the rate of catalysis in biphasic reaction systems is disclosed. The additive is an ionic molecule comprising an organic cation such as a heterocyclic compound or a quaternary ammonium or phosphonium cation, and an anion which may be organic or inorganic. A process for improved catalysis in an aqueous biphasic system wherein the catalyst is substantially dissolved in the aqueous phase and the substrate is substantially contained in the non-aqueous phase is also described. A suitable additive is 1-octyl-3-methylimidazolium halide. Examples of suitable catalytic reactions include the hydrogenation, hydrosilation, hydroboration, hydrovinylation, hydroformylation, oxidation and hydroxycarbonylation of alkenes, and Heck, Suzuki, Stille, and Sonigashira coupling.
摘要翻译：公开了用于提高双相反应体系中催化速率的添加剂。添加剂是包含有机阳离子如杂环化合物或季铵或鏻阳离子的离子分子，以及可以是有机或无机的阴离子。还描述了在水相双相系统中改进催化的方法，其中催化剂基本上溶解在水相中，并且底物基本上包含在非水相中。合适的添加剂是1-辛基-3-甲基咪唑鎓卤化物。合适的催化反应的实例包括氢化，硅氢化，氢化，氢化，加氢甲酰化，烯烃的氧化和羟基羰基化，以及Heck，Suzuki，Stille和Sonigashira偶联。

10. 发明授权

US5534635A Process for preparing pyridine-2-carboxamides 失效
标题翻译：制备吡啶-2-甲酰胺的方法
公开(公告)号：US5534635A
公开(公告)日：1996-07-09
申请号：US304460
申请日：1994-09-12
申请人： Michelangelo Scalone , Peter Vogt
发明人： Michelangelo Scalone , Peter Vogt
IPC分类号： B01J31/24 , C07B61/00 , C07D213/81 , C07D213/56
CPC分类号： B01J31/2452 , B01J31/0237 , B01J31/1845 , B01J31/2295 , B01J31/24 , B01J31/2404 , B01J31/2409 , B01J31/2414 , C07D213/81 , B01J2231/34 , B01J2231/4205 , B01J2231/4266 , B01J2231/4283 , B01J2531/0205 , B01J2531/824 , B01J2531/842 , B01J31/0235
摘要： It has been found that pyridine-2-carboxamides of the formula ##STR1## wherein R is amino or a residue convertible into amino, and pharmaceutically usable acid addition salts of that carboxamide in which R is amino can be prepared in a simple manner and in good yield by reacting 2,5-dichloropyridine in the presence of a palladium-phosphine catalyst with an alkyne of the formulaR.sup.1 --C.tbd.CH IIIwherein R.sup.1 is hydrogen, lower-alkyl, trimethylsilyl or the group --(R.sup.2)(R.sup.3)--COH and R.sup.2 and R.sup.3 each independently are hydrogen or lower-alkyl or together are cyclopentyl or cyclohexyl,oxidizing the resulting alkyne to give 5-chloropyridine-2-carboxylic acid and reacting this acid or a reactive functional derivative thereof with an amino compound of the formulaor with carbon monoxide and an amino compound of formula VI or with carbon monoxide and a lower alkanol which is optionally mixed with water and reacting the resulting acid or the resulting ester with an amino compound of formula VI. The compound of formula I in which R is amino is a known compound which is a reversible and highly active MAO-B inhibitor.
摘要翻译：已经发现，其中R是氨基或可转化成氨基的残基的式I的吡啶-2-甲酰胺和其中R是氨基的该甲酰胺的药学上可用的酸加成盐可以以简单的方式制备，在钯 - 膦催化剂存在下与式R 1 -C 3的CH 2 CH 3其中R 1是氢，低级烷基，三甲基甲硅烷基或 - （R 2）（R 3）基团的反应，使2,5-二氯吡啶反应， -COH和R 2和R 3各自独立地为氢或低级烷基或一起为环戊基或环己基，氧化得到的炔烃，得到5-氯吡啶-2-羧酸，并使该酸或其反应性官能衍生物与式或与一氧化碳和式VI的氨基化合物或一氧化碳和低级链烷醇反应，任选与水混合，并使所得酸或所得酯与式VI的氨基化合物反应。其中R是氨基的式I化合物是已知的化合物，其是可逆的和高活性的MAO-B抑制剂。

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