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1. 发明申请

US20140124083A1 Rigid Disposable Flow Path 审中-公开
标题翻译：刚性一次性流路
公开(公告)号：US20140124083A1
公开(公告)日：2014-05-08
申请号：US14153114
申请日：2014-01-13
申请人： EMD Millipore Corporation
发明人： Martin Morrissey , Neil Schauer
IPC分类号： F16L9/00
CPC分类号： F16L9/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00808 , B01J2219/00813 , B01J2219/00833 , B01J2219/00968 , B01L3/502707 , B01L3/502715 , B01L3/561 , B01L2200/027 , B01L2200/0689 , B01L2300/0887 , F16L9/127 , F16L9/133 , F16L9/22 , Y10T137/87153
摘要： A disposable flow path having a manifold system that provides pressure resistance for the disposable device. The disposable device is comprised of a first rigid plastic sheet and a second rigid plastic sheet. Each sheet has two major surfaces and a thickness between them. At least one sheet surface has flow channels formed in it. The flow channels extend away from a first major surface and beyond the normal plane of a second major surface of the sheet. The sheets are liquid tightly sealed to each other at their adjoining first major surfaces. When each sheet contains a flow channel, the flow channels are aligned and in register with each other. One or more fittings can be secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets. Alternatively, tubing is placed in the channels before the sheets are secured to one another.
摘要翻译：一次性流路，其具有为一次性装置提供耐压性的歧管系统。一次性装置包括第一刚性塑料片和第二刚性塑料片。每片具有两个主表面和它们之间的厚度。至少一个片材表面上形成有流动通道。流动通道远离第一主表面并超过板的第二主表面的法线平面。片材在相邻的第一主要表面彼此液体密封。当每个纸张包含流动通道时，流动通道对齐并彼此对准。一个或多个配件可以固定在两个液密封片的边缘处的流动通道中。或者，在片彼此固定之前，将管道放置在通道中。

2. 发明申请

US20170225163A1 GENERAL-PURPOSE RECONFIGURABLE CONDUIT AND REACTION CHAMBER MICROFLUIDIC ARRANGEMENTS FOR LAB-ON-CHIP AND MINIATURE CHEMICAL PROCESSING 审中-公开
公开(公告)号：US20170225163A1
公开(公告)日：2017-08-10
申请号：US15499767
申请日：2017-04-27
申请人： Lester F. LUDWIG
发明人： Lester F. LUDWIG
IPC分类号： B01L3/00 , B01J19/00 , G01N35/00
CPC分类号： B01L3/502738 , B01J19/0033 , B01J19/0093 , B01J2219/00835 , B01J2219/00871 , B01J2219/00873 , B01J2219/00894 , B01J2219/00905 , B01J2219/00932 , B01J2219/00957 , B01J2219/00959 , B01J2219/00961 , B01J2219/00968 , B01J2219/0097 , B01J2219/00986 , B01J2219/00997 , B01L3/502715 , B01L3/567 , B01L9/52 , B01L13/02 , B01L2200/10 , B01L2200/143 , B01L2200/146 , B01L2200/147 , B01L2300/0654 , B01L2300/0663 , B01L2300/0864 , B01L2300/0867 , B01L2300/18 , B01L2400/0421 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , B01L2400/086 , G01N35/00871 , G01N35/0092 , G01N2035/00346 , Y10T436/12
摘要： A general-purpose software-reconfigurable chemical process system useful in a wide range of applications is disclosed. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or small-scale chemical manufacturing.

3. 发明授权

US10067249B2 Disposable radiochemistry device with radiation dose recordal 有权
公开(公告)号：US10067249B2
公开(公告)日：2018-09-04
申请号：US14653907
申请日：2013-12-20
申请人： GE Healthcare Limited
发明人： Alok M. Srivastava , Victor Samper , Stefan Riese
IPC分类号： B01J19/00 , B01J19/24 , G01T1/10 , G01T7/00
CPC分类号： G01T7/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00927 , B01J2219/00954 , B01J2219/00968 , G01T1/10
摘要： Radiation-sensitive material embedded in a disposable radiochemistry device gives the device the additional capability of recording radiation dose, for readout at a later time. There is provided a device comprising means for the introduction of a precursor compound, means for the introduction of a radionuclide, a reaction vessel for reacting said precursor compound and said suitable source of a radionuclide to obtain a radiolabelled compound, and one or more pieces of radiation-sensitive material embedded into said device wherein at least one of said pieces is positioned to be exposed to radioactivity associated with said radiolabelled compound.

4. 发明申请

US20190176122A1 SYSTEMS AND METHODS FOR PRODUCING A CHEMICAL PRODUCT 审中-公开
公开(公告)号：US20190176122A1
公开(公告)日：2019-06-13
申请号：US16094091
申请日：2017-04-24
申请人： Purdue Research Foundation
发明人： Andy Koswara , Zoltan Kalman Nagy , Conor Douglas Parks
IPC分类号： B01J19/00 , C07D207/16 , C07C213/06
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00792 , B01J2219/0081 , B01J2219/00813 , B01J2219/00867 , B01J2219/00873 , B01J2219/0088 , B01J2219/00891 , B01J2219/00905 , B01J2219/00909 , B01J2219/00916 , B01J2219/00954 , B01J2219/00959 , B01J2219/00968 , B01J2219/0097 , B01J2219/00986 , B01J2219/00995 , B01J2219/00997 , C07C213/06 , C07D207/16
摘要： The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

5. 发明申请

US20150301204A1 DISPOSABEL RADIOCHEMISTRY DEVICE WITH RADIATION DOSE RECORDAL 审中-公开
标题翻译：具有放射剂量记录的放射性放射化学装置
公开(公告)号：US20150301204A1
公开(公告)日：2015-10-22
申请号：US14653907
申请日：2013-12-20
申请人： GE HEALTHCARE LIMITED
发明人： Alok M. SRIVASTAVA , Victor SAMPER , Stefan RIESE
IPC分类号： G01T7/00 , B01J19/00
CPC分类号： G01T7/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00927 , B01J2219/00954 , B01J2219/00968 , G01T1/10
摘要： Radiation-sensitive material embedded in a disposable radiochemistry device gives the device the additional capability of recording radiation dose, for readout at a later time. There is provided a device comprising means for the introduction of a precursor compound, means for the introduction of a radionuclide, a reaction vessel for reacting said precursor compound and said suitable source of a radionuclide to obtain a radiolabelled compound, and one or more pieces of radiation-sensitive material embedded into said device wherein at least one of said pieces is positioned to be exposed to radioactivity associated with said radiolabelled compound.
摘要翻译：嵌入在一次性放射化学装置中的辐射敏感材料为装置提供了记录辐射剂量的附加能力，以便稍后读出。提供了一种装置，其包括用于引入前体化合物的装置，用于引入放射性核素的装置，用于使所述前体化合物和所述合适的放射性核素源反应以获得放射性标记化合物的反应容器，以及一种或多种辐射敏感材料嵌入到所述装置中，其中至少一个所述片被定位成暴露于与所述放射性标记化合物相关的放射性。

6. 发明申请

US20120000566A1 RIGID DISPOSABLE FLOW PATH 审中-公开
标题翻译：刚性流通路径
公开(公告)号：US20120000566A1
公开(公告)日：2012-01-05
申请号：US13170926
申请日：2011-06-28
申请人： Martin Morrissey , Neil Schauer
发明人： Martin Morrissey , Neil Schauer
IPC分类号： F16L9/00
CPC分类号： F16L9/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00808 , B01J2219/00813 , B01J2219/00833 , B01J2219/00968 , B01L3/502707 , B01L3/502715 , B01L3/561 , B01L2200/027 , B01L2200/0689 , B01L2300/0887 , F16L9/127 , F16L9/133 , F16L9/22 , Y10T137/87153
摘要： The present invention provides a disposable rigid flow path which by itself or in conjunction with a clam shell or manifold system provides additional pressure resistance for the disposable device. In a first embodiment, the device is comprised of a first sheet of rigid plastic material and a second sheet of plastic material. Each sheet has a first major surface and a second major surface and a thickness between the first and second major surfaces. At least one and preferably both have flow channels formed in them. The flow channels are formed in the sheet(s) in manner such that the area of the sheet where the flow channels are formed extend away from the first major surface of the sheet and beyond the normal plane of the second major surface of the sheet. The first and second sheets are liquid tightly sealed to each other at their adjoining first major surfaces. In the embodiment where each sheet contains a flow channel, the flow channels of the two sheets are aligned and in register with each other. One or more fittings are secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets so as to function as an inlet, outlet or other port for the system. In another embodiment tubing is placed in the channels before the sheets are secured to one another.
摘要翻译：本发明提供了一次性刚性流动路径，其自身或与蛤壳或歧管系统结合为一次性装置提供额外的耐压性。在第一实施例中，该装置由第一片刚性塑料材料和第二片塑料材料构成。每个片材具有第一主表面和第二主表面以及第一和第二主表面之间的厚度。至少一个并且优选地两者都具有在其中形成的流动通道。流动通道以片材的形式形成，使得形成流动通道的片材的面积远离片材的第一主表面并超过片材的第二主表面的法线平面。第一和第二片在其邻接的第一主表面彼此液密地密封。在每个片材包含流动通道的实施例中，两个片材的流动通道彼此对齐并且彼此对准。一个或多个配件固定在两个液密封片的边缘处的流动通道中，以便用作系统的入口，出口或其他端口。在另一个实施例中，在片彼此固定之前，将管道放置在通道中。

7. 发明授权

US11835500B2 Device and method for changing solution conditions in serial flow 有权
公开(公告)号：US11835500B2
公开(公告)日：2023-12-05
申请号：US15518658
申请日：2015-10-13
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： Wayne F. Reed
IPC分类号： C08F2/00 , B01J19/24 , B01J19/00 , B01F33/81 , B01F33/80 , G01N30/78 , B01J4/00 , B01F35/21 , B01F35/71 , C12M1/34 , G01N1/38 , G01N15/02 , G01N15/00
CPC分类号： G01N30/78 , B01F33/811 , B01F35/2132 , B01F35/2133 , B01F35/7176 , B01J4/00 , B01J19/0093 , B01J19/245 , C12M1/34 , B01D2313/08 , B01F33/834 , B01J2219/00813 , B01J2219/00867 , B01J2219/00871 , B01J2219/00889 , B01J2219/00894 , B01J2219/00952 , B01J2219/00968 , B01J2219/00997 , G01N1/38 , G01N15/02 , G01N2015/0092
摘要： Disclosed herein is a device and method for changing the conditions of a solution flowing in a serial path. In particular, disclosed herein is a device that includes a chemical reactor, a first system, and a second system that are each serial to one another. Each of the first system and the second system include a mixing chamber, a solvent reservoir, a solvent pump, and one or more detectors. Also disclosed herein is a method for changing the condition of a solution that includes flowing a liquid sample in a path, serially mixing the sample with at least two discrete solvents while it flows through the path, and detecting the condition of the sample after it is mixed with each solvent.

8. 发明申请

US20170234842A1 DEVICE AND METHOD FOR CHANGING SOLUTION CONDITIONS IN SERIAL FLOW 审中-公开
公开(公告)号：US20170234842A1
公开(公告)日：2017-08-17
申请号：US15518658
申请日：2015-10-13
申请人： ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： Wayne F. Reed
IPC分类号： G01N30/78 , C12M1/34
CPC分类号： G01N30/78 , B01D2313/08 , B01F13/1016 , B01F15/0022 , B01F15/00227 , B01F15/0243 , B01F2013/1052 , B01J4/00 , B01J19/0093 , B01J19/245 , B01J2219/00813 , B01J2219/00867 , B01J2219/00871 , B01J2219/00889 , B01J2219/00894 , B01J2219/00952 , B01J2219/00968 , B01J2219/00997 , C12M1/34 , G01N1/38 , G01N15/02 , G01N2015/0092
摘要： Disclosed herein is a device and method for changing the conditions of a solution flowing in a serial path. In particular, disclosed herein is a device that includes a chemical reactor, a first system, and a second system that are each serial to one another. Each of the first system and the second system include a mixing chamber, a solvent reservoir, a solvent pump, and one or more detectors. Also disclosed herein is a method for changing the condition of a solution that includes flowing a liquid sample in a path, serially mixing the sample with at least two discrete solvents while it flows through the path, and detecting the condition of the sample after it is mixed with each solvent.

9. 发明授权

US09494259B2 Rigid disposable flow path 有权
标题翻译：刚性一次性流路
公开(公告)号：US09494259B2
公开(公告)日：2016-11-15
申请号：US14074815
申请日：2013-11-08
申请人： EMD Millipore Corporation
发明人： Martin Morrissey , Neil Schauer
IPC分类号： F16L9/127 , F16L9/00 , F16L9/133 , F16L9/22 , B01L3/00 , B01J19/00
CPC分类号： F16L9/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00808 , B01J2219/00813 , B01J2219/00833 , B01J2219/00968 , B01L3/502707 , B01L3/502715 , B01L3/561 , B01L2200/027 , B01L2200/0689 , B01L2300/0887 , F16L9/127 , F16L9/133 , F16L9/22 , Y10T137/87153
摘要： A disposable flow path having a manifold system that provides pressure resistance for the disposable device. The disposable device is comprised of a first rigid plastic sheet and a second rigid plastic sheet. Each sheet has two major surfaces and a thickness between them. At least one sheet surface has flow channels formed in it. The flow channels extend away from a first major surface and beyond the normal plane of a second major surface of the sheet. The sheets are liquid tightly sealed to each other at their adjoining first major surfaces. When each sheet contains a flow channel, the flow channels are aligned and in register with each other. One or more fittings can be secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets. Alternatively, tubing is placed in the channels before the sheets are secured to one another.
摘要翻译：一次性流路，其具有为一次性装置提供耐压性的歧管系统。一次性装置包括第一刚性塑料片和第二刚性塑料片。每片具有两个主表面和它们之间的厚度。至少一个片材表面上形成有流动通道。流动通道远离第一主表面并超过板的第二主表面的法线平面。片材在相邻的第一主要表面彼此液体密封。当每个纸张包含流动通道时，流动通道对齐并彼此对准。一个或多个配件可以固定在两个液密封片的边缘处的流动通道中。或者，在片彼此固定之前，将管道放置在通道中。

10. 发明申请

US20140090738A1 Rigid Disposable Flow Path 有权
公开(公告)号：US20140090738A1
公开(公告)日：2014-04-03
申请号：US14074815
申请日：2013-11-08
申请人： EMD Millipore Corporation
发明人： Martin Morrissey , Neil Schauer
IPC分类号： F16L9/127
CPC分类号： F16L9/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00808 , B01J2219/00813 , B01J2219/00833 , B01J2219/00968 , B01L3/502707 , B01L3/502715 , B01L3/561 , B01L2200/027 , B01L2200/0689 , B01L2300/0887 , F16L9/127 , F16L9/133 , F16L9/22 , Y10T137/87153
摘要： A disposable flow path having a manifold system that provides pressure resistance for the disposable device. The disposable device is comprised of a first rigid plastic sheet and a second rigid plastic sheet. Each sheet has two major surfaces and a thickness between them. At least one sheet surface has flow channels formed in it. The flow channels extend away from a first major surface and beyond the normal plane of a second major surface of the sheet. The sheets are liquid tightly sealed to each other at their adjoining first major surfaces. When each sheet contains a flow channel, the flow channels are aligned and in register with each other. One or more fittings can be secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets. Alternatively, tubing is placed in the channels before the sheets are secured to one another.

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