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1. 发明授权

US09751983B2 Flow reactor synthesis of polymers 有权
公开(公告)号：US09751983B2
公开(公告)日：2017-09-05
申请号：US15261441
申请日：2016-09-09
申请人： The Boeing Company
发明人： Patrick John Kinlen , Andrew M. Zweig
IPC分类号： C08F2/00 , C08F4/00 , C08F20/06 , C08G73/02 , B01J19/24
CPC分类号： C08G73/0266 , B01J19/0093 , B01J19/2415 , B01J19/242 , B01J19/2425 , B01J19/243 , B01J2219/00087 , B01J2219/00164 , B01J2219/00795 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00963 , B01J2219/24 , C09D179/02
摘要： A flow reactor system and methods having tubing useful as polymerization chamber. The flow reactor has at least one inlet and at least one mixing chamber, and an outlet. The method includes providing two phases, an aqueous phase and a non-aqueous phase and forming an emulsion for introduction into the flow reactor.

2. 发明申请

US20170101508A1 FLOW REACTOR SYNTHESIS OF POLYMERS 有权
公开(公告)号：US20170101508A1
公开(公告)日：2017-04-13
申请号：US15261441
申请日：2016-09-09
申请人： The Boeing Company
发明人： Patrick John Kinlen , Andrew M. Zweig
IPC分类号： C08G73/02 , B01J19/24
CPC分类号： C08G73/0266 , B01J19/0093 , B01J19/2415 , B01J19/242 , B01J19/2425 , B01J19/243 , B01J2219/00087 , B01J2219/00164 , B01J2219/00795 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00963 , B01J2219/24 , C09D179/02
摘要： A flow reactor system and methods having tubing useful as polymerization chamber. The flow reactor has at least one inlet and at least one mixing chamber, and an outlet. The method includes providing two phases, an aqueous phase and a non-aqueous phase and forming an emulsion for introduction into the flow reactor.

3. 发明申请

US20160327310A1 EFFICIENT DISSOCIATION OF WATER VAPOR IN ARRAYS OF MICROCHANNEL PLASMA DEVICES 审中-公开
标题翻译：水蒸汽在微波等离子体装置阵列中的有效分解
公开(公告)号：US20160327310A1
公开(公告)日：2016-11-10
申请号：US15150107
申请日：2016-05-09
申请人： The Board of Trustees of the University of Illinois
发明人： Zhen Dai , Thomas J. Houlahan , J. Gary Eden , Sung-Jin Park
IPC分类号： F24H1/18 , B01J19/08 , C01B3/04
CPC分类号： F24H1/186 , B01J19/0093 , B01J19/088 , B01J2219/00786 , B01J2219/00795 , B01J2219/00824 , B01J2219/0084 , B01J2219/00853 , B01J2219/0086 , B01J2219/00959 , B01J2219/0841 , B01J2219/0894 , C01B3/045 , C01B13/0207 , C01B2203/0861 , Y02E60/364
摘要： The invention provides methods and systems for water dissociation with microplasma generated in microchannel plasma arrays or chips. Preferred methods and systems introduce water vapor into a microchannel plasma array. Electrical power is applied to the microchannel plasma array to create a plasma chemical reaction of the water vapor in the micorchannel plasma array. Dissociated hydrogen and/or oxygen gas is collected at an output of the microchannel plasma array. The water vapor can be entrained in a carrier gas, but is preferably introduced without carrier gas. Direct introduction of water vapor has been demonstrated to provide efficiencies at an above 60%. The use of carrier gas reduces efficiency, but still exceeds efficiencies of prior methods discussed in the background.
摘要翻译：本发明提供了在微通道等离子体阵列或芯片中产生的用于水解离的微生物的方法和系统。优选的方法和系统将水蒸气引入微通道等离子体阵列。将电功率施加到微通道等离子体阵列以产生微通道等离子体阵列中的水蒸气的等离子体化学反应。在微通道等离子体阵列的输出处收集离解的氢和/或氧气。水蒸汽可以夹带在载气中，但优选在没有载气的情况下引入。已经证明直接引入水蒸汽提供了高于60％的效率。载气的使用降低了效率，但是仍然超过了在背景技术中讨论的现有方法的效率。

4. 发明申请

US20150376111A1 METHOD FOR PRODUCING NITROALKANES IN A MICROSTRUCTURED REACTOR 有权
标题翻译：在微结构反应器中生产硝基的方法
公开(公告)号：US20150376111A1
公开(公告)日：2015-12-31
申请号：US14768391
申请日：2014-04-25
申请人： BASF SE
发明人： Ralf BOEHLING , Michael HAYER , Alwin REHFINGER , Michael SCHELPER , Johann-Peter MELDER , Martin ERNST , Joaquim Henrique TELES
IPC分类号： C07C201/08
CPC分类号： C07C201/08 , B01J19/0093 , B01J2219/00792 , B01J2219/00795 , B01J2219/00824 , B01J2219/00826 , B01J2219/00831 , B01J2219/00835 , B01J2219/00842 , B01J2219/0086 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , Y02P20/582 , C07C205/02
摘要： The invention relates to a process for preparing nitroalkanes by reaction of at least one alkane with at least one nitrating agent in the gas phase, wherein the nitration is carried out in a microstructured reaction zone having parallel channels having hydraulic diameters of less than 2.5 mm and a total specific internal surface area of more than 1600 m2/m3 and the alkane and the nitrating agent are conveyed under a pressure of from 1 bar to 20 bar through the reaction zone and reacted at a temperature of from 150° C. to 650° C. and the reaction products are cooled downstream of the reaction zone and discharged and the at least one nitrating agent is introduced over from two to ten introduction points along the reaction zone.
摘要翻译：本发明涉及通过在气相中至少一种烷烃与至少一种硝化剂反应来制备硝基烷烃的方法，其中硝化在具有水力直径小于2.5mm的平行通道的微结构反应区中进行，以及超过1600m 2 / m 3的总比表面积和烷烃和硝化剂在1巴-20巴的压力下通过反应区输送，并在150℃至650℃的温度下反应并且反应产物在反应区的下游冷却并排出，并且将至少一种硝化剂沿着反应区引入二至十个引入点。

5. 发明申请

US20180311638A1 RECONFIGURABLE CHEMICAL SYNTHESIS SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20180311638A1
公开(公告)日：2018-11-01
申请号：US15953983
申请日：2018-04-16
申请人： Massachusetts Institute of Technology
发明人： Klavs F. Jensen , Dale Arlington Thomas, III
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J19/004 , B01J2219/00788 , B01J2219/00795 , B01J2219/00889 , B01J2219/00894 , B01J2219/00905 , B01L3/502 , B01L3/561 , B01L2200/026 , B01L2200/028 , B01L2400/0487
摘要： Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In some embodiments, the described systems comprise one or more fluidic connector units, wherein each fluidic connector unit comprises a plurality of flexible conduits. In certain cases, a system comprising one or more fluidic connector units is configured to synthesize a first chemical compound by providing a plurality of fluidic connections between a plurality of fluid outlets (e.g., outlets of chemical reagent sources, outlets of pumps) and a plurality of fluid inlets (e.g., inlets of reaction modules, inlets of pumps) through the plurality of flexible conduits. In certain cases, the system is subsequently reconfigured by resetting the system (e.g., disconnecting each fluidic connection) and/or configuring the system to synthesize a second, different chemical compound (e.g., disconnecting one or more fluidic connections and providing one or more additional fluidic connections). According to some embodiments, in order to avoid tangling the flexible conduits during reconfiguration of the system, the fluidic connections are disconnected according to certain inventive methods described herein. In certain embodiments, fluidic connections are disconnected in reverse order relative to the order in which they were formed (e.g., the newest fluidic connection is disconnected first, the oldest fluidic connection is disconnected last). In certain embodiments, certain fluidic connections are targeted for disconnection, and additional fluidic connections are disconnected if they overlap the targeted fluidic connections and were formed more recently than the targeted fluidic connections. The fluidic connection and/or disconnection steps may, in some embodiments, be performed by a robotic manipulator.

6. 发明申请

US20170181972A1 Microfluidic Liposome Synthesis, Purification and Active Drug Loading 审中-公开
公开(公告)号：US20170181972A1
公开(公告)日：2017-06-29
申请号：US15456111
申请日：2017-03-10
申请人： Renee Hood , Donald Lad DeVoe
发明人： Renee Hood , Donald Lad DeVoe
IPC分类号： A61K9/127 , B01J13/08 , B01J19/00 , A61K31/704
CPC分类号： A61K9/1277 , A61K9/1278 , A61K31/00 , A61K31/5415 , A61K31/704 , A61K31/7048 , A61K31/7068 , B01J13/08 , B01J19/0093 , B01J2219/00783 , B01J2219/00792 , B01J2219/00795 , B01J2219/0086 , B01J2219/00894 , B01J2219/00905
摘要： Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.

7. 发明授权

US09676735B2 Process for the preparation of efavirenz and devices suitable therefore 有权
公开(公告)号：US09676735B2
公开(公告)日：2017-06-13
申请号：US14837500
申请日：2015-08-27
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： Camille A. Correia , Kerry Gilmore , David Tyler McQuade , Peter H. Seeberger
IPC分类号： C07D265/18 , C07C265/12 , B01J19/00 , C07F1/08 , C07C29/00 , C07C29/68 , C07C45/00 , C07C33/50
CPC分类号： C07D265/18 , B01J19/0093 , B01J2219/00792 , B01J2219/00795 , B01J2219/0081 , B01J2219/00813 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/00963 , C07C29/00 , C07C29/42 , C07C29/68 , C07C33/50 , C07C45/00 , C07C45/46 , C07C265/12 , C07C2601/02 , C07F1/08 , C07C49/80
摘要： The invention relates to a process for the preparation of Efavirenz via an efficient transition metal catalyzed cyclization, to a device suitable to perform such process as well as to novel intermediates.

8. 发明申请

US20160311789A1 METHOD FOR PREPARING HIGH-QUALITY EPOXIDIZED FATTY ACID ESTER WITH MICRO-REACTION DEVICE 有权
标题翻译：用微反应装置制备高品质环氧化脂肪酸酯的方法
公开(公告)号：US20160311789A1
公开(公告)日：2016-10-27
申请号：US15201274
申请日：2016-07-01
申请人： NANJING TECH UNIVERSITY (CN)
发明人： Kai Guo , Zheng Fang , Xin Li , Ning Zhu , Li Wan , Wei He , Kai Zhang , Pingkai Ouyang
IPC分类号： C07D301/16 , B01J19/00
CPC分类号： C07D301/16 , B01J19/0093 , B01J2219/00795 , B01J2219/00873 , B01J2219/00889 , B01J2219/00905
摘要： A method for preparing a high-quality epoxidized fatty acid ester with a micro-reaction device, including: respectively pumping an aqueous hydrogen peroxide solution and a carboxylic acid at the same time into a first micro-mixer; after the reaction in the first micro-reactor, respectively pumping the output material and an unsaturated fatty acid ester into a second micro-mixer;completely mixing them and then introducing the mixture into a second micro-reactor; and after a complete reaction, water-rinsing the organic phase part of the resultant reaction liquid and drying the same to obtain the epoxidized fatty acid ester.
摘要翻译：完全混合，然后将混合物引入第二个微反应器; 在完全反应之后，水洗所得反应液的有机相部分并将其干燥，得到环氧化脂肪酸酯。

9. 发明授权

US07998418B1 Evaporator and concentrator in reactor and loading system 有权
标题翻译：蒸发器和浓缩器在反应堆和装载系统中
公开(公告)号：US07998418B1
公开(公告)日：2011-08-16
申请号：US11754623
申请日：2007-05-29
申请人： Joseph C. Matteo
发明人： Joseph C. Matteo
IPC分类号： B01L99/10 , G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： B01J19/0093 , B01J2219/00795 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00867 , B01J2219/00873 , B01J2219/0088 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/2575 , Y10T436/25875
摘要： An evaporator and concentrator in a reactor and loading system concentrates ions such as fluoride ions in some embodiments, and evaporates micro- to milliliter volumes of liquid solutions including intermediate and final product in other embodiments. It efficiently re-dissolves the evaporated solution generating a product, which is transferred to an external system as desired. The external system may be a micro-fluidic reactor system and/or loading system. The evaporator/concentrator has an input port for introducing liquids and solids. A capillary tube introduces gas, such as nitrogen gas, into a volume of solution contained within a v-vial, which produces an evaporating micro bubbler. A concentric tube, surrounding the capillary tube in some embodiments, introduces gas into the empty volume above the solution inside the v-vial, which is referred to as a vapor sweep. The vapor sweep assists in removing the evaporated solution from the v-vial through a vacuum tube.
摘要翻译：在一些实施方案中，反应器和负载系统中的蒸发器和浓缩器集中离子如氟离子，并且在其它实施方案中蒸发微至数毫升的液体溶液，包括中间体和最终产物。它有效地重新溶解产生产品的蒸发溶液，根据需要将其转移到外部系统。外部系统可以是微流体反应器系统和/或加载系统。蒸发器/浓缩器具有用于引入液体和固体的输入端口。毛细管将诸如氮气的气体引入包含在v型小瓶内的一定体积的溶液中，其产生蒸发的微型起泡器。在一些实施例中，围绕毛细管的同心管将气体引入V型瓶内溶液上方的空体积，这被称为蒸气扫描。蒸汽扫描有助于通过真空管从V型瓶中除去蒸发的溶液。

10. 发明申请

US20180221844A1 FLOW ELEMENT HAVING AN INTEGRATED CAPILLARY LINE FOR TRANSFERRING FLUIDS 审中-公开
公开(公告)号：US20180221844A1
公开(公告)日：2018-08-09
申请号：US15749616
申请日：2016-08-05
申请人： hte GmbH the high throughput experimentation company
发明人： Armin BRENNER , Oliver KOECHEL , Sebastian KEIM , Frank GUELLICH , Joerg BRASCHKAT
IPC分类号： B01J19/00 , G01N31/10 , B01J4/00 , B01J19/24
CPC分类号： B01J19/0093 , B01J4/008 , B01J19/0046 , B01J19/0073 , B01J19/243 , B01J19/2445 , B01J2219/00286 , B01J2219/0031 , B01J2219/00322 , B01J2219/00389 , B01J2219/00418 , B01J2219/00587 , B01J2219/00747 , B01J2219/00783 , B01J2219/00795 , B01J2219/00808 , B01J2219/00813 , B01J2219/00891 , G01N31/10
摘要： The invention relates to a flow element for transferring fluids comprising a capillary cartridge (1) having an integrated capillary line (3). The capillary cartridge according to the invention (1) has a ring-shaped channel (8) and securing grooves (6, 6′), wherein the flow element is characterized in that the capillary line (3) is arranged in the ring-shaped channel (8). The ends of the capillary lines (3) are connected to connection elements (9) in which securing grooves (6, 6′) are secured in a positive locking manner. The flow elements according to the invention contribute toward improved manageability and effectiveness of components. In a preferred embodiment, the flow elements are used as a distribution system in the form of a plurality of capillary cartridges (1-1, 1-2, . . . ). Such distribution systems are of technical importance in the field of catalyst testing apparatuses with reactors arranged in parallel.

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