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1. 发明申请

US20080187472A1 Magnetic bead-based arrays 审中-公开
标题翻译：磁珠阵列
公开(公告)号：US20080187472A1
公开(公告)日：2008-08-07
申请号：US12004806
申请日：2007-12-22
申请人： Chong H. Ahn , Hyoung J. Cho , Jin-Woo Choi
发明人： Chong H. Ahn , Hyoung J. Cho , Jin-Woo Choi
IPC分类号： B03C1/00
CPC分类号： B01F13/0076 , B01F3/08 , B01F5/0403 , B01F13/0001 , B01F13/0005 , B01F13/0077 , B01F2215/0037 , B01J19/0046 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/0054 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00655 , B01J2219/00659 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/0487 , B03C1/00 , B03C1/0332 , B03C1/034 , B03C1/28 , B03C2201/18 , B03C2201/26 , C40B40/06 , C40B40/10 , C40B70/00 , G01N30/6095 , G01N35/0098 , G01N2030/347 , H01F10/16 , H01F41/16 , H01F41/26 , H01F41/34 , G01N2030/0035
摘要： The present invention relates to magnetic particle separators using micromachined magnetic arrays and more particularly, to magnetic particle separators or manipulators using controlled magnetization on micromachined magnetic arrays for the separation of cells and other biological materials. The present invention also pertains to using such devices for the separation and analysis of biological materials for immunoassays, DNA sequencing, protein analysis, and biochemical detection applications. The present invention can also be viewed as a novel method for fabricating fully integrated permanent magnet components within any microelectromechanical system (“MEMS”) structures. The present invention also provides a magnetic particle separation and manipulation system for rapid separation and accurate manipulation of magnetic particles in two-dimensional electromagnetic arrays, which utilize high throughput biological analyses. A disposable cartridge can be produced in low cost using a low cost substrate such as plastic or other polymer, glass, or metal. Magnetic flux is generated by conventional or micromachined electromagnets a platform system consisting of magnetic flux sources, magnetic flux guidance, and a microprocessor control interface. By controlling direction of electric currents into inductors on the platform system, arbitrary magnetic poles can be generated on Permalloy structures of the cartridge to separate and manipulate magnetic particles. The magnetic particle separator and manipulator in the present invention can be easily combined with automated detection systems such as a fluorescent monitoring system.
摘要翻译：本发明涉及使用微加工磁阵列的磁性颗粒分离器，更具体地说，涉及使用微加工磁阵列上的受控磁化的磁性颗粒分离器或操纵器来分离细胞和其它生物材料。本发明还涉及使用这种装置来分离和分析用于免疫测定，DNA测序，蛋白质分析和生物化学检测应用的生物材料。本发明还可以被看作是在任何微机电系统（“MEMS”）结构内制造完全集成的永磁体部件的新方法。本发明还提供一种用于快速分离和精确操作二维电磁阵列中的磁性粒子的磁性粒子分离和操纵系统，其利用高通量生物分析。可以使用低成本的基材例如塑料或其它聚合物，玻璃或金属，可以低成本地生产一次性盒。磁通由常规或微机电电磁铁产生，由磁通源，磁通引导和微处理器控制接口组成的平台系统。通过控制平台系统中电感器的电流方向，可以在墨盒的坡莫合金结构上产生任意磁极，以分离和操纵磁性颗粒。本发明的磁粉分离器和机械手可以容易地与诸如荧光监视系统的自动检测系统组合。

2. 发明申请

US20070189972A1 Method of forming nanobubbles 审中-公开
标题翻译：形成纳米气泡的方法
公开(公告)号：US20070189972A1
公开(公告)日：2007-08-16
申请号：US10591977
申请日：2005-02-28
申请人： Kaneo Chiba , Masayoshi Takahashi
发明人： Kaneo Chiba , Masayoshi Takahashi
IPC分类号： A61K49/22 , A01G25/09
CPC分类号： A61K49/223 , B01F3/04439 , B01F3/04978 , B01F13/0005 , B01F2003/04858
摘要： The present invention relates to a method of forming nanobubbles that have potential utility in every industrial application and that impart special functions, especially to water. The present invention is a method of forming nanobubbles by applying physical irritation to microbubbles contained in a liquid so that the microbubbles are abruptly contracted to form nanobubbles.
摘要翻译：本发明涉及一种形成在每个工业应用中具有潜在效用并且特别赋予水的特殊功能的纳米气泡的方法。本发明是通过对包含在液体中的微泡进行物理刺激而形成纳米气泡的方法，使得微泡突然收缩以形成纳米气泡。

3. 发明申请

US20110240539A1 WATER TREATMENT SYSTEM 审中-公开
标题翻译：水处理系统
公开(公告)号：US20110240539A1
公开(公告)日：2011-10-06
申请号：US13128976
申请日：2009-09-10
申请人： Taisuke Nose , Yosuke Tashima , Yasushi Minamitani
发明人： Taisuke Nose , Yosuke Tashima , Yasushi Minamitani
IPC分类号： C02F1/78 , C02F101/10 , C02F101/30
CPC分类号： C02F1/4608 , B01F3/04241 , B01F3/04496 , B01F3/04503 , B01F5/0415 , B01F5/043 , B01F5/20 , B01F13/0001 , B01F13/0005 , C02F1/36 , C02F1/727 , C02F1/78 , C02F2001/46152 , C02F2201/003 , C02F2201/4619 , C02F2305/023
摘要： [Object] An object of the present invention is to provide a water treatment system capable of increasing the treatment rate by causing active species, such as radicals, produced by discharge to efficiently act on treatment water.[Solution] The water treatment system is characterized by including: at least a pair of cylindrical electrode 3 and a linear electrode 4 in a treatment chamber 2, the linear electrode 4 being disposed along the central axis of the cylindrical electrode 3; and treatment water mist supply means 7 for supplying treatment water in the form of mist composed of droplets having a particle diameter of 1500 μm or less to a discharge space generated by applying a high voltage between the cylindrical electrode 3 and the linear electrode 4.
摘要翻译：本发明的目的是提供一种水处理系统，其能够通过使由放电产生的活性物质例如自由基有效地作用于处理水来提高处理率。 [处理]水处理系统的特征在于，在处理室2中至少具有一对圆筒状电极3和线状电极4，沿着圆筒状电极3的中心轴配置线状电极4，以及处理用水雾供给装置7，用于将由粒径为1500μm以下的液滴形成的雾状的处理水供给到通过在圆筒状电极3和线状电极4之间施加高电压而产生的放电空间。

4. 发明申请

US20040167231A1 Method for producing W/O-type suspension 审中-公开
标题翻译：生产W / O型悬浮液的方法
公开(公告)号：US20040167231A1
公开(公告)日：2004-08-26
申请号：US10368563
申请日：2003-02-20
发明人： Tetsuo Kawagoe
IPC分类号： B01F003/08
CPC分类号： B01F3/0815 , B01F13/0001 , B01F13/0005 , B01F2003/0842
摘要： A method for producing W/O-type suspension may comprise: mixing water and oil to form water-oil mixture; and driving the water-oil mixture in a flow path so as to make the water-oil mixture into W/O-type emulsion in a static electrification condition. The flow path may include a metal heat exchanger. The method may further comprise: adding activity compound of hydrophobic nature into the water-oil mixture, the activity compound having atoms with an electronegativity higher than electronegativity of hydrogen; slowing down the driving of the water-oil mixture in the flow path so as to adsorb the activity compound on the surface of the heat exchanger; and cooling the heat exchanger on the opposite side of the emulsion while circulating the emulsion through the flow path so as to produce W/O-type suspension. The oil and the activity compound are preferably non-cognate.
摘要翻译：一种生产W / O型悬浮液的方法可包括：将水和油混合以形成水 - 油混合物; 并在流路中驱动水 - 油混合物，以便在静电充气条件下使水 - 油混合物成为W / O型乳液。流动路径可以包括金属热交换器。该方法还可以包括：将具有疏水性的活性化合物加入到水 - 油混合物中，该活性化合物具有电负性高于氢的电负性的原子; 减缓流路中的水 - 油混合物的驱动，以便将活性化合物吸附在热交换器的表面上; 并在乳液的相对侧冷却热交换器，同时使乳液循环通过流路，从而产生W / O型悬浮液。油和活性化合物优选是非同源的。

5. 发明申请

US20030031090A1 Micro chaotic mixer 有权
标题翻译：微混沌混合器
公开(公告)号：US20030031090A1
公开(公告)日：2003-02-13
申请号：US09923477
申请日：2001-08-07
申请人： University of California
发明人： Chih-Ming Ho , Patrick Tabeling , Yi-Kuen Lee , Joanne Helene Deval
IPC分类号： B01F013/00
CPC分类号： B01F13/0076 , B01F5/0618 , B01F5/0646 , B01F5/065 , B01F5/0654 , B01F5/0655 , B01F13/0001 , B01F13/0005 , B01F13/0006 , B01F13/0077 , Y10S366/01 , Y10S366/02
摘要： A micro mixer for use in a microdevice which utilizes time-varying force fields to induce bulk fluid and/or sample component motion leading to homogenization of sample components. Time-varying force fields employed includes at least one of a physical displacement field, electrical field, pressure field or magnetic field to generate transverse forces which induce the mixing of samples within the micro mixer.
摘要翻译：用于微型装置的微型混合器，其利用时变力场来诱导体液和/或样品组分运动，导致样品组分的均匀化。使用的时变力场包括物理位移场，电场，压力场或磁场中的至少一个，以产生诱导微混合器内的样品混合的横向力。

6. 发明申请

US20160175792A1 STIRRING DEVICE AND METHOD USING ELECTROSTATIC CHARGE 有权
标题翻译：振动装置和使用静电充电的方法
公开(公告)号：US20160175792A1
公开(公告)日：2016-06-23
申请号：US14574983
申请日：2014-12-18
申请人： FLEXTRONICS AP, LLC
发明人： Susan Abraham , Dennis Willie
IPC分类号： B01F15/00
CPC分类号： B01F13/0003 , B01F13/0005 , B01F13/0076
摘要： A stirring device and method for stirring a material using an applicator with an electrically controllable element placed on an outside surface of the applicator so that a controllable power source coupled to the electrically controllable element provides a controlled electrostatic charge to the element. The controlled electrostatic charge provided by the power source creates a variable electric field exterior to the outside surface of the applicator. The variable electric field induces a stirring movement to the material.
摘要翻译：一种搅拌装置和方法，用于使用具有放置在涂抹器外表面上的电可控元件的涂抹器搅拌材料，使得耦合到电可控元件的可控电源为元件提供受控的静电荷。由电源提供的受控静电电荷在施加器的外表面外部产生可变电场。可变电场引起对材料的搅拌运动。

7. 发明申请

US20140120604A1 Biological Detection System and Method of Use 审中-公开
标题翻译：生物检测系统及其使用方法
公开(公告)号：US20140120604A1
公开(公告)日：2014-05-01
申请号：US14110635
申请日：2012-04-06
申请人： Mauro Aguanno , Brian Barrett , Brian Chawke , Kieran Curran , Damian Curtin , Tara Dalton , Mark Davies , Xiaona Hou , David Kinahan , Damien King , Mark Korenke , Conor McCarthy , David McGuire , Michael Sayers , Noel Sirr , Ryan J. Talbot
发明人： Mauro Aguanno , Brian Barrett , Brian Chawke , Kieran Curran , Damian Curtin , Tara Dalton , Mark Davies , Xiaona Hou , David Kinahan , Damien King , Mark Korenke , Conor McCarthy , David McGuire , Michael Sayers , Noel Sirr , Ryan J. Talbot
IPC分类号： G01N21/64 , B01F13/00
CPC分类号： C12Q1/686 , B01F13/0005 , B01F13/0071 , B01F15/00214 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/143 , B01L2300/06 , B01L2300/0654 , B01L2300/0867 , G01N21/6428 , G01N35/00623 , G01N2021/6439 , G01N2021/6441 , G01N2035/00465 , G01N2201/062
摘要： Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.
摘要翻译：本文提供了一种生物检测系统和使用方法，其中生物检测系统包括用于组合至少两个液滴的至少一个混合器或液体桥，以及用于检测是否适当混合或组合两个组分液滴的误差校正系统已经发生

8. 发明授权

US06482306B1 Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer 失效
标题翻译：介质和微流体连续流动和停止流动电渗流混合器
公开(公告)号：US06482306B1
公开(公告)日：2002-11-19
申请号：US09404454
申请日：1999-09-22
申请人： Paul Yager , Mark R. Holl , Andrew Kamholz , Catherine Cabrera , Katerina Macounova
发明人： Paul Yager , Mark R. Holl , Andrew Kamholz , Catherine Cabrera , Katerina Macounova
IPC分类号： B01F1300
CPC分类号： B01F13/0076 , B01F13/0001 , B01F13/0005 , B01F13/0077 , B01L3/5027 , Y10T137/2087 , Y10T137/2191
摘要： An electroösmotic mixing device and a method for mixing one or more fluids for use in meso- or microfluidic device applications. The mixing device provides batch or continuous mixing of one or more fluids in meso- or microfluidic channels. An electric field is generated in the channel in substantial contact with chargeable surfaces therein. No alterations of the geometry of existing flow paths need be made, and the degree of mixing in the device can be controlled by the length of the electrodes, the flow rate past the electrodes, and the voltage applied to those electrodes. The degree of mixing is affected by choice of materials for the chargeable surface (in some cases by the selection of materials or coatings for channel walls) and the ionic strength of the fluids and the type and concentration of ions in the fluids. The ionic strength of fluids to be mixed is sufficiently low to allow electroosmotic flow. The method and device of this invention is preferably applied to fluids to having low ionic strength less than or equal to about 1 mM.
摘要翻译：一种电渗混合装置和用于混合用于中等或微流体装置应用的一种或多种流体的方法。混合装置在中等或微流体通道中提供一种或多种流体的间歇或连续混合。在通道中产生与其中的可充电表面实质接触的电场。不需要改变现有流路的几何形状，并且可以通过电极的长度，通过电极的流速和施加到这些电极的电压来控制装置中的混合程度。混合的程度受到可充电表面的材料选择（在某些情况下通过选择通道壁的材料或涂层）以及流体的离子强度以及流体中离子的类型和浓度的影响。要混合的流体的离子强度足够低以允许电渗流。本发明的方法和装置优选应用于具有小于或等于约1mM的低离子强度的流体。

9. 发明授权

US07070681B2 Electrokinetic instability micromixer 失效
公开(公告)号：US07070681B2
公开(公告)日：2006-07-04
申请号：US10056944
申请日：2002-01-24
申请人： Juan G. Santiago , Michael H. Oddy , James C. Mikkelsen, Jr.
发明人： Juan G. Santiago , Michael H. Oddy , James C. Mikkelsen, Jr.
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： B01F13/0076 , B01F13/0001 , B01F13/0005 , B01F13/0077 , B01L3/5027 , Y10T137/87652
摘要： A novel electrokinetic instability (EKI) micromixer and method takes advantage of the EKI to effect active rapid stirring of confluent microstreams of biomolecules without moving parts or complex microfabrication processes. The EKI is induced using an alternating current (A/C) electric field. Within seconds, the randomly fluctuating, three-dimensional velocity field created by the EKI rapidly and effectively stirs an initially heterogeneous solution and generates a homogeneous solution that is useful in a variety of biochemical and bioanalytical systems. Microfabricated on a glass substrate, the inventive EKI micromixer can be easily and advantageously integrated in molecular diagnostics apparatuses and systems, such as a chip-based “Lab-on-a-Chip” microfluidic device.

10. 发明申请

US20040009614A1 Magnetic bead-based arrays 审中-公开
标题翻译：磁珠阵列
公开(公告)号：US20040009614A1
公开(公告)日：2004-01-15
申请号：US10276099
申请日：2003-08-04
发明人： Chong H Ahn , Hyoung J Cho , Jin-Woo Choi
IPC分类号： G01N033/553
CPC分类号： B01F13/0076 , B01F3/08 , B01F5/0403 , B01F13/0001 , B01F13/0005 , B01F13/0077 , B01F2215/0037 , B01J19/0046 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/0054 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00655 , B01J2219/00659 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2400/0415 , B01L2400/0487 , B03C1/00 , B03C1/0332 , B03C1/034 , B03C1/28 , B03C2201/18 , B03C2201/26 , C40B40/06 , C40B40/10 , C40B70/00 , G01N30/6095 , G01N35/0098 , G01N2030/347 , H01F10/16 , H01F41/16 , H01F41/26 , H01F41/34 , G01N2030/0035
摘要： The present invention relates to magnetic particle separators using micromachined magnetic arrays and more particularly, to magnetic particle separators or manipulators using controlled magnetization on micromachined magnetic arrays for the separation of cells and other biological materials. The present invention also pertains to using such devices for the separation and analysis of biological materials for immunoassays, DNA sequencing, protein analysis, and biochemical detection applications. The present invention can also be viewed as a novel method for fabricating fully integrated permanent magnet components within any microelectromechanical system (nullMEMSnull) structures. The present invention also provides a magnetic particle separation and manipulation system for rapid separation and accurate manipulation of magnetic particles in two-dimensional electromagnetic arrays, which utilize high throughput biological analyses. A disposable cartridge can be produced in low cost using a low cost substrate such as plastic or other polymer, glass, or metal. Magnetic flux is generated by conventional or micromachined electromagnets a platform system consisting of magnetic flux sources, magnetic flux guidance, and a microprocessor control interface. By controlling direction of electric currents into inductors on the platform system, arbitrary magnetic poles can be generated on Permalloy structures of the cartridge to separate and manipulate magnetic particles. The magnetic particle separator and manipulator in the present invention can be easily combined with automated detection systems such as a fluorescent monitoring system.
摘要翻译：本发明涉及使用微加工磁阵列的磁性颗粒分离器，更具体地说，涉及使用微加工磁阵列上的受控磁化的磁性颗粒分离器或操纵器来分离细胞和其它生物材料。本发明还涉及使用这种装置来分离和分析用于免疫测定，DNA测序，蛋白质分析和生物化学检测应用的生物材料。本发明还可以被看作是在任何微机电系统（“MEMS”）结构内制造完全集成的永磁体部件的新方法。本发明还提供一种用于快速分离和精确操作二维电磁阵列中的磁性粒子的磁性粒子分离和操纵系统，其利用高通量生物分析。可以使用低成本的基材例如塑料或其它聚合物，玻璃或金属，可以低成本地生产一次性盒。磁通由常规或微机电电磁铁产生，由磁通源，磁通引导和微处理器控制接口组成的平台系统。通过控制平台系统中电感器的电流方向，可以在墨盒的坡莫合金结构上产生任意磁极，以分离和操纵磁性颗粒。本发明的磁粉分离器和机械手可以容易地与诸如荧光监视系统的自动检测系统组合。

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