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1. 发明申请

US20110185442A1 Method of generating transgenic organisms using transposons 审中-公开
标题翻译：使用转座子产生转基因生物的方法
公开(公告)号：US20110185442A1
公开(公告)日：2011-07-28
申请号：US12655114
申请日：2009-12-23
申请人： Charalambos Savakis , Frank Grosveld
发明人： Charalambos Savakis , Frank Grosveld
IPC分类号： A01K67/02
CPC分类号： C12N15/902 , A01K67/0275 , A01K67/0334 , A01K67/0336 , A01K67/0337 , A01K67/0338 , A01K67/0339 , A01K2217/05 , A01K2217/20 , A01K2227/105 , C12N15/8202 , C12N15/8509 , C12N2800/30
摘要： The invention relates to a method for generating a transgenic organism. The invention also relates to a method for detecting and characterizing a genetic mutation in a transgenic organism. The invention further relates to a method for isolating a gene which is correlated with a phenotypic characteristic in a transgenic animal. The invention further relates to a method for isolating an exon in a transgenic animal. The invention also relates to a method for modulating the expression of a gene in an organism.
摘要翻译：本发明涉及一种产生转基因生物体的方法。本发明还涉及用于检测和表征转基因生物体中的遗传突变的方法。本发明还涉及分离与转基因动物中的表型特征相关的基因的方法。本发明还涉及用于分离转基因动物中的外显子的方法。本发明还涉及调节生物体中基因表达的方法。

2. 发明授权

US07435591B2 Compositions and methods for increasing animal size growth rate 失效
标题翻译：用于增加动物大小增长率的组合物和方法
公开(公告)号：US07435591B2
公开(公告)日：2008-10-14
申请号：US10502001
申请日：2003-01-27
申请人： Nisar P. Malek , James M. Roberts
发明人： Nisar P. Malek , James M. Roberts
IPC分类号： C12N5/06 , C12N5/10 , C12N5/00 , C12N5/02 , C12N15/00 , C12N15/87
CPC分类号： A01K67/0275 , A01K67/0338 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/02 , C07K14/4738 , C12N15/8509 , C12N2800/30
摘要： The present invention relates to germ line and somatic cells comprising a mutant p27kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making such transgenic animals which have increased size and/or growth rate.
摘要翻译：本发明涉及包含缺少Cdk2磷酸化位点的突变型p27Kip1蛋白的种系和体细胞。还提供了转基因动物和制备具有增加的大小和/或生长速率的转基因动物的方法。

3. 发明授权

US09049850B2 Insulin-like gene of prawns and uses thereof 有权
标题翻译：虾类胰岛素样基因及其用途
公开(公告)号：US09049850B2
公开(公告)日：2015-06-09
申请号：US12865854
申请日：2009-02-04
申请人： Amir Sagi , Tomer Ventura
发明人： Amir Sagi , Tomer Ventura
IPC分类号： C12N15/11 , A01K67/00 , A01K67/033 , C07K14/435 , C12N15/113
CPC分类号： A01K67/0338 , A01K2207/05 , A01K2217/058 , A01K2227/70 , A01K2267/02 , C07K14/43509 , C12N15/1136 , C12N2310/14
摘要： Nucleic acid molecules encoding an insulin-like factor of the androgenic gland of the freshwater prawn Macrobrachium rosenbergii (M. rosenbergii) are disclosed. Also disclosed are methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in M. rosenbergii, useful for producing male monosex populations.
摘要翻译：公开了编码淡水虾罗氏沼虾（Rosenbergii）雄激素腺的胰岛素样因子的核酸分子。还公开了沉默十二指甲甲壳类动物中的胰岛素样因子基因表达的方法，特别是在罗氏沼虾中，可用于产生雄性单体种群。

4. 发明申请

US20050223417A1 Compositions and methods for increasing animal size and growth rate 失效
标题翻译：用于增加动物大小和生长速度的组合物和方法
公开(公告)号：US20050223417A1
公开(公告)日：2005-10-06
申请号：US10502001
申请日：2003-01-27
申请人： Nisar Malek , James Roberts
发明人： Nisar Malek , James Roberts
IPC分类号： A01K67/027 , A01K67/033 , C07K14/47 , C12N5/02 , C12N15/85
CPC分类号： A01K67/0275 , A01K67/0338 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/02 , C07K14/4738 , C12N15/8509 , C12N2800/30
摘要： The present invention relates to germ line and somatic cells comprising a mutant p27kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making such transgenic animals which have increased size and/or growth rate.
摘要翻译：本发明涉及包含缺少Cdk2磷酸化位点的突变型p27Kip1蛋白的种系和体细胞。还提供了转基因动物和制备具有增加的大小和/或生长速率的转基因动物的方法。

5. 发明申请

US20040194156A1 Transgenic aquatic invertebrates as a bioreactor for production of recombinant polypeptides 审中-公开
标题翻译：转基因水生无脊椎动物作为重组多肽生产的生物反应器
公开(公告)号：US20040194156A1
公开(公告)日：2004-09-30
申请号：US10745288
申请日：2003-12-23
申请人： Califa LLC
发明人： Hao Fan
IPC分类号： A01K067/033
CPC分类号： A01K67/0338 , A01K2217/05 , A01K2227/70 , A01K2267/02
摘要： Disclosed are transgenic aquatic invertebrate for use as bioreactors to express heterologous recombinant polypeptides and its application. Also included are methods for producing transgenic Brine species and Brine cysts, and methods for expressing heterologous proteins is said cysts. The method includes introducing the foreign genes into cysts of a Brine shrimp, identification of transgenic individual and the generation of a parthenogenesis culture for transgene expression. The transgenic aquatic invertebrates described will be used as an alternative method for the low cost large-scale production of recombinant proteins, such as therapeutic proteins, polypeptide based vaccine or anti-microbial proteins, proteins for use as a food source in humans, animals and aquaculture.
摘要翻译：公开了用作生物反应器来表达异源重组多肽的转基因水生无脊椎动物及其应用。还包括生产转基因盐水种类和盐水囊肿的方法，表达异源蛋白质的方法就是囊肿。该方法包括将外来基因引入盐水虾的囊肿中，鉴定转基因个体和产生转基因表达的单性生殖培养物。所述的转基因水生无脊椎动物将被用作低成本大规模生产重组蛋白质的替代方法，所述重组蛋白质例如治疗性蛋白质，基于多肽的疫苗或抗微生物蛋白质，用作人类，动物中的食物来源的蛋白质水产养殖。

6. 发明授权

US06376743B1 Mammalian transgenesis by intracytoplasmic sperm injection 有权
标题翻译：通过胞质内精子注射的哺乳动物转基因
公开(公告)号：US06376743B1
公开(公告)日：2002-04-23
申请号：US09371648
申请日：1999-08-10
申请人： Ryuzo Yanagimachi
发明人： Ryuzo Yanagimachi
IPC分类号： A01K67027
CPC分类号： A01K67/0275 , A01K67/0335 , A01K67/0338 , A01K2217/05 , C12N15/87 , C12N15/89
摘要： Coinjection of unfertilized mouse oocytes with sperm heads and exogenous nucleic acid encoding a transgene results in transgene-expressing embryos, reflecting nucleic acid-sperm head association before coinjection. Nonselective transfer to surrogate mothers of embryos resulting from coinjection produced offspring expressing the integrated transgene.
摘要翻译：注射未受精的小鼠卵母细胞与精子头和编码转基因的外源核酸导致转基因表达的胚胎，反映核心 - 精子头关联在共注射之前。转移到由共同产生的胚胎替代母亲的无效转移产生表达整合的转基因的后代。

7. 发明授权

US07914998B2 Neurotransmitter signaling can regulate life span in C. elegans 有权
标题翻译：神经递质信号可以调节秀丽隐杆线虫的寿命
公开(公告)号：US07914998B2
公开(公告)日：2011-03-29
申请号：US10813324
申请日：2004-03-29
申请人： Heidi A. Tissenbaum , Christian Grove , Nenad Svrzikapa , Seung Wook Oh , Melissa Grabowski , Yamei Wang
发明人： Heidi A. Tissenbaum , Christian Grove , Nenad Svrzikapa , Seung Wook Oh , Melissa Grabowski , Yamei Wang
IPC分类号： G01N33/53
CPC分类号： A01K67/0338 , A01K2217/075 , A01K2227/703 , A01K2267/03
摘要： The present invention features methods of identifying modulators of longevity. Also featured are organisms, cell systems and compositions for performing those methods. Further featured are therapeutic methods for the use of modulators identified according to said methodologies.
摘要翻译：本发明特征在于识别寿命调节剂的方法。还具有用于进行这些方法的生物体，细胞系统和组合物。进一步的特征是使用根据所述方法鉴定的调节剂的治疗方法。

8. 发明申请

US20110065638A1 NOVEL CRUSTACEAN ANDROGENIC GLAND HORMONE 失效
标题翻译：新的CRUSTACEAN ANDROGENIC GLAND HORMONE
公开(公告)号：US20110065638A1
公开(公告)日：2011-03-17
申请号：US12736048
申请日：2009-03-05
申请人： Frank Van Breusegem , Jan Staelens , Marnik Vuylsteke
发明人： Frank Van Breusegem , Jan Staelens , Marnik Vuylsteke
IPC分类号： A61K38/22 , C07K14/575 , C07H21/00 , A61K31/7088 , C12Q1/68 , A61P15/00
CPC分类号： A01K67/0338 , A01K2207/05 , A01K2227/70 , A01K2267/02 , A61K38/00 , C07K14/43509
摘要： The present invention relates to a novel crustacean androgenic gland hormone. More specifically, the invention relates to an androgenic gland hormone derived from Penaeus monodon. The invention relates further to the use of the hormone to influence the sex ratio in prawn and shrimp cultures, and to set up monosex cultures. It is also related to the use of the hormone and its gene or fragments thereof in sex determination.
摘要翻译：本发明涉及一种新型甲壳动物激素腺激素。更具体地，本发明涉及源自对虾（Monica）的雄激素腺激素。本发明进一步涉及激素在虾和虾培养物中的性别比例的使用，以及建立单体培养物。它也与激素及其基因或其片段在性别测定中的应用有关。

9. 发明申请

US20060242719A1 Nucleotide sequences of shrimp beta-actin and actin promoters and their use in gentic transformation technology 审中-公开
标题翻译：虾β-肌动蛋白和肌动蛋白启动子的核苷酸序列及其在龙胆转化技术中的应用
公开(公告)号：US20060242719A1
公开(公告)日：2006-10-26
申请号：US10497583
申请日：2002-12-04
申请人： Piera Sun , Kristi Arakaki , Samuel Sun
发明人： Piera Sun , Kristi Arakaki , Samuel Sun
IPC分类号： A01K67/033 , A01K67/027 , C07H21/04 , C07K5/06 , A61K48/00
CPC分类号： A01K67/0338 , A01K67/0333 , A01K2217/05 , A01K2227/40 , A01K2267/02 , C12N15/85 , C12N15/8509 , C12N2830/00 , C12N2830/15 , C12N2830/75
摘要： The present invention relates to isolated actin and β-actin nucleic acid promoter molecules from shrimp; nucleic acid expression cassettes including actin and β-actin promoter molecules isolated from shrimp; and expression vectors, host cells, and transgenic animals transduced with the isolated actin and β-actin nucleic acid promoter. Also disclosed are methods for imparting to an animal resistance against a pathogen; regulating growth of an animal; increasing stress tolerance in an animal; and increasing cold tolerance in an animal that involve transforming an animal with a nucleic acid construct including the isolated actin and β-actin nucleic acid promoter molecules of the present invention. The present invention also relates to isolated nucleic acid molecules encoding for actin and β-actin proteins or polypeptides, as well as the proteins or polypeptides themselves.
摘要翻译：本发明涉及来自虾的分离的肌动蛋白和β-肌动蛋白核酸启动子分子; 核酸表达盒包括从虾分离的肌动蛋白和β-肌动蛋白启动子分子; 和用分离的肌动蛋白和β-肌动蛋白核酸启动子转导的表达载体，宿主细胞和转基因动物。还公开了赋予动物抗病原体抗性的方法; 调节动物的生长; 增加动物的耐力; 以及增加动物中的耐寒性，其涉及用包含本发明的分离的肌动蛋白和β-肌动蛋白核酸启动子分子的核酸构建体来转化动物。本发明还涉及编码肌动蛋白和β-肌动蛋白或多肽的分离的核酸分子，以及蛋白质或多肽本身。

10. 发明申请

US20050241011A1 Enclosed aquacultural systems for production of purified recombinant proteins 审中-公开
标题翻译：封闭的水产养殖系统用于生产纯化的重组蛋白
公开(公告)号：US20050241011A1
公开(公告)日：2005-10-27
申请号：US10510624
申请日：2003-04-08
申请人： F C Allnut , Moti Harel
发明人： F C Allnut , Moti Harel
IPC分类号： A01K61/00 , A01K67/027 , A01K67/033 , C12N15/85
CPC分类号： A01K67/0338 , A01K61/10 , A01K61/20 , A01K61/59 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/40 , A01K2227/70 , A01K2267/01 , C12N15/8509 , C12N2799/026
摘要： The invention provides a production method for purified recombinant proteins of commercial value prepared in enclosed aquatic systems. The production system provides biosecure containment of genetically engineered aquatic organisms for an alternative production method for complex proteins requiring post-translational modification that is best done in eukaryotic expression systems. Possible aquatic organisms that can be utilized by this invention are crustaceans (e.g. penaeid shrimp or Artemia) and teleost fish (e.g. trout or tilapia).
摘要翻译：本发明提供了在封闭水生系统中制备的商业价值的纯化重组蛋白的制备方法。生产系统提供生物安全控制基因工程水生生物，用于需要翻译后修饰的复杂蛋白质的替代生产方法，该方法最好在真核表达系统中进行。可用于本发明的可能的水生生物是甲壳类动物（例如对虾或卤虫）和硬骨鱼（例如鳟鱼或罗非鱼）。

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