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1. 发明授权

US07858327B2 Methods of identifying longevity modulators and therapeutic methods of use thereof 有权
标题翻译：识别寿命调节剂的方法及其使用的治疗方法
公开(公告)号：US07858327B2
公开(公告)日：2010-12-28
申请号：US10746910
申请日：2003-12-23
申请人： Heidi A. Tissenbaum , Seung Wook Oh
发明人： Heidi A. Tissenbaum , Seung Wook Oh
IPC分类号： A61K49/00 , G01N33/53 , G01N33/567
CPC分类号： G01N33/573
摘要： The present invention is based at least in part on the discovery of a role for the JNK signaling pathway in longevity. In particular, the present inventors have shown that modulation of the c-jun N-terminal kinase (JNK) signaling pathway in an organism, optionally in combination with modulation of the insulin receptor (IR) signaling pathway, can enhance longevity in an organism. Accordingly, the present invention features methods of identifying modulators of longevity in assays featuring organisms and/or cells having either a functional or deregulated JNK signaling pathway and, optionally, a functional or deregulated IR signaling pathway. Also featured is an in vitro method of identifying an agent capable of enhancing longevity featuring an assay composition having a JNK signaling pathway molecule and insulin signaling pathway molecule. Further featured are therapeutic methods for the use of JNK signaling pathway modulators to enhance longevity.
摘要翻译：本发明至少部分地基于JNK信号通路在长寿中的作用的发现。特别地，本发明人已经表明，生物体中c-jun N-末端激酶（JNK）信号传导途径的调节，任选地与调节胰岛素受体（IR）信号通路组合可以增强生物体的寿命。因此，本发明的特征在于鉴定具有功能性或失调的JNK信号传导途径的生物体和/或细胞的测定中鉴定长寿命调节剂的方法，以及任选的功能性或去调节的IR信号通路。还特征在于鉴定能够增强寿命特性的具有JNK信号传导途径分子和胰岛素信号通路分子的测定组合物的试剂的体外方法。进一步的特征是使用JNK信号通路调节剂来延长寿命的治疗方法。

2. 发明授权

US07932049B2 Methods of identifying longevity modulators and therapeutic methods of use thereof 有权
标题翻译：识别寿命调节剂的方法及其使用的治疗方法
公开(公告)号：US07932049B2
公开(公告)日：2011-04-26
申请号：US11372469
申请日：2006-03-08
申请人： Heidi A. Tissenbaum , Seung Wook Oh
发明人： Heidi A. Tissenbaum , Seung Wook Oh
IPC分类号： C12Q1/48 , G01N33/53
CPC分类号： G01N33/573
摘要： The present invention is based at least in part on the discovery of a role for the JNK signaling pathway in longevity. In particular, the present inventors have shown that overexpression of c-jun N-terminal kinase 1 (jnk-1) extends lifespan and that said extended lifespan is associated with DAF-16 phosphorylation by JNK-1 and the consequent DAF-16 localization to the nucleus. Accordingly, the present invention features methods of identifying modulators of longevity in assays featuring organisms and/or cells having a JNK signaling pathway and, optionally, an IR signaling pathway. Also featured is an in vitro method of identifying an agent capable of enhancing longevity featuring an assay composition having a JNK signaling pathway molecule and insulin signaling pathway molecule. Further featured are therapeutic methods for the use of JNK signaling pathway modulators to enhance longevity, to prevent or reduce obesity and to prevent or treat type II diabetes.
摘要翻译：本发明至少部分地基于JNK信号通路在长寿中的作用的发现。特别地，本发明人已经表明，c-jun N-末端激酶1（jnk-1）的过表达延长了寿命，并且所述延长的寿命与JNK-1的DAF-16磷酸化和随后的DAF-16定位相关核心因此，本发明的特征在于鉴定具有JNK信号传导途径和任选的IR信号传导途径的生物体和/或细胞的测定中鉴定寿命调节剂的方法。还特征在于鉴定能够增强寿命特性的具有JNK信号传导途径分子和胰岛素信号通路分子的测定组合物的试剂的体外方法。进一步的特征是使用JNK信号通路调节剂来增强寿命，预防或减少肥胖和预防或治疗II型糖尿病的治疗方法。

3. 发明授权

US07914998B2 Neurotransmitter signaling can regulate life span in C. elegans 有权
标题翻译：神经递质信号可以调节秀丽隐杆线虫的寿命
公开(公告)号：US07914998B2
公开(公告)日：2011-03-29
申请号：US10813324
申请日：2004-03-29
申请人： Heidi A. Tissenbaum , Christian Grove , Nenad Svrzikapa , Seung Wook Oh , Melissa Grabowski , Yamei Wang
发明人： Heidi A. Tissenbaum , Christian Grove , Nenad Svrzikapa , Seung Wook Oh , Melissa Grabowski , Yamei Wang
IPC分类号： G01N33/53
CPC分类号： A01K67/0338 , A01K2217/075 , A01K2227/703 , A01K2267/03
摘要： The present invention features methods of identifying modulators of longevity. Also featured are organisms, cell systems and compositions for performing those methods. Further featured are therapeutic methods for the use of modulators identified according to said methodologies.
摘要翻译：本发明特征在于识别寿命调节剂的方法。还具有用于进行这些方法的生物体，细胞系统和组合物。进一步的特征是使用根据所述方法鉴定的调节剂的治疗方法。

4. 发明申请

US20110286930A1 METHODS OF IDENTIFYING MODULATORS OF THE PP2A B56 BETA REGULATORY SUBUNIT 审中-公开
标题翻译：鉴定PP2A B56测定子调节剂的方法
公开(公告)号：US20110286930A1
公开(公告)日：2011-11-24
申请号：US13120613
申请日：2009-09-24
申请人： Heidi A. Tissenbaum , Srivatsan Padmanabhan , Arnab Mukhopadhyay , Sri Devi Narasimhan
发明人： Heidi A. Tissenbaum , Srivatsan Padmanabhan , Arnab Mukhopadhyay , Sri Devi Narasimhan
IPC分类号： A61K49/00 , C12Q1/02 , A61P3/04 , A61P35/00 , A61K31/713 , A61P3/10
CPC分类号： G01N33/5041 , G01N33/5085 , G01N2333/43534 , G01N2333/9121
摘要： The present invention is based at least in part on the discovery that the PP2A B56 regulatory subunit plays a role in regulating insulin signaling by directly regulating phosphorylation of AKT-I. Accordingly, the present invention features methods of identifying modulators of the PP2A B56 regulatory subunit in assays featuring organisms and/or cells. Further featured are therapeutic methods for the use of PP2A B56 regulatory subunit modulators to enhance longevity, to prevent or treat cancer, to prevent or reduce obesity and to prevent or treat type II diabetes.
摘要翻译：本发明至少部分地基于以下发现：PP2A B56调节亚基通过直接调节AKT-1的磷酸化来调节胰岛素信号传导的作用。因此，本发明的特征在于鉴定具有生物体和/或细胞的测定中鉴定PP2A B56调节亚基的调节剂的方法。进一步的特征是使用PP2A B56调节亚基调节剂来增强寿命，预防或治疗癌症，预防或减少肥胖症和预防或治疗II型糖尿病的治疗方法。

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