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1. 发明授权

US12121512B2 Anti-fungal agent 有权
公开(公告)号：US12121512B2
公开(公告)日：2024-10-22
申请号：US17602139
申请日：2020-04-06
申请人： SEREN PHARMACEUTICALS INC. , NIHON UNIVERSITY
发明人： Rui Kano , Osamu Ogawa
IPC分类号： A61K31/427 , A61P31/10
CPC分类号： A61K31/427 , A61P31/10
摘要： An object of the present invention is to provide an antifungal agent which is effective against cryptococcosis. The present invention provides an antifungal agent comprising ravuconazole as an active ingredient, wherein the agent is administered to an animal suffering from cryptococcosis. Further, the present invention provides an antifungal agent comprising ravuconazole as an active ingredient, wherein the agent is administered to an animal suffering from cryptococcus that is resistant to triazole-based antifungal agents selected from the group consisting of fluconazole, itraconazole and voriconazole.

2. 发明授权

US11104120B2 Three-dimensional printing system, three-dimensional printing method, molding device, fiber-containing object, and production method thereof 有权
公开(公告)号：US11104120B2
公开(公告)日：2021-08-31
申请号：US15313644
申请日：2015-05-27
申请人： Nihon University , Tokyo University of Science Foundation
发明人： Masahito Ueda , Yoshiyasu Hirano , Ryosuke Matsuzaki
IPC分类号： B29C64/209 , B33Y50/02 , B33Y80/00 , B33Y10/00 , B33Y30/00 , B29C64/118 , B29C64/295 , B29C70/38 , B29K105/08
摘要： A three-dimensional printing system (1) includes: a head (2) to which a first continuous material (FL) including a resin and a second continuous material (FB) including fibers are fed; a platform (3) on which a printing material based on the first and second continuous materials from the head is stacked; a cutting device (10) which is capable of cutting at least fibers; and a controller (5) which controls an operation device including at least one of the head, the platform, and the cutting device.

3. 发明授权

US09555466B2 Substrate joining method using rivet, and joining structure 有权
标题翻译：基板接合方法采用铆钉和接合结构
公开(公告)号：US09555466B2
公开(公告)日：2017-01-31
申请号：US14002297
申请日：2012-03-01
申请人： Masahito Ueda , Hiroyuki Hasegawa , Kinya Watanabe , Naoya Fujii
发明人： Masahito Ueda , Hiroyuki Hasegawa , Kinya Watanabe , Naoya Fujii
IPC分类号： B21J15/02 , F16B19/08 , B29C65/56 , B29C65/60 , B29C65/74 , B29C65/82 , B29C65/00 , F16B5/04
CPC分类号： B21J15/02 , B21J15/025 , B21J15/147 , B29C65/562 , B29C65/602 , B29C65/7437 , B29C65/8253 , B29C66/1122 , B29C66/21 , B29C66/43 , B29C66/721 , B29C66/7212 , B29C66/72143 , B29C66/7392 , B29C66/7394 , B29C66/81422 , B29C66/81423 , B29C66/81429 , B29C66/8322 , F16B5/04 , F16B19/08 , F16B19/086 , Y10T29/49956 , B29K2307/04 , B29K2309/08
摘要： A joining method includes punching respective laminated plate materials by a rivet shaft portion of a SPR, forming a crimp portion at the front end of the rivet shaft portion, and fastening and joining the laminated plate materials between the rivet head portion and the crimp portion. Washers are laid on and brought into contact with respective opposite surfaces relative to joining surfaces of the laminated plate materials, the washers each having an inner hole through which the rivet shaft portion is allowed to pass, the washers are used as jigs at the time of the punching, the punching by means of the rivet shaft portion is performed along the inner holes of the washers, and the joining is performed so that the washers left between the rivet head and the crimp portion and the opposite surfaces.
摘要翻译：接合方法包括通过SPR的铆钉轴部冲压各层压板材料，在铆钉轴部的前端形成压接部，并且将铆接头部和压接部之间的层叠板材紧固并接合。洗衣机相对于层压板材的接合面铺设在相应的相对表面上，每个垫圈具有内孔，铆钉轴部分可以通过该内孔，垫圈在夹具时被用作夹具通过冲压，沿着垫圈的内孔进行铆钉轴部的冲压，进行接合，使得垫圈保持在铆钉头和压接部之间以及相对的表面。

4. 发明申请

US20160374188A1 Magnetized Coaxial Plasma Generation Device 有权
标题翻译：磁化同轴等离子体发生装置
公开(公告)号：US20160374188A1
公开(公告)日：2016-12-22
申请号：US14902477
申请日：2014-06-30
申请人： NIHON UNIVERSITY
发明人： Tomohiko Asai , Jun'ichi Sekiguchi , Tadafumi Matsumoto
IPC分类号： H05H1/12 , H05H1/48
CPC分类号： H05H1/12 , H05H1/02 , H05H1/24 , H05H1/46 , H05H1/48 , H05H2001/466
摘要： Provided is a magnetized coaxial plasma generation device having increased magnetization efficiency and capable of improving power conservation and reducing the thermal load on a coil. The magnetized coaxial plasma generation device generating spheromak plasma comprises: an external electrode (1); an internal electrode (2); a plasma generation gas supply section (3); a power supply circuit (4); a bias coil (5); a pulse power supply (6) for the bias coil; a magnetic flux conservation section (7); and a control section (8). The bias coil (5) is disposed inside the internal electrode and generates a bias magnetic field between the external and internal electrodes. The pulse power supply (6) for the bias coil pulse-drives the bias coil. The magnetic flux conservation section (7) is disposed outside the external electrode. The control section controls the pulse power supply for the bias coil so as to pulse-drive the bias coil for a time sufficient to apply a bias magnetic field necessary to generate the spheromak plasma between the external and internal electrodes and within a time shorter than a skin time of the magnetic flux of the bias magnetic field into the magnetic flux conservation section.
摘要翻译：提供了一种磁化同轴等离子体产生装置，其具有增加的磁化效率并且能够改善功率节省并降低线圈上的热负荷。产生Spheromak等离子体的磁化同轴等离子体产生装置包括：外部电极（1）; 内部电极（2）; 等离子体产生气体供给部（3）; 电源电路（4）; 偏置线圈（5）; 用于偏置线圈的脉冲电源（6）; 磁通保护部（7）; 和控制部（8）。偏置线圈（5）设置在内部电极内部，并且在外部和内部电极之间产生偏置磁场。用于偏置线圈的脉冲电源（6）对偏置线圈进行脉冲驱动。磁通保护部（7）配置在外部电极的外侧。控制部分控制用于偏置线圈的脉冲电源，以便将偏置线圈脉冲驱动一段足以施加在外部和内部电极之间产生脉冲等离子体所需的偏置磁场的时间，并且在短于偏磁场的磁通量的皮肤时间进入磁通保护部。

5. 发明申请

US20160113970A1 PERIODONTAL TISSUE REGENERATION MATERIAL 审中-公开
标题翻译：周围组织再生材料
公开(公告)号：US20160113970A1
公开(公告)日：2016-04-28
申请号：US14895998
申请日：2014-06-02
申请人： NIHON UNIVERSITY
发明人： Masaki HONDA , Daisuke AKITA , Koichiro KANO , Taro MATSUMOTO , Tadashi KANEKO , Katsuyuki YAMANAKA , Yuuhiro SAKAI
IPC分类号： A61K35/35 , A61K47/34
CPC分类号： A61K35/35 , A61K47/34 , A61L27/18 , A61L27/3834 , A61L27/3865 , A61L27/3895 , A61L27/54 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61L2300/64 , A61L2430/12 , C08L67/04
摘要： It is a problem of the present invention to provide a convenient and safe periodontal tissue regeneration material and provide a method of regenerating a periodontal tissue. The present invention provides a periodontal tissue regeneration material comprising dedifferentiated fat cells (DFAT) as the convenient and safe periodontal tissue regeneration material. The present invention provides a method of regenerating a periodontal tissue with the periodontal tissue regeneration material.
摘要翻译：本发明的问题在于提供一种便利且安全的牙周组织再生材料，并提供再生牙周组织的方法。本发明提供了一种牙周组织再生材料，其包含去分化脂肪细胞（DFAT）作为便利且安全的牙周组织再生材料。本发明提供了用牙周组织再生材料再生牙周组织的方法。

6. 发明授权

US09185558B2 Authentication server and authentication method by authentication server 有权
标题翻译：认证服务器认证服务器和认证方式
公开(公告)号：US09185558B2
公开(公告)日：2015-11-10
申请号：US13883967
申请日：2011-11-02
申请人： Masami Kihara , Takahiro Tsuchiya
发明人： Masami Kihara , Takahiro Tsuchiya
IPC分类号： G06F7/04 , G06F15/16 , G06F17/30 , H04L29/06 , H04W12/06 , G06F21/55 , H04W12/08
CPC分类号： H04W12/06 , G06F21/554 , H04L63/102 , H04W12/08
摘要： An authentication server capable of determining securely and accurately whether an access source is a cellular phone or a computer when a content is accessed with being limited to cellular phone users. The authentication server including a transmission delay time measuring unit that measures a transmission delay time between the authentication server and a communication terminal over a plurality of times, a transmission delay time distribution property determining unit that determines whether or not a distribution property of the transmission delay time measured over the plurality of times is discrete, and a content access authentication unit recognizing that the communication terminal is a wireless communication terminal and approving the access to the contents when the distribution property of the transmission delay time is determined as being discrete and recognizing that the communication terminal is a wired communication terminal and denying the access to the contents when the distribution property of the transmission delay time is determined as not being discrete.
摘要翻译：一种身份验证服务器，能够在限制蜂窝电话用户访问内容时，能够安全准确地确定访问源是移动电话还是计算机。所述认证服务器包括传输延迟时间测量单元，其测量所述认证服务器和通信终端之间的传输延迟时间多次;传输延迟时间分布特性确定单元，确定所述传输延迟的分布属性多个时间测量的时间是离散的，并且当传输延迟时间的分布属性被确定为离散时，内容访问认证单元识别出通信终端是无线通信终端并且批准对内容的访问，并且识别通信终端是有线通信终端，并且当传输延迟时间的分布属性被确定为不是离散的时，拒绝对内容的访问。

7. 发明授权

US08895564B2 Biguanide derivative compound 有权
标题翻译：双胍衍生物
公开(公告)号：US08895564B2
公开(公告)日：2014-11-25
申请号：US13991344
申请日：2011-12-01
申请人： Muneharu Miyake , Tadashi Kusama , Takashi Masuko
发明人： Muneharu Miyake , Tadashi Kusama , Takashi Masuko
IPC分类号： C07D241/34 , C07D241/28 , A61K31/4965
CPC分类号： C07D241/34 , A61K31/4965 , C07D241/28
摘要： Provided is a novel compound which simultaneously inhibits both NMDA receptors and ASIC1a, which are associated with neurodegenerative disease and so on, and thus is useful for the prevention and treatment of various nervous system diseases. A biguanide derivative represented by the following general formula (1), a salt thereof, or a hydrate of the derivative or the salt: wherein, X1 represents a halogen atom, R1 represents an alkyl group, an optionally substituted aryl group, or an optionally substituted aralkyl group.
摘要翻译：提供同时抑制与神经变性疾病等相关的NMDA受体和ASIC1a的新型化合物，因此可用于预防和治疗各种神经系统疾病。由以下通式（1）表示的双胍衍生物，其盐或其衍生物或盐的水合物：其中，X1表示卤素原子，R1表示烷基，任选取代的芳基或任意取代的芳基取代的芳烷基。

8. 发明申请

US20130281464A1 BIGUANIDE DERIVATIVE COMPOUND 有权
标题翻译： BIGUANIDE衍生化合物
公开(公告)号：US20130281464A1
公开(公告)日：2013-10-24
申请号：US13991344
申请日：2011-12-01
申请人： Muneharu Miyake , Tadashi Kusama , Takashi Masuko
发明人： Muneharu Miyake , Tadashi Kusama , Takashi Masuko
IPC分类号： C07D241/34
CPC分类号： C07D241/34 , A61K31/4965 , C07D241/28
摘要： Provided is a novel compound which simultaneously inhibits both NMDA receptors and ASIC1a, which are associated with neurodegenerative disease and so on, and thus is useful for the prevention and treatment of various nervous system diseases. A biguanide derivative represented by the following general formula (1), a salt thereof, or a hydrate of the derivative or the salt: wherein, X1 represents a halogen atom, R1 represents an alkyl group, an optionally substituted aryl group, or an optionally substituted aralkyl group.
摘要翻译：提供同时抑制与神经变性疾病等相关的NMDA受体和ASIC1a的新型化合物，因此可用于预防和治疗各种神经系统疾病。由以下通式（1）表示的双胍衍生物，其盐或其衍生物或盐的水合物：其中，X1表示卤素原子，R1表示烷基，任选取代的芳基或任意取代的芳基取代的芳烷基。

9. 发明申请

US20130232550A1 AUTHENTICATION SERVER AND AUTHENTICATION METHOD BY AUTHENTICATION SERVER 有权
标题翻译：认证服务器认证服务器和认证方法
公开(公告)号：US20130232550A1
公开(公告)日：2013-09-05
申请号：US13883967
申请日：2011-11-02
申请人： Masami Kihara , Takahiro Tsuchiya
发明人： Masami Kihara , Takahiro Tsuchiya
IPC分类号： H04W12/06
CPC分类号： H04W12/06 , G06F21/554 , H04L63/102 , H04W12/08
摘要： An authentication server capable of determining securely and accurately whether an access source is a cellular phone or a computer when a content is accessed with being limited to cellular phone users. The authentication server including a transmission delay time measuring unit that measures a transmission delay time between the authentication server and a communication terminal over a plurality of times, a transmission delay time distribution property determining unit that determines whether or not a distribution property of the transmission delay time measured over the plurality of times is discrete, and a content access authentication unit recognizing that the communication terminal is a wireless communication terminal and approving the access to the contents when the distribution property of the transmission delay time is determined as being discrete and recognizing that the communication terminal is a wired communication terminal and denying the access to the contents when the distribution property of the transmission delay time is determined as not being discrete.
摘要翻译：一种身份验证服务器，能够在限制蜂窝电话用户访问内容时，能够安全准确地确定访问源是移动电话还是计算机。所述认证服务器包括传输延迟时间测量单元，其测量所述认证服务器和通信终端之间的传输延迟时间多次;传输延迟时间分布特性确定单元，确定所述传输延迟的分布属性多个时间测量的时间是离散的，并且当传输延迟时间的分布属性被确定为离散时，内容访问认证单元识别出通信终端是无线通信终端并且批准对内容的访问，并且识别通信终端是有线通信终端，并且当传输延迟时间的分布属性被确定为不是离散的时，拒绝对内容的访问。

10. 发明授权

US08372587B2 Proliferative disease detection method 失效
标题翻译：增生病检测方法
公开(公告)号：US08372587B2
公开(公告)日：2013-02-12
申请号：US12937407
申请日：2009-04-14
申请人： Hiroki Nagase , Yui Shinojima , Tadashi Terui
发明人： Hiroki Nagase , Yui Shinojima , Tadashi Terui
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要： In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.
摘要翻译：在本发明中，使用在增殖性疾病中特异性发现的Zar1基因的基因组DNA的甲基化作为标记。具体地，本发明提供了检测增殖性疾病的方法，其包括检测生物样品中Zar1基因的基因组DNA的甲基化。由此提供了使用具有高检测率和低假阳性率的标记物来检测增殖性疾病的方法。

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